GenomeNet

Database: Pfam
Entry: BID
LinkDB: BID
Original site: BID 
#=GF ID   BID
#=GF AC   PF06393.12
#=GF DE   BH3 interacting domain (BID)
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_16321 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   25.70 25.40;
#=GF NC   24.50 23.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   BH3_interacting-domain_death_agonist
#=GF RN   [1]
#=GF RM   10089878
#=GF RT   Solution structure of the proapoptotic molecule BID: a
#=GF RT   structural basis for apoptotic agonists and antagonists. 
#=GF RA   McDonnell JM, Fushman D, Milliman CL, Korsmeyer SJ, Cowburn D; 
#=GF RL   Cell 1999;96:625-634.
#=GF DR   INTERPRO; IPR010479;
#=GF DR   SCOP; 1ddb; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   BID is a member of the BCL-2 superfamily of proteins are  key
#=GF CC   regulators of programmed cell death, hence this family is
#=GF CC   related to Pfam:PF00452 .  BID is a pro-apoptotic member of the
#=GF CC   Bcl-2 superfamily and as such posses the ability to target
#=GF CC   intracellular membranes and contains the BH3 death domain. The
#=GF CC   activity of BID is regulated by a Caspase 8-mediated cleavage
#=GF CC   event, exposing  the BH3 domain and significantly changing the
#=GF CC   surface  charge and hydrophobicity, which causes a change of 
#=GF CC   cellular localisation [1].
#=GF SQ   187
#=GS A0A2K6H0X5_PROCO/18-208     AC A0A2K6H0X5.1
#=GS A0A2U9BY77_SCOMX/6-212      AC A0A2U9BY77.1
#=GS G1NL76_MELGA/4-193          AC G1NL76.2
#=GS A0A2Y9NIT3_DELLE/10-136     AC A0A2Y9NIT3.1
#=GS A0A0P7VIW7_SCLFO/113-226    AC A0A0P7VIW7.1
#=GS A0A2I2ZUR1_GORGO/3-91       AC A0A2I2ZUR1.1
#=GS A0A452GFC5_9SAUR/3-188      AC A0A452GFC5.1
#=GS A0A3Q4HJ11_NEOBR/16-96      AC A0A3Q4HJ11.1
#=GS W5PVK6_SHEEP/4-189          AC W5PVK6.1
#=GS A0A455BD19_PHYMC/43-230     AC A0A455BD19.1
#=GS A0A3B4XYR2_SERLL/5-197      AC A0A3B4XYR2.1
#=GS A0A402G659_9SAUR/1-44       AC A0A402G659.1
#=GS A0A2K6KDR5_RHIBE/3-91       AC A0A2K6KDR5.1
#=GS G3W5W2_SARHA/3-194          AC G3W5W2.1
#=GS A0A384D7H6_URSMA/3-192      AC A0A384D7H6.1
#=GS A0A2R9A786_PANPA/49-238     AC A0A2R9A786.1
#=GS A0A1U7UWY1_TARSY/3-192      AC A0A1U7UWY1.1
#=GS A0A091E645_FUKDA/33-223     AC A0A091E645.1
#=GS A0A2K5VRH4_MACFA/3-192      AC A0A2K5VRH4.1
#=GS A0A3B3TE11_9TELE/2-187      AC A0A3B3TE11.1
#=GS A0A2U3Z8M2_LEPWE/1-71       AC A0A2U3Z8M2.1
#=GS H0W5F0_CAVPO/1-187          AC H0W5F0.2
#=GS G1PYL8_MYOLU/1-188          AC G1PYL8.1
#=GS A0A060X7H5_ONCMY/33-229     AC A0A060X7H5.1
#=GS A0A151NIJ8_ALLMI/4-137      AC A0A151NIJ8.1
#=GS A0A2K6KDS4_RHIBE/2-191      AC A0A2K6KDS4.1
#=GS A0A2I3LMR4_PAPAN/3-101      AC A0A2I3LMR4.1
#=GS A0A3Q1IZ74_ANATE/3-191      AC A0A3Q1IZ74.1
#=GS A0A091FUS3_9AVES/2-182      AC A0A091FUS3.1
#=GS G3W5W1_SARHA/1-185          AC G3W5W1.1
#=GS G3R4T6_GORGO/3-192          AC G3R4T6.2
#=GS K7G3T4_PELSI/1-184          AC K7G3T4.1
#=GS A0A1A6HG53_NEOLE/3-193      AC A0A1A6HG53.1
#=GS A0A2U3X9I4_LEPWE/37-223     AC A0A2U3X9I4.1
#=GS A0A3L8SGY4_CHLGU/60-239     AC A0A3L8SGY4.1
#=GS A0A455BCB8_PHYMC/42-229     AC A0A455BCB8.1
#=GS A0A093RUG0_9PASS/53-207     AC A0A093RUG0.1
#=GS A0A3B4T2I8_SERDU/5-198      AC A0A3B4T2I8.1
#=GS A0A1V4K844_PATFA/119-309    AC A0A1V4K844.1
#=GS B2ZP78_HUMAN/3-90           AC B2ZP78.1
#=GS A0A1D5P8E8_CHICK/94-284     AC A0A1D5P8E8.2
#=GS A0A401NJ83_SCYTO/8-189      AC A0A401NJ83.1
#=GS A0A2U4AKA6_TURTR/48-117     AC A0A2U4AKA6.1
#=GS BID_CHICK/3-193             AC Q8JGM8.2
#=GS F7IH28_CALJA/46-232         AC F7IH28.2
#=GS A0A2K6Q4K8_RHIRO/3-90       AC A0A2K6Q4K8.1
#=GS F7ACD0_HORSE/3-191          AC F7ACD0.2
#=GS W5NIN1_LEPOC/1-185          AC W5NIN1.1
#=GS A0A2R8QUD1_DANRE/5-187      AC A0A2R8QUD1.1
#=GS A0A2I3SGG1_PANTR/3-91       AC A0A2I3SGG1.1
#=GS A0A452EKW9_CAPHI/65-141     AC A0A452EKW9.1
#=GS A0A3M0JNW1_HIRRU/2174-2394  AC A0A3M0JNW1.1
#=GS A0A3Q3VJ22_MOLML/107-185    AC A0A3Q3VJ22.1
#=GS A0A3B3WE88_9TELE/83-144     AC A0A3B3WE88.1
#=GS A0A1U8CZB5_ALLSI/4-191      AC A0A1U8CZB5.1
#=GS A0A4D9DWN7_9SAUR/3-188      AC A0A4D9DWN7.1
#=GS A0A2Y9NTR1_DELLE/3-190      AC A0A2Y9NTR1.1
#=GS G3HQ86_CRIGR/3-191          AC G3HQ86.1
#=GS A0A091INR9_EGRGA/1-184      AC A0A091INR9.1
#=GS A0A452EKQ3_CAPHI/3-188      AC A0A452EKQ3.1
#=GS A0A2K6BWX2_MACNE/3-105      AC A0A2K6BWX2.1
#=GS A0A3Q1FBA7_9TELE/2-189      AC A0A3Q1FBA7.1
#=GS A0A3Q2U873_CHICK/64-254     AC A0A3Q2U873.1
#=GS A0A091ECP1_CORBR/1-179      AC A0A091ECP1.1
#=GS H2QL73_PANTR/49-238         AC H2QL73.1
#=GS A0A1S3WES5_ERIEU/11-228     AC A0A1S3WES5.1
#=GS A0A2K5YT85_MANLE/52-241     AC A0A2K5YT85.1
#=GS A0A2K6Q4M0_RHIRO/34-223     AC A0A2K6Q4M0.1
#=GS A0A093HWC3_STRCA/2-188      AC A0A093HWC3.1
#=GS A0A2D0QTM1_ICTPU/3-197      AC A0A2D0QTM1.1
#=GS A0A091WNX5_OPIHO/1-184      AC A0A091WNX5.1
#=GS A0A401S896_CHIPU/33-225     AC A0A401S896.1
#=GS A0A2K5LVW2_CERAT/3-192      AC A0A2K5LVW2.1
#=GS A0A2K6H0Y1_PROCO/1-189      AC A0A2K6H0Y1.1
#=GS A0A1S3FSZ5_DIPOR/3-194      AC A0A1S3FSZ5.1
#=GS A0A2K5J9S2_COLAP/3-94       AC A0A2K5J9S2.1
#=GS F7A8I6_HORSE/3-191          AC F7A8I6.2
#=GS A0A099ZHG9_TINGU/1-190      AC A0A099ZHG9.1
#=GS A0A3P8UU20_CYNSE/5-193      AC A0A3P8UU20.1
#=GS A0A3Q0CI41_MESAU/3-192      AC A0A3Q0CI41.1
#=GS A0A452EL04_CAPHI/3-188      AC A0A452EL04.1
#=GS G1TB99_RABIT/12-207         AC G1TB99.1
#=GS A0A498MMI5_LABRO/5-192      AC A0A498MMI5.1
#=GS A0A401NUJ8_SCYTO/1-111      AC A0A401NUJ8.1
#=GS F7DQE5_ORNAN/1-96           AC F7DQE5.1
#=GS A0A0D9RP74_CHLSB/45-234     AC A0A0D9RP74.1
#=GS A0A0A0A4E6_CHAVO/1-184      AC A0A0A0A4E6.1
#=GS A0A2K5YT65_MANLE/3-106      AC A0A2K5YT65.1
#=GS F7CU55_MONDO/68-258         AC F7CU55.2
#=GS A0A3P8P5L6_ASTCA/80-161     AC A0A3P8P5L6.1
#=GS A0A3P8YQW5_ESOLU/13-203     AC A0A3P8YQW5.1
#=GS G1KMF0_ANOCA/7-186          AC G1KMF0.1
#=GS A0A2I3GK37_NOMLE/3-84       AC A0A2I3GK37.1
#=GS Q17QH5_BOVIN/3-190          AC Q17QH5.1
#=GS A0A383ZU89_BALAS/3-189      AC A0A383ZU89.1
#=GS BID_HUMAN/3-192             AC P55957.1
#=GS BID_HUMAN/3-192             DR PDB; 2BID A; 5-194;
#=GS BID_HUMAN/3-192             DR PDB; 5AJJ B; 81-109;
#=GS BID_HUMAN/3-192             DR PDB; 4ZIG B; 79-98;
#=GS BID_HUMAN/3-192             DR PDB; 1ZY3 B; 201-220;
#=GS BID_HUMAN/3-192             DR PDB; 4ZEQ B; 79-104;
#=GS BID_HUMAN/3-192             DR PDB; 4QVE B; 77-104;
#=GS BID_HUMAN/3-192             DR PDB; 2KBW B; 76-106;
#=GS BID_HUMAN/3-192             DR PDB; 4ZII C; 76-99;
#=GS BID_HUMAN/3-192             DR PDB; 5C3F B; 80-101;
#=GS BID_HUMAN/3-192             DR PDB; 2M5B B; 80-101;
#=GS BID_HUMAN/3-192             DR PDB; 4BD2 C; 76-105;
#=GS BID_HUMAN/3-192             DR PDB; 2M5I A; 61-192;
#=GS F7DQF1_ORNAN/9-135          AC F7DQF1.1
#=GS M3WEH6_FELCA/3-193          AC M3WEH6.3
#=GS F7DU73_XENTR/4-185          AC F7DU73.1
#=GS A0A287BP00_PIG/1-186        AC A0A287BP00.1
#=GS A0A1D5QH89_MACMU/3-192      AC A0A1D5QH89.1
#=GS A0A2K6Q4M4_RHIRO/3-192      AC A0A2K6Q4M4.1
#=GS A0A2I0MKV4_COLLI/2-191      AC A0A2I0MKV4.1
#=GS A0A2K5ER11_AOTNA/47-233     AC A0A2K5ER11.1
#=GS A0A2K6BWV9_MACNE/3-192      AC A0A2K6BWV9.1
#=GS A0A2Y9RIT4_TRIMA/3-197      AC A0A2Y9RIT4.1
#=GS A0A3B4ZSP9_9TELE/2-197      AC A0A3B4ZSP9.1
#=GS G1MGI0_AILME/3-192          AC G1MGI0.1
#=GS A0A1S3KQ61_SALSA/2-196      AC A0A1S3KQ61.1
#=GS I3N331_ICTTR/3-192          AC I3N331.2
#=GS A0A3B4C8R3_PYGNA/3-179      AC A0A3B4C8R3.1
#=GS A0A340Y8Y3_LIPVE/85-272     AC A0A340Y8Y3.1
#=GS A0A287AYM3_PIG/3-189        AC A0A287AYM3.1
#=GS A0A3Q7WWF4_URSAR/3-192      AC A0A3Q7WWF4.1
#=GS A0A087R1G3_APTFO/1-183      AC A0A087R1G3.1
#=GS A0A2K6TCL3_SAIBB/3-189      AC A0A2K6TCL3.1
#=GS W5JYR5_ASTMX/10-201         AC W5JYR5.1
#=GS Q56VD1_XENLA/4-183          AC Q56VD1.1
#=GS F6WQU1_MACMU/32-221         AC F6WQU1.2
#=GS A0A3Q0CCS6_MESAU/130-190    AC A0A3Q0CCS6.1
#=GS A0A2K6H0U2_PROCO/1-96       AC A0A2K6H0U2.1
#=GS M7ARC5_CHEMY/27-215         AC M7ARC5.1
#=GS A0A2K5J9S8_COLAP/63-252     AC A0A2K5J9S8.1
#=GS U3K4T9_FICAL/2-184          AC U3K4T9.1
#=GS A0A140T8G9_CHICK/3-193      AC A0A140T8G9.1
#=GS G3T1D2_LOXAF/1-192          AC G3T1D2.1
#=GS A0A091VX00_NIPNI/1-184      AC A0A091VX00.1
#=GS A0A226PLU2_COLVI/5-193      AC A0A226PLU2.1
#=GS BID_PIG/3-189               AC Q4JHS0.1
#=GS BID_PIG/3-189               DR PDB; 5UA4 B; 26-57;
#=GS A0A2R9A2N2_PANPA/3-91       AC A0A2R9A2N2.1
#=GS A0A2K5VRS6_MACFA/3-105      AC A0A2K5VRS6.1
#=GS A0A401NUN7_SCYTO/22-146     AC A0A401NUN7.1
#=GS A0A2D0PKI1_ICTPU/7-136      AC A0A2D0PKI1.1
#=GS A0A2Y9KY95_ENHLU/3-192      AC A0A2Y9KY95.1
#=GS A0A455BFC5_PHYMC/121-308    AC A0A455BFC5.1
#=GS A0A0Q3UPY0_AMAAE/2216-2401  AC A0A0Q3UPY0.1
#=GS A0A2K5LVY0_CERAT/3-104      AC A0A2K5LVY0.1
#=GS A0A2U4AKA6_TURTR/108-188    AC A0A2U4AKA6.1
#=GS G5BWN8_HETGA/3-193          AC G5BWN8.1
#=GS A0A218V0Q7_9PASE/4-181      AC A0A218V0Q7.1
#=GS A0A2K5J9S4_COLAP/3-192      AC A0A2K5J9S4.1
#=GS A0A3Q3EY88_9LABR/5-173      AC A0A3Q3EY88.1
#=GS A0A452R4Q9_URSAM/4-193      AC A0A452R4Q9.1
#=GS A0A2K5LVW4_CERAT/52-241     AC A0A2K5LVW4.1
#=GS A0A2K5S4T7_CEBCA/3-189      AC A0A2K5S4T7.1
#=GS F7H9R6_MACMU/1-93           AC F7H9R6.2
#=GS A0A226N1M7_CALSU/23-212     AC A0A226N1M7.1
#=GS A0A2K5YT47_MANLE/3-192      AC A0A2K5YT47.1
#=GS F1Q0Y3_CANLF/12-203         AC F1Q0Y3.2
#=GS A0A3Q3CUM7_HAPBU/96-172     AC A0A3Q3CUM7.1
#=GS A0A2K6KDQ7_RHIBE/1-96       AC A0A2K6KDQ7.1
#=GS H0ZQI0_TAEGU/1-140          AC H0ZQI0.1
#=GS R0M701_ANAPL/2-188          AC R0M701.1
#=GS L5JTG3_PTEAL/77-267         AC L5JTG3.1
#=GS A0A2U3WEE1_ODORO/1-96       AC A0A2U3WEE1.1
#=GS A0A2J8RJ32_PONAB/1-96       AC A0A2J8RJ32.1
#=GS A0A3Q7W0M9_URSAR/3-161      AC A0A3Q7W0M9.1
#=GS A0A3B4ZSR6_9TELE/2-178      AC A0A3B4ZSR6.1
#=GS A0A2K6BWY8_MACNE/52-241     AC A0A2K6BWY8.1
#=GS A0A2K5VRT7_MACFA/52-241     AC A0A2K5VRT7.1
#=GS Q1LX52_DANRE/5-187          AC Q1LX52.1
#=GS A0A455BCZ9_PHYMC/3-190      AC A0A455BCZ9.1
#=GS A0A093GWD1_DRYPU/1-184      AC A0A093GWD1.1
#=GS A0A455BRX2_PHYMC/121-308    AC A0A455BRX2.1
#=GS H0WLJ8_OTOGA/1-198          AC H0WLJ8.1
#=GS A0A091HJX1_CALAN/1-115      AC A0A091HJX1.1
#=GS A0A2K5S4T3_CEBCA/47-233     AC A0A2K5S4T3.1
#=GS A0A3Q0CCS6_MESAU/2-80       AC A0A3Q0CCS6.1
#=GS H2P4Y4_PONAB/102-224        AC H2P4Y4.1
#=GS A0A3P9Q8R4_POERE/83-144     AC A0A3P9Q8R4.1
#=GS U3IN21_ANAPP/3-193          AC U3IN21.2
#=GS A0A402F8W0_9SAUR/26-108     AC A0A402F8W0.1
#=GS A0A3Q7S5Z1_VULVU/3-192      AC A0A3Q7S5Z1.1
#=GS A0A1D5QI48_MACMU/3-105      AC A0A1D5QI48.1
#=GS A0A096NVY7_PAPAN/52-241     AC A0A096NVY7.2
#=GS A0A2I3GZZ6_NOMLE/22-211     AC A0A2I3GZZ6.1
#=GS G3UR49_MELGA/3-196          AC G3UR49.1
#=GS BID_MOUSE/3-192             AC P70444.2
#=GS BID_MOUSE/3-192             DR PDB; 1DDB A; 3-192;
#=GS BID_MOUSE/3-192             DR PDB; 2VOI B; 78-101;
#=GS D3Z463_MOUSE/3-52           AC D3Z463.1
#=GS BID_RAT/3-193               AC Q9JLT6.2
#=GS L7N431_XENTR/5-185          AC L7N431.1
#=GS A0A3P8RQQ9_AMPPE/4-189      AC A0A3P8RQQ9.1
#=GS A0A452EKW9_CAPHI/3-71       AC A0A452EKW9.1
#=GS A0A3Q1CSC4_AMPOC/4-189      AC A0A3Q1CSC4.1
#=GS A0A2D0QVL4_ICTPU/11-208     AC A0A2D0QVL4.1
#=GS A0A3Q7S014_VULVU/3-192      AC A0A3Q7S014.1
#=GS A0A1L8GQT1_XENLA/4-183      AC A0A1L8GQT1.1
A0A2K6H0X5_PROCO/18-208                ...............................................a-AVSNGSGLKDARITDLLVFGFL.Q..S..C..S..SN.SFQAELEALGYE..........................L.P.V...Q.DH.......LW.......E...D.HE.................DE.LQTDGSR.A.SR.........F.H..AQ.......R....I.E.......A....D.......S.........E..SE.........E..D..L...IQNLARQLAQ...IGDSMDR..S..IP.PRLVNHLAMQFMNPNLLEE.D.RRRHLATALE....QLM..Q....T....C....P...A...DLEQEKATLVLTMLLAKKVADHTPSLLRDVFRTTVNFINQNLLT.YVRNLARN...........................
A0A2U9BY77_SCOMX/6-212                 ..........................rsgtggqdaalvilaflqtdgg-----------------------.-..-..-..-..NS.EYSKELLSLGNDfnltrdvncn.....vpghnqhqqhqH.Q.R...S.IA.......IT.......Q...D.DD.................GD.LETDGHL.P.SCp.......lL.Y..TR.......D....L.Q.......P....S.......V.........E..LQwli...gnhE..A..Aa.eLRRVAEELRE...IGAQIEQ..E..VV.ARATRNLRRNISA--SPSE.Q.WRTYLTREVE....QVM..R....R....Gv..gL...E...QLPQERVLMALTLTLVKGVCEQAPHFLRNLFNAALQYIGQ----.--------sg.........................
G1NL76_MELGA/4-193                     ............................................diys----DGS----DHMERMLLFAFL.A..E..S..S..GC.EFREQLPFLQSRg.......................llC.A.V...K.GV.......QS.......Y...D.SD.................GE.LQTDGNR.S.GH.........L.Q..NG.......E....L.V.......L....D.......P.........E..VN.........E..E..I...VRTIAAQLAE...IGDQLDK..Q..IK.AKVVNDLVQHFLNENLPRE.E.ITRCLSQAVE....GLA..R....A....V....P...S...DLEQEKAMLVLAMLLTKKVANQVPSLLQRVFSTTVNYISQHLHN.YIVRMLRE...........................
A0A2Y9NIT3_DELLE/10-136                ...........................................lpkcd-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......T....E.T.......Q....N.......S.........E..TQ.........E..E..V...VRDIARQLAQ...IGDRMEC..S..IC.PGLVAGLAAQFGNTSLSEE.D.RRRCLAAALQ....QLT..Q....L....Y....P...A...DVDREKTLLLLTLLVAKKVADHSPAVLQDVFHTTVTFINQNLLA.YVRNLVQN...........................
A0A0P7VIW7_SCLFO/113-226               .......................................lsgrtgdrv-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..-D.........P..A..V...LRAVAEELVR...IADQLEN..R..VV.SRSVERLMERLQG--APNQ.S.WKDYLSEEVM....IML..HgslgP....E....L...N...QLPMERMLLALTFTLVKGVCERAPRFLRGLFHAAVQYVD-----.--------gi.........................
A0A2I2ZUR1_GORGO/3-91                  ................................................CEVNNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LG.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasaeeeteaa...............
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A0A2K5VRH4_MACFA/3-192                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A3B3TE11_9TELE/2-187                 .........................................dqetdpr--------------TALLLFCFL.EdgS..S..D..NK.DLQEELTTLKSC..........................L.T.P...S.CG.......I-.......P...A.EE.................DD.VQSDGHI.C.CNp.......rQ.Y..LD.......E....L.Q.......P....Q.......Alpl..qrgdI..ID.........E..E..A...VRIVAGELVQ...IADQLER..T..VIfQATFWNLFRNLQN--RPEE.N.WKFCLSREVE....KML..HggltQ....S....L...D...QLPKERLMLALTFTFVKGVCQHAPNMLQRLFRTALQYVH-----.--------nf.........................
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H0W5F0_CAVPO/1-187                     ................................................--VGNGAGTRGELVTDLLVFGFL.C..S..R..D..NS.NFHSELKALGQE..........................L.P.G...R.PE.......V-.......-...D.HD.................DE.LQTDGNR.L.SH.........F.H..GG.......R....R.E.......A....D.......S.........E..SQ.........E..E..L...IQHIASQLAL...IGDEMEH..K..IQ.ASVVHQLSTQLRDSSLTPE.G.RRHCLAATLG....EVM..Q....T....C....P...A...DVEQEKAVLIMTMLLARKVADHTPRLFRVVYDTVVDFINQNLLT.YVRDLVRN...........................
G1PYL8_MYOLU/1-188                     ................................................---SNGSCLQDERITDLLVFGFL.Q..N..C..S..NY.NFHKELQVLGHD..........................L.S.V...P.AC.......LW.......E...N.HD.................DE.LQTDGSQ.Y.SH.........F.V..LE.......S....R.E.......T....D.......S.........E..SQ.........D..E..I...IQNIARQLAH...IGDRMDR..S..IP.PRLVNHLAIQFMNGNLSEE.D.RRECLAAALE....QVM..H....T....Y....P...K...DMEKEKTMLMLTMLLAKKVADHTPSLLHDVFRTTVNVINQNLLT.YVRNLVRN...........................
A0A060X7H5_ONCMY/33-229                ...........................................amdcg----------DVQCTPLVFLTFL.QqqS..C..S..SA.ELRIELDSLARE..........................L.K.L...T.QD.......IN.......A...N.GLgln..........iheeGE.LQTDGHF.C.SSssillegleP.Q..AA.......Q....A.W.......P....D.......N.........P..AN.........E..E..A...LRGVAAGLIE...IADQLER..S..VM.AQAAENLTKKLQK--YSIG.L.WKHHLALEVE....WVK..K....QglgpV....L...D...YLPQEKVIMALTLTLVKGVCEHAPLLLRNLFSTAVQFINP----.--------tva........................
A0A151NIJ8_ALLMI/4-137                 ........................................gtysdgfs------------QLESLLLYSFL.D..N..S..Q..DC.AFKEKLQTLSCRht.....................pqcV.P.H...R.RD.......FH.......S..fS.DD.................GE.LQTDGNR.S.GH.........F.Q..NG.......E....-.-.......P....G.......S.........E..TG.........E..-..I...YRIIGAQLAE...IGDQLAA..E..MQ.AGPVDDLVQQFLNANLSSE.E.ITRCLSQMVE....Q--..-....-....-....-...-...--------------------------------------------.--------pkk........................
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A0A2I3LMR4_PAPAN/3-101                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasveeeteaagsvvvelgrh.....
A0A3Q1IZ74_ANATE/3-191                 ...........................................dfrnl---------SSEQNAALVIFTFL.Q..A.dC..I..NT.EYCKELISLGKEyd......................pnC.-.N...G.PR.......ID.......T...L.DD.................GD.LETDGHL.P.TSltia.ldgvL.P..SV.......Q....L.H.......R....-.......N.........P..EE.........E..A..A...LQRVAEELRE...IAAQLEE..N..VV.AQATQNLRRNILI--TPCN.H.WRYYLNREVE....RVM..S....W....Vv..gL...E...HLPYERVIVALTLTLVKGVCEQTPQLLKNLFYTALQYIT-----.--------sssr.......................
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G3W5W1_SARHA/1-185                     ..............................................md---------QDNRQTSLLLYNFL.Q..S..S..G..NN.LFQTELKELDSE..........................L.A.Vf.gS.RN.......GC.......S...E.QD.................YE.LQTDGNR.C.YF.........D.M..SR.......E....E.F.......S....D.......S.........E..NQ.........E..-..I...IQRIATHLAQ...IGDNIES..S..IQ.PSLVDNLIQQFRIINLSAE.D.KRRYLDAAMQ....QMM..Q....T....I....P...L...DLEQEKAQLLLAMLLAKKVMTHAPSLFRSIFYITVDYMNQNLIT.YIRNLVRN...........................
G3R4T6_GORGO/3-192                     ................................................CEVNNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LG.......R....I.E.......A....D.......S.........E..SQ.........E..D..I...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...R...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRT.YVRSLARN...........................
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A0A1V4K844_PATFA/119-309               ...........................................meqvn-----GS----LQMESVLLYSFL.D..V..S..P..DC.MFREQLHSLQSQg........................iV.P.V..lQ.GK.......YC.......Y...D.DE.................ME.LQTDGNR.S.GH........lL.Q..NG.......E....P.V.......F....E.......P.........Q..VD.........E..E..V...VRLIAAQLAE...IGDQFDR..E..IK.TRLVNDLVQQFLNENLPGE.V.ITRRMSEAVE....GLV..R....A....L....P...P...DMEQEKATLVLAMVLTKKIVNTVPSLLPRVFRTTVNYINQHLHN.YIVRMVR-g..........................
B2ZP78_HUMAN/3-90                      ................................................CEVNNGSSLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LG.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasaeeetea................
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BID_CHICK/3-193                        ............................................qdiy---SNGS----DHMERMLLFAFL.A..E..S..S..GC.EFQEQLPSLQSQg.......................vlC.S.V...K.DA.......LC.......Y...D.SD.................GE.LQTDGNR.S.GH.........L.Q..NG.......E....L.V.......P....D.......P.........E..VN.........E..A..I...VRTIAAQLAE...IGDQLDK..Q..IK.AKVVNDLVQHFLNENLPRE.E.ITRCLSQAVE....GLA..R....A....I....P...S...DLEQEKAMLVLAMLLTKKVANQMPSLLQRVFSTTVNYISQHFHN.YIVRMLRE...........................
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A0A2K6Q4K8_RHIRO/3-90                  ................................................CEVSNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDVLGRE..........................L.P.V...P.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....G.......V.........S..NN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------stasveeetea................
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A0A2I3SGG1_PANTR/3-91                  ................................................CEVNNGSSLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LG.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasaeeeteaa...............
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A0A3Q3VJ22_MOLML/107-185               ...............................slctvlspclrplqewi-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...-------..-..--.-------------------.-.--DHLSWEVN....RLMgqN....V....T....F...K...DLAQEQVIVALTLTLVKGVCKHTPQLLRNLFNTALRTLNR----.--------kgsd.......................
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G3HQ86_CRIGR/3-191                     ...............................................s-QVSNGSGLDTEHITNLLVFGFL.Q..N..-..S..KY.HFHRELEVLGQE..........................L.P.V...P.VY.......LD.......A...D.E-.................DE.LQTDGSR.A.SR.........S.Y..HG.......R....I.Q.......P....D.......S.........E..SQ.........E..D..V...IQRIAHHLAQ...VGDELNH..S..IQ.PTLVRQLAAQFMNVSLSEE.D.RRNCLAKALD....EVK..T....A....F....P...R...DMENEKAMLIMTLLLAKSVASHEPSLLRDVFRTTVNFINQNLFT.SVRNLLRN...........................
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A0A452EKQ3_CAPHI/3-188                 ...............................................l-QVSNGPGLGDERTTSLLLLGFL.Q..S..C..P..NS.CFQRELEALGHE..........................F.S.G...H.L-.......--.......-...F.HD.................DE.LQTDGNR.S.SY.........F.S..V-.......A....A.E.......T....D.......S.........E..RQ.........E..E..A...VREVARQLAQ...IGDRLEG..S..IR.PGMVASLASRFSVRSLSEE.D.RRQCLADALE....QLM..R....T....C....P...A...DVDHEKTQLLLTMLLAKKIADHSPALLRDVFRTTVTFINQNLLA.SVRNLVR-s..........................
A0A2K6BWX2_MACNE/3-105                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....G.......V.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasveeeteaagsvvvelgrhgaat.
A0A3Q1FBA7_9TELE/2-189                 ........................................enlnvqna---------------SLVILAFL.K..A.dC..W..DS.DYRRELISLGSH..........................L.N.L...T.KD.......INsngpwieS...S.ED.................EG.LECDGHL.Q.SN.........I.R..DS.......L....Q.D.......L....E.......PlvelqwprdH..VE.........A..A..A...VRRIAEDLRE...VAAQLEH..H..IV.ARAIRNLSSNIQA-SH-SE.Q.WKLHLAREVE....RVM..R....Q....Gv..gL...E...HLPQERVAVALTLTLVKGVCVSAPRLLRGLFNAALQYL------.--------r..........................
A0A3Q2U873_CHICK/64-254                ............................................qdiy---SNGS----DHMERMLLFAFL.A..E..S..S..GC.EFKEQLPSLQSQg.......................vlC.S.V...K.DA.......LC.......Y...D.SD.................GE.LQTDGNR.S.GH.........L.Q..NG.......E....L.V.......P....D.......P.........E..VN.........E..A..I...VRTIAAQLAE...IGDQLDK..Q..IK.AKVVNDLVQHFLNENLPRE.E.ITRCLSQAVE....GLA..R....A....I....P...S...DLEQEKAMLVLAMLLTKKVANQMPSLLQRVFSTTVNYISQHFHN.YIVRMLRE...........................
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H2QL73_PANTR/49-238                    ................................................CEVNNGSSLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LG.......R....I.E.......A....D.......S.........E..SQ.........E..D..I...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...R...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRT.YVRSLARN...........................
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A0A2K5YT85_MANLE/52-241                ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A2K6Q4M0_RHIRO/34-223                ................................................CEVSNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDVLGRE..........................L.P.V...P.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTNHISE.P.GCVDLATALE....QLL..Q....A....Y....P...T...DMEKEKAMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
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A0A2D0QTM1_ICTPU/3-197                 .........................................dvhsfsq--------------TPLLFLTFL.Q..Q..R..P.lNS.ELKRELEKMHCDmklr.................aaptgI.-.-...-.--.......--.......-...-.TDhivytqnhdldsniecdGE.LQTDGHS.V.QRivl...hdvP.Q..VE.......H....V.L.......P....V.......P.........F..DE.........A..N..A...VREVAAELVR...MADELNH..I..IV.SQAAERLTKTLST--SPQK.C.LWSCLSQGVD....TLL..K....D....V....P...-...GMHSERMVTALTFSLARAVCERAPRLLRDLCNTMMQYT------.--------ftnt.......................
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A0A2K6H0Y1_PROCO/1-189                 ................................................--VSNGSGLKDARITDLLVFGFL.Q..S..C..S..SN.SFQAELEALGYE..........................L.P.V...Q.DH.......LW.......E...D.HE.................DE.LQTDGSR.A.SR.........F.H..AQ.......R....I.E.......A....D.......S.........E..SE.........E..D..L...IQNLARQLAQ...IGDSMDR..S..IP.PRLVNHLAMQFMNPNLLEE.D.RRRHLATALE....QLM..Q....T....C....P...A...DLEQEKATLVLTMLLAKKVADHTPSLLRDVFRTTVNFINQNLLT.YVRNLARN...........................
A0A1S3FSZ5_DIPOR/3-194                 ...............................................p-EVSNAAGFGRERITSLLVFGFL.Q..S..S..S..-D.KFRQELDTLGHE..........................L.F.D...G.AL.......PQ......pF...C.AD.................DE.LQTDGLQ.V.SR.........S.-..YG.......R....I.E.......A....D.......S.........E..SQ.........D..E..V...IRSIARHLAQ...AGDEMEH..HlrIH.PGLVSSLAAKFMDRSLSEE.D.RRSCLASALK....EVG..Q....A....Y....P...K...DMETEKATLIMAMLLARKVVTLTPSLCRDVFRTTVNFINQNLLI.YVRNLVQN...........................
A0A2K5J9S2_COLAP/3-94                  ................................................CEVSNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFHRELDALGRE..........................L.P.V...P.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....E.......V.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasveeeteaagsv............
F7A8I6_HORSE/3-191                     ................................................SKVSNGSGLQDEHITHLLVFSFL.Q..N..C..S..KR.HFYKELEVLGHE..........................L.P.V...Q.AY.......LW.......E...D.H-.................DE.LQTDGNR.C.SH.........F.V..-A.......R....A.E.......A....D.......S.........E..SQ.........E..E..I...IQHIARQLAQ...IGDRMDD..S..IH.PRLVNNLAMQFMNVNLSEE.D.RRQCLTSALE....QVM..Q....T....Y....P...K...DMEKEKTMLMLSMLLAKKVANHTPSLLRDVFRTTVNFINQNLLT.YVRNLVRN...........................
A0A099ZHG9_TINGU/1-190                 ...........................................dihsd-----GS----SRMERILLYSFL.Q..S..S..S..NC.EFRDQLQTLQGQw........................iF.P.V...AkQV.......CH.......Y...D.DD.................GD.LQTDGNR.S.GH.........L.Q..NG.......E....L.V.......L....A.......A.........EdmGN.........E..E..I...FRIIGAQLAE...IGDQLDK..E..IQ.ARVVNDLVQHFLNENLSRE.E.ITRCLSQAVE....GLA..R....A....I....P...S...DMEQEKALLVLAMVLTKKVANRVPSLLQRIFSTTVNYINQHLHT.YIVRMV--...........................
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G1TB99_RABIT/12-207                    ...............................................p-KVSSGPGPRDEHITNLLVLGFL.Q..S..C..C..SC.SFHEELQVLGRE..........................L.L.S...E.AE.......LA.......D...S.YDccs...........yddDE.LQTDGNH.A.SF.........L.Q..MG.......R....A.E.......A....G.......S.........E..SQ.........E..E..V...IRNIARRLAQ...IGDRMDH..H..IQ.PELLNNLVVEFVN-DHSEE.D.RRRRLASAVE....QAM..E....T....W....P...A...DMEREKATLMLTMLLAKKLAEHTPSLLRAAFRAAVTLINQDLLA.YVRNLAGN...........................
A0A498MMI5_LABRO/5-192                 ........................................rnfenfph--------------TSLVLLSFL.Q..QkgC..Q..NI.ELKRELNDLDEH..........................L.N.L...P.TN.......HN.......Y..iE.GD.................DE.LQADGHS.I.SLsyre.llleF.Q..HE.......V....Q.P.......Q....L.......P.........V..NA.........E..EahA...AREMAAELIR...IADLLEH..R..VL.SQATDSLTKKLSR---SQE.QfWAGHLSDGVQ....ALL..R....Q....Va..gA...K...EFKKELVEMAFTFVLMKNVCEHVPEYLFRLYGTVVQYF------.--------lpnr.......................
A0A401NUJ8_SCYTO/1-111                 ..............................................de-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..E...ILNIARCLRK...LGDEYNE..V..IQ.SHM-KNLKPTIKNLETDQGvE.TFSGMVSQLE....SIP..E...lQ....T....H...L...QLGSEMNLLRIAVVLGMQITKEVPELLPKVKVAMVNLFNTKLLS.WVQ-----kg.........................
F7DQE5_ORNAN/1-96                      ................................................-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...----LDG..N..IQ.QGLVRDVARQFMNANLSEE.D.RRKYLAATME....RVM..Q....A....V....P...Q...ELEREKATLLFALLLAKQVVNHSPTLLRSVFRTTVDYINRSLLA.YTRNLARN...........................
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A0A2K5YT65_MANLE/3-106                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasveeeteaagsvvvelgrhgtatv
F7CU55_MONDO/68-258                    ...........................................dfamd---------QDNRKTSLLLFNFL.Q..C..S..S..NS.FIQTELKELGQE..........................L.N.R...P.PH.......FQ.......GgglE.DN.................YE.LQTDGNR.S.CH.........F.E..E-.......E....E.E.......S....D.......S.........E..SQ.........E..E..I...IQRIAMQLAK...IGDNIEN..S..IQ.PRVVDELVQWLRNVNLSTQ.E.KKKYLAATME....KVMdmQ....T....I....S...L...DIGQEKATLLLTMLLAKKVMTHAPPLFRSVFQLTVDYINQNLRT.YMRNLTRN...........................
A0A3P8P5L6_ASTCA/80-161                ...........................vdlqirgnvwtdlfvsafqkw-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...-------..-..--.-------------------.-.-KDYLAFEVE....RVM..M....C....W....V..gP...DLPRERVIIALALTLVKRVCVQTPQRLRNLFHTALQYINT----.--------awa........................
A0A3P8YQW5_ESOLU/13-203                ..........................................gdfrts--------------TPLIFLTFL.Q..QhsS..N..NA.ELKRELNSLSHD..........................L.K.R...T.QN.......IHfpglgtnT...H.EE.................GE.LQTDGHY.G.SS........rI.L..LE.......E....L.V.......P....QvelalpmS.........R..AD.........E..V..A...VRAVAAGLIE...IADQLER..R..VV.AQASENLTKKLMK--YSVQ.L.WRHHLALEVEwlkkQAL..G....S....V....L...D...QLPQERVILALTLTLVRGVCERAPVLLRNLFNTALQFT------.--------aar........................
G1KMF0_ANOCA/7-186                     ..........................................ndwpdt-------------STSVLLYSFL.Q..H..S..R..DC.TFVSDLNCLKNE..........................L.L.V...S.RI.......SD.......D...D.DD.................DE.LQTDGNR.C.GR.........F.Q..AR.......E....E.V.......P....-.......-.........-..-D.........E..E..I...FRIIGAQLAE...IGDKLTA..E..IE.TSVIQNLAQHFRRENMSKE.V.MTMQISHVVQ....ELV..R....K....M....P...L...DMEKEKAMLVISMALAKKVVNSVPSLLQQVFNATVNYINQNLHD.YVNNLA--pe.........................
A0A2I3GK37_NOMLE/3-84                  ................................................CEVNNGSGLSDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LE.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasa......................
Q17QH5_BOVIN/3-190                     ...............................................l-KVSNGPGPGDERTTSLLLLGFL.Q..S..C..P..HS.CFQRELEALGHE..........................L.P.G...H.LF.......--.......-...-.HD.................DE.LQTDGNR.C.SH.........FpL..AA.......E....A.E.......T....D.......S.........E..RQ.........E..E..A...VREVARQLAQ...IGDRLEG..S..IH.PGMVAGLASRFSVRSLSEE.D.RRQCLAAALE....QLM..Q....T....C....P...P...DVDHEKTQLLLTMLLAKKIADHSPALLRDVFHTTVTFINQNLLA.YVRNLVRN...........................
A0A383ZU89_BALAS/3-189                 ................................................SKVSNGASPQDERTTSLLVFAFL.Q..S..C..P..RS.RCHQELEVLGHK..........................L.P.V...R.AA.......H-.......-...-.-D.................DE.LQTDGNW.C.SH.........F.R..EG.......A....A.E.......T....D.......S.........E..TQ.........E..E..V...VRDIARQLAQ...IGDRMEC..S..IR.PGLVAGLAAQFRNRSLSEE.D.RRRCLAAALE....QLM..Q....L....Y....P...A...DVDHEKTLLLLTMLVAKKVADHSPALLQDVFHTTVTFINQNLLA.YVRNLVQN...........................
BID_HUMAN/3-192                        ................................................CEVNNGSSLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LG.......R....I.E.......A....D.......S.........E..SQ.........E..D..I...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...R...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRT.YVRSLARN...........................
#=GR BID_HUMAN/3-192             SS    ................................................SSXXXSXXXXXTHHHHHHHHHHH.H..H..T..S..XS.SSHHHHHHHGGG..........................X.X.X...X.XS.......XS.......S...X.S-.................XS.SXXX-S-.S.--.........-.T..TT.......-....S.T.......T....S.......-.........H..CH.........H..H..H...HHHHHHHHHH...HHHHHHH..C..SS.TTSHHHHHHHHHCHCCCCC.C.CCHHHHHHHH....HHH..C....T....S....-...-...SSHCHHHHHHHHHHHHHHHHHH-TTTHHHHHHHHHHHHHCCCHH.HHHHHCCT...........................
F7DQF1_ORNAN/9-135                     ........................................vllprspr-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......P....E.......S.........G..HE.........E..E..A...IRLIAEQLAQ...IGDELDG..N..IQ.QGLVRDVARQFMNANLSEE.D.RRKYLAATME....RVM..Q....A....V....P...Q...ELEREKATLLFALLLAKQVVNHSPTLLRSVFRTTVDYINRSLLA.YTRNLARN...........................
M3WEH6_FELCA/3-193                     ...............................................s-QVSNGSSLQDEHITNLLVFGFL.Q..N..C..S..NY.NFHKELEVLGRE..........................L.P.V...PpAY.......LQ.......E...D.HD.................DG.LQTDGNR.C.SR.........F.L..-D.......S....E.E.......T....D.......S.........E..SQ.........E..E..I...IQDIARQLAQ...IGDRMDH..S..IH.PRVVNNLAMQFMNVNLSEE.D.RRKHLAAALE....QVL..Q....T....Y....P...K...DMEREKTVLMLAMVLAKKVADHTPSLLRDVFRTTVNFINQNLLT.YVRNLVRN...........................
F7DU73_XENTR/4-185                     ...............................svekillsyleidlpst-----------------------.-..-..-..-..NE.ELREELSLFAGGk.......................prL.Q.G...R.A-.......-L.......F...Q.LE.................GE.LETDGNV.Q.LRds.....gtI.A..YE.......-....-.G.......V....E.......Q.........E..VD.........E..E..L...CRRIAAQLAE...MGDKLERemK..IK.PEVVNGLVDAMLNQTLLEE.-.---HLAATVQ....SLV..Q....T....V....P...P...GVEQEVAAVAIAMILTKKAVTNVPSLLQNICRTTTRFVERNYRA.CLERLAR-q..........................
A0A287BP00_PIG/1-186                   ................................................-QVSNGSSLQDERITNLLVFGFL.Q..S..C..P..HA.SFHKELEVLGHE..........................L.P.V...H.TS.......GS.......-...-.--.................DE.LQTDGNR.C.SY.........F.M..ED.......A....A.E.......T....D.......S.........E..SQ.........E..A..V...IRDIARHLAR...IGDRMEY..G..IR.PGLVDSLAAQFRNQSLSEE.D.RRQGLAAVLQ....QLV..H....S....Y....P...A...DMGQEKTLLVLTMLLARKVAEHSPALLRDVFHTTVNFINQNLLT.YLRNLVQ-s..........................
A0A1D5QH89_MACMU/3-192                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A2K6Q4M4_RHIRO/3-192                 ................................................CEVSNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDVLGRE..........................L.P.V...P.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTNQSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKAMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A2I0MKV4_COLLI/2-191                 ...........................................eqvng------S----VQMESVLLYSFL.E..V..S..P..DC.MFREQLHSLQSQe........................iV.P.V..lQ.GK.......YW.......Y...D.DE.................ME.LQTDGNR.S.GH........lL.Q..NG.......E....P.V.......F....E.......P.........Q..VD.........E..E..V...VRLIAVQLAE...IGDQFDK..E..IK.TRLVNDLVQQFLNENLPGE.A.ITRRMSEAVE....GLV..R....A....M....P...P...DMEQEKATLVLAMVLTKKIVNTVPSLLPRVFRTTVNYINQHLHN.YIVRMLR-g..........................
A0A2K5ER11_AOTNA/47-233                ................................................CEVSNGSGLQDERITKLLVFGFL.Q..S..C..S..NH.SFHAELEALGRE..........................L.P.-...-.--.......EW.......E...E.PD.................EE.LQTDGNR.S.SH.........S.H..VG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNRLALQLRNAGRSEE.D.RRRDLASALE....QLL..Q....A....H....P...M...DMDKEKTMLVLALLLAKEVANHTPSLLRDVFRTTVNFINQNLRA.YVRSLARN...........................
A0A2K6BWV9_MACNE/3-192                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A2Y9RIT4_TRIMA/3-197                 ...............................................p-QVSNGSVLPNEHITNILVFSFF.K..N..C..S..NC.NFRVELEVLGDE..........................L.P.V...P.AY.......LK.......E...E.CD.................DE.LQTDGNR.S.SH.........L.R..LG.......RpeirL.E.......A....D.......S.........G..SQ.........E..E..V...IQIIAEHLAQ...IGDEIES..K..VH.PSLVQNLAMQFMNMNLSEA.E.RSECLGTALE....QAM..Q....T....C....L...M...DMELEKKKLMLILLLAKKVANHKPSLLRDIFRTTVNFINQNLFT.YLRNLARN...........................
A0A3B4ZSP9_9TELE/2-197                 .............................................etl---------QNGQNASLVMLAFL.Q..A.dC..R..DS.DYSKELNSLGTHlnl....................tkdI.N.S...N.SH.......WP.......D...S.QE.................DEgLECDGHLpC.SSss....iteL.L..HGiqpvaelR....W.P.......Q....-.......D.........R..EE.........A..A..A...LRGIAEDLRE...VAAQLEH..N..VV.ARATQNLSRNIQV--CPSE.Q.WTYFLANEVE....RVM..R....Q....GvglgL...E...HLPQERVIVALTLTLVRGVCEQAPRMLIGLFNSALQYI------.--------wra........................
G1MGI0_AILME/3-192                     ...............................................a-QVSNGPGLQDEHITNLLVFGFL.Q..N..C..S..NS.NFHKELEVLGHE..........................V.S.M...P.AY.......LQ.......E...D.YD.................DG.LQTDGNR.C.SY.........F.L..-E.......S....G.E.......R....D.......S.........Q..GQ.........E..E..I...IQDIARQLAQ...IGDDMDH..S..IH.PGLMNNLAMQFMNVNLSEE.D.RRKSLTAALE....QVM..Q....T....Y....P...M...DMEEEKTMLILAMLLAKKVADHTPSLLRDVFRTTVNFINQNLFT.YVRNLVRN...........................
A0A1S3KQ61_SALSA/2-196                 ...........................................dcgnv------------QCTPLVFLTFL.QqqS..C..S..SA.ELRIQLDSLAQE..........................L.K.R...T.QD.......IN.......G...N.GLgln..........iheeGE.LQTDGHF.C.SSs.......rI.L..LE.......G....L.EpqaalawP....D.......N.........P..AD.........E..E..A...LRGVAAGLIE...IADQLER..S..VM.AQAAENLTKKLQK--YSIG.R.WKHHLALEVE....WVK..K....QglgpV....L...D...YLPQEKVIMALTLTLVKGVCERAPLLLRNLFSAAVQFINP----.--------tva........................
I3N331_ICTTR/3-192                     ................................................SEVSNGSDLRNEYITNLLVLDFL.Q..S..F..S..DC.KFHQELRTLGQE..........................L.P.V...R.TY.......LE.......G...E.RE.................DE.LQTDGNR.A.S-.........L.F..MG.......R....I.E.......A....D.......S.........E..SQ.........E..E..V...IQNIARHLAQ...VGDEMDR..S..IQ.PELVNELVARFMNAGLSEE.D.RSNCLDTTLK....AAM..Q....T....Y....P...K...DMENEKTMLIMTMLLAKKVANHTPSLLHDVFRATVNFINQNLFT.YVRDLVRN...........................
A0A3B4C8R3_PYGNA/3-179                 ........................................andnldcv---------------SLVFLTFL.D..QtpC..Q..NK.DLEKELHRLGYD..........................L.K.L...T.TDs....ggTN.......I...E.CD.................GE.LETDGNI.P.TNp......rdF.L..QG.......V....LpEvh...laL...pV.......N.........P..EE.........A..Q..A...VREVAAELIR...IADELNL..M..IV.SRAAEGLARKLNS-TSSLE.-.-------SVD....NLL..K....E....V....P...-...GVHTEQVVMALTFSLVKAVCEHTPPLLRGLYNVVMQYIS-----.--------pa.........................
A0A340Y8Y3_LIPVE/85-272                ................................................SKVSKGASPQDERTTSLLVFSFL.Q..S..C..P..HS.RCHQELEMLGHK..........................L.P.M...R.AA.......--.......-...-.HD.................DE.LQTDGNW.C.SH.........F.R.dEG.......A....A.E.......T....D.......S.........E..TQ.........E..E..V...VRDIARQLAQ...IGDGMEC..S..IC.PGLVAGLAAQFSNTSLSEE.D.RRRCLAAALE....QLT..Q....L....Y....P...A...DVDREKTLLLLTMLVAKKVADHSPAVLQDVFHTTVTFINQNLLA.YVRNLAQN...........................
A0A287AYM3_PIG/3-189                   ................................................SKVSNGSSLQDERITNLLVFGFL.Q..S..C..P..HA.SFHKELEVLGHE..........................L.P.V...H.TS.......GS.......-...-.--.................DE.LQTDGNR.C.SY.........F.M..ED.......A....A.E.......T....D.......S.........E..SQ.........E..A..V...IRDIARHLAR...IGDRMEY..G..IR.PGLVDSLAAQFRNQSLSEE.D.RRQGLAAVLQ....QLV..H....S....Y....P...A...DMGQEKTLLVLTMLLARKVAEHSPALLRDVFHTTVNFINQNLLT.YLRNLVQ-s..........................
A0A3Q7WWF4_URSAR/3-192                 ................................................CKVSNGPGLQDEHITNLLVFGFL.Q..N..C..S..NS.NFHKELEVLGRE..........................V.S.M...P.AY.......LP.......E...D.YD.................DG.LQTDGNR.C.SY.........F.L..-E.......S....G.E.......R....D.......S.........Q..GQ.........E..E..I...IQDIARQLAQ...IGDDMDH..S..IH.PGLMNNLAMQFMNVNLSEE.D.RRKSLAAALE....QVM..Q....T....Y....P...M...DMEEEKTMLILAMLLAKKVADHTPSLLRDVFRTTVNFINQNLFT.YVRNLVRN...........................
A0A087R1G3_APTFO/1-183                 .............................................ngs-----------VRMEHVLLYTFL.E..V..S..S..DC.NFREQLHSLQSQg........................iV.PfL...K.GS.......YC.......Y...D.DE.................VE.LQTDGNR.S.GH.........L.Q..NG.......E....L.V.......H....D.......P.........E..IN.........E..-..I...LRIVATQLAE...IGDQLDK..E..IK.PRTVNDLVQHFLNENLSGE.E.ITRYMSEAVE....GLA..R....A....L....P...S...DMEQEKAMLVLAMVLTKKIANTMPSLLQRVFSTTVNYISQQFHN.YIVRMV--...........................
A0A2K6TCL3_SAIBB/3-189                 ...............................................r-EVSNGSGLQDERITNLLVFGFL.Q..S..C..S..NH.SFQAELEALGRE..........................L.P.-...-.--.......HW.......E...E.PD.................EE.LQTDGNR.G.SH.........A.H..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..I...IRNIARQLAQ...VGDSMDR..S..IP.PGLVNRLALQLRNAGRSEE.D.QRRDLASALE....QLL..Q....V....H....P...M...DMDKEKTMLVLALLLAKEVANHTPSLLRDVFRTTVNFINQNLRA.YVRSLARN...........................
W5JYR5_ASTMX/10-201                    ..........................................afsqps----------------ILFLTFL.Q..Q..T..PshNP.EFKRELQLLTCD..........................M.A.L...Q.AD.......QCv....ysG...E.MDysdhsmi...dpniecdGE.LEADGHG.L.SIq......rnL.L..QDi....lpQ....A.H.......L....G.......L.........P..VN.........N..E..V...IREVAAELIT...IADDLNN..T..IM.SRAADSLTSELRR-TSSMQ.T.WPALLRRSVT....ELI..N....C....V....P...G...-AHNEQVTMALTFSLVKAVCERAPPLLRGLFSVLMQYI------.--------yp.........................
Q56VD1_XENLA/4-183                     ................................nvktilvsyleidikn-----------------------.-..-..-..H..KD.EFWEELSWFARE..........................E.G.K...L.VA.......QM.......G...R.ND.................GD.LETDGNV.Q.FR.........S.T..GT......iV....Y.E.......G....E.......A.........E..VD.........E..E..L...CRRIATQLAE...MGDKLER..EmrIK.PEVVNGIVDALLNHTLNEE.-.---YLAATVQ....SLV..Q....T....A....P...P...GVEQELMSVAIALILTKKAVTNVPSLLHNICCTTTHFIERNYRA.CLERLAR-q..........................
F6WQU1_MACMU/32-221                    ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A3Q0CCS6_MESAU/130-190               ...........................................cekpg-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.-K.........L.H..SP.......Y....E.E.......G....D.......S.........E..SQ.........E..D..I...IQRIAHQLVQ...VGDELDH..S..IQ.PTLVRQLAAQFMNVSLSEE.-.----------....---..-....-....-....-...-...--------------------------------------------.--------...........................
A0A2K6H0U2_PROCO/1-96                  ................................................-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...----MDR..S..IP.PRLVNHLAMQFMNPNLLEE.D.RRRHLATALE....QLM..Q....T....C....P...A...DLEQEKATLVLTMLLAKKVADHTPSLLRDVFRTTVNFINQNLLT.YVRNLARN...........................
M7ARC5_CHEMY/27-215                    ........................................tavrglrg----------DVQVERILVYSFL.Q..N..C..H..NC.DFREELDSLRSQ..........................V.M.VsppK.NF.......LS.......D...E.FD................dGE.LQTDGNR.S.GR.........F.S..NG.......-....-.E.......P....D.......S.........V..VD.........E..D..I...FRLIGAQLAE...IGDQVAR..E..IQ.PRVVNDLVQQFVNENLSKE.E.IMRRLSNTVE....GLV..R....T....I....P...L...EMEQEKAMLVLAMVLARTVANKMPSLLHRVFNTTVNYVNQNLHN.YVVNL---g..........................
A0A2K5J9S8_COLAP/63-252                ................................................CEVSNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFHRELDALGRE..........................L.P.V...P.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....S....P...T...DMEKEKAMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
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BID_PIG/3-189                          ................................................SKVSNGSSLQDERITNLLVFGFL.Q..S..C..P..HA.SFHKELEVLGHE..........................L.P.V...H.TS.......GS.......-...-.--.................DE.LQTDGNR.C.SY.........F.M..ED.......A....A.E.......T....D.......S.........E..SQ.........E..A..V...IRDIARHLAR...IGDRMEY..G..IR.PGLVDSLAAQFRNQSLSEE.D.RRQGLAAVLQ....QLV..H....S....Y....P...A...DMGQEKTLLVLTMLLARKVAEHSPALLRDVFHTTVNFINQNLLT.YLRNLVQ-s..........................
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A0A2R9A2N2_PANPA/3-91                  ................................................CEVNNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFRRELDALGHE..........................L.P.V...L.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..LG.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasaeeeteaa...............
A0A2K5VRS6_MACFA/3-105                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....G.......V.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasveeeteaagsvvvelgrhgaat.
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A0A2K5LVY0_CERAT/3-104                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....G.......A.........S..DN.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------ntasveeeteaagsvvvelgrhgaa..
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G5BWN8_HETGA/3-193                     ...............................................a-KVGNGAGFRDESITNLLVYSFL.H..T..R..N..NS.NFHPELEALGQE..........................L.P.V...G.VC.......LE.......A...D.HD.................DE.LQTDGNR.G.SR........lL.Y..GG.......R....R.E.......G....D.......S.........E..NQ.........E..-..I...IHSIAWHLAE...IGDELDR..S..IQ.PGLVNQLAMHFRNPGLSEE.G.RRHYLAATVE....EVM..Q....T....Y....A...T...DMEQEKAKLITAMLLVRKVADHTPSLLRDIFHTTVNFINQNLLT.YMRDLIRN...........................
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A0A2K5J9S4_COLAP/3-192                 ................................................CEVSNGSGLRDECITNLLVFGFL.Q..S..C..S..DN.SFHRELDALGRE..........................L.P.V...P.AP.......QW.......E...G.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....S....P...T...DMEKEKAMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A3Q3EY88_9LABR/5-173                 ...........................................rrpna---------------ALLVLTFL.Q..A.dC..R..NS.ECVKELHSLGQE..........................L.H.L...R.--.......L-.......-...-.ED.................GD.LETDGHL.P.VFi.......rA.S..LD.......D....I.Q.......P....S.......V.........E..LQ.........N..R..A..kYVRFALELRE...IAAQLEH..N..IV.AQATQNLNGKISNS--PFH.Q.WKDHLSREVE....RVM..R....Q....Gv..gL...E...HLARERVIMALTLTLVKGVCEQAPRLLRNLFNIALQYVS-----.--------gg.........................
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A0A2K5S4T7_CEBCA/3-189                 ................................................CEVSNGSGLQDERITNLLVFGFL.Q..S..C..S..NH.SFHAELEALGRE..........................L.P.-...-.--.......QW.......E...E.PD.................EE.LQTDGNR.S.SH.........A.H..VG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARQLAQ...VGDSLDR..S..IP.PGLVNRLALQLRNAGRSEE.D.RRRDLASALE....QLL..Q....A....H....P...T...DMDKEKTMLVLALLLAKEVANHTPSLLRDVFRTTVNFINQNLRA.YVRSLARN...........................
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A0A2K5YT47_MANLE/3-192                 ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
F1Q0Y3_CANLF/12-203                    ................................................SKVSNGSGPQDERITNLLVFGFL.Q..N..C..S..NY.NFHEELELLGRE..........................L.P.V...P.AY.......LK.......E...D.YD.................DE.LQTDGNR.C.SY........fL.D..GG.......A....R.G.......L....D.......S.........E..SQ.........E..E..I...IQDIARQLAQ...IGDRMDH..S..IH.PGLVNNLAMQFMNVNLSEE.D.RRKHLAAALE....QAM..Q....T....Y....P...K...DMEKEKTMLMLAMLLAKKVADHTPSLLRDVFHTTVNFISQNLLT.YVRNLVRN...........................
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A0A2K6KDQ7_RHIBE/1-96                  ................................................-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...----MDR..S..IP.PGLVNGLALQLRNTNQSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKAMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
H0ZQI0_TAEGU/1-140                     ................................................-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.-D.................DE.LQTDGNR.S.GH.........F.Q..NA.......V...lR.E.......W....L.......A.........Q..TN.........E..E..V...IRIIAAQLAE...IGDQFDR..E..IQ.ERVVNGLAQHFLNENLSYE.E.IIQHMNRAVR....ELT..R....A....I....P...A...DMEQEKAMLVLAMVLTRRIVNSVPSLLRRVITTTLNYMNQQFHN.YILEMV--sa.........................
R0M701_ANAPL/2-188                     ..........................................ihsggf-----------NQMERMLLFAFL.E..E..S..S..GC.EFKEQLPSLRSQg.......................ivY.P.L...Q.DI.......LY.......C...D.SD.................GE.LQTDGNR.S.GH.........F.Q..NG.......E....Q.V.......F....D.......P.........E..VN.........E..E..I...VRTIAAQLAE...IGDQLDK..E..VK.AKVVNDLVQHFLNENLSRE.E.ITRCLSQAVE....VLA..R....A....I....P...S...DLEREKAMLVLAMVLTKKVANKVPFLLQRVFSTTVNYISQHFHG.YVARMV--...........................
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A0A2U3WEE1_ODORO/1-96                  ................................................-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...----MDR..S..IH.PGLVNNLAMQFMNVNLSEE.D.RRRYLATALE....RIM..Q....T....Y....P...T...DMEEEKTMLMLVMLLAKKVADHTPSLLRDVFRTTVNFINQNLFT.YVRNLVRN...........................
A0A2J8RJ32_PONAB/1-96                  ................................................-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...----MDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRT.YVRSLARN...........................
A0A3Q7W0M9_URSAR/3-161                 ................................................CKVSNGPGLQDEHITNLLVFGFL.Q..N..C..S..NS.NFHKELEVLGRE..........................V.S.M...P.AY.......LP.......E...D.YD.................DG.LQTDGNR.C.SY.........F.L..-E.......S....G.E.......R....D.......S.........Q..GQ.........E..E..I...IQDIARQLAQ...IGDDMDH..S..IH.PGLMNNLAMQFMNVNLSEE.D.RRKSLAAALE....QVM..Q....T....Y....P...M...DMEEEKTMLILAMLLAKK--------------------------.--------emd........................
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A0A2K6BWY8_MACNE/52-241                ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
A0A2K5VRT7_MACFA/52-241                ................................................CEVSNGSGLRDECVTNLLVFGFL.Q..S..C..S..DN.SFRRELDALGRE..........................L.P.V...P.AA.......QW.......E...A.Y-.................DE.LQTDGNR.S.SH.........S.R..MG.......R....I.E.......A....D.......S.........E..SQ.........E..D..V...IRNIARHLAQ...VGDSMDR..S..IP.PGLVNGLALQLRNTSRSEE.D.RNRDLATALE....QLL..Q....A....Y....P...T...DMEKEKTMLVLALLLAKKVASHTPSLLRDVFQTTVNFINQNLRA.YVRSLARN...........................
Q1LX52_DANRE/5-187                     ........................................rnfdhiph--------------TSLVLLSFL.D..Q..-..K..DC.QNGESGRVFDYR..........................E.D.N...L.ST.......NH.......I...D.SD.................GD.IETDGQS.P.PAty....rdlL.H..EL.......Q....H.E.......V....Qp....glS.........V..NA.........E..EarA...AREMAAELIR...IADLLEQ..S..VL.SQAAESLTKKLRS--SQEQ.V.WASHLSKGVQ....TLL..Q....H....V....Aa.aK...EFKKELVEMAFTFMLMKTVCERTPDFLFGLYGTVVQFFG-----.--------sn.........................
A0A455BCZ9_PHYMC/3-190                 ................................................SKVSNGTSPQDERTTSLLVFGFL.Q..S..Y..P..HS.RCHQELEVLGHK..........................L.A.M...R.V-.......--.......-...A.HD.................DE.LQTDGNW.C.SH.........F.R.dEG.......A....A.E.......T....D.......S.........E..TQ.........E..E..V...VRDIARQLAQ...IGDRMEC..S..IR.PGLVAGLAAQFRNTSLSEE.E.RRRCLAAALE....QLV..Q....L....C....P...A...DVDREKTLLLLTMLVAKKVADHSPALLQDVFHTTVTFINQNLLA.YVRNLVQN...........................
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A0A3P9Q8R4_POERE/83-144                ..............................................lg-----------------------.-..-..-..-..--.------------..........................-.-.-...-.--.......--.......-...-.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...-------..-..--.-------------------.-.--NHLVNEVE....RLL..R....E....V...sV...K...DLPQEQVVVALTLTLVKGVCIQAPRLLKGLFDTAVQFICH----.--------rwt........................
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A0A3Q7S5Z1_VULVU/3-192                 ................................................SKVSNGSGPQDERITNLLVFGFL.Q..N..C..S..NY.NFHEELELLGRE..........................L.P.V...P.AY.......LK.......E...D.HD.................DE.LQTDGNR.C.SY.........F.L..DG.......G....A.-.......R....D.......S.........E..SQ.........E..E..I...IQDIARQLAQ...IGDRMDH..S..IH.PGLVNNLAMQFMNVNLSEE.D.RRKHLAAALE....QAM..Q....T....Y....P...K...DMEKEKTMLMLAMLLAKKVADHTPSLLRDVFHTTVNFISQNLLT.YVRNLVRN...........................
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D3Z463_MOUSE/3-52                      ................................................SEVSNGSGLGAEHITDLLVFGFL.Q..S..-..S..GC.T-RQELEVLGRE..........................L.P.V...Q.AY.......WE.......A...D.--.................--.-------.-.--.........-.-..--.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------l..........................
BID_RAT/3-193                          ................................................SEVSNGSGLGAEHITNLLVFGFL.R..N..-..N..DR.DFHQELEVLGQE..........................L.P.V...Q.VY.......LE.......G...D.RE.................DE.LQTDGSR.A.SR........sF.Y..HG.......R....I.E.......P....D.......S.........E..SQ.........D..E..V...IHNIARHLAQ...AGDELDH..S..IQ.PTLVRQLAAQFMNGSLSEE.D.KRNCLAKALD....EVK..T....S....F....P...R...DMENDKAMLIMTMLLAKKVASHAPSLLRDVFRTTVNFINQNLFS.YVRDLVRN...........................
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A0A452EKW9_CAPHI/3-71                  ...............................................l-QVSNGPGLGDERTTSLLLLGFL.Q..S..C..P..NS.CFQRELEALGHE..........................F.S.G...H.L-.......--.......-...F.HD.................DE.LQTDGNR.S.SY.........F.S..V-.......-....-.-.......-....-.......-.........-..--.........-..-..-...----------...-------..-..--.-------------------.-.----------....---..-....-....-....-...-...--------------------------------------------.--------aaetg......................
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#=GC SS_cons                           ................................................SSXXXSXXXXXTHHHHHHHHHHH.H..H..T..S..SS.SSHHHHHHHHGG..........................X.X.S...S.XS.......XS.......S...X.SX.................XS.SXXXXSX.S.XX........SX.T..TT.......X....S.T.......T....S.......X.........H..CH.........H..H..H...HHHHHHHHHH...HHHHHHH..C..SS.TSSHHHHHHHHHCCCCCCC.C.CCHHHHHHHH....HHH..C....C....S....X...S...TCHCHHHHHHHHHHHHHHHHHHXTTTHHHHHHHHHHHHHCCCCH.HHHHHCCC...........................
#=GC seq_cons                          ............................................................phssLLlauFL.p..s..s..s..ss.pF+cELcsLupc..........................l.s.h.....s.....................t..-.................sE.LQTDGNR.s.u+...........p...s.......p....h.p.......s....-.......s.........p..sp.........E..-..l...lppIAtpLAp...lGDph-+..p..I..stlVssLs.phhN.shScE.-.hpppLupulE....plh..p....s....h....P...t...Dh-pEKshLlLshlLsKKVsscsPuLL+cVFpTTVsaINQpLhs.Ylhphh.............................
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