KEGG   Rattus norvegicus (rat): 24598
Entry
24598             CDS       T01003                                 
Symbol
Nos1
Name
(RefSeq) nitric oxide synthase 1
  KO
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00220  Arginine biosynthesis
rno00330  Arginine and proline metabolism
rno01100  Metabolic pathways
rno04020  Calcium signaling pathway
rno04081  Hormone signaling
rno04145  Phagosome
rno04371  Apelin signaling pathway
rno04713  Circadian entrainment
rno04730  Long-term depression
rno04926  Relaxin signaling pathway
rno04970  Salivary secretion
rno05010  Alzheimer disease
rno05014  Amyotrophic lateral sclerosis
rno05022  Pathways of neurodegeneration - multiple diseases
rno05410  Hypertrophic cardiomyopathy
rno05412  Arrhythmogenic right ventricular cardiomyopathy
rno05414  Dilated cardiomyopathy
rno05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    24598 (Nos1)
   00330 Arginine and proline metabolism
    24598 (Nos1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    24598 (Nos1)
   04020 Calcium signaling pathway
    24598 (Nos1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    24598 (Nos1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    24598 (Nos1)
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    24598 (Nos1)
  09154 Digestive system
   04970 Salivary secretion
    24598 (Nos1)
  09156 Nervous system
   04730 Long-term depression
    24598 (Nos1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    24598 (Nos1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    24598 (Nos1)
   05014 Amyotrophic lateral sclerosis
    24598 (Nos1)
   05022 Pathways of neurodegeneration - multiple diseases
    24598 (Nos1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    24598 (Nos1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    24598 (Nos1)
   05414 Dilated cardiomyopathy
    24598 (Nos1)
   05416 Viral myocarditis
    24598 (Nos1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     24598 (Nos1)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 PDZ PDZ_6 PDZ_2
Other DBs
NCBI-GeneID: 24598
NCBI-ProteinID: NP_434686
RGD: 3184
Ensembl: ENSRNOG00000001130
UniProt: P29476 D3ZEW7
Structure
Position
12:complement(44276011..44456371)
AA seq 1463 aa
MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAI
DPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLD
GKSHKAPPLGGDNDRVFNDLWGKDNVPVVLNNPYSEKEQSPTSGKQSPTKNGSPSRCPRF
LKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKE
FLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQ
WSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLI
RYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPEL
VLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCD
NSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIK
HMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTN
GTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHA
FDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKY
PEPLRFFPRKGPSLSHVDSEAHSLVAARDSQHRSYKVRFNSVSSYSDSRKSSGDGPDLRD
NFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEA
FRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSN
VHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNA
LIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTP
LQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQ
LSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPC
FVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQS
KIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHI
YVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTN
RLRSESIAFIEESKKDADEVFSS
NT seq 4392 nt   +upstreamnt  +downstreamnt
atggaagagaacacgtttggggttcagcagatccaacccaatgtaatttctgttcgtctc
ttcaaacgcaaagtgggaggtctgggcttcctggtgaaggaacgggtcagcaagcctccc
gtgatcatctcagacctgattcgaggaggtgctgcggagcagagcggccttatccaagct
ggagacatcattctcgcagtcaacgatcggcccttggtagacctcagctatgacagtgcc
ctggaggttctcaggggcattgcctctgagacccacgtggtcctcattctgaggggccct
gagggcttcactacacatctggagaccaccttcacaggggatggaacccccaagaccatc
cgggtgacccagcccctcggtcctcccaccaaagccgtcgatctgtctcaccagccttca
gccagcaaagaccagtcattagcagtagacagagtcacaggtctgggtaatggccctcag
catgcccaaggccatgggcagggagctggctcagtctcccaagctaatggtgtggccatt
gaccccacgatgaaaagcaccaaggccaacctccaggacatcggggaacatgatgaactg
ctcaaagagatagaacctgtgctgagcatcctcaacagtgggagcaaagccaccaacaga
gggggaccagccaaagcagagatgaaagacacaggaatccaggtggacagagacctcgat
ggcaaatcgcacaaagctccgcccctgggcggggacaatgaccgcgtcttcaatgacctg
tgggggaaggacaacgttcctgtggtccttaacaacccgtattcagagaaggaacagtcc
cctacctcggggaaacagtctcccaccaagaacggcagcccttccaggtgcccccgtttc
ctcaaggtcaagaactgggagacggacgtggtcctcaccgacaccctgcacctgaagagc
acactggaaacggggtgcacagagcacatctgcatgggctcgatcatgctgccttcccag
cacacgcggaagccagaagatgtccgcacaaaggaccagctcttccctctagccaaagaa
tttctcgaccaatactactcatccattaagagatttggctccaaggcccacatggacagg
ctggaggaggtgaacaaggagattgaaagcaccagcacctaccagctcaaggacaccgag
ctcatctatggcgccaagcatgcctggcggaacgcctctcgatgtgtgggcaggatccag
tggtccaagctgcaggtgttcgatgcccgagactgcaccacagcccacggcatgttcaac
tacatctgtaaccatgtcaagtatgccaccaacaaagggaatctcaggtcggccatcacg
atattccctcagaggactgacggcaaacatgacttccgagtgtggaactcgcagctcatc
cgctacgcgggctacaagcagccagatggctctaccttgggggatccagccaatgtgcag
ttcacggagatctgtatacagcagggctggaaagccccaagaggccgcttcgacgtgctg
cctctcctgcttcaggccaatggcaatgaccctgagctcttccagatccccccagagctg
gtgctggaagtgcccatcaggcaccccaagttcgactggtttaaggacctggggctcaaa
tggtatggcctccccgctgtgtccaacatgctgctggagatcgggggcctggagttcagc
gcctgtcccttcagcggctggtacatgggcacagagatcggcgtccgtgactactgtgac
aactctcgatacaacatcctggaggaagtagccaagaagatggatttggacatgaggaag
acctcgtccctctggaaggaccaagcactggtggagatcaacattgctgttctatatagc
ttccagagtgacaaggtgaccatcgttgaccaccactctgccacggagtccttcatcaaa
cacatggagaatgaataccgctgcagagggggctgccccgccgactgggtgtggattgtg
cctcccatgtcgggcagcatcacccctgtcttccaccaggagatgctcaactatagactc
accccgtcctttgaataccagcctgatccatggaacacccacgtgtggaagggcaccaac
gggacccccacgaagcggcgagctatcggctttaagaaattggcagaggccgtcaagttc
tcagccaagctaatggggcaggccatggccaagagggtcaaggcgaccattctctacgcc
acagagacaggcaaatcacaagcctatgccaagaccctgtgtgagatcttcaagcacgcc
ttcgatgccaaggcaatgtccatggaggagtatgacatcgtgcacctggagcacgaagcc
ctggtcttggtggtcaccagcacctttggcaatggagacccccctgagaacggggagaaa
ttcggctgtgctttaatggagatgaggcaccccaactctgtgcaggaggagagaaagtac
ccggaacccttgcgtttctttccccgtaaagggccttccctctcccatgttgactctgaa
gcccacagtctggttgctgcccgtgacagccaacacaggagctacaaggtccgattcaac
agcgtctcctcctattctgactcccgaaagtcatcgggcgacggacccgacctcagagac
aactttgaaagtactggacccctggccaatgtgaggttctcagtgttcggcctcggctct
cgggcgtacccccacttctgtgcctttgggcatgcggtggacaccctcctggaggaactg
ggaggggagaggattctgaagatgagggagggggatgagctttgcggacaggaagaagct
ttcaggacctgggccaagaaagtcttcaaggcagcctgtgatgtgttctgcgtgggggat
gacgtcaacatcgagaaggcgaacaactccctcattagcaatgaccgaagctggaagagg
aacaagttccgcctcacgtatgtggcggaagctccagatctgacccaaggtctttccaat
gttcacaaaaaacgagtctcggctgctcgactcctcagccgccaaaacctgcaaagccct
aagtccagccgatcgaccatcttcgtgcgtctccacaccaacgggaatcaggagctgcag
taccagccaggggaccacctgggtgtcttccccggcaaccacgaggacctcgtgaatgca
ctcattgaacggctggaggatgcaccgcctgccaaccacgtggtgaaggtggagatgctg
gaggagaggaacactgctctgggtgtcatcagtaattggaaggatgaatctcgcctccca
ccctgcaccatcttccaggccttcaagtactacctggacatcaccacgccgcccacgccc
ctgcagctgcagcagttcgcctctctggccactaatgagaaagagaagcagcggttgctg
gtcctcagcaaggggctccaggaatatgaggagtggaagtggggcaagaaccccacaatg
gtggaggtgctggaggagttcccgtccatccagatgccggctacacttctcctcactcag
ctgtcgctgctgcagcctcgctactactccatcagctcctctccagacatgtaccccgac
gaggtgcacctcaccgtggccatcgtctcctaccacacccgagacggagaaggaccggtc
caccacggggtgtgctcctcctggctcaacagaatacaggctgacgatgtagtcccctgc
ttcgtgagaggtgcccctagcttccacctgcctcgaaacccccaggtgccttgcatcctg
gttggcccaggcactggcatcgcacccttccgaagcttctggcaacagcgacaatttgac
atccaacacaaaggaatgaatccgtgccccatggttctggtctttgggtgtcgacaatcc
aagatagatcatatctacagagaggagaccctgcaggccaagaacaagggcgtcttcaga
gagctgtacactgcctattcccgggaaccggacaggccaaagaaatatgtacaggacgtg
ctgcaggaacagctggctgagtctgtgtaccgcgccctgaaggagcaaggaggccacatt
tatgtctgtggggacgttaccatggccgccgatgtcctcaaagccatccagcgcataatg
acccagcaggggaaactctcagaggaggacgctggtgtattcatcagcaggctgagggat
gacaaccggtaccacgaggacatctttggagtcaccctcagaacgtatgaagtgaccaac
cgccttagatctgagtccatcgccttcatcgaagagagcaaaaaagacgcagatgaggtt
ttcagctcctaa

  All links  
Gene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (17)   
   RefSeq(nuc) (7)   
   GenBank (5)   
   EMBL (5)   
3D Structure (317)   
   PDB (317)   
Protein domain (7)   
   Pfam (7)   
All databases (356)   

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