KEGG   PATHWAY: tgo03040
Entry
tgo03040                    Pathway                                
Name
Spliceosome - Toxoplasma gondii
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
tgo03040  Spliceosome
tgo03040

Other DBs
GO: 0005681
Organism
Toxoplasma gondii [GN:tgo]
Gene
TGME49_221660  DEAD/DEAH box helicase domain-containing protein [KO:K12811] [EC:5.6.2.7]
TGME49_263820  DEAD/DEAH box helicase domain-containing protein [KO:K12811] [EC:5.6.2.7]
TGME49_216860  DDX39; DEAD (Asp-Glu-Ala-Asp) box polypeptide DDX39 [KO:K12812] [EC:5.6.2.7]
TGME49_263650  pre-mRNA-processing protein 8, putative [KO:K12813] [EC:5.6.2.6]
TGME49_260200  helicase associated domain (ha2) protein [KO:K12815] [EC:5.6.2.6]
TGME49_265410  G-protein beta WD-40 repeat containing protein [KO:K12816]
TGME49_321290  Prp18 domain-containing protein [KO:K12817]
TGME49_312280  pre-mRNA-splicing factor ATP-dependent RNA helicase, putative [KO:K12818] [EC:5.6.2.6]
TGME49_216950  helicase [KO:K12818] [EC:5.6.2.6]
TGME49_310820  SLU7 splicing factor, putative [KO:K12819]
TGME49_233520  ATP-dependent RNA helicase [KO:K12820] [EC:5.6.2.6]
TGME49_300280  LSM domain-containing protein [KO:K11086]
TGME49_267350  LSM domain-containing protein [KO:K11087]
TGME49_270830  small nuclear ribonucleoprotein [KO:K11096]
TGME49_309740  LSM domain-containing protein [KO:K11088]
TGME49_275750  small nuclear ribonucleoprotein E, putative [KO:K11097]
TGME49_213410  small nuclear ribonucleoprotein f (snrnp-f), putative [KO:K11098]
TGME49_314790  small nuclear ribonucleoprotein G, putative [KO:K11099]
TGME49_205180  RNA recognition motif-containing protein [KO:K11093]
TGME49_309800  RNA recognition motif-containing protein [KO:K11091]
TGME49_306380  U1 zinc finger protein [KO:K11095]
TGME49_306220  hypothetical protein [KO:K12821]
TGME49_270770  PWI domain-containing protein [KO:K12822]
TGME49_236650  DDX17; DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 [KO:K12823] [EC:5.6.2.7]
TGME49_313240  ethylene-responsive RNA helicase, putative [KO:K12823] [EC:5.6.2.7]
TGME49_316180  hypothetical protein [KO:K12824]
TGME49_229210  small nuclear ribonucleoprotein polypeptide A', putative [KO:K11092]
TGME49_246500  surp module domain-containing protein [KO:K12825]
TGME49_228000  splicing factor 3A subunit 2, putative [KO:K12826]
TGME49_221950  splicesome-associated protein, putative [KO:K12827]
TGME49_205010  U2 small nuclear ribonucleoprotein family protein, putative [KO:K12828]
TGME49_314740  PSP protein [KO:K12829]
TGME49_230960  splicing factor 3b, subunit 3, putative [KO:K12830]
TGME49_224580  RNA recognition motif-containing protein [KO:K12831]
TGME49_314830  pre-mRNA splicing factor subunit, putative [KO:K12832]
TGME49_305010  pre-mRNA branch site protein P14, putative [KO:K12833]
TGME49_248250  translation initiation factor IF-2, putative [KO:K12834]
TGME49_236910  U2 snRNP auxiliary factor, putative [KO:K12836]
TGME49_234520  U2 snRNP auxilliary factor, large subunit, splicing factor subfamily protein [KO:K12837]
TGME49_308920  splicing factor U2AF protein [KO:K12837]
TGME49_291950  RNA recognition motif-containing protein [KO:K12837]
TGME49_202770  RNA recognition motif-containing protein [KO:K12838]
TGME49_321630  RNA recognition motif-containing protein [KO:K12838]
TGME49_286440  malic enzyme [KO:K12839]
TGME49_214820  G-patch domain-containing protein [KO:K12840]
TGME49_240710  RNA recognition motif-containing protein [KO:K12842]
TGME49_297140  U6 snRNA-associated sm family protein Lsm2, putative [KO:K12621]
TGME49_298970  LSM3, U6 small nuclear RNA associated isoform 2 family protein [KO:K12622]
TGME49_278950  LSM domain-containing protein [KO:K12623]
TGME49_247610  small nuclear ribonucleoprotein E, putative [KO:K12624]
TGME49_261470  U6 snRNA-associated Sm family protein LSm6, putative [KO:K12625]
TGME49_286560  U6 snRNA-associated Sm family protein [KO:K12626]
TGME49_272630  U6 snRNA-associated Sm family protein LSm8, putative [KO:K12627]
TGME49_219790  pre-mRNA processing factor PRP3 [KO:K12843]
TGME49_243540  WD domain, G-beta repeat-containing protein [KO:K12662]
TGME49_285760  U-snRNP-associated cyclophilin family protein [KO:K09567] [EC:5.2.1.8]
TGME49_244100  snoRNA binding domain-containing protein [KO:K12844]
TGME49_236580  Prp31-15.5k-U4 Snrna Complex family protein [KO:K12845]
TGME49_264010  hypothetical protein [KO:K12846]
TGME49_294360  ubiquitin specific protease 39 isoform 2, putative [KO:K12847]
TGME49_318140  SART-1 family protein [KO:K11984]
TGME49_266030  pre-mRNA splicing factor, putative [KO:K12849]
TGME49_285230  PRP38 family protein [KO:K12850]
TGME49_286080  elongation factor 2 family protein [KO:K12852]
TGME49_223390  activating signal cointegrator 1 complex subunit 3 family 1 ASCC3L1, putative [KO:K12854] [EC:5.6.2.6]
TGME49_205220  U5 snRNP-associated subunit, putative [KO:K12855]
TGME49_231970  PRP8; pre-mRNA processing splicing factor PRP8 [KO:K12856]
TGME49_310860  U5 snRNP-specific protein [KO:K12857]
TGME49_298020  DEAD-family helicase [KO:K12858] [EC:5.6.2.7]
TGME49_270140  DIM1; splicing factor DIM1, putative [KO:K12859]
TGME49_320210  WD domain, G-beta repeat domain containing protein [KO:K10599] [EC:2.3.2.27]
TGME49_275480  Myb family DNA-binding domain-containing protein [KO:K12860]
TGME49_243620  hypothetical protein [KO:K12861]
TGME49_218420  WD domain, G-beta repeat-containing protein [KO:K12862]
TGME49_270740  Cwf15/Cwc15 cell cycle control protein [KO:K12863]
TGME49_239930  beta-catenin family protein 1, putative [KO:K12864]
TGME49_273760  HSP70; heat shock protein HSP70 [KO:K03283]
TGME49_233190  SKIP/SNW domain-containing protein [KO:K06063]
TGME49_305240  XPA binding protein 2 family protein [KO:K12867]
TGME49_269200  crooked neck family 1 protein isoform 2, putative [KO:K12869]
TGME49_203870  RAB43, member RAS oncogene family protein [KO:K12870]
TGME49_270560  peptidyl-prolyl cis-trans isomerase family 1 [KO:K12733] [EC:5.2.1.8]
TGME49_279430  cwf18 pre-mRNA splicing factor protein [KO:K12871]
TGME49_254650  zinc finger protein [KO:K12872]
TGME49_246620  G10 family protein [KO:K12873]
TGME49_314410  aquarius, putative [KO:K12874]
TGME49_256770  eukaryotic translation initiation factor 4A, isoform 3, putative [KO:K13025] [EC:5.6.2.7]
TGME49_233230  RNA-binding protein 8A family protein [KO:K12876]
TGME49_267420  mago nashi family protein 2, putative [KO:K12877]
TGME49_291330  RNA recognition motif-containing protein [KO:K12881]
TGME49_249610  hypothetical protein [KO:K12882]
TGME49_289560  RNA recognition motif-containing protein [KO:K12883]
TGME49_264610  RNA recognition motif-containing protein [KO:K12741]
TGME49_217540  RNA recognition motif-containing protein [KO:K12890]
TGME49_211420  RNA recognition motif-containing protein [KO:K12892]
TGME49_319530  SF2; splicing factor SF2 [KO:K12893]
TGME49_272440  RNA recognition motif-containing protein [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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Genome (1)   
   KEGG GENOME (1)   
Gene (97)   
   KEGG GENES (97)   
All databases (98)   

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