KEGG   Rattus norvegicus (rat): 309361Help
Entry
309361            CDS       T01003                                 

Gene name
Chuk, Ikbka, Ikka
Definition
(RefSeq) conserved helix-loop-helix ubiquitous kinase
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01523  Antifolate resistance
rno04010  MAPK signaling pathway
rno04014  Ras signaling pathway
rno04062  Chemokine signaling pathway
rno04064  NF-kappa B signaling pathway
rno04068  FoxO signaling pathway
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04380  Osteoclast differentiation
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04623  Cytosolic DNA-sensing pathway
rno04625  C-type lectin receptor signaling pathway
rno04657  IL-17 signaling pathway
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04668  TNF signaling pathway
rno04920  Adipocytokine signaling pathway
rno05135  Yersinia infection
rno05142  Chagas disease (American trypanosomiasis)
rno05145  Toxoplasmosis
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05162  Measles
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05200  Pathways in cancer
rno05212  Pancreatic cancer
rno05215  Prostate cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    309361 (Chuk)
   04010 MAPK signaling pathway
    309361 (Chuk)
   04064 NF-kappa B signaling pathway
    309361 (Chuk)
   04668 TNF signaling pathway
    309361 (Chuk)
   04068 FoxO signaling pathway
    309361 (Chuk)
   04151 PI3K-Akt signaling pathway
    309361 (Chuk)
   04150 mTOR signaling pathway
    309361 (Chuk)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    309361 (Chuk)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    309361 (Chuk)
   04621 NOD-like receptor signaling pathway
    309361 (Chuk)
   04622 RIG-I-like receptor signaling pathway
    309361 (Chuk)
   04623 Cytosolic DNA-sensing pathway
    309361 (Chuk)
   04625 C-type lectin receptor signaling pathway
    309361 (Chuk)
   04660 T cell receptor signaling pathway
    309361 (Chuk)
   04658 Th1 and Th2 cell differentiation
    309361 (Chuk)
   04659 Th17 cell differentiation
    309361 (Chuk)
   04657 IL-17 signaling pathway
    309361 (Chuk)
   04662 B cell receptor signaling pathway
    309361 (Chuk)
   04062 Chemokine signaling pathway
    309361 (Chuk)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    309361 (Chuk)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    309361 (Chuk)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    309361 (Chuk)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    309361 (Chuk)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    309361 (Chuk)
   05221 Acute myeloid leukemia
    309361 (Chuk)
   05220 Chronic myeloid leukemia
    309361 (Chuk)
   05215 Prostate cancer
    309361 (Chuk)
   05222 Small cell lung cancer
    309361 (Chuk)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    309361 (Chuk)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    309361 (Chuk)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    309361 (Chuk)
   05170 Human immunodeficiency virus 1 infection
    309361 (Chuk)
   05162 Measles
    309361 (Chuk)
   05164 Influenza A
    309361 (Chuk)
   05161 Hepatitis B
    309361 (Chuk)
   05160 Hepatitis C
    309361 (Chuk)
   05168 Herpes simplex virus 1 infection
    309361 (Chuk)
   05163 Human cytomegalovirus infection
    309361 (Chuk)
   05167 Kaposi sarcoma-associated herpesvirus infection
    309361 (Chuk)
   05169 Epstein-Barr virus infection
    309361 (Chuk)
   05165 Human papillomavirus infection
    309361 (Chuk)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    309361 (Chuk)
   05142 Chagas disease (American trypanosomiasis)
    309361 (Chuk)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    309361 (Chuk)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    309361 (Chuk)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     309361 (Chuk)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   309361 (Chuk)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: IKBKB_SDD Pkinase Pkinase_Tyr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Motif
Other DBs
NCBI-GeneID: 309361
NCBI-ProteinID: NP_001101058
RGD: 1306661
Ensembl: ENSRNOG00000022485
UniProt: G3V926
Position
1q54
AA seq 745 aa AA seqDB search
MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNNLCSLIVEPMESWLQLMLNWDPQQRGGPIDPPLKQPKC
FVLMDNILNLKIVHILNMTSAKIISFLLPYDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPV
TQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPTDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGTVTPPVSAWLPPTLADREHPLTCVVTPQDGETLAQMIEENLNCLGHL
STIIREANEDQSSSMMSLDWSWLAE
NT seq 2238 nt NT seq  +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggcctggcgccggcggcccctgggagatgcgggagagg
cttggcaccggcggcttcgggaacgtcagtctgtaccagcaccgggaacttgatctcaaa
atagcaattaagtcttgtcgcttagagctaagtaccaaaaacagagaacgatggtgccat
gaaatccagatcatgaaaaagttgaaccatgcaaatgttgtaaaggcctgtgatgttcct
gaggaattgaattttttaattaacgatgtgcctcttctagcaatggagtactgttctgga
ggggacctccggaagctactcaacaaaccagaaaattgttgtggacttaaagagagccag
atcctttctttactgagtgacataggatctgggattcgttatttgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaatatagtgcttcaagatgttggtgggaagataatg
cataaaataattgatttgggttatgccaaagatgtcgatcaaggaagtctctgtacatct
tttgtgggaacattacagtatttggccccagagctctttgaaaataagccatacacagcc
actgtggattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgaaaagattaagaagaaagatccaaag
tgtatatttgcttgtgaagagatgaccggagaagttcggtttagtagccatttacctcag
ccaaacaacctttgtagtttaatagtagagccaatggaaagctggctacagttgatgctg
aattgggacccacagcagagagggggacctattgaccctcctttgaagcagccaaaatgc
tttgtgttaatggataacatcctcaacttgaagatagtgcacatcctaaatatgacttct
gcaaaaatcatttcttttctgttaccatatgatgaaagtctccattcactacagtctcga
attgagcgtgaaacaggaataaatacaggttctcaagaacttctgtcagagacaggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagtgagaggctgtgat
agctacatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcatcc
agaagtttatctgattgtgtaaattatattgtgcaagacagcaagatacagcttccagtt
acacagcttcgcaaagtgtgggctgaagcagtgcactatgtatctgggctaaaggaggac
tacagcaggctctttcagggacaaagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaatactttgatctcagcatcacagcaactcaaagctaaattg
gagttttttcgcaaaagcattcagcttgacttggagagatatagtgagcagatgacttat
gggatatcttcagaaaaaatgctgaaagcatggaaagaaatggaagaaaaggccattcac
tattctgaggttggtgtcattggataccttgaggatcaaattatgtctttgcacactgaa
atcatggagctgcagaagagcccctatgggagacgccagggagacctgatggaatccctg
gaacagcgtgccattgatctctataagcagctaaaacacagacccaccgatcactcctac
agtgacagcacggagatggtgaagatcattgtgcacactgtgcagagtcaggaccgagtt
ctcaaggagctgtttggtcacctgagcaagttgttgggctgcaagcagaagattattgat
ctactccccaaggtggaagtggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatttggcacctccttaaaattgcttgtacacag
agttctgctcgctctcttgtaggatccagtctagaaggcacagtaacccctccagtatca
gcatggctgccccctactctagcagaccgtgaacatcctctgacatgtgtggtaactcct
caagatggcgagacgttagcacaaatgatagaagaaaatctgaactgtcttggccattta
agtactattattcgtgaagcaaatgaggaccagagcagtagtatgatgagtcttgattgg
agttggttagcagaatga

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