KEGG   PATHWAY: smm03040
Entry
smm03040                    Pathway                                
Name
Spliceosome - Schistosoma mansoni
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
smm03040  Spliceosome
smm03040

Other DBs
GO: 0005681
Organism
Schistosoma mansoni [GN:smm]
Gene
Smp_sma.U4.1.1  Smp_sma.U4.1.1 [KO:K14278]
Smp_sma.U5.1.1  Smp_sma.U5.1.1 [KO:K14279]
Smp_sma.U5-1.1.1  Smp_sma.U5-1.1.1 [KO:K14279]
Smp_sma.U6-7.1.1  Smp_sma.U6-7.1.1 [KO:K14280]
Smp_sma.U6.1.1  Smp_sma.U6.1.1 [KO:K14280]
Smp_174210.1  uncharacterized protein [KO:K12811] [EC:5.6.2.7]
Smp_003660  putative dead box ATP-dependent RNA helicase [KO:K12812] [EC:5.6.2.7]
Smp_027970  ATP-dependent RNA helicase, putative [KO:K12813] [EC:5.6.2.6]
Smp_156060  hypothetical protein [KO:K12815] [EC:5.6.2.6]
Smp_074370  putative pre-mRNA splicing factor [KO:K12816]
Smp_059360  pre-mRNA processing factor, putative [KO:K12817]
Smp_157510  putative atp-dependent RNA helicase [KO:K12818] [EC:5.6.2.6]
Smp_019190  step II splicing factor slu7, putative [KO:K12819]
Smp_087270  putative atp-dependent RNA helicase [KO:K12820] [EC:5.6.2.6]
Smp_075560  putative small nuclear ribonucleoprotein Sm D2 [KO:K11096]
Smp_068420  putative small nuclear ribonucleoprotein SM-D3 [KO:K11088]
Smp_205570  unnamed protein product [KO:K11097]
Smp_060910  putative small nuclear ribonucleoprotein f (snrnp-f) [KO:K11098]
Smp_038680  putative small nuclear ribonucleoprotein G (snrnp-G) [KO:K11099]
Smp_013360  putative u1 small nuclear ribonucleoprotein 70 kD [KO:K11093]
Smp_069870  putative small nuclear ribonucleoprotein U)1a,U)2b [KO:K11091]
Smp_113660  cleavage and polyadenylation specificity factor,putative [KO:K11095]
Smp_091300  cleavage and polyadenylation specificity factor,putative [KO:K11095]
Smp_056640  huntingtin interacting protein-related [KO:K12821]
Smp_078610  putative rna binding motif protein 25 [KO:K12822]
Smp_013790  DEAD box ATP-dependent RNA helicase, putative [KO:K12823] [EC:5.6.2.7]
Smp_142100  hypothetical protein [KO:K12824]
Smp_000240.1  fusion [KO:K13098]
Smp_141330  hypothetical protein [KO:K11092]
Smp_069880  putative small nuclear ribonucleoprotein U)1a,U)2b [KO:K11094]
Smp_120320.1  spliceosome-associated protein, putative [KO:K12825]
Smp_076880  hypothetical protein [KO:K12826]
Smp_003630  putative splicing factor 3a [KO:K12827]
Smp_141630.1  splicing factor 3b, subunit 1-related [KO:K12828]
Smp_096810.1  hypothetical protein [KO:K12829]
Smp_137430  Splicing factor 3B subunit 3, 5' fragment [KO:K12830]
Smp_067420  splicing factor 3b, subunit 4 (fragment),putative [KO:K12831]
Smp_135740  hypothetical protein [KO:K12832]
Smp_032060  hypothetical protein [KO:K12833]
Smp_011720  hypothetical protein [KO:K12834]
Smp_131770  DEAD box ATP-dependent RNA helicase, putative [KO:K12835] [EC:5.6.2.7]
Smp_093100  putative u2 snRNP auxiliary factor, small subunit [KO:K12836]
Smp_019690  splicing factor u2af large subunit, putative [KO:K12837]
Smp_012900  putative fuse-binding protein-interacting repressor siahbp1 [KO:K12838]
Smp_129720  fuse-binding protein-interacting repressor siahbp1, putative [KO:K12838]
Smp_064830  putative survival motor neuron protein [KO:K12839]
Smp_161750  hypothetical protein [KO:K12840]
Smp_007180  sr-related ctd associated factor [KO:K12841]
Smp_161730  hypothetical protein [KO:K12842]
Smp_078640  putative snrnp sm protein [KO:K12622]
Smp_157680  U6 snrna-associated sm-like protein lsm4 [KO:K12623]
Smp_129760  hypothetical protein [KO:K12624]
Smp_094150  small nuclear ribonucleoprotein f (snrnp-f),putative [KO:K12625]
Smp_210830  family S9 non-peptidase homologue (S09 family) [KO:K12626]
Smp_175550  putative lsm1 [KO:K12627]
Smp_060900.1  U4/U6-associated RNA splicing factor-related [KO:K12843]
Smp_169060  hypothetical protein [KO:K12662]
Smp_173280  peptidyl-prolyl cis-trans isomerase h, ppih,putative [KO:K09567] [EC:5.2.1.8]
Smp_161460  hypothetical protein [KO:K12844]
Smp_163030  hypothetical protein [KO:K12844]
Smp_104660  ribosomal protein l7ae, putative [KO:K12845]
Smp_140290  U4/U6.U5 tri-snRNP-associated protein 3 (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (Nucleic acid-binding protein RY-1), putative [KO:K12846]
Smp_017890  family C19 non-peptidase homologue (C19 family) [KO:K12847]
Smp_176840  putative hypoxia associated factor [KO:K11984]
Smp_046980  hypothetical protein [KO:K12849]
Smp_133110  hypothetical protein [KO:K12850]
Smp_096450.1  putative 116 kD U5 small nuclear ribonucleoprotein component [KO:K12852]
Smp_140890  splicing factor Prp8, putative [KO:K12856]
Smp_025100  U5 snrnp-specific protein-related [KO:K12857]
Smp_093690.1  putative dead box ATP-dependent RNA helicase [KO:K12858] [EC:5.6.2.7]
Smp_106050  putative mitosis protein dim1 [KO:K12859]
Smp_167150  putative wd-repeat protein [KO:K10599] [EC:2.3.2.27]
Smp_129320  cell division control protein, putative [KO:K12860]
Smp_054600  hypothetical protein [KO:K12861]
Smp_104870  WD-repeat protein, putative [KO:K12862]
Smp_033680  hypothetical protein [KO:K12863]
Smp_089400  hypothetical protein [KO:K12864]
Smp_106930  putative heat shock protein 70 [KO:K03283]
Smp_089630  putative polyglutamine binding protein [KO:K12865]
Smp_163260  hypothetical protein [KO:K12866]
Smp_105860  putative nuclear protein SkiP [KO:K06063]
Smp_166240  hcnp homolog, putative [KO:K12867]
Smp_064500  hypothetical protein [KO:K12868]
Smp_148230  putative pre-mRNA-splicing factor CLF1 [KO:K12869]
Smp_126720  hypothetical protein [KO:K12870]
Smp_029900.1  peptidyl-prolyl cis-trans isomerase-like 1,ppil1 [KO:K12733] [EC:5.2.1.8]
Smp_094810  peptidyl-prolyl cis-trans isomerase (PPIase) E [KO:K09564] [EC:5.2.1.8]
Smp_080110  putative pre-mRNA splicing factor [KO:K12871]
Smp_025130  putative rna binding motif protein [KO:K12872]
Smp_092380  putative g10 protein homolog [KO:K12873]
Smp_124640  putative dna2/nam7 helicase family member [KO:K12874]
Smp_039490.1  hypothetical protein [KO:K12875]
Smp_031010  putative dead box ATP-dependent RNA helicase [KO:K13025] [EC:5.6.2.7]
Smp_034190.1  putative dead box ATP-dependent RNA helicase [KO:K13025] [EC:5.6.2.7]
Smp_002550.1  putative serine/arginine rich splicing factor [KO:K12876]
Smp_103470.1  mago nashi protein homolog [KO:K12877]
Smp_160600  putative nuclear matrix protein [KO:K12878]
Smp_086460  tho2 protein, putative [KO:K12879]
Smp_045620.1  hypothetical protein [KO:K12880]
Smp_005260.1  RNA and export factor binding protein, putative [KO:K12881]
Smp_031360.1  putative cap binding protein [KO:K12882]
Smp_166430  putative 20 kD nuclear cap binding protein [KO:K12883]
Smp_043100  putative heterogeneous nuclear ribonucleoprotein [KO:K12741]
Smp_065580.1  putative heterogeneous nuclear ribonucleoprotein k [KO:K12886]
Smp_005860.1  hypothetical protein [KO:K12886]
Smp_185230  arginine/serine-rich splicing factor, putative [KO:K12890]
Smp_113620.1  putative serine/arginine rich splicing factor [KO:K12891]
Smp_036270.1  putative arginine/serine-rich splicing factor [KO:K12893]
Smp_071640.1  putative arginine/serine-rich splicing factor [KO:K12896]
Smp_098890.1  arginine/serine-rich splicing factor, putative [KO:K12896]
Smp_086600.1  putative arginine/serine-rich splicing factor [KO:K12896]
Smp_045950.1  transformer-2-related [KO:K12897]
Smp_050920  transformer-2-related [KO:K12897]
Smp_032320.1  putative serine/arginine rich splicing factor [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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Genome (1)   
   KEGG GENOME (1)   
Gene (114)   
   KEGG GENES (114)   
All databases (115)   

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