KEGG   PATHWAY: loa04120
Entry
loa04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Loa loa (eye worm)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
loa04120  Ubiquitin mediated proteolysis
loa04120

Other DBs
GO: 0016567
Organism
Loa loa (eye worm) [GN:loa]
Gene
LOAG_17371  ubiquitin-60S ribosomal protein L40 [KO:K02927]
LOAG_04017  ubiquitin [KO:K02977]
LOAG_04428  polyubiquitin 1 [KO:K02977]
LOAG_16473  ubiquitin-activating enzyme E1 [KO:K03178] [EC:6.2.1.45]
LOAG_02750  hypothetical protein [KO:K10684] [EC:6.2.1.45]
LOAG_07505  ThiF family protein [KO:K10685] [EC:6.2.1.45]
LOAG_01766  ectopic membrane ruffles in embryo protein 1 [KO:K10686] [EC:6.2.1.64]
LOAG_02518  ubiquitin-conjugating enzyme E2 1 [KO:K10573] [EC:2.3.2.23]
LOAG_02883  ubiquitin-conjugating enzyme E2 2 [KO:K06689] [EC:2.3.2.23]
LOAG_06620  ubiquitin-conjugating enzyme E2 2 [KO:K06689] [EC:2.3.2.23]
LOAG_01130  ubiquitin-conjugating enzyme family protein [KO:K20217] [EC:2.3.2.23]
LOAG_03433  ubiquitin-conjugating enzyme family protein [KO:K10687] [EC:2.3.2.34]
LOAG_00879  ubiquitin-conjugating enzyme E [KO:K10575] [EC:2.3.2.23]
LOAG_01940  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
LOAG_05352  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
LOAG_08716  ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
LOAG_05393  SUMO-conjugating enzyme UBC9 [KO:K10577]
LOAG_05499  hypothetical protein [KO:K10578] [EC:2.3.2.23]
LOAG_03681  ubiquitin conjugating enzyme 6 [KO:K04554] [EC:2.3.2.23]
LOAG_03682  ubiquitin-conjugating enzyme family protein [KO:K04554] [EC:2.3.2.23]
LOAG_10437  hypothetical protein [KO:K04649] [EC:2.3.2.23]
LOAG_08767  ubiquitin-conjugating enzyme [KO:K04552] [EC:2.3.2.23]
LOAG_09096  ubiquitin-conjugating enzyme family protein [KO:K04552] [EC:2.3.2.23]
LOAG_08714  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
LOAG_03706  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
LOAG_12047  ubiquitin-conjugating enzyme E2Q [KO:K10582] [EC:2.3.2.23]
LOAG_11770  ubiquitin conjugating enzyme protein 3 [KO:K02207] [EC:2.3.2.23]
LOAG_02096  hypothetical protein [KO:K10688] [EC:2.3.2.23 2.3.2.25]
LOAG_06133  ubiquitin-protein ligase UBE3B [KO:K10588] [EC:2.3.2.26]
LOAG_16627  ubiquitin protein ligase [KO:K10589] [EC:2.3.2.26]
LOAG_18030  WW domain-containing protein [KO:K05633] [EC:2.3.2.26]
LOAG_17760  thyroid hormone receptor interactor 12 [KO:K10590] [EC:2.3.2.26]
LOAG_07133  Nedd4-PD [KO:K10591] [EC:2.3.2.26]
LOAG_16448  WWE domain-containing protein [KO:K10592] [EC:2.3.2.26]
LOAG_18553  E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
LOAG_16556  hect domain and RLD 4 [KO:K10615] [EC:2.3.2.26]
LOAG_04004  U-box domain-containing protein [KO:K10597] [EC:2.3.2.27]
LOAG_16502  hypothetical protein [KO:K09561] [EC:2.3.2.27]
LOAG_17970  peptidyl-prolyl cis-trans isomerase [KO:K10598] [EC:5.2.1.8]
LOAG_04853  nuclear matrix protein SNEV [KO:K10599] [EC:2.3.2.27]
LOAG_05836  signal transduction protein CBL-B [KO:K04707] [EC:2.3.2.27]
LOAG_05984  IBR domain-containing protein [KO:K04556] [EC:2.3.2.31]
LOAG_09726  hypothetical protein [KO:K04506] [EC:2.3.2.27]
LOAG_16548  E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
LOAG_05528  MIZ zinc finger family protein [KO:K04706] [EC:2.3.2.-]
LOAG_09127  hypothetical protein [KO:K10601] [EC:2.3.2.27]
LOAG_03239  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
LOAG_02338  S-phase kinase-associated protein 1 [KO:K03094]
LOAG_17244  hypothetical protein [KO:K03094]
LOAG_03465  hypothetical protein [KO:K03362]
LOAG_16563  F-box domain-containing protein [KO:K10260]
LOAG_02553  hypothetical protein [KO:K10260]
LOAG_00325  hypothetical protein [KO:K03870]
LOAG_01824  transcription elongation factor B polypeptide 1 [KO:K03872]
LOAG_04024  hypothetical protein [KO:K03873]
LOAG_17040  hypothetical protein [KO:K03871]
LOAG_09049  Cullin 3 [KO:K03869]
LOAG_05672  BTB/POZ domain-containing protein [KO:K03876]
LOAG_04763  hypothetical protein [KO:K10609]
LOAG_18703  CPSF A subunit region family protein [KO:K10610]
LOAG_08405  hypothetical protein [KO:K10570]
LOAG_16674  hypothetical protein [KO:K10571]
LOAG_09011  RING finger protein [KO:K10611]
LOAG_16572  Cullin-5 [KO:K10612]
LOAG_01568  hypothetical protein [KO:K03358]
LOAG_03389  hypothetical protein [KO:K03349]
LOAG_09228  hypothetical protein [KO:K03363]
LOAG_01868  hypothetical protein [KO:K03364]
LOAG_17680  hypothetical protein [KO:K03348]
LOAG_18004  TPR Domain containing protein [KO:K03350]
LOAG_05004  hypothetical protein [KO:K03351]
LOAG_17376  hypothetical protein [KO:K03352]
LOAG_16726  CBR-EMB-27 protein [KO:K03353]
LOAG_04786  TPR Domain containing protein [KO:K03354]
LOAG_01755  anaphase promoting complex subunit 8/cdc23 family protein [KO:K03355]
LOAG_00259  anaphase promoting complex subunit 10 [KO:K03357]
LOAG_01662  anaphase promoting complex subunit 13 [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
loa03050  Proteasome
KO pathway
ko04120   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (77)   
   KEGG GENES (77)   
All databases (78)   

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