KEGG   Rattus norvegicus (rat): 64300
Entry
64300             CDS       T01003                                 

Gene name
Mthfd1
Definition
(RefSeq) methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00670  One carbon pool by folate
rno01100  Metabolic pathways
rno01240  Biosynthesis of cofactors
Module
rno_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    64300 (Mthfd1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:rno04147]
    64300 (Mthfd1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     64300 (Mthfd1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     64300 (Mthfd1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     64300 (Mthfd1)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   64300 (Mthfd1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH AP_endonuc_2
Other DBs
NCBI-GeneID: 64300
NCBI-ProteinID: NP_071953
RGD: 708531
Ensembl: ENSRNOG00000005602
UniProt: P27653
Position
6q24
AA seq 935 aa
MAPAGILNGKVVSAQIRNRLKTQVTQMQEQVPGFTPGLAILQVGDRDDSNLYINVKLKAA
QEIGIKATHIKLPRTSTESEVLKYVISLNEDATVHGFIVQLPLDSENSINTEAVINAIAP
EKDVDGLTSINAGKLARGDLKDCFIPCTPKGCLELIKETGVQIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTADLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINY
VPDDTKPNGRKVVGDVAYDEAKEKASFITPVPGGVGPMTVAMLMQSTVESAQRFLKKFKP
GKWTIQYNKLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSAL
DRLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRKFSDIQIRRLRRLGIEKTDPAALTDDEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRARLGKMVVASSKKGEPI
SCEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYTEEDLDLVEKGFSNLRKQIENARMFGVPVVVAMNAFKTDTDTELDLIGRLSREHGAF
DAVKCTHWAEGGQGALALAQAVQRASQAPSSFQLLYDLKLSVEDKIRIIAQKIYGADDIE
LLPEAQNKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcaccagcgggaatcctgaacgggaaagtggtctccgcgcaaatcaggaatcgactg
aagacccaggttactcagatgcaggagcaggtacctggcttcacccctggcctggcaatc
ctgcaggttggcgacagagatgattccaatctttatataaatgtgaagctgaaggctgct
caagagatcgggatcaaagccactcacattaaattaccaagaacttccacagagtcggag
gtgttaaaatacgtcatctccctgaatgaggatgccactgtgcacggattcatagtacag
ctgcctttagactccgagaattccattaacacagaggcagtcatcaatgccattgcccct
gagaaggatgtggacgggttgacgagcatcaatgccgggaagcttgccagaggtgatcta
aaggactgcttcattccgtgcacacccaaaggatgcttggaactcatcaaagagacagga
gtgcagattgcaggaaggcacgccgtggtggtcgggcgaagtaaaatagttggtgcaccc
atgcacgacctgcttctgtggaacaatgccacggtgaccacctgccactccaagactgcc
gatctggacaaggaggtaaataaaggagacattctggtggttgcaacaggacagcctgag
atggtgaaaggggagtggatcaagcctggagctgtggtcatagactgtgggatcaattat
gttccagatgatacaaaaccaaatggaaggaaagttgtgggtgacgtagcatatgacgag
gccaaggagaaggcgagctttatcacgcctgtccccggtggcgtggggcccatgaccgtg
gcaatgctgatgcagagcacagtagagagcgcacagcgcttcctgaagaaatttaagcca
gggaagtggacaattcagtataacaagctgaacctcaagacgcctgtaccaagtgacatt
gctatatcacgatcttgcaaacccaagctcatcggtaacctggcccgagaaattgggcta
ctcactgaggaggtggaattgtatggagaaacaaaggccaaggtcttactgtcagcacta
gatcgcctgaagcatcagccagatgggaaatacgttgtggtgactggaattactccaaca
cccctgggagaagggaagagcacaaccaccatcgggcttgtgcaagcccttggcgcccac
ctgcatcagaatgtttttgcgtgtgtgcgacagccttctcagggccccacctttgggata
aaaggtggcgctgcaggaggcggctattcccaggtcattcctatggaagagtttaatctc
cacctcactggtgacatccacgccatcactgccgctaataaccttgtggctgctgctatt
gacgctcggatatttcatgagctgacccagacagacaaggctctctttaatcgtctggta
ccctcagtaaatggagtaagaaagttctctgacatccaaatccgcaggttacggaggcta
ggcattgagaagactgaccccgctgcgctgacagatgatgagataaacagatttgcaaga
ctagatattgatccagaaaccataacatggcagagagtgctggatactaacgatagattc
ctgaggaagatcaccattggacaggctccaaccgagaaaggccacacacgcacggcccag
tttgatatctctgtggccagtgaaatcatggcagtcctggccctcactagttctctggaa
gacatgagagcaaggctgggcaaaatggtggtagcgtccagtaagaaaggggagcctatc
agctgtgaagacctgggcgtgagcggggcgctgacggtgctcatgaaggatgcgatcaag
cccaatctcatgcagaccttagagggcacgccggtatttgtccatgctgggccttttgcc
aacattgcacatgggaattcctccatcattgcagaccggattgcactcaagctggttggc
cctgagggctttgtagtgacagaagcaggattcggagcagacataggaatggaaaagttc
ttcaacatcaagtgccggtattctggtctccagcctcatgtggtggttcttgttgccact
gtcagggctcttaagatgcacgggggtggccccacggtcaccgctggactgcctcttccc
aaggcttacacagaagaggacctggacctggtggaaaagggcttcagtaacttgaggaaa
cagatagaaaatgctagaatgtttggagtgcctgtcgtggtggccatgaatgcattcaag
acagatacagatactgagctggacctcatcggccgcctctccagagagcatggggctttc
gatgctgtcaagtgcacccactgggcagaagggggccagggagccttagccctggctcag
gctgtccagagagcttcacaggcccccagcagcttccagctcctctatgacctcaagctc
tcagttgaagataaaatcaggattattgcacagaagatctacggggccgatgacatcgaa
ttgctccctgaagcacaaaacaaagcagaaatctacacaaagcagggctttgggaatcta
cccatctgcatggccaaaacacacttgtctttatctcacaacccagagcaaaaaggggtg
cctactggcttcgttctgcccatccgggacatccgggccagcgttggggctggtttcctg
taccctttagtaggaacgatgagcacaatgcctggactccctactcgaccctgtttttat
gatatcgatttggaccctgaaactgaacaagtgaatggattgttttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (4)   
   Pfam (4)   
All databases (46)   

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