Entry |
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Name |
(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase
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Definition |
(3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+
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Equation |
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Reaction class |
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Enzyme |
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Pathway |
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Module |
M00083 | Fatty acid biosynthesis, elongation |
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Brite |
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.100
R04536 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+
1.1.1.-
R04536 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+
2. Transferase reactions
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.85
R04536 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+
2.3.1.86
R04536 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+
2.3.1.-
R04536 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] + NADP+ <=> 3-Oxooctanoyl-[acp] + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
1. Oxidoreductase reactions
1.1.1.100
R02767 (3R)-3-Hydroxyacyl-[acyl-carrier protein] <=> 3-Oxoacyl-[acyl-carrier protein]
R04536 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] <=> 3-Oxooctanoyl-[acp]
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Orthology |
K11533 | fatty acid synthase, bacteria type [EC:2.3.1.-] |
K11539 | carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-] |
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Reference |
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Authors |
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z |
Title |
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. |
Journal |
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Reference |
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Authors |
Hiltunen JK, Kastaniotis AJ, Autio KJ, Jiang G, Chen Z, Glumoff T. |
Title |
17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes. |
Journal |
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