GenomeNet

Database: Pfam
Entry: ApoC-I
LinkDB: ApoC-I
Original site: ApoC-I 
#=GF ID   ApoC-I
#=GF AC   PF04691.13
#=GF DE   Apolipoprotein C-I (ApoC-1)
#=GF AU   Kerrison ND;0000-0002-1471-953X
#=GF SE   DOMO:DM04729;
#=GF GA   28.30 28.30;
#=GF TC   28.50 31.30;
#=GF NC   27.90 28.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Apolipoprotein_C1
#=GF RN   [1]
#=GF RM   11580293
#=GF RT   Solution conformation of human apolipoprotein C-1 inferred from
#=GF RT   proline mutagenesis: far- and near-UV CD study. 
#=GF RA   Gursky O; 
#=GF RL   Biochemistry 2001;40:12178-12185.
#=GF RN   [2]
#=GF RM   11353333
#=GF RT   Apolipoproteins C-I and C-III as important modulators of
#=GF RT   lipoprotein metabolism. 
#=GF RA   Shachter NS; 
#=GF RL   Curr Opin Lipidol 2001;12:297-304.
#=GF RN   [3]
#=GF RM   11741391
#=GF RT   Apolipoprotein C-I expression in the brain in Alzheimer's
#=GF RT   disease. 
#=GF RA   Petit-Turcotte C, Stohl SM, Beffert U, Cohn JS, Aumont N,
#=GF RA   Tremblay M, Dea D, Yang L, Poirier J, Shachter NS; 
#=GF RL   Neurobiol Dis 2001;8:953-963.
#=GF DR   INTERPRO; IPR006781;
#=GF DR   SCOP; 1ale; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Apolipoprotein C-I (ApoC-1) is a water-soluble protein component
#=GF CC   of plasma lipoprotein.  It solubalises lipids and regulates
#=GF CC   lipid metabolism.  ApoC-1 transfers among HDL (high density
#=GF CC   lipoprotein), VLDL (very low-density lipoprotein) and
#=GF CC   chylomicrons.  ApoC-1 activates lecithin:choline
#=GF CC   acetyltransferase (LCAT), inhibits cholesteryl ester transfer
#=GF CC   protein, can inhibit hepatic lipase and phospholipase 2 and can
#=GF CC   stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL
#=GF CC   by inhibiting its uptake via the LDL receptor-related pathway
#=GF CC   [1]. ApoC-1 has been implicated in hypertriglyceridemia [2], and
#=GF CC   Alzheimer's disease [3].
#=GF SQ   132
#=GS A0A2K6KMR3_RHIBE/7-46     AC A0A2K6KMR3.1
#=GS L9L7Z9_TUPCH/27-77        AC L9L7Z9.1
#=GS A0A0D9S1R2_CHLSB/27-65    AC A0A0D9S1R2.1
#=GS A0A091EE09_FUKDA/27-87    AC A0A091EE09.1
#=GS A0A060XXG0_ONCMY/14-74    AC A0A060XXG0.1
#=GS A0A3B3IF59_ORYLA/20-79    AC A0A3B3IF59.1
#=GS APO1A_CERAT/25-80         AC P0DPG0.1
#=GS APO1B_PANTR/27-82         AC P0CE38.1
#=GS K7EKP1_HUMAN/27-53        AC K7EKP1.8
#=GS F7F732_CALJA/31-69        AC F7F732.2
#=GS A0A3Q0SIQ8_AMPCI/23-81    AC A0A3Q0SIQ8.1
#=GS A0A452QM77_URSAM/28-88    AC A0A452QM77.1
#=GS A0A1U7SMQ6_ALLSI/27-87    AC A0A1U7SMQ6.1
#=GS M0R547_RAT/27-87          AC M0R547.1
#=GS APOC1_URSMA/27-87         AC P0DPH6.1
#=GS APO1B_CERAT/27-82         AC P0DPG1.1
#=GS K7ELM9_HUMAN/27-66        AC K7ELM9.1
#=GS A0A2K6QV36_RHIRO/27-82    AC A0A2K6QV36.1
#=GS A0A0G2K9R5_RAT/27-69      AC A0A0G2K9R5.1
#=GS A0A2I3S0Y0_PANTR/27-66    AC A0A2I3S0Y0.1
#=GS APO1B_MACNE/27-82         AC P0DOA2.1
#=GS G3NGS3_GASAC/26-84        AC G3NGS3.1
#=GS APO1A_PANPA/27-82         AC P86336.2
#=GS A0A3Q3W075_MOLML/23-76    AC A0A3Q3W075.1
#=GS A0A2I2Y9E5_GORGO/27-66    AC A0A2I2Y9E5.1
#=GS A0A2K5UBW4_MACFA/27-66    AC A0A2K5UBW4.1
#=GS A0A2K5YU00_MANLE/27-66    AC A0A2K5YU00.1
#=GS APOC1_AOTNA/30-85         AC P0DKV2.1
#=GS A0A2K5YTZ0_MANLE/27-82    AC A0A2K5YTZ0.1
#=GS A0A3B4D990_PYGNA/23-81    AC A0A3B4D990.1
#=GS A0A1U7SQ56_TARSY/27-82    AC A0A1U7SQ56.1
#=GS A0A2Y9TD48_PHYMC/27-86    AC A0A2Y9TD48.1
#=GS F6Z2H8_MACMU/27-66        AC F6Z2H8.2
#=GS A0A2K6KMS7_RHIBE/7-46     AC A0A2K6KMS7.1
#=GS APOC1_RABIT/1-28          AC P33047.1
#=GS A0A2K5N8J7_CERAT/27-66    AC A0A2K5N8J7.1
#=GS A0A452SDT4_URSAM/63-123   AC A0A452SDT4.1
#=GS A0A3Q7TP54_URSAR/27-87    AC A0A3Q7TP54.1
#=GS A0A498LXY1_LABRO/23-78    AC A0A498LXY1.1
#=GS A0A2U3VZJ4_ODORO/27-87    AC A0A2U3VZJ4.1
#=GS A0A1L8FN76_XENLA/29-88    AC A0A1L8FN76.1
#=GS A0A3Q2X0K0_HAPBU/23-82    AC A0A3Q2X0K0.1
#=GS A0A2K6BA99_MACNE/27-66    AC A0A2K6BA99.1
#=GS A0A3B4U3M2_SERDU/22-81    AC A0A3B4U3M2.1
#=GS A0A3B3DPW3_ORYME/20-79    AC A0A3B3DPW3.1
#=GS A0A2K5N8G3_CERAT/27-82    AC A0A2K5N8G3.1
#=GS F6R091_MONDO/27-87        AC F6R091.1
#=GS K7EPF9_HUMAN/27-66        AC K7EPF9.1
#=GS A0A1S3GHG3_DIPOR/27-83    AC A0A1S3GHG3.1
#=GS A0A3B3UI00_9TELE/15-74    AC A0A3B3UI00.1
#=GS APOC1_MOUSE/27-87         AC P34928.1
#=GS APO1A_MACMU/25-80         AC G8F204.1
#=GS A0A2K6QV44_RHIRO/27-66    AC A0A2K6QV44.1
#=GS A0A3B3UHZ0_9TELE/22-81    AC A0A3B3UHZ0.1
#=GS A0A2R9BCB5_PANPA/27-67    AC A0A2R9BCB5.1
#=GS A0A2I3TRS5_PANTR/27-66    AC A0A2I3TRS5.1
#=GS A0A2Y9NT54_DELLE/27-86    AC A0A2Y9NT54.1
#=GS A0A3Q7U1S2_VULVU/27-87    AC A0A3Q7U1S2.1
#=GS A0A3Q4AWR8_MOLML/23-77    AC A0A3Q4AWR8.1
#=GS A0A1S3RYY8_SALSA/24-84    AC A0A1S3RYY8.1
#=GS A0A2K5LFP1_CERAT/25-80    AC A0A2K5LFP1.1
#=GS APOC1_LEPWE/27-87         AC P0DM83.1
#=GS A0A2I3M1V7_PAPAN/27-66    AC A0A2I3M1V7.1
#=GS A0A3Q3AYU5_KRYMA/20-79    AC A0A3Q3AYU5.1
#=GS APOC1_RAT/27-87           AC P19939.1
#=GS A0A2U3Y4E9_LEPWE/101-161  AC A0A2U3Y4E9.1
#=GS A0A2Q0E1U3_CEBCA/30-85    AC A0A2Q0E1U3.1
#=GS APO1B_PAPAN/27-82         AC A0A096P2H7.1
#=GS K7EJI9_HUMAN/27-66        AC K7EJI9.1
#=GS M7BAL9_CHEMY/27-77        AC M7BAL9.1
#=GS A0A2Y9L3B7_ENHLU/27-87    AC A0A2Y9L3B7.1
#=GS APOC1_HUMAN/27-82         AC P02654.1
#=GS APOC1_HUMAN/27-82         DR PDB; 6DZ6 A; 3-54;
#=GS APOC1_HUMAN/27-82         DR PDB; 1ALE A; 1-18;
#=GS APOC1_HUMAN/27-82         DR PDB; 6DVU B; 3-55;
#=GS APOC1_HUMAN/27-82         DR PDB; 6NF3 B; 4-54;
#=GS APOC1_HUMAN/27-82         DR PDB; 1IOJ A; 1-56;
#=GS APOC1_HUMAN/27-82         DR PDB; 1OPP A; 1-38;
#=GS APOC1_HUMAN/27-82         DR PDB; 6DXR B; 2-56;
#=GS APOC1_HUMAN/27-82         DR PDB; 6DXR A; 5-55;
#=GS APOC1_HUMAN/27-82         DR PDB; 6DVU A; 5-55;
#=GS APOC1_HUMAN/27-82         DR PDB; 6DZ6 B; 5-54;
#=GS APOC1_HUMAN/27-82         DR PDB; 6NF3 A; 8-53;
#=GS APOC1_HUMAN/27-82         DR PDB; 1ALF A; 1-19;
#=GS A0A1S3WNK4_ERIEU/27-86    AC A0A1S3WNK4.1
#=GS A0A3P9AGQ8_ESOLU/33-93    AC A0A3P9AGQ8.1
#=GS A0A3Q3LIT6_9TELE/22-81    AC A0A3Q3LIT6.1
#=GS A0A3P8W7U9_CYNSE/22-78    AC A0A3P8W7U9.1
#=GS B5XE16_SALSA/24-84        AC B5XE16.1
#=GS APO1B_MACFA/27-82         AC P18657.2
#=GS A0A3B4WGB2_SERLL/24-83    AC A0A3B4WGB2.1
#=GS A0A2K5SID6_CEBCA/30-70    AC A0A2K5SID6.1
#=GS B6S6L6_RABIT/27-86        AC B6S6L6.1
#=GS I6L580_PONAB/27-82        AC I6L580.1
#=GS A0A3B4GDE2_9CICH/23-82    AC A0A3B4GDE2.1
#=GS A0A2U3VZJ8_ODORO/101-161  AC A0A2U3VZJ8.1
#=GS A0A2U3Y4E1_LEPWE/27-87    AC A0A2U3Y4E1.1
#=GS A0A2K6I494_PANTR/27-84    AC A0A2K6I494.1
#=GS A0A402FNK0_9SAUR/82-142   AC A0A402FNK0.1
#=GS A0A3Q1I8I3_ANATE/22-77    AC A0A3Q1I8I3.1
#=GS A0A2Y9RTQ3_TRIMA/28-84    AC A0A2Y9RTQ3.1
#=GS G3TCR3_LOXAF/27-69        AC G3TCR3.1
#=GS APO1B_PONAB/27-65         AC P0CE40.1
#=GS A0A0P7YF15_SCLFO/30-85    AC A0A0P7YF15.1
#=GS A0A3Q2ECG4_CYPVA/22-81    AC A0A3Q2ECG4.1
#=GS A0A2I3SWP8_PANTR/27-66    AC A0A2I3SWP8.1
#=GS A0A060YLA8_ONCMY/24-84    AC A0A060YLA8.1
#=GS APO1A_PONAB/27-82         AC P0CE39.1
#=GS A0A3B1J6A2_ASTMX/65-125   AC A0A3B1J6A2.1
#=GS A0A3P9B4G7_9CICH/23-66    AC A0A3P9B4G7.1
#=GS K7ERI9_HUMAN/27-77        AC K7ERI9.1
#=GS APOC1_CANLF/27-87         AC P56595.1
#=GS A0A1D5REJ1_MACMU/27-66    AC A0A1D5REJ1.1
#=GS A0A1U7QUM6_MESAU/27-87    AC A0A1U7QUM6.1
#=GS A0A452SDT0_URSAM/76-136   AC A0A452SDT0.1
#=GS A0A2D0QY70_ICTPU/23-82    AC A0A2D0QY70.1
#=GS A0A3P8RHK7_ASTCA/23-82    AC A0A3P8RHK7.1
#=GS APOC1_ODORO/27-87         AC P0DPH4.1
#=GS G5CBM5_HETGA/27-87        AC G5CBM5.1
#=GS A0A3Q7TWR0_VULVU/27-87    AC A0A3Q7TWR0.1
#=GS G1M242_AILME/27-87        AC G1M242.1
#=GS A0A2I2YNH6_GORGO/27-82    AC A0A2I2YNH6.1
#=GS A0A087XQE1_POEFO/26-68    AC A0A087XQE1.1
#=GS H0WAV6_CAVPO/27-87        AC H0WAV6.2
#=GS A0A3B5Q6K8_XIPMA/78-137   AC A0A3B5Q6K8.1
#=GS A0A3B3ZIJ2_9GOBI/22-79    AC A0A3B3ZIJ2.1
#=GS APOC1_OTOGA/27-80         AC P0DMP0.1
#=GS A0A4D9DJX7_9SAUR/41-100   AC A0A4D9DJX7.1
#=GS APOC1_SAIBB/31-85         AC P0DKV5.1
#=GS A0A2Y9E9C7_TRIMA/27-83    AC A0A2Y9E9C7.1
#=GS E9QFX0_DANRE/23-83        AC E9QFX0.1
#=GS A0A1A6FVC0_NEOLE/27-87    AC A0A1A6FVC0.1
#=GS APO1A_GORGO/27-82         AC P0CF78.1
#=GS A0A2K5TIZ9_GORGO/27-66    AC A0A2K5TIZ9.1
#=GS A0A3Q0FT94_ALLSI/212-272  AC A0A3Q0FT94.1
#=GS A0A3B3QR43_9TELE/72-132   AC A0A3B3QR43.1
#=GS APO1A_PANTR/27-82         AC P0CE37.1
#=GS A0A3B3YXC4_9TELE/79-138   AC A0A3B3YXC4.1
#=GS APO1B_MACMU/27-82         AC H9FNA4.1
#=GS E9QDI1_DANRE/24-84        AC E9QDI1.1
#=GS A0A3Q3E7A6_9LABR/23-81    AC A0A3Q3E7A6.1
#=GS A0A3P9NB05_POERE/21-80    AC A0A3P9NB05.1
#=GS A0A1S3N6L4_SALSA/24-84    AC A0A1S3N6L4.1
#=GS M3Y497_MUSPF/27-87        AC M3Y497.1
A0A2K6KMR3_RHIBE/7-46                .......v-PDVSNPF----DVLEEFGKTLEDNVREVIKLITQSELPAKTR.-...-----------------l.......
L9L7Z9_TUPCH/27-77                   ........APDFSSTLEGLPDKLKEFGNTLEDKAKKAIERIKQSDLPAKTR.S...CLQ--------------sase....
A0A0D9S1R2_CHLSB/27-65               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSELPAKTR.-...-----------------........
A0A091EE09_FUKDA/27-87               .......a-SDFTSTLEGLPAKLKEFGSALENKARAAIEHIKQSDLPAKTR.N...LLSEAVSKIREKFKASF........
A0A060XXG0_ONCMY/14-74               .......e-KTIEEHFTTFGNQMKDLSEDLTVKTKDIVEKIGDSEFITKTR.T...WFTEQFDKMKAKIDETF........
A0A3B3IF59_ORYLA/20-79               .......a-QDGDQTYTQLKDQITEFGKTFAEKAKNTFETIHNSEFAETTR.N...WFTSAFDKLKTKFEE--i.......
APO1A_CERAT/25-80                    .......v-PDVSNPF----DVLEEFGKTLEDNVREFINLITQSELPAKTR.D...WFSETFRKVKEKLKI--n.......
APO1B_PANTR/27-82                    ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQNELSAKMR.E...WFSETFQKVKEKLKID-........
K7EKP1_HUMAN/27-53                   ........TPDVSSAL----DKLKEFGNTLEDKARELI-------------.-...-----------------s.......
F7F732_CALJA/31-69                   ....vdts-----SGF----DKLKEFGNTMEDKVREFFNRVKESDIPN---.-...-----------------pshw....
A0A3Q0SIQ8_AMPCI/23-81               .......e-ETLDQKLSAFGDKLTEFGRSIADKAKTTFQDIHNSEFGTNAR.N...WFREAFEKMKAK-----ade.....
A0A452QM77_URSAM/28-88               ......as--QISRTLDCIPDKLTEFGNGLEDKAQADIESIKQSDIPVKTR.N...WVLETFNKVKEWFNTIF........
A0A1U7SMQ6_ALLSI/27-87               ........EPTLMQKLEQFKENVKDFADTIGEKTKAALQELRDSEFSTKTR.N...WFSEHFKKVKEKLKDTF........
M0R547_RAT/27-87                     ........APDLSGTLESIPDKLKEFGNTLEDKARAAIEHIKQKEILTKTR.A...WFSEAFGKVKEKLKTTF........
APOC1_URSMA/27-87                    ........APEISSTLGSIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFNKVKEQLKTAF........
APO1B_CERAT/27-82                    ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.D...WFSETFRKVKEKLKI--n.......
K7ELM9_HUMAN/27-66                   ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.-...-----------------l.......
A0A2K6QV36_RHIRO/27-82               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.D...WFSETFRKVKEKLKI--n.......
A0A0G2K9R5_RAT/27-69                 ........APDFSSAMESLPDKLKEFGNTLEDKARAAIEHIKQKEIMIKTR.-...-----------------........
A0A2I3S0Y0_PANTR/27-66               ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQNELSAKMR.-...-----------------l.......
APO1B_MACNE/27-82                    ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.D...WFSETFRKVKEKLKI--n.......
G3NGS3_GASAC/26-84                   ........EQTVEQRFNRFGEQVAEVSKGLAEKAKTTFEEISTSQFAEDTR.N...WFQTQFESLKAKL----sp......
APO1A_PANPA/27-82                    ........APEVSNPF----DGLEELGKTLEDNTREFINRITQSELPAKMW.D...WFSETFRKVKEKLKID-........
A0A3Q3W075_MOLML/23-76               .......e-ETVGSTFTRFGDHVTDMTRGLVDRTRDAFHKIKTSDFATKTN.HylcWFNNQ------------pv......
A0A2I2Y9E5_GORGO/27-66               ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.K...-----------------........
A0A2K5UBW4_MACFA/27-66               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.-...-----------------l.......
A0A2K5YU00_MANLE/27-66               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTW.-...-----------------l.......
APOC1_AOTNA/30-85                    avdtssgl------------DKLKEFGTTLEDKVREFFNRVKESDIPAKTR.N...WFSETLQKVKEKLRI--e.......
A0A2K5YTZ0_MANLE/27-82               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTW.D...WFSETFRKVKEKLKI--n.......
A0A3B4D990_PYGNA/23-81               ........EPTIEQHFATFQTKVMELGKDLSEKATAAFKKLEESEFATKTK.S...WLDEQVTKLKDAF----sk......
A0A1U7SQ56_TARSY/27-82               .......a-PDGSSAL----DKLKDLGQTLGEKAREVIDRIKQSEISTKTR.N...WFSETLQKVKEKLKID-........
A0A2Y9TD48_PHYMC/27-86               .......g-PDINSILDHILEXVKETGNTLEEKTQDVVDYIRQTNIPAKAW.H...WLSGIFHKIEEGLNTT-........
F6Z2H8_MACMU/27-66                   ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.-...-----------------l.......
A0A2K6KMS7_RHIBE/7-46                .......v-PDVSNPF----DVLEEFGKTLEDNVREVIKLITQSELPAKTR.-...-----------------l.......
APOC1_RABIT/1-28                     ........APDF-STLELIPDKLKEFGNTLEEKARMA--------------.-...-----------------........
A0A2K5N8J7_CERAT/27-66               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.-...-----------------l.......
A0A452SDT4_URSAM/63-123              ........APEISSTLGSIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFNKVKEQLKTAF........
A0A3Q7TP54_URSAR/27-87               ........APEISSTLGSIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFNKVKEQLKTAF........
A0A498LXY1_LABRO/23-78               ........EPTLEQQFAKFQTQVKEIADDLTEKTKTTFEQIENSEFAIKTK.N...WFTEQFEKM--------srl.....
A0A2U3VZJ4_ODORO/27-87               ........APEISSTLERIPDKLKEFGNTLEDKTRAAIESIKQSDIPAKTR.N...WFSETFKKVKEQLKTAF........
A0A1L8FN76_XENLA/29-88               ......sk--TIKDHLETAGTAIKDFGTKVGEKTKDFFKDLHNSEPMTKTR.N...WFSETFKKIKEKVS---ss......
A0A3Q2X0K0_HAPBU/23-82               .....dts---FTDKFDRFGQKLTEIGQSLAEKTKTAFNDMHNSEFGTSTR.N...WFSDAFEKMKAKF----gem.....
A0A2K6BA99_MACNE/27-66               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.-...-----------------l.......
A0A3B4U3M2_SERDU/22-81               .......e-DTIQQRFTKFGEEMSEMGRNLAEKAKTSFEGFQSSDIAVNSR.N...WFQEQLESLRAKL----gel.....
A0A3B3DPW3_ORYME/20-79               ......aq--EADATYTKIRDQLTEFGKTFAEKAKSTFDTIQTSEFAETTR.N...WFTSTFDKLKTKFD---em......
A0A2K5N8G3_CERAT/27-82               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.D...WFSETFRKVKEKLKI--n.......
F6R091_MONDO/27-87                   ......ss--SLAQSFEQFQKKVKEFTETVVEKTKAAITQIKHSDLPSKTR.T...WITENIQKVKDKVESTF........
K7EPF9_HUMAN/27-66                   ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.-...-----------------l.......
A0A1S3GHG3_DIPOR/27-83               ........APDFSSTL----EKVKEIGNTLENKTRTTIDRIKNSEFLAKTR.S...WISEKWDKAKERIRGAF........
A0A3B3UI00_9TELE/15-74               .....dds---LAEKFSNFGDQITEFGKNVAEKAKTHFDTIATSEFAENTR.N...WFSEKFRALQNKVN---em......
APOC1_MOUSE/27-87                    ........APDLSGTLESIPDKLKEFGNTLEDKARAAIEHIKQKEILTKTR.A...WFSEAFGKVKEKLKTTF........
APO1A_MACMU/25-80                    .......v-PDVSNPF----DVLEEFGKTLEDNVGEFINLITQSELPAKTR.D...WFSETFRKVKEKLRI--n.......
A0A2K6QV44_RHIRO/27-66               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.-...-----------------l.......
A0A3B3UHZ0_9TELE/22-81               .....dds---LAEKFSNFGDQITEFGKNVAEKAKTHFDTIATSEFAENTR.N...WFSEKFRALQNKVN---em......
A0A2R9BCB5_PANPA/27-67               ........APEVSNPF----DGLEELGKTLEDNTREFINRITQSELPAKMW.-...-----------------le......
A0A2I3TRS5_PANTR/27-66               ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQNELSAKMR.-...-----------------l.......
A0A2Y9NT54_DELLE/27-86               .......g-PDINSILGHILEXVKEFGNTLEEKTWGVVDYIKQTNIPPKAW.H...WLSGIFHKIEEGLNTT-........
A0A3Q7U1S2_VULVU/27-87               ......as--QITRTLECIPDKLKEFGNTXEDKAWEAIESIKLSDIPAKIR.N...WFMETYNKVKEWLKTN-y.......
A0A3Q4AWR8_MOLML/23-77               .......e-ETVGSTFTRFGDHVTDMTRGLVDRTRDAFHKIKTSDFATKTK.N...WFE--------------sfktrige
A0A1S3RYY8_SALSA/24-84               .......e-KTIEERFTTFSNQMKELTDDLTVKTKDMFEKIGDSEFAIKTK.T...WFTEQLDKMKAKVDETF........
A0A2K5LFP1_CERAT/25-80               .......v-PDVSNPF----DVLEEFGKTLEDNVREFINLITQSELPAKTR.D...WFSETFRKVKEKLKI--n.......
APOC1_LEPWE/27-87                    ........APEISSTLGRIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFHKVKEQLKTAF........
A0A2I3M1V7_PAPAN/27-66               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.-...-----------------l.......
A0A3Q3AYU5_KRYMA/20-79               .......a-QDADSGFANFQDRLSEFGRNVAEKAKDTIDTIKNSEVAQKTQ.N...WFEEKFAKLKTHFQQ--d.......
APOC1_RAT/27-87                      ........APDFSSAMESLPDKLKEFGNTLEDKARAAIEHIKQKEIMIKTR.N...WFSETLNKMKEKLKTTF........
A0A2U3Y4E9_LEPWE/101-161             ........APEISSTLGRIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFHKVKEQLKTAF........
A0A2Q0E1U3_CEBCA/30-85               avdassgl------------DKLKEFGNTLENKVREFFSRIKESDIPTKTR.N...WFSETLQKVKEKLNI--e.......
APO1B_PAPAN/27-82                    ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.D...WFSETFRKVKEKLKI--n.......
K7EJI9_HUMAN/27-66                   ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.E...-----------------........
M7BAL9_CHEMY/27-77                   ......el--TLSEKFENFQNRLQAFADSIANITKAAFQELHHSELSEKTR.-...-----------------ctcfiwfv
A0A2Y9L3B7_ENHLU/27-87               ........APEISSTFERIPDKLKEFGNTLEDKARAAIETIKQSDIPAKTR.T...WFSETYNKVKERLKTAF........
APOC1_HUMAN/27-82                    ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.E...WFSETFQKVKEKLKID-........
#=GR APOC1_HUMAN/27-82         SS    ........XXXHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.H...HHHHHHHHHHHHTHTT-........
A0A1S3WNK4_ERIEU/27-86               ........APDFSSTLEEIQSKLKTFGSSVSEKTRAIVDKIKEKEITTKAR.N...WFLDTVTKLKEKLNI--k.......
A0A3P9AGQ8_ESOLU/33-93               ......ek--SIEDHFTEFGAKLKEFTDGISVKTKDVVDKVGDSEFVTKTR.T...WFTEQFDKLKTKMDETF........
A0A3Q3LIT6_9TELE/22-81               .......e-ETIKQRVVKISEQLSEGVKTLADKAKTGFDQLHNSDFAVSTR.N...WFQEQFDKVKTKL----gel.....
A0A3P8W7U9_CYNSE/22-78               .......e-ETVQEKLNKFAERVADAGRTVADGARTQYDRLRNSEFATNAK.N...WFQRQVEKLQSK-----s.......
B5XE16_SALSA/24-84                   .......e-KTIEERFTTFSNQMKELTDDLTVKTKDMFEKIGDSEFAIKTK.T...WFTEQLDKMKAKVDETF........
APO1B_MACFA/27-82                    ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.D...WFSETFRKVKEKLKI--n.......
A0A3B4WGB2_SERLL/24-83               .......e-DTIEQRFTKFGEQMTEMGRSLAEKAKTSFEGFQSSDIAVSSK.N...WFQEQLESIKAKFEE--i.......
A0A2K5SID6_CEBCA/30-70               avdassgl------------DKLKEFGNTLENKVREFFSRIKESDIPTKTR.-...-----------------le......
B6S6L6_RABIT/27-86                   ........APDF-STLELIPDKLKEFGNTLEEKARMAIEHIKQSEITTKTR.N...WFSETISKVKEKFKSTF........
I6L580_PONAB/27-82                   ........APDVSSAL----DKLKEFGNTLEDKAREVINRIKQSELSAKTR.D...WFSETFRRVKEKLKID-........
A0A3B4GDE2_9CICH/23-82               .....dss---FTDKFDRFGQKLTEIGQSLAEKTKTAFDDMHNSEFGTSTR.N...WFSDAFEKMKAKF----gem.....
A0A2U3VZJ8_ODORO/101-161             ........APEISSTLERIPDKLKEFGNTLEDKTRAAIESIKQSDIPAKTR.N...WFSETFKKVKEQLKTAF........
A0A2U3Y4E1_LEPWE/27-87               ........APEISSTLGRIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFHKVKEQLKTAF........
A0A2K6I494_PANTR/27-84               ........APEVSNPF----DGLEELGKTLEDNTREFINRITQSELPAKMWlE...PFPGTIRKGKEKLKID-s.......
A0A402FNK0_9SAUR/82-142              ........EPTLSQKFERFQEDVQTFFDDVGEKAKGALHDLHNSEISNKTR.N...WFAEKFRKLKERFQTTF........
A0A3Q1I8I3_ANATE/22-77               .......d-KTLQQRLSEFGEQIGEIGRTVAEKAKDGYQSFHNSEFVSNAR.N...WLQEQMEKVK-------ti......
A0A2Y9RTQ3_TRIMA/28-84               .......v-PDFSCTLERIPDKLKEFGNTLEDKAKAAIDRIKQSDIYAKTR.S...WFN----KMKEKLKTAF........
G3TCR3_LOXAF/27-69                   ........APDFSGTLEGIPDKLKEFGSTLENKAKKLYDRIKESDFTTKTR.-...-----------------........
APO1B_PONAB/27-65                    ........APDVSSAL----DKLKEFGNTLEDKAREVINRIKQSELSAKTR.-...-----------------........
A0A0P7YF15_SCLFO/30-85               ........EPTLQEHFTNLQQHVKDLGESFLEKAKAAIQKIQESTIATNAR.N...WLNEQMEKLM-------pk......
A0A3Q2ECG4_CYPVA/22-81               .....dds---IQDRLSTFRDQVTEFSKTVAEKAKTHFDTMRTSEFAESTK.N...WFTERFQQIKQKID---ei......
A0A2I3SWP8_PANTR/27-66               ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQNELSAKMR.K...-----------------........
A0A060YLA8_ONCMY/24-84               .......e-KTIEERFTTFGNQMKELTDDLTVKTKDMFEKIGDSEFATKTK.T...WFTEQFDKMKAKVDETF........
APO1A_PONAB/27-82                    ........APDVSNPF----DGLEELGKTLEDNTREFINRITQSELPAKMW.D...WFSETFRRVKEKLKID-........
A0A3B1J6A2_ASTMX/65-125              ........EPTIEQHFANFHTKVKEFGSDVAEKTMATIKEIEQSEFAAKTK.N...WFTEQFEKMKKHIDETF........
A0A3P9B4G7_9CICH/23-66               .....dts---FTDKFDRFGQKLTEIGQSLAEKTKTAFDDIHNSEFGTRTR.-...-----------------y.......
K7ERI9_HUMAN/27-77                   ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.E...WFSETFQKVKE------........
APOC1_CANLF/27-87                    .......a-GEISSTFERIPDKLKEFGNTLEDKARAAIESIKKSDIPAKTR.N...WFSEAFKKVKEHLKTAF........
A0A1D5REJ1_MACMU/27-66               ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.-...-----------------l.......
A0A1U7QUM6_MESAU/27-87               ........TPDLSSAFENLPEKLKEFGNTLEDKARAAIEHIKQKEILTKTR.T...WFSETFGKLKEKLKTTF........
A0A452SDT0_URSAM/76-136              ........APEISSTLGSIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFNKVKEQLKTAF........
A0A2D0QY70_ICTPU/23-82               .......e-STIEQQFANFQARFKEFGDDVTEKTKNALKQIENSEIVSKTK.D...WLTEQLEKVRQKFD---ev......
A0A3P8RHK7_ASTCA/23-82               .....dts---FTDKFDRFGQKLTEIGQSLAEKTKNAFDDIHNSEFGTSTR.N...WFSDAFEKMKAKF----gem.....
APOC1_ODORO/27-87                    ........APEISSTLERIPDKLKEFGNTLEDKTRAAIESIKQSDIPAKTR.N...WFSETFKKVKEQLKTAF........
G5CBM5_HETGA/27-87                   ........APDFTSTLEGLPAKLKEFGSILEDKALAAIEHIKQSELPAKTR.N...WFSDAFSKVQEKFKATF........
A0A3Q7TWR0_VULVU/27-87               .......a-GEISSTFERIPDKLKEFGNTLEDKARAAIESIKKSDIPAKTR.N...WFSEAFNKVKNHLKTAF........
G1M242_AILME/27-87                   ........APEISSTLGSIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTR.N...WFSETFNKVKERFKTAF........
A0A2I2YNH6_GORGO/27-82               ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.D...WFSETFQKVKEKLKID-........
A0A087XQE1_POEFO/26-68               .....dds---LAEKFSNFGDQITEFGKNVAEKAKTHFDTIATSEFAENTR.-...-----------------........
H0WAV6_CAVPO/27-87                   ........APDLGSALESLPGKLKEFGSTVESKARAAIEHIKQSDFPTKTW.K...WLSKTVSKVREKFKATF........
A0A3B5Q6K8_XIPMA/78-137              .....dds---FAERFSNFGDQITEFSKNVAEKAKTHFDTITTSEFAENTR.N...WFTEQFQKIKSKVN---em......
A0A3B3ZIJ2_9GOBI/22-79               ......ev--TMEERFNNLGQQMSEFGKTVAEKAKTALDGLNNNENVQKAK.N...WFQEQFQKMQEHF----n.......
APOC1_OTOGA/27-80                    ...tmdld----------FTRHLKEFGNTMGDKAREVIDRIKQSDIPAKTR.N...WFSETFQKVKEKLKI--........
A0A4D9DJX7_9SAUR/41-100              ........EPTLTQKFEKFQNKLQAFADSIADKTKAAFQELHHSEFSEKTR.N...WFSEQFQKIKEKFS---rd......
APOC1_SAIBB/31-85                    .veassgl------------DKLKEFGNNLEDKVREFFKRIKESDIPAKTR.N...WFSETLQKVKEKLRI--e.......
A0A2Y9E9C7_TRIMA/27-83               ........APDFSSTLERIPDKLKEFGNTLKDKAKAAFDRIKQSDIYAKTG.S...WFN----KMKEKLKTAF........
E9QFX0_DANRE/23-83                   ........EPTLEQHFTKFGTQMKEIAEDLADKTKTAFQNIEQSELGTKTR.N...WFNDQYEKLKQKMTETF........
A0A1A6FVC0_NEOLE/27-87               ........TPDLASTFENLPDKLKEFGSALEDKTRAAIEHIKQKGILTKTR.T...WFSETFDKVKEKFKTTF........
APO1A_GORGO/27-82                    ........APEVSNPF----DGLEELGKTLEDNTQELINRITQSELPAKMW.D...WFSETFRKVKEKLKID-........
A0A2K5TIZ9_GORGO/27-66               ........TPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMR.-...-----------------l.......
A0A3Q0FT94_ALLSI/212-272             ........EPTLMQKLEQFKENVKDFADTIGEKTKAALQELRDSEFSTKTR.N...WFSEHFKKVKEKLKDTF........
A0A3B3QR43_9TELE/72-132              ........EPTLEEQFAKFQNQMKDFADDVAVKTKSTLDQIHQSEFAAKTR.N...WFTEQFDKMKQKIDEAF........
APO1A_PANTR/27-82                    ........APEVSNPF----DGLEELGKTLEDNTREFINRITQSELPAKMW.D...WFSETFRKVKEKLKID-........
A0A3B3YXC4_9TELE/79-138              .....dds---LAEKFSNFGDQITEFGKNVAEKAKTHFDTIATSEFAENTR.N...WFSEKFRALQNKVN---em......
APO1B_MACMU/27-82                    ........APDVSSAL----DKLKEFGNTLEDKAWEVINRIKQSEFPAKTR.D...WFSETFRKVKEKLKI--n.......
E9QDI1_DANRE/24-84                   ........EPTLEQHFTKFGTQMKEIAEDLADKTKTAFQNIEQSELGTKTR.N...WFNDQYEKLKQKMTETF........
A0A3Q3E7A6_9LABR/23-81               .......e-ETVQQKLSNLGDQMTEMGKNLAEKAKTTFDELSNSQFASDTR.D...WFTKHIEQLKSKF----gd......
A0A3P9NB05_POERE/21-80               .......q-DDFAERFSNFGDQLTEFGKNVAEKAKTHYDTISTSEFAVSTR.N...WFTEQFQKIKTKVN---em......
A0A1S3N6L4_SALSA/24-84               .......e-KTIEEHFTNFGNQMKELSDDLTVKTKDIVEKIGDSEFVTKTR.T...WFTEQLDKMKAKIDETF........
M3Y497_MUSPF/27-87                   ........APEISSTFERIPDKLKEFGNTLEDKARAAIETIKQSDIPAKTR.N...WFSETYSKLKERLKTAF........
#=GC SS_cons                         ........XXXHHHHH----HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.H...HHHHHHHHHHHHTHTT-........
#=GC seq_cons                        .........P-lossht.h.DKLKEFGsTLEDKA+pslpcI+pSEhssKTR.s...WFsEphpKlKp+hp...........
//
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