KEGG   Rattus norvegicus (rat): 257648
Entry
257648            CDS       T01003                                 

Gene name
Cacna1b
Definition
(RefSeq) voltage-dependent N-type calcium channel subunit alpha-1B isoform 1
  KO
K04849  voltage-dependent calcium channel N type alpha-1B
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04721  Synaptic vesicle cycle
rno04723  Retrograde endocannabinoid signaling
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04727  GABAergic synapse
rno04728  Dopaminergic synapse
rno04930  Type II diabetes mellitus
rno05016  Huntington disease
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05032  Morphine addiction
rno05033  Nicotine addiction
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    257648 (Cacna1b)
   04020 Calcium signaling pathway
    257648 (Cacna1b)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    257648 (Cacna1b)
   04725 Cholinergic synapse
    257648 (Cacna1b)
   04728 Dopaminergic synapse
    257648 (Cacna1b)
   04726 Serotonergic synapse
    257648 (Cacna1b)
   04723 Retrograde endocannabinoid signaling
    257648 (Cacna1b)
   04721 Synaptic vesicle cycle
    257648 (Cacna1b)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    257648 (Cacna1b)
   05020 Prion disease
    257648 (Cacna1b)
   05022 Pathways of neurodegeneration - multiple diseases
    257648 (Cacna1b)
  09165 Substance dependence
   05032 Morphine addiction
    257648 (Cacna1b)
   05033 Nicotine addiction
    257648 (Cacna1b)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    257648 (Cacna1b)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    257648 (Cacna1b)
Ion channels [BR:rno04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   257648 (Cacna1b)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel
Other DBs
NCBI-GeneID: 257648
NCBI-ProteinID: NP_001182128
RGD: 628852
Ensembl: ENSRNOG00000004560
UniProt: E1AW38
Structure
PDB: 
4DEX

Position
3
AA seq 2354 aa
MVRFGDELGGRYGGTGGGERARGGGAGGAGGPGQGGLPPGQRVLYKQSIAQRARTMALYN
PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD
GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA
TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAII
GLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNI
LFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA
KERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRA
ATKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMV
KAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPR
SYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLV
VSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQI
LTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT
KDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVSRSSSVSSVNSPQQ
NSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVV
EPGRDGLRGPAGNKSKPEGTEATEGADPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAE
STETGAREERARPRRSHSKEAPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQ
DSSKEGKEGTAPVLVPKGERRARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPERE
VAEKESNVVEGDKETRNHQPKEPRCDLEAIAVTGVGSLHMLPSTCLQKVDEQPEDADNQR
NVTRMGSQPSDPSTTVHVPVTLTGPPGEATVVPSANTDLEGQAEGKKEAEADDVLRRGPR
PIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNNA
LKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGK
DINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQ
LFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVS
TGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQ
GDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIA
LNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVT
VLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYV
CLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSATGEAWHEIML
SCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILG
PHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPI
SNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVP
PHKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQP
AVLRGARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDVLYEARAPLERGHSAE
IPVGQPGALAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSI
STLAPRPHGTQLCNTVLDRPPPSQVSHHHHHRCHRRRDKKQRSLEKGPSLSVDTEGAPST
AAGSGLPHGEGSTGCRRERKQERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQPKPSL
SSHPISPTAALEPGPHPQGSGSVNGSPLMSTSGASTPGRGGRRQLPQTPLTPRPSITYKT
ANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLASGSRIGSDPYLGQRLD
SEASAHNLPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSTGVR
ARHSYHHPDQDHWC
NT seq 7065 nt   +upstreamnt  +downstreamnt
atggtccgcttcggggacgagctaggcggccgctatgggggcaccggcggcggggagcgg
gctcggggcggcggggccggcggggccggtggcccgggccaggggggtctgccgccgggc
cagcgggtcctgtacaagcagtccattgcgcaacgcgcacggaccatggccctgtacaac
cccatcccagtcaagcagaactgcttcaccgtcaaccgctcgctcttcgtcttcagcgag
gacaacgtcgtccgcaaatatgctaagcgcatcaccgaatggccgcccttcgaatatatg
atcctggccaccatcatcgccaactgtattgtcctggccctggagcagcacctccctgat
ggggacaagactcccatgtctgaacgactggatgacacggaaccttacttcatcggcatc
ttttgcttcgaggcgggcatcaagatcatagctctgggcttcgtgttccacaaaggctcc
tacctccggaatggctggaacgtcatggacttcgtggtggtcctcacagggattcttgcc
acagctggaactgactttgatctgcgcaccctgagggctgtgcgtgtgcttaggcccctg
aagttggtgtctggaattccaagcttgcaggtggtgctcaagtccatcatgaaggccatg
gtcccgctgctgcagatcgggctgctgctcttcttcgccatcctcatgttcgctatcatc
ggcctcgagttctatatgggcaaattccataaggcctgcttccccaacagcacagatgca
gagcctgtgggtgactttccttgtggcaaggaggcccctgctcgtctgtgtgacagtgac
accgaatgccgggagtactggccaggacccaactttggcatcaccaattttgacaacatc
ctgtttgccatcttgaccgtgttccagtgtatcaccatggagggctggactgacatcctc
tacaatacaaatgatgcggccggcaacacgtggaactggttgtacttcatccccctcatc
atcattggctccttcttcatgctcaacctggtgctcggtgtgctttcaggagagtttgcc
aaagagcgggagcgagtcgagaaccgccgtgccttcctgaagctccgcaggcagcagcag
attgagcgagaactgaatgggtacttggagtggatcttcaaggcggaggaagtcatgttg
gcagaggaggacaagaacgcagaagagaagtcccctttggatgcagtgttgaagagagct
gctaccaagaagagccgaaatgacctcatccatgcagaagagggggaggaccggtttgta
gacctctgtgctgctgggtctccctttgctcgtgccagcctcaagagtgggaagacagag
agctcatcgtacttccggaggaaggagaagatgttccggttccttatccgtcgtatggtg
aaagcacagagcttctactgggtggtactgtgcgtggtggccctgaacacgttgtgtgtg
gccatggtacactataatcagcctcagcggcttaccactgcactgtactttgcagagttt
gttttcctgggtctcttcctcacagagatgtccctgaagatgtacggtctagggcccaga
agctacttccggtcttccttcaactgctttgactttggggtgattgtggggagtatcttt
gaagtagtctgggctgccatcaagccaggaacctccttcggaatcagtgtgctgcgggct
ctccgactgctgaggattttcaaagtcaccaagtattggaactccctgaggaacctggtt
gtttccctcctcaactccatgaagtccatcatcagccttctcttcctgcttttccttttc
attgtggtcttcgctctgttggggatgcagctgtttgggggacagttcaactttcaagat
gagactccaaccaccaattttgataccttcccagctgccatcctcactgtgtttcagatt
ctgacaggagaggactggaatgcagtcatgtatcatgggattgagtcacaaggaggagtc
agcaaaggcatgttttcatccttttacttcatcgtcctgacactgtttggaaactacacc
ctgttgaacgttttcttggccattgctgtggacaaccttgccaatgcccaggagttgacc
aaggatgaagaggagatggaagaggcagccaatcagaagcttgctcttcagaaggccaaa
gaagtagctgaagtcagccccatgtctgctgccaacatctccattgctgcttttgtaaag
caaactcgaggtactgtatctcgcagctcatctgtctccagcgtaaactcaccgcagcag
aactcggccaaggcgcgctcagtatgggagcagcgggccagtcagctaaggctccagaac
ctgcgtgccagctgtgaggcactgtacagtgagatggacccggaggagcgcctgcgttat
gccagcacgcgccacgtgaggccagacatgaagacacacatggaccgacccctagtggtg
gaacctggtcgggatggcctgcggggacccgccgggaacaagtcaaagcctgagggcacg
gaggccaccgaaggtgcggatccaccacgccgacaccaccggcatcgtgatagggacaag
acctcagcctcaacccctgctggaggcgaacaggacaggacagactgcccaaaggccgaa
agcaccgagaccggggcccgggaggaacgtgcgcgccctcgtcgaagtcacagcaaggag
gctccaggggctgacacacaagtgcgttgtgagcgcagtagacgtcaccaccggcgcgga
tccccggaggaggccactgaacgggaacctcggcgccaccgtgcccaccggcacgcacag
gactcaagcaaggaaggcaaggagggcactgcaccggtgcttgtacccaagggcgagcgt
cgcgcaagacatcgaggcccgcgtacgggcccccgtgagacagagaacagtgaggagccc
acacgcaggcaccgtgcaaagcataaggtgccaccaacacttgagcccccagagagggag
gttgcagagaaggagagcaacgtggtggaaggggataaggaaactcgaaatcaccagccc
aaggaacctcgctgtgacctggaggccattgcggttacaggcgtgggctctctgcacatg
ctgcccagcacctgtctccagaaagtggacgaacagccagaggatgcagacaaccagcgt
aatgtcacccggatgggcagtcagccctcagaccccagcaccactgtgcatgtcccagtg
acactgacaggccctcccggggaggccactgtagttcccagtgctaacacggacctggaa
ggccaagcggagggcaagaaggaggcagaggctgacgatgtgctgagaagaggccccagg
cccatcgttccctacagttccatgttctgcctcagccccaccaacctactccgtcgcttc
tgccattacattgtgaccatgcggtactttgagatggtgattcttgtggtcatcgccttg
agcagcattgccctggctgctgaggatcccgtgcggaccgactcattccggaacaatgct
ctgaagtacatggactacatctttacaggagtcttcacctttgagatggtcataaagatg
atagacttgggcctgctgctgcaccctggggcctacttccgggacctgtggaacattctg
gacttcattgttgtcagtggagccctggtggcatttgcattctcaggatccaaagggaaa
gacatcaataccatcaagtctctgagagtcctgcgagtcctgcggcccctcaagaccatc
aagcggctgcctaaactcaaggctgtgtttgactgtgtggtgaactctctgaagaatgtc
ttgaacatcctgatcgtctacatgctcttcatgtttatatttgccgtcatcgccgtccaa
ctcttcaaagggaagttcttttactgcactgatgagtccaaggagctggagcgggactgc
aggggtcagtatttggattatgagaaggaagaggtagaagcccagccaaggcagtggaag
aaatatgacttccactatgacaatgtgctctgggccttgctgactctgtttacggtgtcc
acaggagaggggtggcccatggtgctgaaacactctgtggacgccacctatgaggagcag
gggccaagccccgggtttcggatggagctttccatcttctatgtggtctactttgtggtc
ttcccttttttctttgtcaacatctttgtggccttgatcatcatcaccttccaggagcag
ggggacaaggtgatgtctgagtgcagtctggaaaagaatgagagggcttgcattgacttt
gccatcagcgccaaacccctgacacggtacatgcctcagaacaagcagtcgttccagtat
aagacatggacatttgtggtctctccaccctttgagtacttcattatggccatgatagcc
ctcaacacagtggtgctgatgatgaagttctacgatgccccttatgagtacgagctgatg
ctgaagtgcttgaacatcgtcttcacatccatgttctctctggagtgcatcctgaagatc
atcgccttcggggtgttgaactacttcagagatgcctggaacgtctttgactttgtcact
gttttgggaagtattactgatattttagtaacggagattgcggaaacgaacaacttcatc
aacttgagcttccttcgcctcttccgggcagcacggctgatcaagctgcttcgccagggc
tacaccatccgcatcttgttatggacctttgtccagtcctttaaggcgctgccctacgtg
tgcctcctcattgccatgctgttcttcatctacgccatcatcggcatgcaggtttttgga
aacattgcccttgatgatggcaccagcatcaaccgacacaacaacttccggacatttctg
caagccttaatgctgttgttcaggagtgccactggggaggcctggcacgaaatcatgctg
tcttgcctgggcaaccgggcctgcgacccacatgccaacgccagcgaatgcgggagcgac
tttgcctatttttattttgtctccttcatcttcctctgttcctttctgatgctgaacctc
tttgttgctgtgatcatggacaatttcgaatacctcacgcgggattcttccatcctaggg
ccgcaccacctcgatgaattcattcgcgtctgggctgaatacgacccagctgcgtgtggg
cgcatcagttacaatgacatgtttgagatgctgaaacacatgtccccacctctgggtttg
gggaagaaatgcccggctcgagttgcatacaagcgcctggttcgaatgaacatgcccata
tccaatgaggacatgacggtacactttacatccacactgatggccctcatccggacggca
ctggagatcaagcttgccccagcggggacaaaacagcaccaatgtgatgctgagctgagg
aaggagatctcttctgtgtgggctaatctgccccagaagactctggacttactggtgcca
ccccacaaacctgacgagatgacagtggggaaggtctatgcggctctcatgatatttgac
ttctacaaacagaacaaaaccaccagagatcagactcaccaagctcctggaggcctgtcc
cagatgggtcctgtttccctgttccatcctctgaaggccaccctggagcagacacagccc
gctgtgctccgaggagctcgggttttccttcgacaaaagagtgcaacttccctcagcaat
gggggcgccatacaaacccaggaaagtggcatcaaggagtccctgtcctggggcacgcag
aggacccaggacgtactttatgaggccagagcacctctagaacgtggccattctgcagag
atccctgtggggcagccaggagcactggctgtagatgtccagatgcagaacatgacattg
agaggaccggatggggagccccagcctggcctggagagccaaggccgagcggcctctatg
ccacgcctggcggcagaaacacagccggcccctaatgccagccccatgaagcgctccatc
tccacactggctccacgcccgcatgggactcagctttgcaacacagtcctggaccggcca
cctcctagccaggtgtcccatcaccaccaccaccgctgccaccggcgcagggacaagaag
cagaggtccctggaaaaggggcccagcctgtctgttgacacagaaggtgcaccaagtact
gctgcaggatctggcctgccccatggagaagggtccacaggctgccggcgggagcgtaag
caagagcgaggccggtcccaggagcggaggcagccctcctcctcttcttcagagaagcag
cgcttctattcctgtgaccgctttgggagccgggagcccccacaacctaagccctccctc
agtagccaccccatatcgccaacagcggcactagagccaggaccccacccgcagggcagt
ggttccgttaatgggagccccttgatgtcaacatctggtgctagcacgccgggccgaggt
gggcggaggcagctcccccagactcccctgaccccacgccccagcatcacctacaagacg
gccaattcctcgcctgtccactttgctgagggtcagagtggccttccagccttctcccct
ggccgtctcagccgcggcctttctgaacacaatgccctgctccagaaagagcccctgagc
cagcctctagcttctggctcccgcattggctctgacccttacctagggcagcgtctggac
agtgaggcctctgcccacaacctgcctgaggatacactcacctttgaagaggccgtggcc
accaactctggccgctcctccaggacttcctatgtgtcctccctcacttcccaatcccac
cctctccgccgtgtacccaatggctaccactgcactttgggactcagcaccggcgtccgg
gcgcggcacagctaccaccacccagaccaggatcactggtgctag

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