KEGG   Rattus norvegicus (rat): 59265
Entry
59265             CDS       T01003                                 

Gene name
Phlpp1, Phlpp, Plekhe1, Scop
Definition
(RefSeq) PH domain and leucine rich repeat protein phosphatase 1
  KO
K16340  PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04151  PI3K-Akt signaling pathway
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    59265 (Phlpp1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:rno01009]
    59265 (Phlpp1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     59265 (Phlpp1)
Protein phosphatases and associated proteins [BR:rno01009]
 Protein serine/threonine phosphatases
  Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
   PPM1 phosphatases (PP2C)
    59265 (Phlpp1)
SSDB
Motif
Pfam: LRR_8 PP2C LRR_4 LRR_6 PH DUF4483 TFIIA
Other DBs
NCBI-GeneID: 59265
NCBI-ProteinID: NP_067689
RGD: 621308
Ensembl: ENSRNOG00000002821
UniProt: Q9WTR8
Position
13p11
AA seq 1696 aa
MEPAAAAPAQRLADPTGEDRAPAAAAAAEGGRSPDSVLSAAAPSGGNGGAAREEAPCEAP
PGPLPGRAGGTGRRRRRGVPQPAAGGAAPVTAAGGGANSLLLRRGRLKRNLSAAASSSSS
PSSASSAAGGLPASCSASASLCTRSLDRKTLLQKHRQLLQLQPSDRDWVRHQLQRGCVHV
FDRHMASSYLRPVLCTLDTTAAEVAARLLQLGHKGGGVVKVLGHGPPPAAAPAASDQTPA
TELGRDVEPPPSSSTVGAVRGPARAPPADLPLPGGAWTRCAPRVNPAPSDSSPGELFAGG
PCSPSRAPRPASDTESFSLSPSAESVSDRLDPYSSGGGSSSSSEELEADPATVLTGPSGP
PHHPVRSSQPRPPSPKTSALLQPKAPTGVDGTGLVVGEGPGDDKAVAAAAPGVPLWTPGR
IRETVQKTSSPPSLYVQLHGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEGMDSEI
GCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDS
SSGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQ
RISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLGELQRFTKLKSLN
LSNNHLGAFPSAVCSIPTLAELNVSCNALQEVPAAVGAMQNLQTFLLDGNFLQSLPAELE
NMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCMETLRLQALRRMPHIKHVDLRLN
ILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNICGYFLKAL
YASSNELVQLDVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLF
CNSSLRKLLAGHNRLARLPERLERTSVEVLDVQHNQIIELPPNLLMKADSLRFLNASANK
LETLPPATLSEETSSILQELYLTNNSLTDKCVPLLTGHPRLKILHMAYNRLQSFPASKMA
KLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEVKCVDLSCNEL
SEITLPENLPPKLQELDLTGNPRLALDHKSLELLNNIRCFKIDQPSAGDASGAPAVWSHG
YTEASGVKNKLCVAALSVNNFRDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTK
NEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIRHDPVDLGGSFTLTSANVGKCQTVLCR
NGKPLSLSRSYTMSCEEERKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHV
QSVLLTPQDEFFILGSKGLWDSLSIEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISA
VVVQLSVTEDSFCCCELSVGGSMPPPSPGIFPPSVSMVIKDRPSDGLGVPSSSSGMASEI
SSELSTSEMSSEVGSTASDEPPSGALSESSPAYPSEQRCMLHPVCLSNSFQRQLSSATFS
SAFSDNGLDSDDEEPIEGVFSNGSRVEVEVDIHCSRAKEKERQQHLLQVPAEASDEGIVI
SANEDESGLSKKTDISAVGTIGRRRANGSVPPQERSHNVIEVATDAPLRKPGGYFAAPAQ
PDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQQQQQQQQQQPPPPPQPPQAQAQAQAQAQ
RPFQMDHLPDCYDTPL
NT seq 5091 nt   +upstreamnt  +downstreamnt
atggagcccgccgccgcagccccggcacagcgactcgcggaccccacgggtgaggaccga
gccccggcggcggcggcggcggccgagggcggacggagtccggattctgtgctgagcgcg
gcggccccgagcggcgggaacggcggcgcggcgcgagaggaggccccctgcgaggcgccg
ccggggccgctgcccggccgcgcgggaggcaccggacgcaggcgtcggcgcggggtgccc
cagcccgcggccggcggggccgccccggtgaccgcggccggcggcggcgccaactcgctg
ctgctgaggagagggcggctgaagaggaatctgtcggccgccgcttcgtcgtcctcatcg
ccgtcctcggcgtcttcggccgctggcggcctcccggcgtcctgctcggcctcggcgtcg
ctgtgcacccggagtctggacaggaagacgctgctccagaagcaccggcagctgcttcag
ctgcagccgtcggaccgggactgggtgaggcaccagctccagcggggctgtgtgcacgtc
tttgaccgccacatggcctcgtcctacctgcgcccagtgctctgcacgctggacaccaca
gccgccgaggtggccgcccggcttctgcagctgggccacaaaggcggcggggtggtgaag
gtgctgggccacgggccacctccggccgctgccccggccgccagcgatcagaccccggcc
acagagctcggaagagacgtggagccaccgccctcgagcagcacggtcggtgctgtccgg
ggccctgcgcgcgcgcctcctgccgatctgccgctgcccgggggcgcctggacgcgctgt
gcacctcgggtcaaccctgcgccctcggactccagccccggagagctgttcgcgggcggc
ccctgttccccgtcccgcgccccgcgcccggcctccgacaccgagagcttcagcctgagc
cccagcgccgagagcgtgtcagaccggctggacccctatagcagcggcggcggctcctcc
tcttcgtccgaggaactagaagctgacccggccacggtcttgacggggccttccgggccg
ccccaccacccagtccgctcctcacagcctcgaccgccttccccgaagacctcggcgtta
ctgcagccgaaagccccgacgggcgtagacggcactggcctagtggtgggcgaaggtccc
ggagacgacaaggcggtggcagctgcagctccaggcgttcctctgtggactccagggagg
atccgggagaccgtgcaaaagacgtcttctccgccctccctgtatgtacagctccatggg
gagactacccggcgcctggaggcggacgagaagccattgcagatccaaaatgactacctc
ttccaactgggatttggggagctgtggagggtgcaggaggaaggcatggattcggagatt
ggctgcctcatccgattctatgcaggaaagcctcatagcactgggagctctgagcggatt
cagctctcgggaatgtacaatgtccgaaaaggcaaaatgcagttgccagtgaacagatgg
acaagacgccaggtcattctgtgtgggacgtgcttgatagtgtcgtctgtgaaagacagc
tcgagtgggaagatgcacgttctgcctctcattggtggaaaagtggaagaagtgaaaaag
caccagcactgtctagcgttcagctcttccgggccccagagccagacttactacatctgc
ttcgatactttcacggagtacttacgatggctgcgtcaagtctccaaggttgcatcacaa
cgcataagctcagtagacctctcatgttgtagccttgagcatctgcctgccaacctcttt
tacagccaagaccttactcatctcaatttaaaacagaacttcctaaggcagaaccccagc
ctcccagctgccagaggacttggtgaactgcagagattcaccaaattgaagagccttaac
ctttccaataaccacctaggagcctttccgtcagcagtctgcagcatcccaaccctggca
gagctgaatgtgtcttgcaatgccctgcaagaagtcccagcagctgttggagctatgcag
aacttacagacgttcttgctggatggaaattttctccagtcccttcctgctgagttggag
aacatgcaccagctcagctatttgggtctttcctttaatgaattcactgacattccagag
gtattggagaagctgactgctgtggataaactgtgcatggctgggaactgtatggagacc
cttagactacaggccttaagaaggatgcctcatattaaacacgtggacctaagactgaac
atactcagaaagcttataacagatgaagtggactttctgcaacatgtcactcagcttgac
ctgcgagacaataaacttggtgatctagatgctatgatcttcaacaacatagaagttctg
cactgcgagaggaatcagctggtgacactgaacatttgtggctatttcctaaaagcactc
tatgcttcttctaacgaactcgttcaacttgatgtctacccagttccaaattatctatcg
tacatggatgtctcaagaaactgcctagaaagtgtgcctgagtgggtatgtgaaagccgg
aagttagaagttttggatattggccataatcaaatatgtgaacttcctgcccgcttattt
tgtaatagtagtctccggaaattgctggcaggacacaaccggttggcaaggcttcctgaa
aggctggagagaacatcagtggaggtcttggacgtacagcataaccagatcattgagctc
ccaccaaaccttctcatgaaggctgacagcctgagattcctcaatgcgtccgcaaacaaa
ctggaaaccctgcctccagccacactttctgaggagacaagcagtatattacaggagttg
tacttgacaaacaacagcctcactgataagtgtgtgcccttgttaacagggcacccccgc
ctgaagatcctacacatggcttataaccggcttcagagcttcccagcaagtaaaatggcg
aaactggaggagcttgaagaaatcgatatcagtgggaataagctgaaagccatcccaaca
accatcatgaactgcaggcgcatgcacacggtgattgctcactcgaactgcatcgaagtc
tttcctgaagtcatgcagctcccagaagtcaagtgtgtagatctgagctgtaatgagctg
agtgaaatcaccctaccagaaaacctgccacctaaactgcaggaactagatctgaccgga
aacccacgccttgccctggaccacaaaagcttggagctgctcaataacatccgctgtttc
aagattgaccagccgtcagctggagatgcatctggagccccagcagtatggagtcatggt
tacactgaagcatcgggagtaaaaaacaagctgtgtgtcgcagccctgtctgtgaataac
ttccgtgacaaccgagaggctctctacggtgtgtttgatggagaccggaatgtggaagtg
ccctaccttctccagtgcaccatgagtgacatcttagctgaggagcttcagaaaacaaaa
aatgaagaagaatacatggtcaatacatttatagtcatgcaaaggaaactgggaacggct
gggcagaaactcggtggtgctgctgtcctgtgtcacatcaggcatgaccctgtggacctg
ggaggatcctttaccctgacctctgctaatgttggcaagtgccaaacggttctctgtcga
aacgggaagccgctgtctctgtccaggtcctataccatgagctgtgaagaagagcggaag
aggattaagcagcacaaagccatcatcactgaggatggcaaggtcaatggagtgacagag
tccacacgcatcctgggctacaccttccttcaccccagtgtggtgcctcgcccccacgta
cagtcggtgcttctgactccacaggatgagtttttcatcctgggcagcaaagggctgtgg
gacagcctgtccatcgaagaggctgtggaagccgtgcgcaacgttccagatgctctagcc
gccgccaagaagctatgcaccctggcccagagctacggctgccacgacagcatcagtgct
gtggtggtgcaactcagtgtcacggaagacagcttctgctgctgtgagctcagtgtggga
ggaagcatgccaccgcccagtcccggaatcttcccgccctccgtcagcatggtgatcaag
gaccggccctcagatgggctgggcgtgccgtcctccagcagcggcatggcatctgagatc
agcagtgaattgtctacctctgagatgagtagtgaggtgggctccacagcttctgacgag
ccgccgtcgggagccctgagtgagagcagccccgcctaccccagcgagcagcgctgcatg
ctccacccggtctgcctgtccaactccttccagcgccagctgtccagcgccactttctcc
agtgcgttctctgacaacggccttgacagtgatgacgaggaacccattgagggcgtgttc
agcaacggcagccgggtggaggtggaagtggacatccattgcagccgggccaaggagaag
gagagacagcagcacctgcttcaggtaccagctgaagccagtgatgagggcattgtcatc
agtgccaatgaggatgagtcaggtctgtccaagaagacagacatttctgctgtggggacc
attgggcgacgcagggctaacggctctgtacctccccaggaaaggagccataatgtaata
gaggttgccacagatgcacctctccggaagccgggaggctattttgcagcccctgctcaa
ccagatccagatgatcagtttatcatccccccagagctggaagaggaagtcaaagaaatc
atgaaacatcaccaggagcagcagcagcagcagcagcagcagcagcagcagcagcagcag
cagccaccacctccaccccagccgccacaggcacaggcacaggcacaggcacaggcacag
aggcccttccagatggatcacctgccggactgttacgacacaccactatga

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