Entry Name African trypanosomiasis - Rattus norvegicus (rat)
Description Trypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brain barrier and cause neurological damage by inducing cytokines like TNF alpha, IFN gamma, and IL1. These cytokines and other metabolites such as nitric oxide and somnogenic prostaglandin D2 disturb circadian rhythms in patients with African trypanosomiasis.
Class Human Diseases; Infectious disease: parasiticBRITE hierarchy
Pathway map Disease H00357 African trypanosomiasis
Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 116677 F2rl1; proteinase-activated receptor 2 precursor [KO:K04234 ]
24602 Nppa; natriuretic peptides A precursor [KO:K12334 ]
246097 Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
24654 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
25031 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
25081 Apoa1; apolipoprotein A-I preproprotein [KO:K08757 ]
25087 Kng2l1; kininogen-1 isoform 1 precursor [KO:K03898 ]
25361 Vcam1; vascular cell adhesion protein 1 precursor [KO:K06527 ]
25385 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
25464 Icam1; intercellular adhesion molecule 1 precursor [KO:K06490 ]
29322 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
301059 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
361619 Hbb-b1; hemoglobin, beta adult major chain [KO:K13823 ]
64546 Il12b; interleukin-12 subunit beta precursor [KO:K05425 ]
81666 Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
84405 Il12a; interleukin-12 subunit alpha precursor [KO:K05406 ]
85240 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Antoine-Moussiaux N, Buscher P, Desmecht D
Title Host-parasite interactions in trypanosomiasis: on the way to an antidisease strategy.
Journal Reference Authors Enanga B, Burchmore RJ, Stewart ML, Barrett MP
Title Sleeping sickness and the brain.
Journal Reference Authors Bisser S, Ouwe-Missi-Oukem-Boyer ON, Toure FS, Taoufiq Z, Bouteille B, Buguet A, Mazier D
Title Harbouring in the brain: A focus on immune evasion mechanisms and their deleterious effects in malaria and human African trypanosomiasis.
Journal Reference Authors Masocha W, Rottenberg ME, Kristensson K
Title Migration of African trypanosomes across the blood-brain barrier.
Journal Reference Authors Lonsdale-Eccles JD, Grab DJ
Title Trypanosome hydrolases and the blood-brain barrier.
Journal Reference Authors Grab DJ, Kennedy PG
Title Traversal of human and animal trypanosomes across the blood-brain barrier.
Journal Reference Authors Kristensson K, Nygard M, Bertini G, Bentivoglio M
Title African trypanosome infections of the nervous system: parasite entry and effects on sleep and synaptic functions.
Journal Reference Authors Pays E, Vanhollebeke B
Title Human innate immunity against African trypanosomes.
Journal Reference Authors Donelson JE, Hill KL, El-Sayed NM
Title Multiple mechanisms of immune evasion by African trypanosomes.
Journal Reference Authors Grab DJ, Garcia-Garcia JC, Nikolskaia OV, Kim YV, Brown A, Pardo CA, Zhang Y, Becker KG, Wilson BA, de A Lima AP, Scharfstein J, Dumler JS
Title Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.
Journal Reference Authors Vanhollebeke B, Pays E
Title The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill.
Journal Related rno04610 Complement and coagulation cascades
rno04620 Toll-like receptor signaling pathway
KO pathway
