KEGG PATHWAY: hsa00760

KEGG

PATHWAY: hsa00760

Entry

hsa00760 Pathway

Name

Nicotinate and nicotinamide metabolism - Homo sapiens (human)

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

Nicotinate and nicotinamide metabolism

Module

NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:hsa00760]

Drug

Forodesine hydrochloride (JAN/USAN)

Peldesine (USAN)

Forodesine (USAN/INN)

Teglarinad chloride (USAN/INN)

Ulodesine (USAN)

Ulodesine succinate (USAN)

Other DBs

UMBBD:

GO:

Organism

Homo sapiens (human) [GN:hsa]

Gene

ASPDH; aspartate dehydrogenase domain containing [KO:K06989] [EC:1.4.1.21]

QPRT; quinolinate phosphoribosyltransferase [KO:K00767] [EC:2.4.2.19]

NAPRT; nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]

4860	PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]

NMRK1; nicotinamide riboside kinase 1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]

NMRK2; nicotinamide riboside kinase 2 [KO:K10524] [EC:2.7.1.22 2.7.1.173]

NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]

NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]

NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]

NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]

NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]

NT5C1B-RDH14; NT5C1B-RDH14 readthrough [KO:K01081] [EC:3.1.3.5]

4907	NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]

NMNAT3; nicotinamide nucleotide adenylyltransferase 3 [KO:K06210] [EC:2.7.7.1 2.7.7.18]

NMNAT1; nicotinamide nucleotide adenylyltransferase 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]

NMNAT2; nicotinamide nucleotide adenylyltransferase 2 [KO:K06210] [EC:2.7.7.1 2.7.7.18]

5167	ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]

5169	ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]

NUDT12; nudix hydrolase 12 [KO:K03426] [EC:3.6.1.22]

NADSYN1; NAD synthetase 1 [KO:K01950] [EC:6.3.5.1]

NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]

952	CD38; CD38 molecule [KO:K01242] [EC:3.2.2.6 2.4.99.20]

683	BST1; bone marrow stromal cell antigen 1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]

SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]

SIRT2; sirtuin 2 [KO:K11412] [EC:2.3.1.286]

SIRT3; sirtuin 3 [KO:K11413] [EC:2.3.1.286]

SIRT4; sirtuin 4 [KO:K11414] [EC:2.3.1.286]

SIRT5; sirtuin 5 [KO:K11415] [EC:2.3.1.286]

SIRT6; sirtuin 6 [KO:K11416] [EC:2.3.1.286]

SIRT7; sirtuin 7 [KO:K11417] [EC:2.3.1.286]

NADK; NAD kinase [KO:K00858] [EC:2.7.1.23]

NADK2; NAD kinase 2, mitochondrial [KO:K00858] [EC:2.7.1.23]

NNT; nicotinamide nucleotide transhydrogenase [KO:K00323] [EC:1.6.1.2 7.1.1.1]

4837	NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]

316	AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]

Compound

NAD+

NADP+

Pyruvate

Succinate

L-Aspartate

Glycerone phosphate

Fumarate

Nicotinamide

Propanoate

Succinate semialdehyde

Nicotinate

4-Aminobutanoate

Nicotinamide D-ribonucleotide

Deamino-NAD+

2,3-Dimethylmaleate

N-Methylnicotinate

6-Hydroxynicotinate

(S)-6-Hydroxynicotine

2,5-Dihydroxypyridine

Nicotinate D-ribonucleotide

6-Hydroxypseudooxynicotine

Maleic acid

Maleamate

Methylitaconate

1-Methylnicotinamide

2-Methyleneglutarate

(R)-6-Hydroxynicotine

2,6-Dihydroxypyridine

Nicotinamide-beta-riboside

2,3,6-Trihydroxypyridine

(2R,3S)-2,3-Dimethylmalate

Quinolinate

6-Oxo-1,4,5,6-tetrahydronicotinate

Nicotinurate

Iminoaspartate

Nicotinate D-ribonucleoside

N1-Methyl-2-pyridone-5-carboxamide

N1-Methyl-4-pyridone-5-carboxamide

1-Methylpyrrolinium

2,6-Dihydroxynicotinate

2,6-Dihydroxypseudooxynicotine

4-Methylaminobutyrate

(R,S)-Nicotine

2,6-Dihydroxy-N-methylmyosmine

Blue pigment

2-Formylglutarate

(S)-2-(Hydroxymethyl)glutarate

N-Formylmaleamic acid

4-Oxo-1-(3-pyridyl)-1-butanone

3-Succinoylpyridine

6-Hydroxy-3-succinoylpyridine

Pseudooxynicotine

3,3'-Bipyridine-2,2',5,5',6,6'-hexol

5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol

N-Methylmyosmine

Reference

Authors

BEHRMAN EJ, STANIER RY.

Title

The bacterial oxidation of nicotinic acid.

Journal

J Biol Chem 228:923-45 (1957)

Reference

Authors

Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.

Title

Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.

Journal

Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103

Reference

Authors

Baitsch D, Sandu C, Brandsch R, Igloi GL.

Title

Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.

Journal

J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001

Reference

Authors

Sachelaru P, Schiltz E, Igloi GL, Brandsch R.

Title

An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.

Journal

J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005

Reference

Authors

Gherna RL, Richardson SH, Rittenberg SC

Title

The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.

Journal

J Biol Chem 240:3669-74 (1965)

Reference

Authors

Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N

Title

Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.

Journal

J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818

Related
pathway

Citrate cycle (TCA cycle)

Alanine, aspartate and glutamate metabolism

Tryptophan metabolism

Pyruvate metabolism

KO pathway

All links

Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG GENES (35)   
All databases (36)   

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