KEGG   Rattus norvegicus (rat): 367072
Entry
367072            CDS       T01003                                 

Gene name
Arhgef12
Definition
(RefSeq) rho guanine nucleotide exchange factor 12
  KO
K07532  Rho guanine nucleotide exchange factor 12
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04270  Vascular smooth muscle contraction
rno04360  Axon guidance
rno04611  Platelet activation
rno04625  C-type lectin receptor signaling pathway
rno04810  Regulation of actin cytoskeleton
rno05135  Yersinia infection
rno05152  Tuberculosis
rno05163  Human cytomegalovirus infection
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    367072 (Arhgef12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    367072 (Arhgef12)
   04625 C-type lectin receptor signaling pathway
    367072 (Arhgef12)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    367072 (Arhgef12)
  09158 Development and regeneration
   04360 Axon guidance
    367072 (Arhgef12)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    367072 (Arhgef12)
   05205 Proteoglycans in cancer
    367072 (Arhgef12)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    367072 (Arhgef12)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    367072 (Arhgef12)
   05152 Tuberculosis
    367072 (Arhgef12)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    367072 (Arhgef12)
Membrane trafficking [BR:rno04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    367072 (Arhgef12)
SSDB
Motif
Pfam: RGS-like PH_16 RhoGEF PDZ PDZ_6 PDZ_2 PH_13 Ribonuc_2-5A
Other DBs
NCBI-GeneID: 367072
NCBI-ProteinID: NP_001013264
RGD: 1305111
Ensembl: ENSRNOG00000008924
UniProt: Q5BMA6
Position
8
AA seq 1546 aa
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERSTSHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIRSGSYVALTVQGRPPGSPQIPLAESEVEPSVIGHMSPIMTSPHSPG
AAGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTATQRLLKEIQ
EAKKHIPQLQEQLSKATGSAQDGAVIAPSRPLGDALTLSEAETDPGDGLCRTDWSSGDAS
RPSSDSADSPKSSLKERVCLEDTPERTEGVQDADTQSLVGSPSTRGAPHIIGAEDDDFGT
EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKQTNSKETRR
VFLEFHQFFLDRSAHLRVSVPEEISVDLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
EDFRQKRSMGLTLAESELTKLDAERDKDRGTLEKERACAEQIVTKIEEVLMTAQAVEEER
SSTMQYVILMYMKYLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDREGEEKGKRRGFPSI
LGPPRRPSRHDNSAIGRAMEIQKLRHPKHLSAPSSMSPELQDPAKLRQSGVANEGTDTGY
LPASSMSSATSGAALSQEGGRENDTGAKQVGDAVAPGDCLDSIPRVPNTVFDFPPPLLDQ
VQEEECEVERVAEHGTPKPFRKFDSIAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
LKPSEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
LHVGLNEQMKAVRKRNETSVIDHIGEDLLLWFSGPGEEKLKHAAATFCSNQPFALEMIKS
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPPEREKV
KKAADQCRQILNYVNQAVREAENKQRLEDYQRRLDTSSLKLSEYPNVDELRNLDLTKRKM
IHEGPLVWKVNRDKSIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
KLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTK
PIPLPQPPPCEGDNDEEEPAKLKVEHHDLSVAGLQSPDRVLGLESPLISSKPQSHSMNTP
GKSEAEAEHLFVTATQFAKEQHANGTFKEGDGGYPVTISDPHLPVSEERWALDALRNLGL
LKQLLVQQLGLTEKTTQEDWRSFSRYRPASEEAQADSGIPDLESVKACHAGEGQMSFKTG
TGDVATCDSPRTSTESCAVQDSVILASQDSQASNIIEMDHMLLTPEVPTTAEPEGGLDDS
GEHFFDAREAHSDDNPSEGDGAVRKEEEDVNVRISGNCLILDGYDAVQESSTDEEIASSF
TLQPVTGLPSVDSSHQQQHSPQNAISEGAISPSTPEFLVQRRWRAVDACSEVQSPSAWTD
SQSQILEYIHKIEADLEHLKKVEESYTLLCQRLAGSALPDKVSDKS
NT seq 4641 nt   +upstreamnt  +downstreamnt
atgagtggcacacagtctactatcacggacaggtttcccctcaaaaaacctataaggcat
ggaagtattttgaaccgagagtcaccaacagataagaaacagaaagtcgaacgcagcaca
tcacatgattttgaccccacagatagctcctccaagaagacaaagtctagttcagaggag
agtagatccgagatctatggtcttgttcagcgctgtgtgatcatccagaaagatgacaat
ggattcgggctgacagtcagcggggacaatccagtcttcgtacaatctgtcaaagaagat
ggagcagccatgcgcgctggagtacaaacaggtgatcgaatcatcaaggtgaatgggact
ctggtgactcattcaaatcatctggaggtggtgaaactaatcagatctggttcctatgta
gctctcactgtccagggacgcccacctgggtcgccccagattccacttgctgagtctgaa
gtagaaccatcagtcattggacatatgtctcccattatgacatcccctcattcccctgga
gcagccgggaacatggagagaatcactagtcctgtgctcatgggggaggaaaacaatgtg
gtccataaccagaaagtagagattctgaggaaaatgttacagaaagaacaggagcgtctg
cagttactgcaggaagattacaaccgaacggctacccagagattgctcaaggagatccag
gaggccaagaagcacatcccccagctgcaggagcagctgtccaaagccacaggctctgct
caggacggagctgtaattgcaccctccaggccattaggtgatgccctaacactcagcgag
gcagaaacggaccctggagacggcctgtgcaggactgactggagcagtggagatgcttct
cggcccagtagtgacagtgcagatagccccaagagtagcctgaaggaaagggtttgtctc
gaggacaccccagagaggactgaaggagttcaggatgctgacacacagtcgctggtcggc
agtccctccacccgtggcgcccctcatattatcggagcagaggatgatgattttggtact
gaacacgagcagatcaatggacagtgcagctgtttccagagcattgagttgctgaagtct
cgccctgcccacttggctgttttcttacaccatgtagtctcacagtttgaccctgcaaca
ttgctctgttatctctattcagacctgtataagcagacgaactccaaggagactcggcgg
gtcttcctggagtttcatcagttcttcttggaccgatctgcacacctgagagtttccgtc
cccgaggaaatctctgtggatctagaaaagagaagacccgagctcattcctgaggatctg
catcgccattacattcaaacaatgcaggagagggttcaccctgaagttcagaggcacttg
gaggattttcgacagaaacgcagcatgggactgaccttggctgagagtgagctgaccaaa
cttgatgcagagagagacaaggaccggggaactctggagaaggagcgagcatgtgcggaa
cagatcgttaccaaaattgaagaagtgttgatgactgctcaggctgtagaagaagaaagg
agttccacaatgcagtatgtaattctcatgtatatgaagtatttgggagtaaaagtgaaa
gaacctcgaaacttggagcacaagcggggtcggatcggcttccttccaaagatcaagcaa
agcatgaagaaagatagagagggcgaagaaaaagggaagcgaagaggattccccagcatt
ttgggacccccaaggagaccaagccgccacgacaacagtgcaattggcagggccatggag
atacagaagcttcgccacccgaagcacttgtccgcaccctcatctatgagtcctgagctt
caggaccctgctaagttgcgccagagtggagtagccaatgaaggaacagacactggatat
ctgcctgccagttccatgtcctctgccacctcaggggctgctctttcccaagagggaggg
agagagaatgacacaggagcaaaacaagttggagacgcggtggcacctggagactgcttg
gatagcatacctcgagtccccaatactgtttttgacttccccccgcctctgctagatcaa
gtgcaggaggaggaatgtgaagtggagagggtggcagaacatggaaccccaaaacccttt
cgaaagtttgacagcatcgcctttggagaaagtcagagtgaggacgagcagtttgaaaat
gacctggaaacagatccacccaactggcagcagctcgttagcagagaagtgctactggga
ctgaaaccctccgagatcaagagacaggaagtgattaatgaattgttctacactgagaga
gcgcatgtccgaacactgaaggttcttgaccaagtattctatcagcgagtgtccagggaa
gggattctatcaccttccgagctgcgcaagattttttcaaacttggaggatatccttcaa
cttcatgttgggttgaatgagcagatgaaagctgtccgaaaaaggaacgagacctcagtt
attgatcatattggggaagatctgctcctttggttcagtggaccaggggaggagaagctg
aagcacgctgctgccacattctgcagtaaccagcctttcgccctggaaatgatcaagtct
cgccagaaaaaggattctcgattccagacttttgtgcaagatgctgagagtaaccccctg
tgccgtcgtcttcagctgaaggatatcattcccacccaaatgcagaggctcaccaagtac
ccccttcttttggataatatcgccaaatacacagaatggcctccagaaagggaaaaggtg
aagaaggctgcagatcaatgtcgtcagatcttaaattatgtaaatcaggctgtcagggag
gcagaaaacaagcagcgcttagaagactatcagcgtcgccttgacacctccagtctcaag
ttgtctgagtacccgaatgttgatgagctcaggaatttggatttaacaaaaagaaagatg
attcatgaagggccgttggtctggaaggtgaatagagataaaagcatcgatctgtataca
ctgctgctggaagacattcttgtgctgttacagaagcaggacgacaggctggtactgagg
tgccacagcaagatcctggcctccacagctgacagcaagcacaccttcagtcctgtcatt
aagctcagcacagtgctggtccgacaggtggccacagataacaaagctttattcgtcatc
tccatgtcagataatggagcccaaatttatgaattggtagcacagacggtttctgaaaag
acggtctggcaagacctcatctgtcggatggccgcatcagtgaaggagcagtccacaaag
ccgattcccctcccacagccgccaccttgcgaaggagacaatgatgaagaagaaccagcc
aagttaaaagtggagcaccatgatctttctgtcgctggtctgcagagtccagacagagtt
ttgggattagaatctcccttaatttcgtcaaaacctcagtcccattcaatgaatacccct
ggcaaatcagaggcagaggcagaacatctctttgtgaccgcaacacagtttgcaaaggag
cagcatgcaaatgggaccttcaaggaaggtgatggcgggtatccagtcacaatctcagat
ccacacttgcccgtgtcagaggagcggtgggcattggacgcactgagaaatttgggcttg
ttgaagcagttgctggttcagcagttggggctcacggagaagactactcaggaagactgg
cggtccttctcaagatacagaccggcttctgaagaggcacaggcggacagtggcattccg
gacttggaaagtgttaaggcttgtcatgccggggaaggacagatgtcttttaaaactgga
actggtgatgttgcaacttgtgacagtccacggacttcaactgagtcctgtgctgtacag
gattcggtgatactggcttcccaagacagccaggcaagcaacatcatagaaatggaccac
atgctcctgaccccagaggtgcctactactgcagagccagaggggggtctggatgacagt
ggagagcacttttttgatgcccgtgaagcacatagcgatgataatccatctgaaggtgat
ggcgcagtcagaaaggaagaggaggatgttaatgtgcgcatctcaggaaactgtttgatc
cttgatggctatgatgcagtgcaggagagctccacagatgaggagattgcctcctcattc
accctgcagcctgtgacaggcctcccttctgtggactccagccaccagcagcaacactcc
cctcagaatgccatttccgagggggcgatttcaccatccaccccagaattcctggtccag
cgacgctggagagctgtggatgcttgctctgaggtccagagtccctctgcttggacagat
tcacaaagccaaatcctggagtacattcataaaatagaggctgacctggaacacttaaag
aaggtggaggaaagttacacccttctttgccaaaggctggctggctcagccctccccgac
aaggtctcagataaaagttag

KEGG   Rattus norvegicus (rat): 60323
Entry
60323             CDS       T01003                                 

Gene name
Arhgef1
Definition
(RefSeq) rho guanine nucleotide exchange factor 1
  KO
K12330  Rho guanine nucleotide exchange factor 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04270  Vascular smooth muscle contraction
rno04611  Platelet activation
rno04810  Regulation of actin cytoskeleton
rno04928  Parathyroid hormone synthesis, secretion and action
rno05135  Yersinia infection
rno05163  Human cytomegalovirus infection
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    60323 (Arhgef1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    60323 (Arhgef1)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    60323 (Arhgef1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    60323 (Arhgef1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    60323 (Arhgef1)
   05205 Proteoglycans in cancer
    60323 (Arhgef1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    60323 (Arhgef1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    60323 (Arhgef1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    60323 (Arhgef1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    60323 (Arhgef1)
Membrane trafficking [BR:rno04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    60323 (Arhgef1)
SSDB
Motif
Pfam: RGS-like PH_16 RhoGEF PH_13 AbiJ_NTD3
Other DBs
NCBI-GeneID: 60323
NCBI-ProteinID: NP_067726
RGD: 620951
Ensembl: ENSRNOG00000020130
UniProt: Q5BK37
Position
1
AA seq 919 aa
MGEVAGGAAPGPPRSGLVSIIIGAEDEDFENELEANPEDQNSQFQSLEQVKRRPAHLMAL
LQHVALQFEPGPLLCCLHADMLSSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPSVAFEL
DRTRPDLISEDVQRRFIQEVVQSQQAAVTRQLEDFRSKRLMGMTPWEQELSLLEPWIGKD
RGNYEARERHVAERLLSHLEEMQHTISTDEEKSAAVVTAISLYMRHLGVRTKSGDKKSGR
NFFRKKVMGNRRSDEPPKTKKGLSSILDPARWNRGEPSAPDCRHLKVEVDEKPGPADRKG
SLGISSRDRTVGTPGQDNPGVSLHPLSVDSLDSREPGVDTPQEPGDTPPQGPTSLEPLAP
PESTEDNGETESPEPGDDGEPGRSGLEQEPEEPPGWRELVPSDTLLGLPKNQVKRQEVIS
ELLVTEAAHVRMLRVLHDLFYQPMAEGGFFPLEELQNIFPSLDELIEVHSLFLDRLMKRR
QESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCAFVQE
AESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPAERAKVELAAECCREILHHV
NQAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKKLVHEGPLTWRLTKDK
AVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDH
KAFYVIFTWDQEAQIYELVAQTSSERKSWCALITETAGSLKVPAPASRPKPRPSPSSTRE
PLLSSSENGTGGTEAAPADARTERILNDLLPFCRPGPEGQLAATALQKVLSLKQILLSTE
EDSGAGPPRDGDGVPGGGAPGPTHTQEVEENLLSLEVVIKQLEELEEEFCRLRPFLSQLG
EILSPNLAAPERSAQTGLS
NT seq 2760 nt   +upstreamnt  +downstreamnt
atgggagaagtcgccggaggggcggccccagggcctccccggtctggcctggtgtccatc
atcatcggggctgaggatgaggactttgagaatgaactggaggcgaacccagaagatcaa
aacagccagttccagagcctggagcaagtgaagcgtcgcccagcccacctcatggccctc
ctgcaacacgtggccctgcagttcgagccaggaccactgctctgctgcctgcatgctgac
atgctaagctcactgggccccaaagaagccaagaaggccttcctcgatttctatcacagt
ttcctggagaagactgcggttctgcgggtgccggtccctcccagcgttgcttttgaactt
gatcgtactcggcctgatctcatctctgaggatgtccagaggcggttcatacaagaggtg
gtacagagccagcaggcagccgtgacccgtcagctagaggacttccgctccaaacggctc
atgggcatgacaccctgggagcaggaactgagcctgctagagccctggattgggaaagac
cggggcaactatgaggcccgggagcggcatgttgcagagcggctgctctcccacctagag
gaaatgcaacataccatctccacagatgaagaaaaaagtgctgctgtggtcactgcaatc
agcctgtatatgcgccaccttggggtccggaccaagagtggggacaagaagtcagggagg
aacttcttccggaaaaaggtgatggggaatcggcggtcagacgagccccccaagacaaag
aaagggctgagcagtatcctagatcctgcccgctggaaccggggagagccatctgctcca
gactgtcgacatctaaaggtcgaggttgatgagaagccaggccctgcagaccggaaggga
agcctgggtatttcatctcgggacaggactgttgggactcctgggcaggacaacccagga
gtctccctgcaccctctgtctgtagacagcctggattcccgggaaccaggtgtggatacc
ccgcaggagccaggagatacacccccacaaggccctacaagcctggagcccctggcaccc
ccagagagcacagaggacaatggcgagactgaaagccctgagcctggagatgatggagag
ccagggcggtcaggcctggaacaggaaccagaagaacctcctgggtggagggaactggtg
ccctcagacaccctgctcggcctgcccaagaaccaagtgaagcggcaagaggtcatcagt
gagctgctggtgacggaggcggctcacgtccgcatgctacgggtactacatgacctcttc
taccagcccatggcagaagggggcttcttccctctggaggaactgcagaacatctttccc
agcctggatgagctcatcgaggtgcactccctgttcctcgatcgcttgatgaagcggaga
caagagagtggctacctcattgaggagattggtgatgtgctactggcccggttcgatggt
gctgagggctcatggttccagaagatctcttcccgcttctgcagccgccagtcattcgct
ctagagcagctcaaagccaagcagcgcaaggagcctcgattctgtgcctttgtgcaggaa
gctgagagccgcccccgctgccggcggctgcagttgaaggacatgatccccactgagatg
cagcggctgaccaagtacccactgctgctgcagagtattgggcagaacacagaagagcct
gccgagcgggcaaaggtggaacttgcagctgagtgctgccgtgagattctgcaccacgtt
aatcaagctgtccgtgacatggaggacctgctgcggctcaaggattaccagcggcgcctg
gacttgactcacctgcggcagagcaatgacccaatgctgagcgagttcaagaacctggat
atcactaagaagaagttggtccatgaaggccccctcacgtggcgactaaccaaagacaaa
gctgtagaggtccacgtgctattgctggacgacctgctgctgctgctccagcgccaggat
gagaggctgctgctcaagtcacacagccggacgctgacacccacacccgacggcaagacc
atgctgcggcctgtgctccggctcacctctgccatgacccgggaggtggccactgatcac
aaagctttttacgtcatttttacctgggaccaggaggcccagatatatgagctggtggca
cagacatcgtcggaacgcaagagctggtgtgccctcatcacagagactgccggatccctg
aaggtccctgcccctgcctcccgccccaaaccccggcccagcccaagcagcacccgagaa
cccctgctcagcagctctgagaatggcactggaggcacagaggccgctccagctgatgcc
cggacagagcggatcctcaacgacctcctgcccttctgcagaccaggcccagagggccag
cttgctgccacagccctccagaaagtactgtccctgaaacagatcctgttgagcactgag
gaagacagtggagcagggcctccccgcgatggggatggggtgcctggtggtggtgcccca
ggcccaacacacacccaggaggttgaggaaaacctgttgagcctagaagtggtcatcaaa
caactggaggagttagaagaggaattttgtcgcctaagacccttcctgtctcagcttggg
gagattctgtcccccaacctggctgcacctgagcgctctgctcagacaggcctttcatga

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