#=GF ID Glyoxalase_5
#=GF AC PF14696.10
#=GF DE Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE CATH:1cjx_A_01
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.00;
#=GF NC 26.90 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0104
#=GF RN [1]
#=GF RM 10467142
#=GF RT Crystal structure of Pseudomonas fluorescens
#=GF RT 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the
#=GF RT tyrosine degradation pathway.
#=GF RA Serre L, Sailland A, Sy D, Boudec P, Rolland A, Pebay-Peyroula
#=GF RA E, Cohen-Addad C;
#=GF RL Structure. 1999;7:977-988.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is one of two barrel-shaped regions that together
#=GF CC form the active enzyme, 4-hydroxyphenylpyruvic acid dioxygenase,
#=GF CC EC:1.13.11.27. As can be deduced from the disposition of the
#=GF CC various Glyoxalase families, _2, _3 and _4 in Pfam,
#=GF CC Pfam:PF00903, Pfam:PF12681, Pfam:PF13468, Pfam:PF13669, these
#=GF CC two regions are similar to be indicative of a gene-duplication
#=GF CC event. At the individual sequence level slight differences in
#=GF CC conformation have given rise to slightly different functions. In
#=GF CC the case of UniProt:P80064, 4-hydroxyphenylpyruvic acid
#=GF CC dioxygenase catalyses the formation of homogentisate from
#=GF CC 4-hydroxyphenylpyruvate, and the pyruvate part of the HPPD
#=GF CC substrate (4-hydroxyphenylpyruvate), derived from L-tyrosine,
#=GF CC and the O2 molecule occupy the three free coordination sites of
#=GF CC the catalytic iron atom in the C-terminal domain. In plants and
#=GF CC photosynthetic bacteria, the tyrosine degradation pathway is
#=GF CC crucial because homogentisate, a tyrosine degradation product,
#=GF CC is a precursor for the biosynthesis of photosynthetic pigments,
#=GF CC such as quinones or tocopherols [1].
#=GF SQ 3436
#=GS A0A8J8AY31_9GAMM/21-160 AC A0A8J8AY31.1
#=GS A0A139WRR9_9CYAN/5-147 AC A0A139WRR9.1
#=GS A0A1W2FTV4_KIBAR/10-142 AC A0A1W2FTV4.1
#=GS A0A2T5B0Y1_MYCDI/15-151 AC A0A2T5B0Y1.1
#=GS A0A418XQI4_9BURK/6-157 AC A0A418XQI4.1
#=GS A0A021X191_9HYPH/15-151 AC A0A021X191.1
#=GS A0A239S946_9BURK/5-143 AC A0A239S946.1
#=GS A0A3N6NKL0_9BURK/6-154 AC A0A3N6NKL0.1
#=GS A0A094L4P7_9GAMM/5-145 AC A0A094L4P7.1
#=GS A3JVK5_9RHOB/24-159 AC A3JVK5.1
#=GS A0A1A5PE87_9ACTN/287-418 AC A0A1A5PE87.1
#=GS A0A0Q5CRZ0_9HYPH/284-422 AC A0A0Q5CRZ0.1
#=GS A0A1V6LUK3_9FLAO/13-158 AC A0A1V6LUK3.1
#=GS A0A1X7A693_9RHOB/283-422 AC A0A1X7A693.1
#=GS A0A0Q7S7D1_9CAUL/15-154 AC A0A0Q7S7D1.1
#=GS A0A843YMU8_9BURK/6-154 AC A0A843YMU8.1
#=GS A0A4R6E3Q4_9RHOO/11-148 AC A0A4R6E3Q4.1
#=GS A0A420WFB4_9PROT/5-146 AC A0A420WFB4.1
#=GS A0A494W5J0_9SPHN/4-131 AC A0A494W5J0.1
#=GS A0A7G9SBW8_9SPHN/5-133 AC A0A7G9SBW8.1
#=GS A0A7G8VWF9_9BURK/302-444 AC A0A7G8VWF9.1
#=GS Q6NDU9_RHOPA/15-153 AC Q6NDU9.1
#=GS A0A0Q7PQF4_9GAMM/22-161 AC A0A0Q7PQF4.1
#=GS D6A5S5_STRV1/274-340 AC D6A5S5.1
#=GS A0A841JLA4_9BACT/13-156 AC A0A841JLA4.1
#=GS L7KHD9_9ACTN/274-388 AC L7KHD9.1
#=GS A0A101U7W2_9ACTN/274-399 AC A0A101U7W2.1
#=GS A0A1V1WAE4_9ACTN/38-179 AC A0A1V1WAE4.1
#=GS A0A4Z0BM46_9BURK/11-148 AC A0A4Z0BM46.1
#=GS A0A327QYY3_9BACT/15-160 AC A0A327QYY3.1
#=GS A0A0B6RUM4_BURPL/6-154 AC A0A0B6RUM4.1
#=GS A0A1G7VGK0_9HYPH/282-422 AC A0A1G7VGK0.1
#=GS A0A0F4Q005_9GAMM/4-141 AC A0A0F4Q005.1
#=GS A0A7W6G7Z9_9SPHN/282-416 AC A0A7W6G7Z9.1
#=GS A0A1J4QHA8_9GAMM/14-151 AC A0A1J4QHA8.1
#=GS A0A1H0VXU1_9HYPH/15-151 AC A0A1H0VXU1.1
#=GS A0A0J7XNG2_9SPHN/284-422 AC A0A0J7XNG2.1
#=GS A0A2S4Y3W0_9ACTN/274-406 AC A0A2S4Y3W0.1
#=GS A0A1C5III4_9ACTN/26-171 AC A0A1C5III4.1
#=GS A0A328AAT6_9CAUL/294-429 AC A0A328AAT6.1
#=GS A0A0Q4G1Y8_9BURK/16-164 AC A0A0Q4G1Y8.1
#=GS H5X123_9PSEU/290-411 AC H5X123.1
#=GS A0A4Q1D7Z9_9BACT/16-160 AC A0A4Q1D7Z9.1
#=GS A0A246JNQ4_9SPHN/5-143 AC A0A246JNQ4.1
#=GS S6AR59_PSERE/290-428 AC S6AR59.1
#=GS A0A3L7E455_9GAMM/5-143 AC A0A3L7E455.1
#=GS A0A0S9NV94_9BURK/5-143 AC A0A0S9NV94.1
#=GS A0A848FC80_9BURK/14-148 AC A0A848FC80.1
#=GS A0A1H0HD50_9PSEU/33-137 AC A0A1H0HD50.1
#=GS A0A7X6BFB4_9SPHN/13-148 AC A0A7X6BFB4.1
#=GS A0A0Q7YUH9_9SPHN/5-143 AC A0A0Q7YUH9.1
#=GS A0A6G6X4K3_9HYPH/15-151 AC A0A6G6X4K3.1
#=GS A0A222P3T0_9GAMM/10-137 AC A0A222P3T0.1
#=GS A0A4S2RAH8_9ACTN/14-165 AC A0A4S2RAH8.1
#=GS Q2KVC6_BORA1/8-154 AC Q2KVC6.1
#=GS A0A1H6CE61_9HYPH/275-413 AC A0A1H6CE61.1
#=GS A0A066UB78_9GAMM/5-143 AC A0A066UB78.1
#=GS A0A0A7LPK1_9BACT/12-157 AC A0A0A7LPK1.1
#=GS K4QYQ0_STRDJ/274-389 AC K4QYQ0.1
#=GS A0A844H3A7_9RHOB/282-422 AC A0A844H3A7.1
#=GS A0A7G6Y4C0_9SPHN/5-130 AC A0A7G6Y4C0.1
#=GS A0A7X8T8H1_9HYPH/281-420 AC A0A7X8T8H1.1
#=GS A0A431TG23_9BURK/12-160 AC A0A431TG23.1
#=GS A0A158FEN9_9BURK/287-427 AC A0A158FEN9.1
#=GS A0A221NTJ8_9ACTN/1-135 AC A0A221NTJ8.1
#=GS A0A4S8PEB2_9ACTN/23-166 AC A0A4S8PEB2.1
#=GS A0A4Q3LKM7_9BURK/21-158 AC A0A4Q3LKM7.1
#=GS A0A059FK28_9PROT/5-143 AC A0A059FK28.1
#=GS A0A372KBX3_9BURK/19-167 AC A0A372KBX3.1
#=GS A0A7Y4C3K6_9VIBR/4-144 AC A0A7Y4C3K6.1
#=GS A0A257GVM4_9BURK/5-137 AC A0A257GVM4.1
#=GS A0A0J7XPY6_9SPHN/284-417 AC A0A0J7XPY6.1
#=GS A0A0N0JID7_9SPHN/285-422 AC A0A0N0JID7.1
#=GS A0A3N1WRU6_9BURK/294-433 AC A0A3N1WRU6.1
#=GS A5P7N9_9SPHN/5-147 AC A5P7N9.1
#=GS A0A7X0IJ04_9ACTN/18-161 AC A0A7X0IJ04.1
#=GS A0A0Q7D2Z6_9CAUL/5-141 AC A0A0Q7D2Z6.1
#=GS S6GN11_9GAMM/5-143 AC S6GN11.1
#=GS A0A1B3PLW0_9BURK/12-149 AC A0A1B3PLW0.1
#=GS A0A1N6G741_9RHOB/15-150 AC A0A1N6G741.1
#=GS A0A225NDB0_9RHOB/15-150 AC A0A225NDB0.1
#=GS A0A4S8PXN7_9ACTN/294-410 AC A0A4S8PXN7.1
#=GS A0A2A8HUL8_9SPHN/5-148 AC A0A2A8HUL8.1
#=GS A0A1Q8IRZ9_9BURK/6-154 AC A0A1Q8IRZ9.1
#=GS K6YBR0_9ALTE/6-146 AC K6YBR0.1
#=GS A0A7Y0GBE4_9SPHN/5-146 AC A0A7Y0GBE4.1
#=GS A0A160T1F1_9CHLR/3-148 AC A0A160T1F1.2
#=GS A0A430DU32_9SPHN/4-136 AC A0A430DU32.1
#=GS A0A0Q4KTJ5_9SPHN/5-140 AC A0A0Q4KTJ5.1
#=GS A0A4Q5M960_9GAMM/4-140 AC A0A4Q5M960.1
#=GS A0A3S9B0H8_9HYPH/283-423 AC A0A3S9B0H8.1
#=GS A0A846VRN9_9RHOB/15-151 AC A0A846VRN9.1
#=GS A0A5B8V3N5_9SPHI/13-158 AC A0A5B8V3N5.1
#=GS A0A239FRM9_9RHOB/15-150 AC A0A239FRM9.1
#=GS A0A2H5EXH3_9RHOB/15-151 AC A0A2H5EXH3.1
#=GS A0A370X2L6_9GAMM/14-155 AC A0A370X2L6.1
#=GS A0A853IJW5_9GAMM/6-146 AC A0A853IJW5.1
#=GS A0A367IVA5_RHIST/12-157 AC A0A367IVA5.1
#=GS X7EID7_9RHOB/15-150 AC X7EID7.1
#=GS A0A1H5RNP7_9RHOB/15-150 AC A0A1H5RNP7.1
#=GS A0A238LJS8_9RHOB/15-150 AC A0A238LJS8.1
#=GS A0A2S3QUJ5_9PROT/7-141 AC A0A2S3QUJ5.1
#=GS A0A553L8C8_9ALTE/5-143 AC A0A553L8C8.1
#=GS A0A845A6E3_9SPHN/9-148 AC A0A845A6E3.1
#=GS A0A6N1VGQ9_9HYPH/15-151 AC A0A6N1VGQ9.1
#=GS W9GY90_9PROT/281-421 AC W9GY90.1
#=GS A0A328ANI7_9CAUL/13-150 AC A0A328ANI7.1
#=GS A0A0N1FX70_9ACTN/14-146 AC A0A0N1FX70.1
#=GS E8RTV8_ASTEC/5-136 AC E8RTV8.1
#=GS A0A157S9U8_9BORD/8-154 AC A0A157S9U8.1
#=GS A0A432W6U1_9GAMM/5-146 AC A0A432W6U1.1
#=GS A0A0Q5Q6V6_9FLAO/13-159 AC A0A0Q5Q6V6.1
#=GS A0A2G8TEZ3_9BURK/10-147 AC A0A2G8TEZ3.1
#=GS A0A397UCU1_9GLOM/12-158 AC A0A397UCU1.1
#=GS A0A562C6L0_9HYPH/15-151 AC A0A562C6L0.1
#=GS A0A2G1XLS6_STRCJ/1-116 AC A0A2G1XLS6.1
#=GS A0A0D1PJ61_BRAEL/15-153 AC A0A0D1PJ61.1
#=GS A0A7W6G6D7_9SPHN/11-149 AC A0A7W6G6D7.1
#=GS A0A1A7KKQ7_9FLAO/13-158 AC A0A1A7KKQ7.1
#=GS A0A1E4QY33_9BURK/7-155 AC A0A1E4QY33.1
#=GS A0A4Y9EQJ4_9SPHN/6-143 AC A0A4Y9EQJ4.1
#=GS A0A221KJN4_VITFI/17-160 AC A0A221KJN4.1
#=GS A0A813AP29_9DINO/64-213 AC A0A813AP29.1
#=GS A0A239IMI7_9ACTN/17-145 AC A0A239IMI7.1
#=GS A0A0L1KBT7_9SPHN/5-147 AC A0A0L1KBT7.1
#=GS A0A0H3CB33_CAUVN/6-143 AC A0A0H3CB33.1
#=GS A0A6N1WX01_9BURK/18-166 AC A0A6N1WX01.1
#=GS A0A1Y2Q8W0_9BURK/14-162 AC A0A1Y2Q8W0.1
#=GS A2SCL9_METPP/6-154 AC A2SCL9.1
#=GS A0A5S9IIK9_9BACT/1-146 AC A0A5S9IIK9.1
#=GS A0A2C1A147_9BACI/19-156 AC A0A2C1A147.1
#=GS A0A653JUA4_9BURK/4-140 AC A0A653JUA4.1
#=GS A0A0R0BTZ9_9GAMM/6-144 AC A0A0R0BTZ9.1
#=GS A0A1U7I1C9_9CYAN/1-127 AC A0A1U7I1C9.1
#=GS A0A0A0DA54_9PROT/15-153 AC A0A0A0DA54.1
#=GS A0A4V6PBA1_9ACTN/284-365 AC A0A4V6PBA1.1
#=GS A0A4P7JL60_9GAMM/5-143 AC A0A4P7JL60.1
#=GS A0A1I5RYY0_9BACT/15-159 AC A0A1I5RYY0.1
#=GS A0A5P8WA93_9NOSO/7-155 AC A0A5P8WA93.1
#=GS A0A7U7IAW8_9PSED/9-149 AC A0A7U7IAW8.1
#=GS A0A5C6TYN7_9SPHN/11-148 AC A0A5C6TYN7.1
#=GS A0A318J453_9BURK/6-154 AC A0A318J453.1
#=GS J3D578_9BURK/17-155 AC J3D578.1
#=GS A0A1W6Z5H6_9BORD/8-154 AC A0A1W6Z5H6.1
#=GS A0A495RTD3_SPHMI/5-143 AC A0A495RTD3.1
#=GS A0A1Z4N3R6_9CYAN/14-181 AC A0A1Z4N3R6.1
#=GS A0A238L8C0_9RHOB/16-151 AC A0A238L8C0.1
#=GS A0A1U9Z1L2_9HYPH/283-422 AC A0A1U9Z1L2.1
#=GS A0A398B6G3_9BACI/16-170 AC A0A398B6G3.1
#=GS A0A1B9SHT2_9HYPH/283-422 AC A0A1B9SHT2.1
#=GS A0A1M5GIG7_9ALTE/7-147 AC A0A1M5GIG7.1
#=GS W8X1J7_CASDE/8-154 AC W8X1J7.1
#=GS A0A520ENU4_SPHSX/1-132 AC A0A520ENU4.1
#=GS A0A239PPC1_9PROT/5-142 AC A0A239PPC1.1
#=GS A0A6J5GR90_9BURK/6-154 AC A0A6J5GR90.1
#=GS A0A1V1V114_9CAUL/14-153 AC A0A1V1V114.1
#=GS A0A8J7JA46_9CYAN/3-147 AC A0A8J7JA46.1
#=GS A0E6B4_PARTE/9-156 AC A0E6B4.1
#=GS A0A3A3FFA2_9BURK/5-143 AC A0A3A3FFA2.1
#=GS A0A1D7XTC7_9FLAO/20-166 AC A0A1D7XTC7.1
#=GS D6CPM1_THIA3/9-156 AC D6CPM1.1
#=GS A0A0K1K0R9_9BURK/6-155 AC A0A0K1K0R9.1
#=GS A0A1C6N576_9BURK/5-143 AC A0A1C6N576.1
#=GS A0A1G9ATF4_9GAMM/6-145 AC A0A1G9ATF4.1
#=GS A0A2N9VV64_9HYPH/283-422 AC A0A2N9VV64.1
#=GS A0A2K9EHW7_9RHOB/282-422 AC A0A2K9EHW7.1
#=GS A0A255ZF86_9BURK/5-143 AC A0A255ZF86.1
#=GS L8M776_9CYAN/3-150 AC L8M776.1
#=GS A0A543AXR4_9ACTN/22-166 AC A0A543AXR4.1
#=GS J2TYF5_9BURK/10-147 AC J2TYF5.1
#=GS A0A4Y4DPY6_GLUUR/289-410 AC A0A4Y4DPY6.1
#=GS A0A4V2EWS0_9BURK/294-433 AC A0A4V2EWS0.1
#=GS A0A8J6VQ67_9CYAN/3-151 AC A0A8J6VQ67.1
#=GS A0A395JQ74_9GAMM/5-143 AC A0A395JQ74.1
#=GS A0A5J5ENY3_9PEZI/296-434 AC A0A5J5ENY3.1
#=GS A0A117PEQ1_9ACTN/276-360 AC A0A117PEQ1.1
#=GS A0A1C4I501_9ACTN/34-178 AC A0A1C4I501.1
#=GS A0A0X3VXR8_9ACTN/8-147 AC A0A0X3VXR8.1
#=GS A0A2B8AQF8_9ACTN/274-395 AC A0A2B8AQF8.1
#=GS A0A0J6NIQ6_9NEIS/7-148 AC A0A0J6NIQ6.1
#=GS A0A5N8XKK9_9ACTN/274-396 AC A0A5N8XKK9.1
#=GS A0A4R2KW65_9GAMM/5-142 AC A0A4R2KW65.1
#=GS A0A8H7S997_9FUNG/14-160 AC A0A8H7S997.1
#=GS A0A5B9DKU7_9HYPH/283-422 AC A0A5B9DKU7.1
#=GS A0A1X7NCZ5_AZOLI/291-431 AC A0A1X7NCZ5.1
#=GS A0A7W6IEM3_9HYPH/15-153 AC A0A7W6IEM3.1
#=GS A0A063B9C7_9BURK/6-154 AC A0A063B9C7.1
#=GS A0A839DXE9_9PSEU/287-423 AC A0A839DXE9.1
#=GS A0A507DH29_9FUNG/13-157 AC A0A507DH29.1
#=GS A0A0N0VJ60_9PSED/289-428 AC A0A0N0VJ60.1
#=GS M4RWD6_9SPHN/5-142 AC M4RWD6.1
#=GS A0A4V1Z228_9ACTN/45-181 AC A0A4V1Z228.1
#=GS A0A7K1L673_9ACTN/3-145 AC A0A7K1L673.1
#=GS A0A1N7SHK8_9BURK/19-167 AC A0A1N7SHK8.1
#=GS A0A6M1TE81_9BACT/19-165 AC A0A6M1TE81.1
#=GS A0A1Z4RNS6_9CHRO/3-136 AC A0A1Z4RNS6.1
#=GS A0A4Q7LS29_9BURK/13-150 AC A0A4Q7LS29.1
#=GS A0A2N5X399_9GAMM/5-143 AC A0A2N5X399.1
#=GS A0A223NU53_9SPHI/14-159 AC A0A223NU53.1
#=GS A0A556ML20_9SPHI/13-157 AC A0A556ML20.1
#=GS A0A3S1AQP2_9RHOB/15-151 AC A0A3S1AQP2.1
#=GS A0A1C4TEB1_9ACTN/12-157 AC A0A1C4TEB1.1
#=GS A0A7W6K4X6_9HYPH/295-436 AC A0A7W6K4X6.1
#=GS A0A238X7C3_9RHOB/283-423 AC A0A238X7C3.1
#=GS A0A1Q8ZKV8_9HYPH/285-422 AC A0A1Q8ZKV8.1
#=GS A0A222FAJ3_9HYPH/15-151 AC A0A222FAJ3.1
#=GS Q124D7_POLSJ/13-161 AC Q124D7.1
#=GS A0A4R7C1Z7_9HYPH/15-153 AC A0A4R7C1Z7.1
#=GS G1Y231_9PROT/26-163 AC G1Y231.1
#=GS A0A1E3GC42_9GAMM/14-152 AC A0A1E3GC42.1
#=GS W9GY27_9PROT/15-153 AC W9GY27.1
#=GS A0A516R820_STRST/15-163 AC A0A516R820.1
#=GS A0A2G4JPW9_9CAUL/5-137 AC A0A2G4JPW9.1
#=GS A0A099L874_9GAMM/5-143 AC A0A099L874.1
#=GS A0A4P9VSX6_9GAMM/7-147 AC A0A4P9VSX6.1
#=GS F3KX88_9BURK/22-159 AC F3KX88.1
#=GS J9J2J6_9SPIT/11-155 AC J9J2J6.1
#=GS A0A6I4NS24_9MICO/301-418 AC A0A6I4NS24.1
#=GS A0A5J5GKP1_9RHOB/283-422 AC A0A5J5GKP1.1
#=GS A0A244E9R7_9BURK/5-143 AC A0A244E9R7.1
#=GS A0A0F4REU0_9RHOB/283-422 AC A0A0F4REU0.1
#=GS A0A0M9GUY2_9BACI/14-159 AC A0A0M9GUY2.1
#=GS A0A6I4SX66_9SPHN/5-147 AC A0A6I4SX66.1
#=GS A0A4U1BHJ5_9GAMM/6-145 AC A0A4U1BHJ5.1
#=GS A0A839VS41_9BURK/10-147 AC A0A839VS41.1
#=GS A0A1M5TA86_9RHOB/285-421 AC A0A1M5TA86.1
#=GS A0A1Z5SEV0_9BACT/14-162 AC A0A1Z5SEV0.1
#=GS A0A1L9RFM1_ASPWE/92-173 AC A0A1L9RFM1.1
#=GS A0A848QMT6_9SPHN/5-147 AC A0A848QMT6.1
#=GS A0A160BTV4_9RALS/6-154 AC A0A160BTV4.1
#=GS A0A2K9MIC1_9RHOB/16-151 AC A0A2K9MIC1.1
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A0A8J7J0Y1_9FLAO/20-165 ...........................................................qdflp------LLGTDYVE.F.Y..V..GN.....A...K..Q..S..A..H.F.....YkT.A.F..GF......QS......Y.......Ayk...glE......T......G......S.......K.......D...T.......V..S..YvlKQ....D....K.I........KL..V....L.......T.......Tp.....lN....S...E....S......P......V....N......D......HI..............V...K....H.G.D.....G......VKIIALWVE.D..A.RK..AYEETIKRG....A....R....S....Y....M....E....P.....V....V....E....K....D....E...H....G.Q.AvragI.Y....T.Y...GETVH.MFV..E.R..-----...................---.-----kdykgpfl.........................................................................
#=GC seq_cons ....................................................................hshsGh-FlE.F.s..s..ss.....s...p..t..L..t..t.h.....a.p.t.h..GF......st......l.......A.......c......H......R......o.......K.......s...l.......p..L..a..+Q....G....c.I........sh..l....l.......N.......s.......-....s...s....u......h......A....t......p......as..............t...p....H.G.s.....u......ssuhAhRVp.D..A.pt..AapcAlphG....A....p....s....h....p....t..........s....s....s....t....-....l...p....l.P.A....I.p....G.l...Gsoll.Yhl..D.+..htt.....................t.a.t.....................................................................................
//
