KEGG   PATHWAY: tcr03040
Entry
tcr03040                    Pathway                                
Name
Spliceosome - Trypanosoma cruzi
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
tcr03040  Spliceosome
tcr03040

Other DBs
GO: 0005681
Organism
Trypanosoma cruzi [GN:tcr]
Gene
507811.30  ATP-dependent DEAD/H RNA helicase [KO:K12811] [EC:5.6.2.7]
508319.40  RNA helicase [KO:K12812] [EC:5.6.2.7]
482471.19  ATP-dependent DEAD/H RNA helicase [KO:K12812] [EC:5.6.2.7]
511139.40  RNA helicase [KO:K12812] [EC:5.6.2.7]
506203.70  pre-mRNA splicing factor [KO:K12815] [EC:5.6.2.6]
504045.10  hypothetical protein [KO:K12816]
510525.60  hypothetical protein [KO:K12817]
507681.220  pre-mRNA splicing factor ATP-dependent RNA helicase, putative [KO:K12818] [EC:5.6.2.6]
509721.20  hypothetical protein [KO:K12819]
503911.20  pre-mRNA splicing factor ATP-dependent RNA helicase [KO:K12820] [EC:5.6.2.6]
507209.10  small nuclear ribonucleoprotein protein [KO:K11086]
510531.54  small nuclear ribonucleoprotein [KO:K11087]
511819.14  small nuclear ribonucleoprotein [KO:K11087]
511189.80  small nuclear ribonucleoprotein SmD2 [KO:K11096]
508667.49  small nuclear ribonucleoprotein SmD2 [KO:K11096]
508257.150  small nuclear ribonucleoprotein SmD3 [KO:K11088]
509965.30  small nuclear ribonucleoprotein Sm-E [KO:K11097]
507007.74  small nuclear ribonucleoprotein Sm-F [KO:K11098]
509551.64  small nuclear ribonucleoprotein Sm-F [KO:K11098]
511725.174  small nuclear ribonucleoprotein Sm-G [KO:K11099]
508973.50  ATP-dependent DEAD/H RNA helicase [KO:K12823] [EC:5.6.2.7]
508547.110  ATP-dependent DEAD/H RNA helicase [KO:K12823] [EC:5.6.2.7]
511801.60  mitochondrial DEAD box protein [KO:K12823] [EC:5.6.2.7]
511283.190  U2 small nuclear ribonucleoprotein 40k Da [KO:K11092]
507023.230  splicing factor 3A [KO:K12827]
509171.90  splicing factor 3A [KO:K12827]
508827.100  splicing factor 3B subunit 1 [KO:K12828]
504071.50  spliceosome-associated protein [KO:K12829]
506789.230  hypothetical protein [KO:K12830]
508461.174  hypothetical protein [KO:K12832]
509715.23  RNA-binding protein [KO:K12833]
507681.60  hypothetical protein [KO:K12834]
503577.20  U2 splicing auxiliary factor [KO:K12836]
510943.60  U2 splicing auxiliary factor [KO:K12836]
504643.40  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
457339.10  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
503479.49  U6 snRNA-associated Sm-like protein LSm7p [KO:K12626]
506855.209  U6 snRNA-associated Sm-like protein LSm7p [KO:K12626]
510091.70  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
510421.314  U6 snRNA-associated Sm-like protein LSm8p [KO:K12627]
511583.30  hypothetical protein [KO:K12843]
503583.40  trans-splicing factor [KO:K12844]
504625.10  trans-splicing factor [KO:K12844]
508277.120  ribosomal protein S6 [KO:K12845]
509943.30  ribosomal protein S6 [KO:K12845]
508461.320  PRP8 protein homologue [KO:K12856]
508045.79  spliceosomal U5 snRNP-specific protein [KO:K12859]
509103.10  hypothetical protein [KO:K10599] [EC:2.3.2.27]
507801.60  hypothetical protein [KO:K10599] [EC:2.3.2.27]
508909.40  hypothetical protein [KO:K12860]
508307.44  hypothetical protein [KO:K12862]
511211.160  heat shock protein 70 (HSP70) [KO:K03283]
511211.170  heat shock protein 70 (HSP70) [KO:K03283]
511211.220  heat shock protein 70 [KO:K03283]
509445.20  hypothetical protein [KO:K06063]
509601.40  hypothetical protein [KO:K12867]
509767.40  hypothetical protein [KO:K12867]
504147.320  hypothetical protein [KO:K12869]
510187.260  hypothetical protein [KO:K12873]
506587.40  ATP-dependent DEAD/H RNA helicase [KO:K13025] [EC:5.6.2.7]
511199.9  ATP-dependent DEAD/H RNA helicase [KO:K13025] [EC:5.6.2.7]
507515.40  hypothetical protein [KO:K12876]
508213.40  hypothetical protein [KO:K12876]
506945.200  mago nashi-like protein [KO:K12877]
504071.80  nuclear cap binding protein [KO:K12883]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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Genome (1)   
   KEGG GENOME (1)   
Gene (65)   
   KEGG GENES (65)   
All databases (66)   

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