KEGG   PATHWAY: pkn03040
Entry
pkn03040                    Pathway                                
Name
Spliceosome - Plasmodium knowlesi
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pkn03040  Spliceosome
pkn03040

Other DBs
GO: 0005681
Organism
Plasmodium knowlesi [GN:pkn]
Gene
PKNH_0935200  U2 spliceosomal RNA [KO:K14277]
PKNH_1236200  U5 spliceosomal RNA [KO:K14279]
PKNH_1024900  pre-mRNA-processing ATP-dependent RNA helicase PRP5, putative [KO:K12811] [EC:5.6.2.7]
PKNH_0411300  ATP-dependent RNA helicase UAP56, putative [KO:K12812] [EC:5.6.2.7]
PKNH_1451000  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP2, putative [KO:K12813] [EC:5.6.2.6]
PKNH_1107000  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16, putative [KO:K12815] [EC:5.6.2.6]
PKNH_1439300  pre-mRNA-processing factor 17, putative [KO:K12816]
PKNH_0720700  pre-mRNA-splicing factor 18, putative [KO:K12817]
PKNH_0614800  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative [KO:K12818] [EC:5.6.2.6]
PKNH_1140100  pre-mRNA-splicing factor SLU7, putative [KO:K12819]
PKNH_0715600  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, putative [KO:K12820] [EC:5.6.2.6]
PKNH_1343300  small nuclear ribonucleoprotein-associated protein B, putative [KO:K11086]
PKNH_0923400  small nuclear ribonucleoprotein Sm D1, putative [KO:K11087]
PKNH_0402400  small nuclear ribonucleoprotein Sm D2, putative [KO:K11096]
PKNH_0707800  small nuclear ribonucleoprotein Sm D3, putative [KO:K11088]
PKNH_1250700  small nuclear ribonucleoprotein E, putative [KO:K11097]
PKNH_0924900  small nuclear ribonucleoprotein F, putative [KO:K11098]
PKNH_1316300  small nuclear ribonucleoprotein G, putative [KO:K11099]
PKNH_1104100  U1 small nuclear ribonucleoprotein 70 kDa homolog, putative [KO:K11093]
PKNH_1427900  uncharacterized protein [KO:K11095]
PKNH_1417200  pre-mRNA-processing factor 40, putative [KO:K12821]
PKNH_1140000  RNA-binding protein 25, putative [KO:K12822]
PKNH_1236300  ATP-dependent RNA helicase DDX5, putative [KO:K12823] [EC:5.6.2.7]
PKNH_1446500  DNA helicase 60, putative [KO:K12823] [EC:5.6.2.7]
PKNH_1101500  U2 small nuclear ribonucleoprotein A', putative [KO:K11092]
PKNH_0733700  U2 small nuclear ribonucleoprotein B'', putative [KO:K11094]
PKNH_1244800  splicing factor 3A subunit 1, putative [KO:K12825]
PKNH_1130400  splicing factor 3A subunit 2, putative [KO:K12826]
PKNH_0722700  splicing factor 3A subunit 3, putative [KO:K12827]
PKNH_0833800  splicing factor 3B subunit 1, putative [KO:K12828]
PKNH_1220100  splicing factor 3B subunit 2, putative [KO:K12829]
PKNH_1454200  splicing factor 3B subunit 3, putative [KO:K12830]
PKNH_1338000  splicing factor 3B subunit 4, putative [KO:K12831]
PKNH_1115700  splicing factor 3B subunit 5, putative [KO:K12832]
PKNH_1444200  splicing factor 3B subunit 6, putative [KO:K12833]
PKNH_0602800  pre-mRNA-splicing factor RDS3, putative [KO:K12834]
PKNH_0819200  ATP-dependent RNA helicase DDX42, putative [KO:K12835] [EC:5.6.2.7]
PKNH_0917000  splicing factor U2AF small subunit, putative [KO:K12836]
PKNH_1212400  splicing factor U2AF large subunit, putative [KO:K12837]
PKNH_1228100  RNA-binding protein, putative [KO:K12840]
PKNH_1355400  U2 snRNP-associated SURP motif-containing protein, putative [KO:K12842]
PKNH_1012800  U6 snRNA-associated Sm-like protein LSm2, putative [KO:K12621]
PKNH_1313700  U6 snRNA-associated Sm-like protein LSm3, putative [KO:K12622]
PKNH_0904600  U6 snRNA-associated Sm-like protein LSm4, putative [KO:K12623]
PKNH_1239000  U6 snRNA-associated Sm-like protein LSm5, putative [KO:K12624]
PKNH_1203800  U6 snRNA-associated Sm-like protein LSm6, putative [KO:K12625]
PKNH_1309100  U6 snRNA-associated Sm-like protein LSm7, putative [KO:K12626]
PKNH_1323500  U6 snRNA-associated Sm-like protein LSm8, putative [KO:K12627]
PKNH_1409700  uncharacterized protein [KO:K12843]
PKNH_1257500  U4/U6 small nuclear ribonucleoprotein PRP4, putative [KO:K12662]
PKNH_0114400  peptidyl-prolyl cis-trans isomerase, putative [KO:K09567] [EC:5.2.1.8]
PKNH_0307100  U4/U6 small nuclear ribonucleoprotein PRP31, putative [KO:K12844]
PKNH_0921700  13 kDa ribonucleoprotein-associated protein, putative [KO:K12845]
PKNH_1417700  U4/U6.U5 tri-snRNP-associated protein 2, putative [KO:K12847]
PKNH_0816700  U4/U6.U5 tri-snRNP-associated protein 1, putative [KO:K11984]
PKNH_0930800  pre-mRNA-splicing factor 38A, putative [KO:K12849]
PKNH_1350800  pre-mRNA-splicing factor 38B, putative [KO:K12850]
PKNH_0802600  U5 small nuclear ribonucleoprotein component, putative [KO:K12852]
PKNH_0907900  pre-mRNA-processing factor 6, putative [KO:K12855]
PKNH_0303500  pre-mRNA-processing-splicing factor 8, putative [KO:K12856]
PKNH_1316800  U5 small nuclear ribonucleoprotein 40 kDa protein, putative [KO:K12857]
PKNH_1014700  ATP-dependent RNA helicase DDX23, putative [KO:K12858] [EC:5.6.2.7]
PKNH_1450900  mitosis protein dim1, putative [KO:K12859]
PKNH_0834100  uncharacterized protein [KO:K10599] [EC:2.3.2.27]
PKNH_0618400  pre-mRNA-splicing factor CEF1, putative [KO:K12860]
PKNH_1135600  pre-mRNA-splicing factor CWF7, putative [KO:K12861]
PKNH_0840700  pre-mRNA-splicing factor PRP46, putative [KO:K12862]
PKNH_0317900  cell cycle control protein cwf15-like protein [KO:K12863]
PKNH_0936800  beta-catenin-like protein 1, putative [KO:K12864]
PKNH_1312700  heat shock protein 70, putative [KO:K03283]
PKNH_0402200  pre-mRNA-processing protein 45, putative [KO:K06063]
PKNH_1455600  uncharacterized protein [KO:K12867]
PKNH_0301700  pre-mRNA-splicing factor CLF1, putative [KO:K12869]
PKNH_1209000  pre-mRNA-splicing factor ISY1, putative [KO:K12870]
PKNH_1004000  peptidyl-prolyl cis-trans isomerase, putative [KO:K12733] [EC:5.2.1.8]
PKNH_1230600  pre-mRNA-splicing factor CWF18, putative [KO:K12871]
PKNH_1467900  pre-mRNA-splicing factor RBM22, putative [KO:K12872]
PKNH_1010100  pre-mRNA-splicing factor BUD31, putative [KO:K12873]
PKNH_1248300  intron-binding protein aquarius, putative [KO:K12874]
PKNH_0514600  eukaryotic initiation factor 4A-III, putative [KO:K13025] [EC:5.6.2.7]
PKNH_1352100  RNA-binding protein 8A, putative [KO:K12876]
PKNH_0320600  mago nashi protein homologue, putative [KO:K12877]
PKNH_1134300  RNA and export factor binding protein, putative [KO:K12881]
PKNH_0507100  nuclear cap-binding protein subunit 2, putative [KO:K12883]
PKNH_1016000  serine/arginine-rich splicing factor 1, putative [KO:K12890]
PKNH_0917500  alternative splicing factor ASF-1, putative [KO:K12890]
PKNH_0929100  RNA-binding protein s1, putative [KO:K12891]
PKNH_0606700  serine/arginine-rich splicing factor 4, putative [KO:K12893]
PKNH_1030300  serine/arginine-rich splicing factor 12, putative [KO:K12900]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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