KEGG   PATHWAY: pvx03040
Entry
pvx03040                    Pathway                                
Name
Spliceosome - Plasmodium vivax
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pvx03040  Spliceosome
pvx03040

Other DBs
GO: 0005681
Organism
Plasmodium vivax [GN:pvx]
Gene
PVX_097995  ATP-dependent RNA helicase, putative [KO:K12811] [EC:5.6.2.7]
PVX_003945  eIF-4A-like DEAD family RNA helicase, putative [KO:K12812] [EC:5.6.2.7]
PVX_100525  pre-mRNA splicing factor RNA helicase, putative [KO:K12813] [EC:5.6.2.6]
PVX_115175  pre-mRNA splicing factor RNA helicase, putative [KO:K12815] [EC:5.6.2.6]
PVX_123645  pre-mRNA splicing factor PRP17, putative [KO:K12816]
PVX_099545  pre-mRNA splicing factor protein, putative [KO:K12817]
PVX_111220  RNA helicase, putative [KO:K12818] [EC:5.6.2.6]
PVX_113655  step II splicing factor, putative [KO:K12819]
PVX_099300  ATP-dependant RNA helicase, putative [KO:K12820] [EC:5.6.2.6]
PVX_085710  small nuclear ribonucleoprotein associated protein B', putative [KO:K11086]
PVX_091895  small nuclear ribonucleoprotein Sm D1, putative [KO:K11087]
PVX_002615  small nuclear ribonucleoprotein Sm D2, putative [KO:K11096]
PVX_098930  small nuclear ribonucleoprotein (snRNP), putative [KO:K11088]
PVX_083405  small nuclear ribonucleoprotein E, putative [KO:K11097]
PVX_091960  U6 snRNA-associated Sm-like protein LSm6, putative [KO:K11098]
PVX_089250  small nuclear ribonucleoprotein G, putative [KO:K11099]
PVX_115315  U1 small nuclear ribonucleoprotein 70 kDa, putative [KO:K11093]
PVX_122180  U1A small nuclear ribonucleoprotein, putative [KO:K11091]
PVX_123135  hypothetical protein, conserved [KO:K11095]
PVX_122645  formin-binding protein, putative [KO:K12821]
PVX_113660  hypothetical protein, conserved [KO:K12822]
PVX_118190  helicase, putative [KO:K12823] [EC:5.6.2.7]
PVX_123985  ATP-dependent RNA helicase, putative [KO:K12823] [EC:5.6.2.7]
PVX_115445  U2 small nuclear ribonucleoprotein A, putative [KO:K11092]
PVX_086965  U2 small nuclear ribonucleoprotein B'', putative [KO:K11094]
PVX_118605  hypothetical protein, conserved [KO:K12825]
PVX_114120  splicing factor 3a subunit, putative [KO:K12826]
PVX_099650  splicesome-associated protein, putative [KO:K12827]
PVX_119560  splicing factor 3B subunit 1, putative [KO:K12828]
PVX_117375  splicing factor 3B subunit 2, putative [KO:K12829]
PVX_100690  Splicing factor 3B subunit 3, putative [KO:K12830]
PVX_085480  spliceosome-associated protein 49, putative [KO:K12831]
PVX_114770  splicing factor, putative [KO:K12832]
PVX_123875  pre-mRNA branch site protein p14, putative [KO:K12833]
PVX_001785  hypothetical protein, conserved [KO:K12834]
PVX_091600  U2 snRNP auxiliary factor, small subunit, putative [KO:K12836]
PVX_117025  U2 snRNP auxiliary factor, putative [KO:K12837]
PVX_116560  splicing factor, putative [KO:K12837]
PVX_117780  RNA binding protein, putative [KO:K12840]
PVX_086295  RNA binding protein, putative [KO:K12842]
PVX_080230  U6 snRNA-associated Sm-like protein LSm4, putative [KO:K12621]
PVX_089370  U6 snRNA-associated Sm-like protein LSm3, putative [KO:K12622]
PVX_091025  U6 snRNA associated Sm-like protein Lsm4, putative [KO:K12623]
PVX_118325  U6 snRNA-associated Sm-like protein LSm5, putative [KO:K12624]
PVX_116625  U6 snRNA-associated Sm-like protein LSm6, putative [KO:K12625]
PVX_084490  U6 snRNA-associated Sm-like protein LSm7, putative [KO:K12626]
PVX_088885  U6 snRNA-associated Sm-like protein LSm8, putative [KO:K12627]
PVX_122295  hypothetical protein, conserved [KO:K12843]
PVX_083090  WD domain, G-beta repeat domain containing protein [KO:K12662]
PVX_093520  cyclophilin, putative [KO:K09567] [EC:5.2.1.8]
PVX_000790  pre-mrna splicing factor, putative [KO:K12844]
PVX_091810  ribosomal protein L7A, putative [KO:K12845]
PVX_122670  ubiquitin carboxyl-terminal hydrolase, putative [KO:K12847]
PVX_095040  hypothetical protein, conserved [KO:K11984]
PVX_092235  hypothetical protein, conserved [KO:K12849]
PVX_086065  hypothetical protein, conserved [KO:K12850]
PVX_094390  U5 small nuclear ribonuclear protein, putative [KO:K12852]
PVX_091160  U5 snRNP-associated 102 kDa protein, putative [KO:K12855]
PVX_000970  hypothetical protein, conserved [KO:K12856]
PVX_089225  U5 snRNP-specific 40 kDa protein, putative [KO:K12857]
PVX_080320  pre-mRNA splicing factor RNA helicase PRP28, putative [KO:K12858] [EC:5.6.2.7]
PVX_100520  hypothetical protein, conserved [KO:K12859]
PVX_119545  WD domain, G-beta repeat domain containing protein [KO:K10599] [EC:2.3.2.27]
PVX_111045  DNA binding protein Myb2, putative [KO:K12860]
PVX_113855  hypothetical protein, conserved [KO:K12861]
PVX_119245  splicing regulatory protein, putative [KO:K12862]
PVX_096230  hypothetical protein, conserved [KO:K12863]
PVX_092545  Beta-catenin-like protein 1, putative [KO:K12864]
PVX_089425  heat shock 70 kDa protein, putative [KO:K03283]
PVX_002605  nuclear protein SkiP, putative [KO:K06063]
PVX_100745  hypothetical protein, conserved [KO:K12867]
PVX_001060  splicing factor, putative [KO:K12869]
PVX_116880  Isy1-like splicing domain containing protein [KO:K12870]
PVX_079815  cyclophilin, putative [KO:K12733] [EC:5.2.1.8]
PVX_117905  hypothetical protein, conserved [KO:K12871]
PVX_101300  RNA binding protein, putative [KO:K12872]
PVX_080110  G10 protein, putative [KO:K12873]
PVX_083530  hypothetical protein, conserved [KO:K12874]
PVX_090175  eukaryotic initiation factor, putative [KO:K13025] [EC:5.6.2.7]
PVX_086130  RNA binding protein, putative [KO:K12876]
PVX_096080  mago nashi domain containing protein [KO:K12877]
PVX_113920  RNA binding function, putative [KO:K12881]
PVX_089730  nuclear cap-binding protein, putative [KO:K12883]
PVX_080385  splicing factor, arginine/serine-rich 1, putative [KO:K12890]
PVX_091625  alternative splicing factor ASF-1, putative [KO:K12890]
PVX_092155  RNA binding protein, putative [KO:K12891]
PVX_111600  pre-mRNA splicing factor, putative [KO:K12893]
PVX_094315  RNA binding protein, putative [KO:K12897]
PVX_097740  Ser/Arg-rich splicing factor, putative [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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Genome (1)   
   KEGG GENOME (1)   
Gene (89)   
   KEGG GENES (89)   
All databases (90)   

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