#=GF ID Tir_receptor_C
#=GF AC PF07489.15
#=GF DE Translocated intimin receptor (Tir) C-terminus
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE PRINTS
#=GF GA 25.00 25.00;
#=GF TC 34.90 359.60;
#=GF NC 23.90 23.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 10890451
#=GF RT Crystal structure of enteropathogenic Escherichia coli
#=GF RT intimin-receptor complex.
#=GF RA Luo Y, Frey EA, Pfuetzner RA, Creagh AL, Knoechel DG, Haynes CA,
#=GF RA Finlay BB, Strynadka NC;
#=GF RL Nature 2000;405:1073-1077.
#=GF RN [2]
#=GF RM 11207537
#=GF RT Identification of the intimin-binding domain of Tir of
#=GF RT enteropathogenic Escherichia coli.
#=GF RA de Grado M, Abe A, Gauthier A, Steele-Mortimer O, DeVinney R,
#=GF RA Finlay BB;
#=GF RL Cell Microbiol 1999;1:7-17.
#=GF DR INTERPRO; IPR022639;
#=GF DR SCOP; 1f02; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Intimin and its translocated intimin receptor (Tir) are
#=GF CC bacterial proteins that mediate adhesion between mammalian cells
#=GF CC and attaching and effacing (A/E) pathogens. A unique and
#=GF CC essential feature of A/E bacterial pathogens is the formation of
#=GF CC actin-rich pedestals beneath the intimately adherent bacteria
#=GF CC and localised destruction of the intestinal brush border. The
#=GF CC bacterial outer membrane adhesin, intimin, is necessary for the
#=GF CC production of the A/E lesion and diarrhoea. The A/E bacteria
#=GF CC translocate their own receptor for intimin, Tir, into the
#=GF CC membrane of mammalian cells using the type III secretion system.
#=GF CC The translocated Tir triggers additional host signalling events
#=GF CC and actin nucleation, which are essential for lesion formation
#=GF CC [1]. This family represents the Tir C-terminal domain which has
#=GF CC been reported to bind uninfected host cells and beta-1 integrins
#=GF CC although the role of intimin binding to integrins is unclear.
#=GF CC This intimin C-terminal domain has also been shown to be
#=GF CC sufficient for Tir recognition [2].
#=GF SQ 2
#=GS D2TKE8_CITRI/335-547 AC D2TKE8.1
#=GS TIR_ECO57/334-558 AC Q7DB77.1
D2TKE8_CITRI/335-547 VESNAQAQQRHDDQQAKRQQELDLSSGIGYGLSSALIVGGGIGAGVTAMLHRRNPPTEQ-TIATTHSV-----.IQQQTGGNTRAQGGADTTGVENASLTRRDSQASVAStQWSDTS-GDVV-NPYAEGWMSRNNPSL..LAPEEPIYDEVAPD-PNYSVIQHFSGNNPVT.GRLVGSPGQGIQSTYALLASSGGLRLGMGGLTGGGESAGSAANAATTPGVERFV
TIR_ECO57/334-558 IENNAQAQKKYDEQQAKRQEELKVSSGAGYGLSGALILGGGIGVAVTAALHRKNQPVEQTTTTTTTTTTTSARtVENKPANNTPAQGNVDTPGSEDTMESRRSSMASTSS.TFFDTSSIGTVQNPYADVKTSLHDSQVptSNSNTSVQNMGNTDSVVYSTIQHPPRDTTDNgARLLGNPSAGIQSTYARLALSGGLRHDMGGLTGGSNSAVNTSNNPPAPGSHRFV
#=GC seq_cons lEsNAQAQp+aD-QQAKRQpELclSSGhGYGLSuALIlGGGIGsuVTAhLHR+N.PsEQ.ThsTTpos......lpppsusNT.AQGssDTsGsEss..oRRsS.ASsuS.pa.DTS.hssV.NPYA-shhShpsspl...ssppsl.s.sssD.ssYSsIQH.stsssss.uRLlGsPutGIQSTYAhLA.SGGLRhsMGGLTGGupSAsssuNssssPGscRFV
//