KEGG   Panthera pardus (leopard): 109275159
Entry
109275159         CDS       T06062                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ppad  Panthera pardus (leopard)
Pathway
ppad00562  Inositol phosphate metabolism
ppad01100  Metabolic pathways
ppad01521  EGFR tyrosine kinase inhibitor resistance
ppad01522  Endocrine resistance
ppad01524  Platinum drug resistance
ppad04012  ErbB signaling pathway
ppad04014  Ras signaling pathway
ppad04015  Rap1 signaling pathway
ppad04024  cAMP signaling pathway
ppad04062  Chemokine signaling pathway
ppad04066  HIF-1 signaling pathway
ppad04068  FoxO signaling pathway
ppad04070  Phosphatidylinositol signaling system
ppad04071  Sphingolipid signaling pathway
ppad04072  Phospholipase D signaling pathway
ppad04140  Autophagy - animal
ppad04150  mTOR signaling pathway
ppad04151  PI3K-Akt signaling pathway
ppad04152  AMPK signaling pathway
ppad04210  Apoptosis
ppad04211  Longevity regulating pathway
ppad04213  Longevity regulating pathway - multiple species
ppad04218  Cellular senescence
ppad04360  Axon guidance
ppad04370  VEGF signaling pathway
ppad04380  Osteoclast differentiation
ppad04510  Focal adhesion
ppad04550  Signaling pathways regulating pluripotency of stem cells
ppad04611  Platelet activation
ppad04613  Neutrophil extracellular trap formation
ppad04620  Toll-like receptor signaling pathway
ppad04625  C-type lectin receptor signaling pathway
ppad04630  JAK-STAT signaling pathway
ppad04650  Natural killer cell mediated cytotoxicity
ppad04660  T cell receptor signaling pathway
ppad04662  B cell receptor signaling pathway
ppad04664  Fc epsilon RI signaling pathway
ppad04666  Fc gamma R-mediated phagocytosis
ppad04668  TNF signaling pathway
ppad04670  Leukocyte transendothelial migration
ppad04722  Neurotrophin signaling pathway
ppad04725  Cholinergic synapse
ppad04750  Inflammatory mediator regulation of TRP channels
ppad04810  Regulation of actin cytoskeleton
ppad04910  Insulin signaling pathway
ppad04914  Progesterone-mediated oocyte maturation
ppad04915  Estrogen signaling pathway
ppad04917  Prolactin signaling pathway
ppad04919  Thyroid hormone signaling pathway
ppad04923  Regulation of lipolysis in adipocytes
ppad04926  Relaxin signaling pathway
ppad04929  GnRH secretion
ppad04930  Type II diabetes mellitus
ppad04931  Insulin resistance
ppad04932  Non-alcoholic fatty liver disease
ppad04933  AGE-RAGE signaling pathway in diabetic complications
ppad04935  Growth hormone synthesis, secretion and action
ppad04960  Aldosterone-regulated sodium reabsorption
ppad04973  Carbohydrate digestion and absorption
ppad05010  Alzheimer disease
ppad05017  Spinocerebellar ataxia
ppad05020  Prion disease
ppad05100  Bacterial invasion of epithelial cells
ppad05132  Salmonella infection
ppad05135  Yersinia infection
ppad05142  Chagas disease
ppad05146  Amoebiasis
ppad05160  Hepatitis C
ppad05161  Hepatitis B
ppad05162  Measles
ppad05163  Human cytomegalovirus infection
ppad05164  Influenza A
ppad05165  Human papillomavirus infection
ppad05166  Human T-cell leukemia virus 1 infection
ppad05167  Kaposi sarcoma-associated herpesvirus infection
ppad05168  Herpes simplex virus 1 infection
ppad05169  Epstein-Barr virus infection
ppad05170  Human immunodeficiency virus 1 infection
ppad05171  Coronavirus disease - COVID-19
ppad05200  Pathways in cancer
ppad05203  Viral carcinogenesis
ppad05205  Proteoglycans in cancer
ppad05206  MicroRNAs in cancer
ppad05207  Chemical carcinogenesis - receptor activation
ppad05208  Chemical carcinogenesis - reactive oxygen species
ppad05210  Colorectal cancer
ppad05211  Renal cell carcinoma
ppad05212  Pancreatic cancer
ppad05213  Endometrial cancer
ppad05214  Glioma
ppad05215  Prostate cancer
ppad05218  Melanoma
ppad05220  Chronic myeloid leukemia
ppad05221  Acute myeloid leukemia
ppad05222  Small cell lung cancer
ppad05223  Non-small cell lung cancer
ppad05224  Breast cancer
ppad05225  Hepatocellular carcinoma
ppad05226  Gastric cancer
ppad05230  Central carbon metabolism in cancer
ppad05231  Choline metabolism in cancer
ppad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ppad05415  Diabetic cardiomyopathy
ppad05417  Lipid and atherosclerosis
ppad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ppad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109275159 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109275159 (PIK3CA)
   04014 Ras signaling pathway
    109275159 (PIK3CA)
   04015 Rap1 signaling pathway
    109275159 (PIK3CA)
   04370 VEGF signaling pathway
    109275159 (PIK3CA)
   04630 JAK-STAT signaling pathway
    109275159 (PIK3CA)
   04668 TNF signaling pathway
    109275159 (PIK3CA)
   04066 HIF-1 signaling pathway
    109275159 (PIK3CA)
   04068 FoxO signaling pathway
    109275159 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    109275159 (PIK3CA)
   04072 Phospholipase D signaling pathway
    109275159 (PIK3CA)
   04071 Sphingolipid signaling pathway
    109275159 (PIK3CA)
   04024 cAMP signaling pathway
    109275159 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    109275159 (PIK3CA)
   04152 AMPK signaling pathway
    109275159 (PIK3CA)
   04150 mTOR signaling pathway
    109275159 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109275159 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    109275159 (PIK3CA)
   04218 Cellular senescence
    109275159 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109275159 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    109275159 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109275159 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109275159 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    109275159 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    109275159 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    109275159 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    109275159 (PIK3CA)
   04660 T cell receptor signaling pathway
    109275159 (PIK3CA)
   04662 B cell receptor signaling pathway
    109275159 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    109275159 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    109275159 (PIK3CA)
   04670 Leukocyte transendothelial migration
    109275159 (PIK3CA)
   04062 Chemokine signaling pathway
    109275159 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109275159 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    109275159 (PIK3CA)
   04929 GnRH secretion
    109275159 (PIK3CA)
   04915 Estrogen signaling pathway
    109275159 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    109275159 (PIK3CA)
   04917 Prolactin signaling pathway
    109275159 (PIK3CA)
   04926 Relaxin signaling pathway
    109275159 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    109275159 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    109275159 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109275159 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109275159 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    109275159 (PIK3CA)
   04722 Neurotrophin signaling pathway
    109275159 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109275159 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    109275159 (PIK3CA)
   04380 Osteoclast differentiation
    109275159 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    109275159 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    109275159 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109275159 (PIK3CA)
   05206 MicroRNAs in cancer
    109275159 (PIK3CA)
   05205 Proteoglycans in cancer
    109275159 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    109275159 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    109275159 (PIK3CA)
   05203 Viral carcinogenesis
    109275159 (PIK3CA)
   05230 Central carbon metabolism in cancer
    109275159 (PIK3CA)
   05231 Choline metabolism in cancer
    109275159 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109275159 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109275159 (PIK3CA)
   05212 Pancreatic cancer
    109275159 (PIK3CA)
   05225 Hepatocellular carcinoma
    109275159 (PIK3CA)
   05226 Gastric cancer
    109275159 (PIK3CA)
   05214 Glioma
    109275159 (PIK3CA)
   05221 Acute myeloid leukemia
    109275159 (PIK3CA)
   05220 Chronic myeloid leukemia
    109275159 (PIK3CA)
   05218 Melanoma
    109275159 (PIK3CA)
   05211 Renal cell carcinoma
    109275159 (PIK3CA)
   05215 Prostate cancer
    109275159 (PIK3CA)
   05213 Endometrial cancer
    109275159 (PIK3CA)
   05224 Breast cancer
    109275159 (PIK3CA)
   05222 Small cell lung cancer
    109275159 (PIK3CA)
   05223 Non-small cell lung cancer
    109275159 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109275159 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    109275159 (PIK3CA)
   05161 Hepatitis B
    109275159 (PIK3CA)
   05160 Hepatitis C
    109275159 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    109275159 (PIK3CA)
   05164 Influenza A
    109275159 (PIK3CA)
   05162 Measles
    109275159 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    109275159 (PIK3CA)
   05163 Human cytomegalovirus infection
    109275159 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109275159 (PIK3CA)
   05169 Epstein-Barr virus infection
    109275159 (PIK3CA)
   05165 Human papillomavirus infection
    109275159 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109275159 (PIK3CA)
   05135 Yersinia infection
    109275159 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    109275159 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109275159 (PIK3CA)
   05142 Chagas disease
    109275159 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109275159 (PIK3CA)
   05017 Spinocerebellar ataxia
    109275159 (PIK3CA)
   05020 Prion disease
    109275159 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109275159 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    109275159 (PIK3CA)
   05415 Diabetic cardiomyopathy
    109275159 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109275159 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    109275159 (PIK3CA)
   04931 Insulin resistance
    109275159 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109275159 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109275159 (PIK3CA)
   01524 Platinum drug resistance
    109275159 (PIK3CA)
   01522 Endocrine resistance
    109275159 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ppad04131]
    109275159 (PIK3CA)
Enzymes [BR:ppad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     109275159 (PIK3CA)
Membrane trafficking [BR:ppad04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109275159 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 109275159
NCBI-ProteinID: XP_019318769
Ensembl: ENSPPRG00000003667
UniProt: A0A9V1GAP7
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgtatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcgtattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcagatt
caatgcaaaggtggcctgaaaggcgcactgcagttcaacagccacacgctacaccagtgg
ctcaaagacaagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (105)   
   KEGG PATHWAY (105)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (8)   
   Pfam (8)   
All databases (132)   

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