KEGG   PATHWAY: tpa00550
Entry
tpa00550                    Pathway                                
Name
Peptidoglycan biosynthesis - Treponema pallidum subsp. pallidum Nichols
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
tpa00550  Peptidoglycan biosynthesis
tpa00550

Organism
Treponema pallidum subsp. pallidum Nichols [GN:tpa]
Gene
TP_0029  UDP-N-acetylglucosamine 1-carboxyvinyltransferase (murA) [KO:K00790] [EC:2.5.1.7]
TP_0090  UDP-N-acetylmuramate dehydrogenase (murB) [KO:K00075] [EC:1.3.1.98]
TP_0341  UDP-N-acetylmuramate--alanine ligase (murC) [KO:K01924] [EC:6.3.2.8]
TP_0903  UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD) [KO:K01925] [EC:6.3.2.9]
TP_0933  UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) [KO:K01928] [EC:6.3.2.13]
TP_0670  D-alanine--D-alanine ligase (ddlA) [KO:K01921] [EC:6.3.2.4]
TP_0386  UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) [KO:K01929] [EC:6.3.2.10]
TP_0603  conserved hypothetical protein [KO:K00806] [EC:2.5.1.31]
TP_0345  phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) [KO:K01000] [EC:2.7.8.13]
TP_0523  UDP-N-glucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (murG) [KO:K02563] [EC:2.4.1.227]
TP_0705  penicillin-binding protein (pbp-2) [KO:K05366] [EC:2.4.99.28 3.4.16.4]
TP_0500  penicillin-binding protein (pbp-1) [KO:K05515] [EC:3.4.16.4]
TP_0760  penicillin-binding protein (pbp-3) [KO:K03587] [EC:3.4.16.4]
TP_0800  serine-type D-Ala-D-Ala carboxypeptidase (dacC) [KO:K07258] [EC:3.4.16.4]
TP_0221  D,D-carboxypeptidase, putative [KO:K07260] [EC:3.4.17.14]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00133  D-Alanine
C00448  trans,trans-Farnesyl diphosphate
C00692  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C00993  D-Alanyl-D-alanine
C01050  UDP-N-acetylmuramate
C01212  UDP-N-acetylmuramoyl-L-alanine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702  UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851  MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896  Crosslinked peptidoglycan
C05897  Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556  di-trans,poly-cis-Undecaprenyl phosphate
C17558  di-trans,poly-cis-Undecaprenol
C22053  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Reference
PMID:18081839
  Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
  Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
  Journal
FEMS Microbiol Rev 32:208-33 (2008)
DOI:10.1111/j.1574-6976.2007.00089.x
Reference
PMID:18077448
  Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
  Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
  Journal
J Biol Chem 283:6402-17 (2008)
DOI:10.1074/jbc.M708105200
Reference
PMID:18266853
  Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
  Title
Cytoplasmic steps of peptidoglycan biosynthesis.
  Journal
FEMS Microbiol Rev 32:168-207 (2008)
DOI:10.1111/j.1574-6976.2008.00104.x
Reference
PMID:11699883
  Authors
van Heijenoort J
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a
Reference
PMID:11320055
  Authors
van Heijenoort  J
  Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
  Journal
Glycobiology 11:25R-36R (2001)
DOI:10.1093/glycob/11.3.25R
Related
pathway
tpa00470  D-Amino acid metabolism
tpa00520  Amino sugar and nucleotide sugar metabolism
tpa00900  Terpenoid backbone biosynthesis
KO pathway
ko00550   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG GENES (15)   
All databases (16)   

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