KEGG   REACTION: R01169
Entry
R01169                      Reaction                               
Name
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase
Definition
L-Histidine + 3 S-Adenosyl-L-methionine + H+ <=> Hercynine + 3 S-Adenosyl-L-homocysteine
Equation
C00135 + 3 C00019 + C00080 <=> C05575 + 3 C00021
Comment
three-step reaction (see R10523+R10524+R04436)
Reaction class
RC00003  C00019_C00021
RC02308  C00135_C05575
Enzyme
2.1.1.44
Pathway
rn00340  Histidine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.44
     R01169  L-Histidine + 3 S-Adenosyl-L-methionine + H+ <=> Hercynine + 3 S-Adenosyl-L-homocysteine
Orthology
K18911  L-histidine Nalpha-methyltransferase [EC:2.1.1.44]
K20246  L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase [EC:2.1.1.44 1.21.3.10]
Reference
1  [PMID:5484456]
  Authors
Ishikawa Y, Melville DB.
  Title
The enzymatic alpha-N-methylation of histidine.
  Journal
J Biol Chem 245:5967-73 (1970)
DOI:10.1016/S0021-9258(18)62649-3
Other DBs
RHEA: 38474

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (2260)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2258)   
All databases (2273)   

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