KEGG   Rattus norvegicus (rat): 29452
Entry
29452             CDS       T01003                                 
Symbol
Epas1
Name
(RefSeq) endothelial PAS domain-containing protein 1
  KO
K09095  hypoxia-inducible factor 2 alpha
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04066  HIF-1 signaling pathway
rno05200  Pathways in cancer
rno05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    29452 (Epas1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    29452 (Epas1)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    29452 (Epas1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:rno03000]
    29452 (Epas1)
   04131 Membrane trafficking [BR:rno04131]
    29452 (Epas1)
Transcription factors [BR:rno03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    29452 (Epas1)
Membrane trafficking [BR:rno04131]
 Autophagy
  Pexophagy
   Other pexophagy associated proteins
    29452 (Epas1)
SSDB
Motif
Pfam: bHLH_HIF1A PAS_3 PAS_11 HIF-1a_CTAD HIF-1 PAS PAS_9 PAS_4 HLH Corona_I
Other DBs
NCBI-GeneID: 29452
NCBI-ProteinID: NP_075578
RGD: 68404
Ensembl: ENSRNOG00000021318
UniProt: Q9JHS1
Position
6:complement(13543252..13626147)
AA seq 874 aa
MTADKEKKRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLTLKTGSGFGKKNKDMSTERDFFMRMKCTVTNRG
RTVNLKSATWKVLHCTGQVRVYNNCPPHSSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SKTFLSRHSMDMKFTYCDDRILELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVVYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SLFKPHLMAMNSIFDSSDDVALSEKSNYLFTKLKEEPEDLAQLAPTPGDAIISLDFGSQN
FDESSTYGKAILPPGQPWATELRSHSAQSESRSLPAFTVPQAGSPGNATPSATSSSSCST
PSSPEDYYSSLENHLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQ
LSPICPEEPLVPESPQPNPQHCFSTMSSIFQPLTPGASQGTFFLDKYPQQLESRKTESEH
WPMSTIFFDAGSKGSLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWSVGNQSAEP
LGPLPLGTSQLEPPSTPPHVSMFKMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLDYEE
PAFQDTSGGDPPGTSSSHLMWKRMKSLMGGTCPLMPDKTVSASMAPDEFTQKSMRGLGQP
LRHLPPSQPPSTRSPGENAKSGFPPQCYASPFQDYSPPGAQKGSGVASRLLGPSFEPYLL
PELTRYDCEVNVPVPGSSTLLQGRDLLRALDQAT
NT seq 2625 nt   +upstreamnt  +downstreamnt
atgacagctgacaaggagaagaaaaggagcagctcggagctgaggaaggagaaatcccga
gatgccgcacggtgccggcgtagcaaggagacggaggtcttctatgaactggctcatgag
ctgccgctgccccacagtgtgagctcccacctggacaaagcctccatcatgcgcctggcc
atcagcttcctgcgaacacataaactcctgtcttcagtgtgctctgaaaatgaatctgaa
gccgaggctgaccagcagatggataacttgtacctgaaagccttggagggcttcattgcc
gtggtgacccaagacggtgatatgatctttctgtcagaaaacatcagcaagttcatggga
cttacccaggtagaactaacaggacacagcatctttgacttcactcatccttgcgaccac
gaggagatccgcgagaacctgacactcaaaactggctctggttttgggaagaagaacaaa
gatatgtctaccgagcgtgacttcttcatgaggatgaagtgtaccgtcaccaacagaggc
cggactgtcaaccttaagtcggccacctggaaggtcttgcactgcaccgggcaagtgaga
gtctacaacaactgcccccctcacagtagcctctgcggctacaaggagcccctgctgtcc
tgcctcatcatcatgtgtgagccaatccagcacccatcccacatggacatccccttggac
agcaagactttcctaagccgccacagcatggacatgaagttcacctactgtgatgacaga
atcttggaactggttggttaccaccccgaggagctacttggccgctctgcctatgaattc
taccacgccctggactcggagaacatgacaaaaagtcaccagaacttgtgcaccaagggg
caagtggtgtctggccagtaccggatgctggccaaacatggaggatatgtgtggttggag
acccaggggaccgtcgtctacaacccccgcaacctgcagccccagtgtatcatgtgtgtc
aactatgtcctgagtgagatagagaagaatgacgtggtgttctccatggaccagactgaa
tccttgttcaagccacacctgatggccatgaacagcatctttgacagcagtgacgacgtg
gccctatccgagaagagcaactacctgttcaccaaactgaaggaggagccagaggacctg
gcccagctggcccccaccccaggggatgctattatttctctggacttcggaagccagaac
tttgatgaatcctcgacctatggcaaggccatccttcccccaggccagccgtgggccaca
gagctgaggagccacagtgcccagagtgagtccaggagcctgccagccttcaccgtgccc
caggcaggttccccagggaatgccacacccagcgccacaagcagcagcagctgctccacg
cccagcagccctgaggattactactcatctctggagaatcacttgaagatcgaagtaatc
gagaagctcttcgccatggacaccgaggcgaaggaccagtgcagtactcagacggacttc
aatgaactggacttggagaccctggcaccctacatccctatggatggcgaggacttccag
ctcagccccatctgcccggaggagccactcgtgccggagagcccccagcccaacccccag
cactgtttcagtaccatgtcaagcatcttccagccgctcaccccgggggccagccaaggc
accttcttccttgacaagtacccgcagcagttggaaagccggaagacggagtccgagcac
tggcccatgtctaccatcttctttgatgctgggagcaaagggtccctgcccccatgctgt
ggccaggccagcacccctctctcctctatggggggcagatctaacactcagtggccccca
gatccaccattacattttggccctacgaagtggtctgtgggcaatcagagcgctgaaccc
ctggggcctctgccactggggacctcgcagttggagcctcccagcaccccgcctcatgtc
tccatgttcaagatgaggtctgcaaaggactttggggctcgaggcccatacatgatgagc
ccggccatgatagccctgtccaacaagctgaagctaaagcgccagctggactacgaggag
ccagccttccaagacacaagtgggggggaccctccaggcaccagcagttcacacttgatg
tggaaacgaatgaagagcctcatgggcgggacctgtcctttgatgcctgacaagaccgtc
agtgcaagcatggctcctgatgaattcacccaaaaatccatgagaggcctgggccagcca
ctgagacacctgccaccttcccagccaccatctaccaggagtccaggagagaacgccaag
agtgggttcccaccacagtgctatgcctccccgttccaggactacagtcctccaggagct
caaaaggggtcaggagtggcaagtcgactgctggggccatcgttcgagccttacctgctg
ccggaactgaccagatatgactgtgaggtgaacgtcccagtgcctggaagttctacactc
ctgcaggggagagaccttctcagagctctggaccaggccacctga

  All links  
Gene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (10)   
   RefSeq(nuc) (6)   
   GenBank (2)   
   EMBL (2)   
Protein domain (10)   
   Pfam (10)   
All databases (33)   

Download RDF
KEGG   Rattus norvegicus (rat): 29560
Entry
29560             CDS       T01003                                 
Symbol
Hif1a
Name
(RefSeq) hypoxia-inducible factor 1-alpha
  KO
K08268  hypoxia-inducible factor 1 alpha
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04066  HIF-1 signaling pathway
rno04137  Mitophagy - animal
rno04140  Autophagy - animal
rno04148  Efferocytosis
rno04659  Th17 cell differentiation
rno04919  Thyroid hormone signaling pathway
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05211  Renal cell carcinoma
rno05230  Central carbon metabolism in cancer
rno05231  Choline metabolism in cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    29560 (Hif1a)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    29560 (Hif1a)
   04137 Mitophagy - animal
    29560 (Hif1a)
   04148 Efferocytosis
    29560 (Hif1a)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    29560 (Hif1a)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    29560 (Hif1a)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    29560 (Hif1a)
   05205 Proteoglycans in cancer
    29560 (Hif1a)
   05208 Chemical carcinogenesis - reactive oxygen species
    29560 (Hif1a)
   05230 Central carbon metabolism in cancer
    29560 (Hif1a)
   05231 Choline metabolism in cancer
    29560 (Hif1a)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    29560 (Hif1a)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    29560 (Hif1a)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    29560 (Hif1a)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:rno03000]
    29560 (Hif1a)
Transcription factors [BR:rno03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    29560 (Hif1a)
SSDB
Motif
Pfam: bHLH_HIF1A PAS_3 PAS_11 HIF-1a_CTAD PAS HIF-1 PAS_9 PAS_4 DDRGK HLH
Other DBs
NCBI-GeneID: 29560
NCBI-ProteinID: NP_077335
RGD: 61928
Ensembl: ENSRNOG00000008292
UniProt: O35800 A6HC66 D4A8P8
Position
6:98357788..98405068
AA seq 826 aa
MEGAGGENEKKNRMSSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASV
MRLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKY
MGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVRKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTSSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDS
KTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQ
VTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTES
VLKPVESSDMKMTQLFTKVESEDTSCLFDKLKKEPDALTLLAPAAGDTIISLDFGSDDTE
TEDQQLEDVPLYNDVMFPSSNEKLNINLAMSPLPASETPKPLRSSADPALNQEVALKLES
SPESLGLSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNVFKLELVEKLF
AEDTEAKNPFSAQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESNSPSPPSVSTVTGFQ
QTQLQKPTITVTAATATTATTTDESKAVTKDNIEDIKILIASPPSTQVPQEMTTAKASAY
SGTHSRTTSPDRAGKRVIEKTDKAHPRSLNLSVTLNQRNTVPEEELNPKTIALQNAQRKR
KMEHDGSLFQAAGIGTLLQQPGDRAPTMSLSWKRVKGYISSEQDGMEQKTIFLIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
NT seq 2481 nt   +upstreamnt  +downstreamnt
atggagggcgccggcggcgagaacgagaagaaaaataggatgagttccgaacgtcgaaaa
gaaaagtctagggatgcagcacgatctcggcgaagcaaagagtctgaagttttttatgag
cttgctcatcagttgccacttccccacaacgtgagctcccatcttgataaagcttctgtt
atgaggctcaccatcagttacttacgtgtgaggaaacttctagatgctggtgatcttgac
attgaagatgaaatgaaagcacagatgaactgcttttatctgaaagccctggatggcttt
gttatggtgctaacagatgatggtgacatgatttacatttctgataacgtgaacaaatac
atggggttgactcagtttgaactaactggacacagtgtgtttgattttacccatccatgt
gaccatgaggaaatgagagaaatgcttacacacagaaatggcccagtgagaaaggggaaa
gaacaaaacacgcagcgaagcttttttctcagaatgaaatgtaccctaacaagccggggg
aggacgatgaacatcaagtcagcaacgtggaaggtgctgcactgcacaggccacattcat
gtgtatgataccagcagtaaccagccgcagtgtggctacaagaaaccgcctatgacgtgc
ttggtgctgatttgtgaacccattcctcatccatcaaacattgaaattcctttagacagc
aagacatttctcagtcgacacagcctcgatatgaaattttcttactgtgatgaaaggatt
actgagttgatgggttatgagccagaagaacttttgggccgttcaatttatgaatattat
catgctttggactctgatcatctgaccaaaactcatcatgacatgtttactaaaggacaa
gtcaccacaggacagtacaggatgcttgcaaaaagaggtggatatgtctgggttgagact
caagcaactgttatatataatacgaagaactctcagccacagtgcattgtgtgtgtgaat
tatgttgtaagtggtattattcagcacgacttgattttctcccttcaacaaacagaatct
gtcctcaaaccagttgaatcttcagatatgaaaatgacccagctgttcactaaagtggaa
tctgaggacacgagctgcctcttcgacaagcttaagaaagagcccgatgccctgactctg
ctagctccagcggctggggacacgatcatatcactggacttcggcagcgatgacacggaa
actgaagaccaacaacttgaagatgtcccgttgtacaatgatgtaatgttcccctcttct
aatgagaaattaaatataaatctggcaatgtctccattacctgcctctgaaactccaaag
ccacttcgaagtagtgctgatcctgcactgaatcaagaggttgcattgaagttagagtca
agcccagagtcactgggactttcttttaccatgccccagattcaagatcagccagcaagt
ccttctgatggaagcactagacaaagctcacctgagcctaacagtcccagtgagtactgc
tttgatgtggacagcgatatggtcaatgtattcaagttggaactggtggaaaaactgttt
gctgaagacacagaagcgaagaatccattttcagctcaggacactgatttagacttggaa
atgctggctccctatatcccaatggatgatgatttccagttacgttcctttgatcagttg
tcaccattagagagcaattctccaagccctccgagtgtgagcacagttacaggattccag
cagacccagttacagaaacctaccatcactgtcactgccgcaactgccaccaccgccacc
accactgatgaatcaaaagcagtgacgaaggacaatatagaagacattaaaatactgatt
gcatctccaccttctacccaagtacctcaagaaatgaccactgctaaggcatcagcatac
agtggtactcacagtcggacaacctcaccagacagagcaggaaagagagtcatagaaaaa
acagacaaagctcatccaaggagccttaacctatctgtcactttgaatcaaagaaatact
gttcctgaagaagaattaaacccaaagacaatagctttgcagaatgctcagaggaagcga
aaaatggaacatgatggctccctttttcaagcagcaggaattggaacgttactgcagcaa
ccaggtgaccgtgcccctactatgtcgctttcttggaaacgagtgaaaggatacatatct
agtgaacaggatggaatggagcagaagacaatttttttaataccctctgatttagcatgt
agactgctggggcagtcaatggatgagagtggattaccacagctgaccagttacgattgt
gaagttaatgctcccatacaaggcagcagaaacctactgcagggtgaagaattactcaga
gctttggatcaagttaactga

  All links  
Gene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (8)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (10)   
   RefSeq(nuc) (4)   
   GenBank (3)   
   EMBL (3)   
Protein domain (10)   
   Pfam (10)   
All databases (33)   

Download RDF
DBGET integrated database retrieval system