KEGG   Rattus norvegicus (rat): 29716
Entry
29716             CDS       T01003                                 

Gene name
Cacna1d
Definition
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1D
  KO
K04851  voltage-dependent calcium channel L type alpha-1D
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04024  cAMP signaling pathway
rno04218  Cellular senescence
rno04260  Cardiac muscle contraction
rno04261  Adrenergic signaling in cardiomyocytes
rno04270  Vascular smooth muscle contraction
rno04530  Tight junction
rno04713  Circadian entrainment
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04727  GABAergic synapse
rno04728  Dopaminergic synapse
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04921  Oxytocin signaling pathway
rno04924  Renin secretion
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04929  GnRH secretion
rno04930  Type II diabetes mellitus
rno04934  Cushing syndrome
rno04935  Growth hormone synthesis, secretion and action
rno04973  Carbohydrate digestion and absorption
rno05010  Alzheimer disease
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05031  Amphetamine addiction
rno05410  Hypertrophic cardiomyopathy
rno05412  Arrhythmogenic right ventricular cardiomyopathy
rno05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    29716 (Cacna1d)
   04020 Calcium signaling pathway
    29716 (Cacna1d)
   04024 cAMP signaling pathway
    29716 (Cacna1d)
   04022 cGMP-PKG signaling pathway
    29716 (Cacna1d)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    29716 (Cacna1d)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    29716 (Cacna1d)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    29716 (Cacna1d)
   04929 GnRH secretion
    29716 (Cacna1d)
   04912 GnRH signaling pathway
    29716 (Cacna1d)
   04921 Oxytocin signaling pathway
    29716 (Cacna1d)
   04935 Growth hormone synthesis, secretion and action
    29716 (Cacna1d)
   04924 Renin secretion
    29716 (Cacna1d)
   04925 Aldosterone synthesis and secretion
    29716 (Cacna1d)
   04927 Cortisol synthesis and secretion
    29716 (Cacna1d)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    29716 (Cacna1d)
   04261 Adrenergic signaling in cardiomyocytes
    29716 (Cacna1d)
   04270 Vascular smooth muscle contraction
    29716 (Cacna1d)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    29716 (Cacna1d)
  09156 Nervous system
   04724 Glutamatergic synapse
    29716 (Cacna1d)
   04727 GABAergic synapse
    29716 (Cacna1d)
   04725 Cholinergic synapse
    29716 (Cacna1d)
   04728 Dopaminergic synapse
    29716 (Cacna1d)
   04726 Serotonergic synapse
    29716 (Cacna1d)
   04723 Retrograde endocannabinoid signaling
    29716 (Cacna1d)
  09159 Environmental adaptation
   04713 Circadian entrainment
    29716 (Cacna1d)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    29716 (Cacna1d)
   05020 Prion disease
    29716 (Cacna1d)
   05022 Pathways of neurodegeneration - multiple diseases
    29716 (Cacna1d)
  09165 Substance dependence
   05031 Amphetamine addiction
    29716 (Cacna1d)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    29716 (Cacna1d)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    29716 (Cacna1d)
   05414 Dilated cardiomyopathy
    29716 (Cacna1d)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    29716 (Cacna1d)
   04934 Cushing syndrome
    29716 (Cacna1d)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    29716 (Cacna1d)
Ion channels [BR:rno04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   29716 (Cacna1d)
SSDB
Motif
Pfam: Ion_trans CAC1F_C Ca_chan_IQ GPHH PKD_channel Rer1
Other DBs
NCBI-GeneID: 29716
NCBI-ProteinID: NP_001376154
RGD: 70973
Ensembl: ENSRNOG00000013147
Structure
PDB: 
1VYT

Position
16
AA seq 2164 aa
MMMMMMMKKMQHQRQQQEDHANEANYARGTRLPISGEGPTSQPNSSKQTVLSWQAAIDAA
RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI
SIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKI
IAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALR
AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKT
CFFADSDIVAEEDPAPCAFSGNGRQCAANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC
ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG
DFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVS
GEGETQGCCGSLWCWWKRRGAAKTGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV
KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ
AYFVSLFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLV
ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQ
ILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES
LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDKDPYPP
CDVPVGEEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCH
KLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTT
FGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKG
LKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFI
LYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGP
VYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYAL
KARPLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDIL
NMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISI
TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKV
AMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGEEYTC
GSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPE
AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVR
TALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDY
FRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEE
DVFKRNGALLGNYVNHVNSDRRESLQQTNTTHRPLHVQRPSIPPASDTEKPLFPPAGNSV
CHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGDLEHVSENGHYSYKHDRELQR
RSSIKRTRYYETYIRSESGDEQLPTICREDPEIHGYFRDPRCFGEQEYFSSEECCEDDSS
PTWSRQNYSYYNRYPGSSMDFERPRGYHHPQGFLEDDDSPIGYDSRRSPRRRLLPPTPPS
HRRSSFNFECLRRQNSQDDVLPSPALPHRAALPLHLMQQQIMAVAGLDSSKAQKYSPSHS
TRSWATPPATPPYRDWTPCYTPLIQVDRSESMDQVNGSLPSLHRSSWYTDEPDISYRTFT
PASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTID
EMESAASTLLNGSVCPRANGDMGPISHRQDYELQDFGPGYSDEEPDPGREEEDLADEMIC
ITTL
NT seq 6495 nt   +upstreamnt  +downstreamnt
atgatgatgatgatgatgatgaaaaaaatgcagcatcaacggcagcagcaagaggaccac
gcgaacgaggcaaactatgcaagaggcaccagactccctatttctggtgaaggaccaact
tctcagccgaacagctccaagcaaaccgtcctgtcttggcaagctgcaattgatgctgct
agacaggccaaggccgcccagaccatgagcacgtctgcacccccacctgtaggatctctc
tcccaaagaaaacgtcagcaatacgccaagagcaaaaaacagggtaactcgtctaacagc
cgacctgcccgtgccctcttctgtttatccctcaataaccccatccgaagagcctgcatt
agtatagtggattggaaaccatttgacatatttatattattggctatttttgccaattgt
gtggccttagctatttacatcccgttccctgaagatgattctaattcaacaaatcataac
ttggaaaaagtagaatatgccttcctgattatttttacagtggagacatttctgaagatt
atagcgtacggactgctgctgcatcctaatgcttacgttaggaacggatggaacttactg
gattttgttatagtaatagtaggattgtttagtgtaattttggaacaattaaccaaagaa
acagaaggcgggaaccactctagtggcaaatcaggaggctttgatgtcaaagccctccgt
gccttccgagtgttaagaccgcttcgacttgtatcaggagtgcccagtttacaagttgtt
ctgaactccattataaaagccatggtccccctcctccacatagcccttttggtgttattc
gtaattatcatctatgcgattatagggttggaactttttattggaaaaatgcacaaaacc
tgtttttttgctgactcagatatagtagctgaagaggacccagctccatgcgcgttctca
gggaatggacgccagtgtgccgccaatggcacggaatgtaggagcggctgggtcggcccc
aatggaggcatcactaattttgacaactttgcctttgccatgctcactgtgttccagtgc
atcaccatggagggctggacagatgtgctctactgggttaatgatgcgataggatgggag
tggccatgggtgtattttgttagtctgatcatccttggctcatttttcgtccttaacctg
gttcttggtgtccttagtggagaattctcaaaggaaagagagaaggctaaagcacgtgga
gatttccagaagcttcgggagaagcagcagctggaagaggatctcaagggctacttggac
tggatcacccaggcagaagacatagatcctgagaatgaagaggagggtggagaggagggc
aaacgaaacactagcatgcccaccagtgagaccgaatctgtgaacacagagaacgtaagt
ggtgaaggcgagacccagggatgctgtggaagtctctggtgctggtggaaaagaagaggc
gcggccaagactgggccctctgggtgtcggcggtggggccaagccatctcaaaatccaag
ctcagccgtcggtggcgtcgctggaaccggttcaatcgcaggagatgcagggcagctgtg
aagtctgtcacgttttactggctggtgatcgttctggtgtttctcaacactctgacgatt
tcctctgagcattacaatcagccagactggctgacgcagattcaagatatagcgaacaaa
gtgctcttggctttgttcacctgtgagatgctggtgaagatgtacagcctgggcctccag
gcctacttcgtctctctcttcaaccgcttcgattgctttgtggtgtgtgggggaatcacc
gaaaccatcctggtggaactggagctcatgtctcccctgggcgtctctgtgttccggtgt
gtacgtctcctgaggatcttcaaagtgaccaggcactggacttccctgagcaacttggtg
gcgtccctgttaaactccatgaagtccatcgcctctctgctgttgctgctcttcctcttc
atcatcatcttctccctgctgggaatgcagctgttcggagggaagttcaatttcgatgag
acacagaccaagcgaagcaccttcgacaacttcccacaggcgctcctgactgtgttccag
atcctgacgggcgaagactggaatgcggtgatgtatgacggcatcatggcctacggaggc
ccgtcctcctctggaatgattgtctgtatttacttcatcatccttttcatctgtggtaac
tatatcctgctgaacgtcttcttggccattgctgtagacaatttggctgatgctgaaagt
ctgaacactgctcagaaagaggaagccgaagaaaaagaaaggaaaaaaattgccagaaaa
gaaagcctagaaaacaaaaaaaacaacaaaccagaggtcaaccagatagccaacagtgac
aacaaggttactattgatgactatcaagaggaggctgaagataaggacccttatccaccc
tgcgatgtgccagtaggtgaagaggaagaggaggaggaagaggacgagcctgaggttcct
gctggtccccgtcctcgaagaatctcagagttgaacatgaaggagaaaattgcacccatc
cccgaaggaagcgcattcttcattcttagcaagaccaacccgatccgtgtgggttgccac
aaactcatcaaccaccacatcttcaccaacctcatcctggtcttcatcatgctgagcagc
gctgccctggccgcagaggatcccatccgcagccactccttccgcaacactatactgggc
tactttgactatgctttcacagccatctttacggttgaaatcctgttaaagatgacaact
tttggagcgttcttgcacaaaggggctttctgtaggaactacttcaatttgctggacatg
ctggtcgttggggtgtctctggtgtcatttgggattcaatccagtgccatctcggttgtg
aagattctgagggtcttaagggtcttgaggcctctcagagcaatcaacagagcaaaagga
cttaagcacgtggtccagtgtgtctttgtggccatccgaaccatcggcaacatcatgatc
gtcacgaccctgctccagttcatgtttgcttgcattggggtccagctgttcaaggggaag
ttctaccgttgcacagatgaggccaaaagtaaccccgaggagtgcagggggcttttcatc
ctttataaggacggcgatgtcgacagtcccgtggtccgtgagaggatctggcaaaacagt
gatttcaatttcgacaatgtcctttcggctatgatggcgctcttcacggtctcgactttt
gagggctggcccgcgttgctgtacaaagctatcgactcaaacggagagaacgttggtcct
gtctacaactaccgtgtggagatctccatcttcttcattatctacatcatcatcgtggcc
ttcttcatgatgaatatcttcgtgggcttcgtcatcgtcaccttccaggagcagggagaa
aaggagtataagaactgtgagctggacaaaaatcagcgtcagtgtgtggaatatgccttg
aaggcccgccccttaaggagatacatccccaaaaacccataccagtacaagttctggtac
gtggtgaactcctcgcctttcgaatatatgatgtttgtcctcatcatgctcaacacgctc
tgcctggccatgcagcactatgagcaatccaagatgttcaatgacgccatggacattctg
aacatggtcttcacgggggtcttcaccgttgagatggttttgaaagtcatcgcatttaag
cccaaggggtattttagtgacgcctggaacacgtttgactccctcatcgtaatcggcagc
attatagacgtggcactcagcgaagctgacaactctgaagagagcaatagaatctccatc
acctttttccgtcttttccgagtgatgcggttggtgaagcttctcagcagaggggaaggc
atccggactctgctatggaccttcattaagtccttccaggcactcccatatgtcgccctc
ctcattgccatgctcttcttcatctacgccgtcattggcatgcagatgtttgggaaggtt
gccatgagagataacaaccagatcaataggaacaacaacttccagacgtttccccaggca
gtgctgctgctcttcaggtgtgcaacaggggaggcctggcaggagatcatgctcgcctgc
ctccctgggaagctgtgtgacccggactcagattacaacccaggagaggaatatacttgt
gggagcaactttgccattgtctacttcatcagcttttacatgctctgtgcgttcctgatc
atcaacctcttcgtggctgtcatcatggacaattttgactatctgacgagggactggtct
attctggggcctcaccacttggacgaattcaaaagaatatggtctgaatatgaccccgag
gcaaagggaaggataaaacaccttgatgtggtcactttgctccgacgtatccagcctccc
ctgggatttggaaagttgtgtccacaccgagtggcgtgtaagagattggtcgccatgaac
atgcctctcaacagtgatgggacagtcatgttcaatgcaactctgtttgctttggtacgg
acggctctcaagatcaagactgaaggcaacctggagcaagctaatgaagagctccgcgct
gtgataaagaaaatctggaagaagacaagcatgaagctacttgaccaagttgtccctcca
gctggtgatgatgaggtaaccgtggggaagttctatgccactttcctgatacaggactac
tttaggaaattcaagaagcggaaagagcaaggcctggtggggaaataccctgcgaagaac
accacgatcgccctacaggcgggattaaggaccctgcatgacattgggccagaaatccga
cgggctatatcctgtgacttgcaagatgacgaaccagaagactccaaaccagaagaggaa
gatgtattcaaaagaaatggtgccctgcttggaaactatgtcaatcatgttaatagtgat
aggagagagtcccttcagcagaccaataccacccaccgtcccctgcatgtccaaaggcct
tcaattccacctgcaagtgatactgagaaaccgctgtttcctccagcaggaaattcggtg
tgtcataaccatcataaccataattccatagggaagcaagttcccacctccacaaatgcc
aatctcaataacgccaatatgtccaaagctgcccacggaaagcggcccagcattggggac
cttgagcatgtgtctgaaaacggccattactcctacaagcacgaccgagagcttcaaaga
aggtccagtattaaaagaacccgctattatgaaacttacattaggtctgagtcaggagac
gagcagcttccaaccatttgccgtgaagaccctgagatacacggctacttccgagacccc
cgctgcttcggggagcaggaatatttcagtagcgaggagtgctgtgaggatgacagttct
cccacctggagcaggcaaaactacagctattacaacaggtacccaggcagctccatggac
tttgagaggccccgaggctaccatcacccccaaggtttcttagaagatgacgactctccc
attggctatgactcacggagatctccaagaagacgccttctacctcctaccccaccatcc
catcggaggtcctccttcaactttgagtgtctgcgcaggcaaaacagccaagatgacgtc
cttccgtcgcctgccctgcctcaccgcgctgccctgcccctgcaccttatgcagcagcag
atcatggccgttgcaggcctagattccagtaaagcccagaagtactcgccgagccactct
acccggtcatgggccacccctccagcaacccctccgtaccgagactggaccccatgctac
acccctttgatccaggtggatcgctcagagtctatggaccaggtcaatggcagcctgccg
tcgctacaccgcagttcctggtatacagatgaacccgacatctcctataggactttcaca
ccggccagcctgaccgtccccagcagcttccggaacaaaaacagcgacaagcagaggagt
gcagacagcctggtggaagcagtcctgatatccgaaggcttgggacgctacgcaagggac
ccaaaatttgtctcagcaacaaaacatgagatcgccgatgcctgtgacctaaccatagac
gagatggagagcgcggccagcaccctgctcaatggaagcgtgtgtcctcgagccaacggg
gacatgggccccatctcacaccgccaggactatgagctccaggactttggtcctggctac
agtgacgaggaaccagaccctgggcgagaggaagaggacctggcagatgaaatgatttgc
atcaccaccttgtag

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