KEGG   Rattus norvegicus (rat): 299827
Entry
299827            CDS       T01003                                 

Gene name
Tbk1
Definition
(RefSeq) serine/threonine-protein kinase TBK1
  KO
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04014  Ras signaling pathway
rno04137  Mitophagy - animal
rno04140  Autophagy - animal
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04623  Cytosolic DNA-sensing pathway
rno04657  IL-17 signaling pathway
rno05014  Amyotrophic lateral sclerosis
rno05022  Pathways of neurodegeneration - multiple diseases
rno05135  Yersinia infection
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05162  Measles
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    299827 (Tbk1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    299827 (Tbk1)
   04137 Mitophagy - animal
    299827 (Tbk1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    299827 (Tbk1)
   04621 NOD-like receptor signaling pathway
    299827 (Tbk1)
   04622 RIG-I-like receptor signaling pathway
    299827 (Tbk1)
   04623 Cytosolic DNA-sensing pathway
    299827 (Tbk1)
   04657 IL-17 signaling pathway
    299827 (Tbk1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    299827 (Tbk1)
   05161 Hepatitis B
    299827 (Tbk1)
   05160 Hepatitis C
    299827 (Tbk1)
   05171 Coronavirus disease - COVID-19
    299827 (Tbk1)
   05164 Influenza A
    299827 (Tbk1)
   05162 Measles
    299827 (Tbk1)
   05168 Herpes simplex virus 1 infection
    299827 (Tbk1)
   05163 Human cytomegalovirus infection
    299827 (Tbk1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    299827 (Tbk1)
   05169 Epstein-Barr virus infection
    299827 (Tbk1)
   05165 Human papillomavirus infection
    299827 (Tbk1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    299827 (Tbk1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    299827 (Tbk1)
   05022 Pathways of neurodegeneration - multiple diseases
    299827 (Tbk1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    299827 (Tbk1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    299827 (Tbk1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    299827 (Tbk1)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     299827 (Tbk1)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   299827 (Tbk1)
Membrane trafficking [BR:rno04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    299827 (Tbk1)
SSDB
Motif
Pfam: TBK1_CCD1 Pkinase TBK1_ULD PK_Tyr_Ser-Thr Pkinase_fungal ABC1 CEP63 DUF713 Kinase-like ubiquitin DNA_topoisoIV
Other DBs
NCBI-GeneID: 299827
NCBI-ProteinID: NP_001100256
RGD: 1588588
Ensembl: ENSRNOG00000005528
UniProt: D4A7D3
Position
7
AA seq 729 aa
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFA
ETSDVLHRMVIHVFSLQHMTALKIYIHSYNTAAVFHELVYKQTKIISSNQELIYEGRRLV
LELGRLAQHFPKTTEENPIFVTSREQLNSIGLRYEKISLPKIHPRYDLDGDASMAKAVTG
VVCYACRTAGTLLLYQELMRKGVRWLIELVKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKVSLDAAELGEISDIHTKLLRLSSSQGTIESSLQDINSRLSPGGSLADTWAHQE
GTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVRKYEAFKDTSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQ
KMLAASSGIKHTVAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
NT seq 2190 nt   +upstreamnt  +downstreamnt
atgcagagcacttccaaccatctgtggcttttgtctgatatcctaggccaaggggctact
gcaaatgtcttccgaggaaggcataagaaaactggtgatctctatgctgtcaaagtattt
aataacataagcttccttcgcccagtggatgttcaaatgagagaatttgaagtgttaaaa
aagctcaatcacaaaaacattgtcaaattatttgctattgaagaagagacaacaacaaga
cataaagtacttatcatggagttctgtccctgtgggagtttatacactgtgttagaggag
ccatccaatgcctatggactgccagaatcagagtttttaattgttttacgagatgtggtg
ggcggaatgaatcatctccgagagaacggcatagtgcaccgtgatatcaagccagggaac
atcatgcgcgtcataggagaagacggacagtctgtgtacaaactcacagactttggtgcc
gctagagagttagaggacgatgagcagttcgtgtctctgtatggcacagaagagtatttg
cacccggacatgtatgagagggcagtgctaaggaaggaccatcagaagaagtacggagcc
accgttgatctgtggagtgtcggagtcacattctaccacgcagccacggggtcgctgccc
tttagacccttcgaggggcctcggaggaacaaagaagtaatgtataaaataatcactggg
aagccttctggtgcaatatctggagtacagaaagcagaaaacggaccaattgactggagt
ggagacatgcctctttcttgtagtctttctcagggtcttcaggcactgcttaccccagtt
cttgcaaacatacttgaagctgatcaggagaagtgctggggctttgaccagttctttgca
gagactagtgatgtgctgcaccgaatggtaatccatgttttctcgctacagcacatgaca
gcgcttaagatctatattcatagctataacacagctgctgtgttccatgaactggtctat
aaacaaaccaagattatttcttcaaatcaagaacttatctacgaaggacgacgcttggtc
ctagaacttggaagactagcccagcatttccctaaaaccacagaagaaaatcctatcttt
gtcacaagccgggaacaactcaattccataggtctgagatatgaaaaaatttccctacct
aaaatacatccacgctatgacctggacggggacgccagcatggccaaggcagtgaccggg
gttgtgtgctacgcctgcagaactgctggcaccctgctgctctatcaagaactaatgcgg
aagggggtgcggtggctgattgaactagttaaagacgactacaatgagactgtccacaag
aagacagaagttgtgatcacactggatttctgcatcagaaacattgagaagactgtgaaa
gtatatgagaagttgatgaaggtcagcctggacgccgcagagctgggtgagatttcagac
atacacaccaagctgctgagactttccagctctcagggaacaatagagagcagtcttcag
gacatcaacagcaggctgtccccagggggatcgctggctgacacctgggcacatcaggaa
ggcactcatccaagagacaggaatgtagaaaagctacaagtcttgttgaattgcatcaca
gagatttactatcagtttaaaaaggacaaggcagagcgcagactagcgtataatgaagaa
cagatccacaagtttgataaacaaaaattgtattaccatgcaacaaaagcaatgacccac
tttaccgatgaatgtgtcaggaagtatgaagcatttaaagacacgtctgaagaatggatg
cgaaagatgcttcatcttcggaaacagctgctatcactgactaatcagtgttttgacatc
gaagaggaggtgtccaagtatcaagactacactaacgagttacaagaaactctgcctcag
aaaatgcttgcagcctccagtggaatcaagcacaccgtggccccgatctaccccagttct
aacaccttagtggagatgactctcggtatgaagaagctgaaggaggagatggagggcgtg
gtcaaggagctggccgaaaacaatcatattttagaaaggtttgggtctttgacaatggat
ggtggcctccgcaatgtggactgtctttag

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