KEGG   PATHWAY: pfa03040
Entry
pfa03040                    Pathway                                
Name
Spliceosome - Plasmodium falciparum 3D7
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pfa03040  Spliceosome
pfa03040

Other DBs
GO: 0005681
Organism
Plasmodium falciparum 3D7 [GN:pfa]
Gene
PF3D7_1137000  U2 spliceosomal RNA [KO:K14277]
PF3D7_0308400  U4 spliceosomal RNA [KO:K14278]
PF3D7_0508700  pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative [KO:K12811] [EC:5.6.2.7]
PF3D7_0209800  ATP-dependent RNA helicase UAP56 [KO:K12812] [EC:5.6.2.7]
PF3D7_1364300  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
PF3D7_1220100  pre-mRNA-processing factor 17, putative [KO:K12816]
PF3D7_0922700  pre-mRNA-splicing factor 18, putative [KO:K12817]
PF3D7_1030100  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative [KO:K12818] [EC:5.6.2.6]
PF3D7_0610100  pre-mRNA-splicing factor SLU7, putative [KO:K12819]
PF3D7_0917600  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative [KO:K12820] [EC:5.6.2.6]
PF3D7_1414800  small nuclear ribonucleoprotein-associated protein B, putative [KO:K11086]
PF3D7_1125500  small nuclear ribonucleoprotein Sm D1, putative [KO:K11087]
PF3D7_0218500  small nuclear ribonucleoprotein Sm D2, putative [KO:K11096]
PF3D7_0909800  small nuclear ribonucleoprotein Sm D3, putative [KO:K11088]
PF3D7_1350200  small nuclear ribonucleoprotein E, putative [KO:K11097]
PF3D7_1126900  small nuclear ribonucleoprotein F, putative [KO:K11098]
PF3D7_0822300  small nuclear ribonucleoprotein G, putative [KO:K11099]
PF3D7_1367100  U1 small nuclear ribonucleoprotein 70 kDa homolog, putative [KO:K11093]
PF3D7_0812700  U1 small nuclear ribonucleoprotein C, putative [KO:K11095]
PF3D7_1316500  pre-mRNA-processing factor 40, putative [KO:K12821]
PF3D7_1227100  DNA helicase 60 [KO:K12823] [EC:5.6.2.7]
PF3D7_1445900  ATP-dependent RNA helicase DDX5, putative [KO:K12823] [EC:5.6.2.7]
PF3D7_1369700  U2 small nuclear ribonucleoprotein A', putative [KO:K11092]
PF3D7_0935000  U2 small nuclear ribonucleoprotein B'', putative [KO:K11094]
PF3D7_1474500  splicing factor 3A subunit 1, putative [KO:K12825]
PF3D7_0619900  splicing factor 3A subunit 2, putative [KO:K12826]
PF3D7_0924700  splicing factor 3A subunit 3, putative [KO:K12827]
PF3D7_0308900  splicing factor 3B subunit 1, putative [KO:K12828]
PF3D7_1461600  splicing factor 3B subunit 2, putative [KO:K12829]
PF3D7_1234800  splicing factor 3B subunit 3, putative [KO:K12830]
PF3D7_1420000  splicing factor 3B subunit 4, putative [KO:K12831]
PF3D7_1355800  splicing factor 3B subunit 5, putative [KO:K12832]
PF3D7_1224900  splicing factor 3B subunit 6, putative [KO:K12833]
PF3D7_1018600  tRNA wybutosine-synthesizing protein, putative [KO:K12834]
PF3D7_1018500  pre-mRNA-splicing factor RDS3, putative [KO:K12834]
PF3D7_1119300  splicing factor U2AF small subunit, putative [KO:K12836]
PF3D7_1468800  splicing factor U2AF large subunit, putative [KO:K12837]
PF3D7_1454000  RNA-binding protein, putative [KO:K12840]
PF3D7_1402700  U2 snRNP-associated SURP motif-containing protein, putative [KO:K12842]
PF3D7_0520300  U6 snRNA-associated Sm-like protein LSm2, putative [KO:K12621]
PF3D7_0819900  U6 snRNA-associated Sm-like protein LSm3, putative [KO:K12622]
PF3D7_1107000  U6 snRNA-associated Sm-like protein LSm4, putative [KO:K12623]
PF3D7_1443300  U6 snRNA-associated Sm-like protein LSm5, putative [KO:K12624]
PF3D7_1325000  U6 snRNA-associated Sm-like protein LSm6, putative [KO:K12625]
PF3D7_1209200  U6 snRNA-associated Sm-like protein LSm7, putative [KO:K12626]
PF3D7_0829300  U6 snRNA-associated Sm-like protein LSm8, putative [KO:K12627]
PF3D7_1309300  U4/U6 small nuclear ribonucleoprotein PRP3, putative [KO:K12843]
PF3D7_1343900  U4/U6 small nuclear ribonucleoprotein PRP4, putative [KO:K12662]
PF3D7_0804800  peptidyl-prolyl cis-trans isomerase [KO:K09567] [EC:5.2.1.8]
PF3D7_0409100  U4/U6 small nuclear ribonucleoprotein PRP31, putative [KO:K12844]
PF3D7_1123900  13 kDa ribonucleoprotein-associated protein, putative [KO:K12845]
PF3D7_1317000  U4/U6.U5 tri-snRNP-associated protein 2, putative [KO:K12847]
PF3D7_0323700  U4/U6.U5 tri-snRNP-associated protein 1, putative [KO:K11984]
PF3D7_1132600  pre-mRNA-splicing factor 38A, putative [KO:K12849]
PF3D7_1407300  pre-mRNA-splicing factor 38B, putative [KO:K12850]
PF3D7_1003800  U5 small nuclear ribonucleoprotein component, putative [KO:K12852]
PF3D7_0422500  pre-mRNA-splicing helicase BRR2, putative [KO:K12854] [EC:5.6.2.6]
PF3D7_1110200  pre-mRNA-processing factor 6, putative [KO:K12855]
PF3D7_0405400  pre-mRNA-processing-splicing factor 8, putative [KO:K12856]
PF3D7_0822800  U5 small nuclear ribonucleoprotein 40 kDa protein, putative [KO:K12857]
PF3D7_0518500  ATP-dependent RNA helicase DDX23, putative [KO:K12858] [EC:5.6.2.7]
PF3D7_1231500  mitosis protein dim1, putative [KO:K12859]
PF3D7_0308600  pre-mRNA-processing factor 19, putative [KO:K10599] [EC:2.3.2.27]
PF3D7_1033600  pre-mRNA-splicing factor CEF1, putative [KO:K12860]
PF3D7_0614400  pre-mRNA-splicing factor CWF7, putative [KO:K12861]
PF3D7_0302000  pre-mRNA-splicing factor PRP46, putative [KO:K12862]
PF3D7_0722500  pre-mRNA-splicing factor CWC15, putative [KO:K12863]
PF3D7_1138600  beta-catenin-like protein 1, putative [KO:K12864]
PF3D7_0818900  heat shock protein 70 [KO:K03283]
PF3D7_0831700  heat shock protein 70 [KO:K03283]
PF3D7_0218700  pre-mRNA-processing protein 45, putative [KO:K06063]
PF3D7_1235900  pre-mRNA-splicing factor SYF1, putative [KO:K12867]
PF3D7_0403700  pre-mRNA-splicing factor CLF1, putative [KO:K12869]
PF3D7_1472000  pre-mRNA-splicing factor ISY1, putative [KO:K12870]
PF3D7_0528700  peptidyl-prolyl cis-trans isomerase [KO:K12733] [EC:5.2.1.8]
PF3D7_1451500  pre-mRNA-splicing factor CWF18, putative [KO:K12871]
PF3D7_1248200  pre-mRNA-splicing factor RBM22, putative [KO:K12872]
PF3D7_0522800  pre-mRNA-splicing factor BUD31, putative [KO:K12873]
PF3D7_1352700  intron-binding protein aquarius, putative [KO:K12874]
PF3D7_0422700  eukaryotic initiation factor 4A-III, putative [KO:K13025] [EC:5.6.2.7]
PF3D7_1406000  RNA-binding protein 8A, putative [KO:K12876]
PF3D7_0725200  mago nashi protein homologue, putative [KO:K12877]
PF3D7_0615700  RNA and export factor binding protein, putative [KO:K12881]
PF3D7_0415500  nuclear cap-binding protein subunit 2, putative [KO:K12883]
PF3D7_1119800  alternative splicing factor ASF-1, putative [KO:K12890]
PF3D7_0517300  serine/arginine-rich splicing factor 1 [KO:K12890]
PF3D7_1022400  serine/arginine-rich splicing factor 4 [KO:K12893]
PF3D7_0503300  serine/arginine-rich splicing factor 12 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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Genome (1)   
   KEGG GENOME (1)   
Gene (88)   
   KEGG GENES (88)   
All databases (89)   

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