#=GF ID Caskin1-CID
#=GF AC PF16600.5
#=GF DE Caskin1 CASK-interaction domain
#=GF PI CID;
#=GF AU Punta M;0000-0002-0050-0676
#=GF SE MobiDB:Q8WXD9
#=GF GA 30.00 30.00;
#=GF TC 31.10 30.80;
#=GF NC 29.40 29.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 12040031
#=GF RT CASK participates in alternative tripartite complexes in which
#=GF RT Mint 1 competes for binding with caskin 1, a novel CASK-binding
#=GF RT protein.
#=GF RA Tabuchi K, Biederer T, Butz S, Sudhof TC;
#=GF RL J Neurosci. 2002;22:4264-4273.
#=GF RN [2]
#=GF RM 21763699
#=GF RT The molecular basis of the Caskin1 and Mint1 interaction with
#=GF RT CASK.
#=GF RA Stafford RL, Ear J, Knight MJ, Bowie JU;
#=GF RL J Mol Biol. 2011;412:3-13.
#=GF DR INTERPRO; IPR032232;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The Caskin1 protein interacts with the CASK protein via this
#=GF CC region [1].CASK and Caskin1 are synaptic scaffolding proteins.
#=GF CC The binding motif on human Caskin1 is EEIWVLRK. A similar motif
#=GF CC is found on protein MINT1 and protein TIAM1, both shown to be
#=GF CC able to bind to CASK though the motif. MINT1 and TIAM1 are not
#=GF CC part of this family [2]. This region is predicted to be natively
#=GF CC unstructured.
#=GF SQ 149
#=GS A0A0P7WSE3_9TELE/374-432 AC A0A0P7WSE3.1
#=GS S9XEX4_CAMFR/270-318 AC S9XEX4.1
#=GS A0A2K5JNB6_COLAP/334-382 AC A0A2K5JNB6.1
#=GS A0A2D0PNN1_ICTPU/423-473 AC A0A2D0PNN1.1
#=GS A0A0R4IGS7_DANRE/367-418 AC A0A0R4IGS7.1
#=GS A0A0R4IIH7_DANRE/287-338 AC A0A0R4IIH7.1
#=GS H2UA09_TAKRU/344-402 AC H2UA09.1
#=GS A0A2D0SZ27_ICTPU/428-480 AC A0A2D0SZ27.1
#=GS F6Z3A3_MONDO/387-424 AC F6Z3A3.2
#=GS I3ITP1_DANRE/381-438 AC I3ITP1.1
#=GS W5MEY2_LEPOC/419-470 AC W5MEY2.1
#=GS H2NPT5_PONAB/353-401 AC H2NPT5.1
#=GS A0A1V4KSY5_PATFA/442-500 AC A0A1V4KSY5.1
#=GS L9L345_TUPCH/392-440 AC L9L345.1
#=GS A0A2D0PQB5_ICTPU/423-472 AC A0A2D0PQB5.1
#=GS A0A1U7T6N7_TARSY/291-339 AC A0A1U7T6N7.1
#=GS I3JHD3_ORENI/325-385 AC I3JHD3.1
#=GS S7PMT8_MYOBR/230-272 AC S7PMT8.1
#=GS A0A2I4B971_9TELE/374-432 AC A0A2I4B971.1
#=GS A0A2D0SZ36_ICTPU/369-421 AC A0A2D0SZ36.1
#=GS CSKI1_MOUSE/373-421 AC Q6P9K8.2
#=GS A0A2G9SMB2_LITCT/24-73 AC A0A2G9SMB2.1
#=GS I3J5L6_ORENI/368-416 AC I3J5L6.1
#=GS A0A2K5JN77_COLAP/334-382 AC A0A2K5JN77.1
#=GS M3W853_FELCA/373-421 AC M3W853.2
#=GS A0A1L8EYF4_XENLA/215-269 AC A0A1L8EYF4.1
#=GS A0A1S3QIF2_SALSA/32-75 AC A0A1S3QIF2.1
#=GS H0XTL5_OTOGA/373-423 AC H0XTL5.1
#=GS A0A1S3QLX6_SALSA/136-174 AC A0A1S3QLX6.1
#=GS A0A1S3SWA6_SALSA/411-467 AC A0A1S3SWA6.1
#=GS A0A151NIX6_ALLMI/12-63 AC A0A151NIX6.1
#=GS A0A2D0Q7K9_ICTPU/487-528 AC A0A2D0Q7K9.1
#=GS W5KH32_ASTMX/103-161 AC W5KH32.1
#=GS A0A2D0S9G0_ICTPU/399-447 AC A0A2D0S9G0.1
#=GS F6PLP7_ORNAN/252-291 AC F6PLP7.1
#=GS A0A2I4D0S3_9TELE/440-487 AC A0A2I4D0S3.1
#=GS G3WW39_SARHA/56-106 AC G3WW39.1
#=GS F1R097_DANRE/381-438 AC F1R097.2
#=GS G3TF78_LOXAF/373-421 AC G3TF78.1
#=GS G3PX04_GASAC/369-417 AC G3PX04.1
#=GS A0A1S3WHU5_ERIEU/290-336 AC A0A1S3WHU5.1
#=GS A0A2I4B8Z7_9TELE/374-432 AC A0A2I4B8Z7.1
#=GS A0A1S3S3M3_SALSA/341-390 AC A0A1S3S3M3.1
#=GS H3D932_TETNG/341-400 AC H3D932.1
#=GS A0A1A6HQS9_NEOLE/355-403 AC A0A1A6HQS9.1
#=GS U3IFU2_ANAPL/271-321 AC U3IFU2.1
#=GS A0A1V4KUA6_PATFA/370-428 AC A0A1V4KUA6.1
#=GS G1MHJ7_AILME/341-389 AC G1MHJ7.1
#=GS A0A1S3S3M2_SALSA/114-164 AC A0A1S3S3M2.1
#=GS A0A0P7XQB2_9TELE/113-171 AC A0A0P7XQB2.1
#=GS U3IFU9_ANAPL/271-321 AC U3IFU9.1
#=GS H0VK50_CAVPO/373-421 AC H0VK50.2
#=GS F7BS58_XENTR/323-380 AC F7BS58.1
#=GS H2TLU6_TAKRU/368-419 AC H2TLU6.1
#=GS U3IFS2_ANAPL/282-320 AC U3IFS2.1
#=GS A0A1U8D9K4_ALLSI/366-417 AC A0A1U8D9K4.1
#=GS A0A2D0S9F9_ICTPU/420-468 AC A0A2D0S9F9.1
#=GS G3RE86_GORGO/336-384 AC G3RE86.2
#=GS A0A1U7R8C0_MESAU/373-421 AC A0A1U7R8C0.1
#=GS W5MEW9_LEPOC/450-507 AC W5MEW9.1
#=GS M4A2P3_XIPMA/374-432 AC M4A2P3.1
#=GS H2QAC6_PANTR/373-421 AC H2QAC6.2
#=GS A0A2D0SYK3_ICTPU/428-480 AC A0A2D0SYK3.1
#=GS H2LXW7_ORYLA/372-425 AC H2LXW7.1
#=GS A0A1S3EQN2_DIPOR/291-339 AC A0A1S3EQN2.1
#=GS U3IFW2_ANAPL/285-327 AC U3IFW2.1
#=GS A0A2I4BGK6_9TELE/417-448 AC A0A2I4BGK6.1
#=GS A0A2D0SA96_ICTPU/420-468 AC A0A2D0SA96.1
#=GS A0A1U8CN26_MESAU/349-397 AC A0A1U8CN26.1
#=GS A0A2D0PM41_ICTPU/312-362 AC A0A2D0PM41.1
#=GS A0A2D0PRD0_ICTPU/423-473 AC A0A2D0PRD0.1
#=GS W5Q8S8_SHEEP/382-430 AC W5Q8S8.1
#=GS H3CLZ0_TETNG/377-428 AC H3CLZ0.1
#=GS A0A1S3QLX6_SALSA/89-133 AC A0A1S3QLX6.1
#=GS F7E8C3_CALJA/56-104 AC F7E8C3.1
#=GS A0A1S3QIF2_SALSA/79-117 AC A0A1S3QIF2.1
#=GS I3LCF2_PIG/373-421 AC I3LCF2.2
#=GS A0A286XKY8_CAVPO/373-421 AC A0A286XKY8.1
#=GS H2UA10_TAKRU/344-402 AC H2UA10.1
#=GS A0A1S3NFU4_SALSA/374-432 AC A0A1S3NFU4.1
#=GS A0A2D0PNQ7_ICTPU/423-473 AC A0A2D0PNQ7.1
#=GS F7IBQ6_CALJA/427-468 AC F7IBQ6.1
#=GS A0A1S3SWA8_SALSA/414-470 AC A0A1S3SWA8.1
#=GS A0A226PQT6_COLVI/299-357 AC A0A226PQT6.1
#=GS G1P245_MYOLU/342-390 AC G1P245.1
#=GS H2TLU5_TAKRU/368-418 AC H2TLU5.1
#=GS A0A1S3S3N4_SALSA/341-391 AC A0A1S3S3N4.1
#=GS F1MB71_BOVIN/343-391 AC F1MB71.2
#=GS A0A0F8C3E1_LARCR/522-569 AC A0A0F8C3E1.1
#=GS A0A0R4IRE4_DANRE/373-425 AC A0A0R4IRE4.1
#=GS H2MQ14_ORYLA/330-388 AC H2MQ14.1
#=GS L5KGS9_PTEAL/362-411 AC L5KGS9.1
#=GS G3HBR4_CRIGR/347-395 AC G3HBR4.1
#=GS A0A1S3RE16_SALSA/292-350 AC A0A1S3RE16.1
#=GS W5KGY2_ASTMX/367-411 AC W5KGY2.1
#=GS A0A1L8EQT3_XENLA/428-485 AC A0A1L8EQT3.1
#=GS A0A1S3NGF0_SALSA/374-432 AC A0A1S3NGF0.1
#=GS G3NQS9_GASAC/344-403 AC G3NQS9.1
#=GS A0A1U7R606_MESAU/373-421 AC A0A1U7R606.1
#=GS M7BMH3_CHEMY/379-429 AC M7BMH3.1
#=GS F6PM80_HORSE/346-394 AC F6PM80.1
#=GS F1Q1A7_CANLF/342-390 AC F1Q1A7.2
#=GS L5LVN5_MYODS/375-421 AC L5LVN5.1
#=GS F6ZWE4_HORSE/344-392 AC F6ZWE4.1
#=GS A0A087X7X2_POEFO/427-479 AC A0A087X7X2.2
#=GS A0A2D0SZ44_ICTPU/344-394 AC A0A2D0SZ44.1
#=GS A0A087YMJ8_POEFO/386-439 AC A0A087YMJ8.2
#=GS A0A2D0SZK3_ICTPU/407-453 AC A0A2D0SZK3.1
#=GS A0A0D9RER6_CHLSB/373-421 AC A0A0D9RER6.1
#=GS A0A2I4BGK6_9TELE/368-414 AC A0A2I4BGK6.1
#=GS F7E897_CALJA/343-391 AC F7E897.1
#=GS A0A1S3RB65_SALSA/423-473 AC A0A1S3RB65.1
#=GS CSKI1_HUMAN/373-421 AC Q8WXD9.1
#=GS I3L7B5_PIG/373-421 AC I3L7B5.2
#=GS I3KTW6_ORENI/370-424 AC I3KTW6.1
#=GS A0A2I4B945_9TELE/374-432 AC A0A2I4B945.1
#=GS I3J5L5_ORENI/368-416 AC I3J5L5.1
#=GS D3ZE17_RAT/373-421 AC D3ZE17.2
#=GS A0A2D0SYL8_ICTPU/428-480 AC A0A2D0SYL8.1
#=GS K7E7V4_ORNAN/27-85 AC K7E7V4.1
#=GS U3IFT0_ANAPL/286-323 AC U3IFT0.1
#=GS A0A2I4BGM4_9TELE/417-448 AC A0A2I4BGM4.1
#=GS I3JHD2_ORENI/456-514 AC I3JHD2.1
#=GS U3IFX3_ANAPL/56-101 AC U3IFX3.1
#=GS H3CLZ1_TETNG/377-428 AC H3CLZ1.1
#=GS A0A226NM71_CALSU/379-437 AC A0A226NM71.1
#=GS A0A096NL17_PAPAN/373-421 AC A0A096NL17.1
#=GS M4AAX2_XIPMA/376-422 AC M4AAX2.1
#=GS G1RDA4_NOMLE/324-372 AC G1RDA4.2
#=GS A0A2I2U7T5_FELCA/373-421 AC A0A2I2U7T5.1
#=GS G5BY43_HETGA/360-408 AC G5BY43.1
#=GS G1N367_MELGA/344-401 AC G1N367.2
#=GS F6QHA2_MACMU/341-389 AC F6QHA2.2
#=GS A0A2I3TA85_PANTR/373-421 AC A0A2I3TA85.1
#=GS G7Q084_MACFA/349-397 AC G7Q084.1
#=GS A0A2G9SMB7_LITCT/46-103 AC A0A2G9SMB7.1
#=GS A0A2D0SAV2_ICTPU/419-467 AC A0A2D0SAV2.1
#=GS A0A0R4IGS7_DANRE/415-451 AC A0A0R4IGS7.1
#=GS I3N4E2_ICTTR/341-389 AC I3N4E2.2
#=GS A0A2I4BGM4_9TELE/368-414 AC A0A2I4BGM4.1
#=GS H2UA11_TAKRU/366-409 AC H2UA11.1
#=GS A0A2I4CHL0_9TELE/407-460 AC A0A2I4CHL0.1
#=GS G3UHQ2_LOXAF/373-421 AC G3UHQ2.1
#=GS A0A2K5NVJ1_CERAT/373-421 AC A0A2K5NVJ1.1
#=GS A0A218U7Z2_9PASE/376-434 AC A0A218U7Z2.1
#=GS A0A0Q3U620_AMAAE/20-78 AC A0A0Q3U620.1
#=GS H2UA08_TAKRU/344-402 AC H2UA08.1
#=GS CSKI1_RAT/373-421 AC Q8VHK2.1
#=GS A0A0R4IIH7_DANRE/335-371 AC A0A0R4IIH7.1
A0A0P7WSE3_9TELE/374-432 ............EEIWVLRKP.TA.V.GDRSSVGSS....GSVASARSSGSGQSAGs..ssQALHAQAE.GVKLLATVLSQ...............
S9XEX4_CAMFR/270-318 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A2K5JNB6_COLAP/334-382 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2D0PNN1_ICTPU/423-473 ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
A0A0R4IGS7_DANRE/367-418 ............EEIWVLRKP.LAaG.GSVGSMGST....GSLS-GRSSASGQSSN.....ANAH----.-----------ltnspvpvptt....
A0A0R4IIH7_DANRE/287-338 ............EEIWVLRKP.LAaG.GSVGSMGST....GSLS-GRSSASGQSSN.....ANAH----.-----------ltnspvpvptt....
H2UA09_TAKRU/344-402 ............EEIWVLRKP.VA.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQAE.GVKLLATVLSQ...............
A0A2D0SZ27_ICTPU/428-480 ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
F6Z3A3_MONDO/387-424 ..........lv---------.LA.G.ADRS--SSL....GGVASGRSGGSGS---.....HALHASSE.GVKV-------g..............
I3ITP1_DANRE/381-438 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVASARSSGSGQSAGs...tSILHAQAE.GVKLLATVLSQ...............
W5MEY2_LEPOC/419-470 .........rcg---------.-Q.G.GDRSSVGSS....GSVASARSSGSGQSAGg..svHALHAQAE.GVKLLATVLSQ...............
H2NPT5_PONAB/353-401 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGGRGSGG-----.....HALHAGSE.GIKLLATVLSQ...............
A0A1V4KSY5_PATFA/442-500 ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHASSE.GVKLLATVLSQ...............
L9L345_TUPCH/392-440 ............EEIWVLRKP.FT.G.GDRS--GSL....SGVASSRSSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2D0PQB5_ICTPU/423-472 ............EDIWVLRNS.CA.-.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
A0A1U7T6N7_TARSY/291-339 ............EEIWVLRKP.FA.G.GERS--SSV....SGMAGSRGSGS-----.....HALHAGSE.GVKLLATVLSQ...............
I3JHD3_ORENI/325-385 ............EEIWVLRKP.VAaG.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAEkGVKLLATVLSQ...............
S7PMT8_MYOBR/230-272 .........grk---------.CT.C.GDRS--GSL....SSVAVGRSSGA-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A2I4B971_9TELE/374-432 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
A0A2D0SZ36_ICTPU/369-421 ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
CSKI1_MOUSE/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSTGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2G9SMB2_LITCT/24-73 .........err---------.--.S.GDRSSMGST....GSGASGRSSGSGQSANs...pHAIPASAE.GVKLLATVLSQ...............
I3J5L6_ORENI/368-416 ............EDIWVLRKP.LA.G.GERS--GSV....GSLGSVRSSSSLR---.....--LHAQAE.GVKLLATVLSQ...............
A0A2K5JN77_COLAP/334-382 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
M3W853_FELCA/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....GSVAGGRSSGG-----.....HTLHAGSE.GVKVGAA----lash...........
A0A1L8EYF4_XENLA/215-269 ............EEIWVLRKP.FA.G.GDRSSMGST....GS---GRSSGSGQSAGs...aHAIHAGAE.GVKLLATVLSQ...............
A0A1S3QIF2_SALSA/32-75 ............EDVWVLRKP.LA.G.GDHS--SSV....GSLGSVRSLGSVQSSG.....NTQHAS--.-----------nta............
H0XTL5_OTOGA/373-423 ............EEIWVLRKP.FA.G.GDRSSSSSV....SSVAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A1S3QLX6_SALSA/136-174 .....atahatn---------.--.-.---------....------TPPGSLNTHGl..naPGLHAQAE.GVKLLATVMSQ...............
A0A1S3SWA6_SALSA/411-467 ............EDIWVLRNS.HT.A.GDRNSVGSAgssaGSVGSSRSAGSGQSSE.....N-------.-----------sfgqngshtrqttat
A0A151NIX6_ALLMI/12-63 ...........f--------P.LA.G.GDRSSLGST....GSVASARSSGSGQSAGs..ggHALHAGSE.GVKLLATVLSQ...............
A0A2D0Q7K9_ICTPU/487-528 sspvpvpttpth---------.--.-.---------....--------STGLNTHGv..nvPGLHAQAE.GVKLLATVLSQ...............
W5KH32_ASTMX/103-161 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVASARSSGSGQSAGs..ssHILHAQAE.GVKLLATVLSQ...............
A0A2D0S9G0_ICTPU/399-447 ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
F6PLP7_ORNAN/252-291 .........isc--------P.FA.A.GDRNSVGSE....GSLGSVRSAGSGQSSE....gN-------.-----------nghvpg.........
A0A2I4D0S3_9TELE/440-487 ............EDIWVLRGS.CH.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....--------.-----------snsatnghqhn....
G3WW39_SARHA/56-106 ............EEIWVLRKP.FT.G.ADRS--SSL....GGVASGRSGGSGS---.....HALHAGSE.GVKLLATVLSQ...............
F1R097_DANRE/381-438 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVASARSSGSGQSAGs...tSILHAQAE.GVKLLATVLSQ...............
G3TF78_LOXAF/373-421 ............EEIWVLRKP.FA.G.GDRS--SSL....SSVPGGRGSGG-----.....HVLHAGSE.GVKLLATVLSQ...............
G3PX04_GASAC/369-417 ............EDIWVLRKP.LA.V.AERS--GSV....GSIGSVRSTSSL----.....-GLHAQAE.GVKLLATVLAQ...............
A0A1S3WHU5_ERIEU/290-336 ............EEIWVLRKP.FA.G.GDRS--GSL....SS--AGRSGGG-----.....HALHAGAE.GVKLLATVLSQ...............
A0A2I4B8Z7_9TELE/374-432 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
A0A1S3S3M3_SALSA/341-390 ............EDIWVLRNS.HT.A.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
H3D932_TETNG/341-400 ............EEIWVLRKPvFA.G.GDRSSLGSS....SSVNSVRSSGSGQSAGs..apHILHAQAE.GVKLLATVLSQ...............
A0A1A6HQS9_NEOLE/355-403 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
U3IFU2_ANAPL/271-321 ............EEIWVLRKP.FA.G.GDRSSLGST....SG--SGQSAGSGA---.....HALHASSE.GVKMLSPVL--la.............
A0A1V4KUA6_PATFA/370-428 ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHASSE.GVKLLATVLSQ...............
G1MHJ7_AILME/341-389 ............EEIWVLRKP.FA.G.GDRG--GSL....SAVAGARGSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A1S3S3M2_SALSA/114-164 ............EDIWVLRNS.HTaA.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
A0A0P7XQB2_9TELE/113-171 ............EEIWVLRKP.FA.G.ADRSSAGSS....GSVTSARSSGSGQSAGs..nvHTLHAQAE.GVKLLATVLSQ...............
U3IFU9_ANAPL/271-321 ............EEIWVLRKP.FA.G.GDRSSLGST....SG--SGQSAGSGA---.....HALHASSE.GVKMLSPVL--la.............
H0VK50_CAVPO/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
F7BS58_XENTR/323-380 ............EEIWVLRKP.LA.G.GDRSSMGST....GSATSGRSSGSGQSAGs...aHAIHAGAE.GVKLLATVLSQ...............
H2TLU6_TAKRU/368-419 ............EDIWVLRKP.LA.G.GERS-----....GSVAN--TPGGVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
U3IFS2_ANAPL/282-320 .........pva---------.QA.G.GDRSSLGST....GS---GQSAGSGA---.....HALHASSE.GVKV-------rl.............
A0A1U8D9K4_ALLSI/366-417 ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..ggHALHAGSE.GVK--------r..............
A0A2D0S9F9_ICTPU/420-468 ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
G3RE86_GORGO/336-384 ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A1U7R8C0_MESAU/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
W5MEW9_LEPOC/450-507 .........war----VYKKT.PA.G.GDRSSVGSS....GSVASARSSGSGQSAGg..svHALHAQAE.GVKLLATVLSQ...............
M4A2P3_XIPMA/374-432 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSATn..aaHILHAQAE.GVKLLATVLSQ...............
H2QAC6_PANTR/373-421 ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2D0SYK3_ICTPU/428-480 ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
H2LXW7_ORYLA/372-425 ............EDIWVLRKP.LA.G.GERS--GST....GSLGSVRSSSSLQSSG.....NTLHAQSE.GVKLLATVLSQ...............
A0A1S3EQN2_DIPOR/291-339 ............EEIWVLRKP.FA.G.GERS--GSL....SSGTGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
U3IFW2_ANAPL/285-327 ........rcpr---------.GT.G.GDRSSLGST....GSSGSGQSAGSGA---.....HALHASSE.GVKV-------rl.............
A0A2I4BGK6_9TELE/417-448 ........aptp---------.--.-.---------....----------GVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
A0A2D0SA96_ICTPU/420-468 ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
A0A1U8CN26_MESAU/349-397 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2D0PM41_ICTPU/312-362 ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
A0A2D0PRD0_ICTPU/423-473 ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
W5Q8S8_SHEEP/382-430 ............EEIWVLRKP.FA.G.GDRS--GSL....SSAAGGRSSGG-----.....HALHAGSE.GVKLLATVLSQ...............
H3CLZ0_TETNG/377-428 ............EEIWVLRKS.GApA.GDRSSVGST....GSVGSTRSAGSGQSS-.....----TGGD.GPRVWSTCIRS...............
A0A1S3QLX6_SALSA/89-133 ............EDVWVLRKP.LA.G.GDRS--SSV....GSLGSVRPLGSVQSSV.....NTQHAS--.-----------ntap...........
F7E8C3_CALJA/56-104 ............EEIWVLRKP.FA.G.GERS--GSV....SGVAGGRGSGG-----.....QALHAGSE.GVKLLATVLSQ...............
A0A1S3QIF2_SALSA/79-117 .....atahatn---------.--.-.---------....------TPPGSLNTHGl..naPGLHAQAE.GVKLLATVMSQ...............
I3LCF2_PIG/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SGVAGGRSSGG-----.....HTLHAGAE.GVKLLATVLSQ...............
A0A286XKY8_CAVPO/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
H2UA10_TAKRU/344-402 ............EEIWVLRKP.VA.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQAE.GVKLLATVLSQ...............
A0A1S3NFU4_SALSA/374-432 ............EEIWVLRKP.GP.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..stHIIHAQAE.GVKLLATVLSQ...............
A0A2D0PNQ7_ICTPU/423-473 ............EDIWVLRNS.CA.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....NT------.-----------ttsngqhstnae...
F7IBQ6_CALJA/427-468 .........wll--------P.PT.A.GDRNSVGSE....GSVGSIRSAGSGQSSE.....--------.-----------gtnghgpgll.....
A0A1S3SWA8_SALSA/414-470 ............EDIWVLRNS.HT.A.GDRNSVGSAgssaGSVGSSRSAGSGQSSE.....N-------.-----------sfgqngshtrqttat
A0A226PQT6_COLVI/299-357 ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSTGs..gaHALHAGSE.GVKLLATVLSQ...............
G1P245_MYOLU/342-390 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAVGRSSGA-----.....HTLHAGSE.GVKLLATVLSQ...............
H2TLU5_TAKRU/368-418 ............EDIWVLRKP.LA.G.GERS-----....GS-AN--TPGGVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
A0A1S3S3N4_SALSA/341-391 ............EDIWVLRNS.HTaA.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
F1MB71_BOVIN/343-391 ............EEIWVLRKP.FA.G.GDRS--GSL....SSAAGGRSVGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A0F8C3E1_LARCR/522-569 ............EDIWVLRDS.CH.A.GDRNSVGST....GSVGSTRSAGSGQSTE.....--------.-----------snnapnglqhn....
A0A0R4IRE4_DANRE/373-425 ............EEIWVLRKP.LAaG.GSVGSMGST....GSLS-GRSSASGQSR-.....--LHAQAE.GVKLLATVLSQ...............
H2MQ14_ORYLA/330-388 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSLRSSGSGQSAGs..apHILHAQAE.GVKLLATVLSQ...............
L5KGS9_PTEAL/362-411 ............EEIWVLRKP.FAaG.GDRS--GSL....SSVAGGRSSGA-----.....HTLHAGSE.GVKLLATVLSQ...............
G3HBR4_CRIGR/347-395 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A1S3RE16_SALSA/292-350 ............EEIWVLRKP.GP.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..stHIIHAQAE.GVKLLATVLSQ...............
W5KGY2_ASTMX/367-411 .........lfl--------P.PV.A.GDRNSVGST....GSVGSTRSAGSGQSTEsnnapNGLHQ---.-----------htt............
A0A1L8EQT3_XENLA/428-485 ............EEIWVLRKP.FA.G.GDRSSMGST....GSATSGRSSGSGQSAGs...aHAIHAGAE.GVKLLATLLSQ...............
A0A1S3NGF0_SALSA/374-432 ............EEIWVLRKP.GP.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..stHIIHAQAE.GVKLLATVLSQ...............
G3NQS9_GASAC/344-403 ............EEIWVLRKS.VAaG.GDRSSLGSS....GSVTSVRSSGSGQSAGs..tgHVLHAQAE.GVKLLATVLSQ...............
A0A1U7R606_MESAU/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
M7BMH3_CHEMY/379-429 ..........wq---------.-A.G.GDRSSLGST....GSVASARSSGRGQSTGs..gsHALHAGSE.GVKLLATVLSQ...............
F6PM80_HORSE/346-394 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
F1Q1A7_CANLF/342-390 ............EEIWVLRKP.FA.G.GDRS--GSL....SGAAGARSGGG-----.....HALHAGSE.GVKLLATVLSQ...............
L5LVN5_MYODS/375-421 .......vkrag-------KS.YP.G.GDRS--GSL....SSVAVGRSSGA-----.....HSLHAGSE.GVKLLATVLSQ...............
F6ZWE4_HORSE/344-392 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSSGG-----.....HTLHAGSE.GVKLLATVLSQ...............
A0A087X7X2_POEFO/427-479 ...........t--------P.TApG.GDRSSVGSS....GSVTSVRSSGSGQSATs..aaHILHAQAE.GVKLLATVLSQ...............
A0A2D0SZ44_ICTPU/344-394 .........vis------KRP.GAtG.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
A0A087YMJ8_POEFO/386-439 ...........q-DIWVLRSS.PT.-.GDRNSVGST....GSVGSSRSAGSGQSSEsgrkqN-------.-----------gthirhhadagk...
A0A2D0SZK3_ICTPU/407-453 ........pisq---------.-K.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
A0A0D9RER6_CHLSB/373-421 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2I4BGK6_9TELE/368-414 ............EDIWVLRKP.MA.G.GERS--GSV....GSLGSXRSSSSLQSSGn...tHVLTT---.-----------papsp..........
F7E897_CALJA/343-391 ............EEIWVLRKP.FA.G.GERS--GSV....SGVAGGRGSGG-----.....QALHAGSE.GVKLLATVLSQ...............
A0A1S3RB65_SALSA/423-473 ............EDIWVLRNS.HTaA.GDRNSVGST....GSVGSTRSAGSGQSTEsntapN-------.-----------gqhqqtt........
CSKI1_HUMAN/373-421 ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
I3L7B5_PIG/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SGVAGGRSSGG-----.....HTLHAGAE.GVKLLATVLSQ...............
I3KTW6_ORENI/370-424 ...........q-EIWVLRSS.PT.GkSDRNSVGSA....GSVGSSRSAGSGQSSEsghkqN-------.-----------gihcchnadag....
A0A2I4B945_9TELE/374-432 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
I3J5L5_ORENI/368-416 ............EDIWVLRKP.LA.G.GERS--GSV....GSLGSVRSSSSLR---.....--LHAQAE.GVKLLATVLSQ...............
D3ZE17_RAT/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSTGG-----.....HALHAGAE.GVKLLATVLSQ...............
A0A2D0SYL8_ICTPU/428-480 ............EEIWVLRKP.AA.G.GDRSSVSSS....SS---ARSSGSGQSNT.....HILHAHAE.GVKLLATVLSQ...............
K7E7V4_ORNAN/27-85 ............EDIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSGGs..gvHTLHPGSE.GVKLLATVLSQ...............
U3IFT0_ANAPL/286-323 ..........pr--------T.CA.G.GDRSSLGST....GS---GQSAGSGA---.....HALHASSE.GVK--------qc.............
A0A2I4BGM4_9TELE/417-448 ........aptp---------.--.-.---------....----------GVNTHGl..naPGLHAQAE.GVKLLATVLSQ...............
I3JHD2_ORENI/456-514 ............EEIWVLRKP.VA.G.GDRSSVGSS....GSVTSVRSSGSGQSAGs..aaHILHAQAE.GVKLLATVLSQ...............
U3IFX3_ANAPL/56-101 ............EEIWVLRKP.FA.G.GDRSSLGST....SG--SGQSAGSGA---.....HALHASSE.GVKV-------rl.............
H3CLZ1_TETNG/377-428 ............EEIWVLRKS.GApA.GDRSSVGST....GSVGSTRSAGSGQSS-.....----TGGD.GPRVWSTCIRS...............
A0A226NM71_CALSU/379-437 ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSTGs..gaHALHAGSE.GVKLLATVLSQ...............
A0A096NL17_PAPAN/373-421 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHPGSE.GIKLLATVLSQ...............
M4AAX2_XIPMA/376-422 ...........q-DIWVLRSS.PT.-.GDRNSVGST....GSVGSSRSAGSGQSS-.....---ESGPE.GAK--------hirl...........
G1RDA4_NOMLE/324-372 ............EEIWVLRKP.FA.V.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2I2U7T5_FELCA/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....GSVAGGRSSGG-----.....HTLHAGSE.GVKVGAA----lash...........
G5BY43_HETGA/360-408 ............EEIWVLRKP.FA.G.GDRS--GSL....SSVAGGRSGGG-----.....HTLHAGSE.GVKLLATVLSQ...............
G1N367_MELGA/344-401 ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSTGs..gaHALHAGSE.GVKL-------gdslla.........
F6QHA2_MACMU/341-389 ............EEIWVLRKP.FT.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2I3TA85_PANTR/373-421 ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGGRGSGG-----.....HALHAGSE.GVKLLATVLSQ...............
G7Q084_MACFA/349-397 ............EEIWVLRKP.FA.G.GDRS--GSI....SGVAGSRGSGG-----.....HTLHAGSE.GIKLLATVLSQ...............
A0A2G9SMB7_LITCT/46-103 ............EEIWVLRKP.FA.G.GDRSSMGST....GSGASGRSSGSGQSANs...pHAIPASAE.GVKLLATVLSQ...............
A0A2D0SAV2_ICTPU/419-467 ............EDIWVLRSS.FT.-.GDRNSVGSA....GSVGSSRSAGSGQSTE....gNFTH----.-----------naqhqtst.......
A0A0R4IGS7_DANRE/415-451 .....vpttpth---------.--.-.---------....--------SPGVNTHGl..nvPGLHAQAE.GVKLLATVLSQ...............
I3N4E2_ICTTR/341-389 ............EEIWVLRKP.SA.G.GDRS--GNL....SSVAGSRSSGA-----.....HALHAGSE.GVKLLATVLSQ...............
A0A2I4BGM4_9TELE/368-414 ............EDIWVLRKP.MA.G.GERS--GSV....GSLGSXRSSSSLQSSGn...tHVLTT---.-----------papsp..........
H2UA11_TAKRU/366-409 .......sfdsm---------.--.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQ--.-----------ekpl...........
A0A2I4CHL0_9TELE/407-460 ...........q-DIWVLRSS.PT.-.GDRNSVGST....GSAGSSRSAGSGQSSE.....-SGHK---.-----------qngthnrhhhdtvk.
G3UHQ2_LOXAF/373-421 ............EEIWVLRKP.FA.G.GDRS--SSL....SSVPGGRGSGG-----.....HVLHAGSE.GVKLLATVLSQ...............
A0A2K5NVJ1_CERAT/373-421 ............EEIWVLRKP.FA.G.GDRS--GSI....SGMAGSRGSGG-----.....HTLHPGSE.GIKLLATVLSQ...............
A0A218U7Z2_9PASE/376-434 ............EEIWVLRKP.FA.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHAGSE.GVKLLATVLSQ...............
A0A0Q3U620_AMAAE/20-78 ............EEIWVLRKP.FT.G.GDRSSLGST....GSVASARSSGSGQSAGs..gaHALHAGSE.GVKLLATVLSQ...............
H2UA08_TAKRU/344-402 ............EEIWVLRKP.VA.G.GDRSSLGSS....SSVNSVRSSGSGQSAAs..apHILHAQAE.GVKLLATVLSQ...............
CSKI1_RAT/373-421 ............EEIWVLRKP.FA.G.GDRS--GSL....SNVAGGRSTGG-----.....HALHAGAE.GVKLLATVLSQ...............
A0A0R4IIH7_DANRE/335-371 .....vpttpth---------.--.-.---------....--------SPGVNTHGl..nvPGLHAQAE.GVKLLATVLSQ...............
#=GC seq_cons ............EEIWVLRKP.hA.G.GDRS..GSs....uSVuuuRSSGSsp........HsLHAtuE.GVKLLATVLSQ...............
//
