KEGG   PATHWAY: sgr00280
Entry
sgr00280                    Pathway                                

Name
Valine, leucine and isoleucine degradation - Streptomyces griseus
Class
Metabolism; Amino acid metabolism
Pathway map
sgr00280  Valine, leucine and isoleucine degradation
sgr00280

Module
sgr_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sgr00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Streptomyces griseus [GN:sgr]
Gene
SGR_1982  putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SGR_5991  putative aminotransferase [KO:K00826] [EC:2.6.1.42]
SGR_3880  putative valine dehydrogenase [KO:K00271] [EC:1.4.1.23]
SGR_5330  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SGR_4769  putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SGR_5810  putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SGR_6453  putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SGR_1563  putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SGR_4756  putative acyl-CoA dehydrogenase [KO:K11410] [EC:1.3.99.12]
SGR_6832  putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SGR_3090  putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SGR_1217  putative enoyl-CoA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]
SGR_5500  putative enoyl-CoA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]
SGR_1219  putative enoyl-CoA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]
SGR_329  putative enoyl-CoA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]
SGR_993  putative fatty acid oxidation complex alpha-subunit [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
SGR_1477  putative 3-oxoacyl-CoA thiolase [KO:K00632] [EC:2.3.1.16]
SGR_3093  putative acetyl/propionyl CoA carboxylase alpha subunit [KO:K01965] [EC:6.4.1.3]
SGR_2616  putative acyl-CoA carboxylase beta subunit [KO:K01966] [EC:6.4.1.3 2.1.3.15]
SGR_2621  putative acyl-CoA carboxylase alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SGR_4758  putative acetyl/propionyl CoA carboxylase alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SGR_2139  conserved hypothetical protein [KO:K05606] [EC:5.1.99.1]
SGR_6745  putative methylmalonyl-CoA mutase alpha subunit [KO:K01847] [EC:5.4.99.2]
SGR_6746  putative methylmalonyl-CoA mutase beta subunit [KO:K01847] [EC:5.4.99.2]
SGR_2730  putative isobutyryl-CoA mutase, chain B [KO:K01849] [EC:5.4.99.2]
SGR_2120  putative isobutyryl-CoA mutase, chain A [KO:K01848] [EC:5.4.99.2]
SGR_1218  putative 3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
SGR_1215  putative NAD-dependent aldehyde dehydrogenase [KO:K00140] [EC:1.2.1.18 1.2.1.27]
SGR_4838  putative methylmalonic acid semialdehyde dehydrogenase IolA [KO:K00140] [EC:1.2.1.18 1.2.1.27]
SGR_6067  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SGR_2630  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SGR_5794  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SGR_4071  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SGR_5177  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SGR_5088  putative acyl-CoA synthetase [KO:K18662] [EC:6.2.1.-]
SGR_1829  putative 4-aminobutyrate aminotransferase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
SGR_4759  putative acetyl/propionyl CoA carboxylase beta subunit [KO:K01969] [EC:6.4.1.4]
SGR_4757  putative hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
SGR_1191  putative 3-oxoadipate CoA transferase subunit A [KO:K01028] [EC:2.8.3.5]
SGR_1192  putative 3-oxoadipate CoA transferase subunit B [KO:K01029] [EC:2.8.3.5]
SGR_6136  putative AMP-binding protein [KO:K01907] [EC:6.2.1.16]
SGR_2138  putative acetoacetyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
SGR_5170  putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SGR_4215  putative ketoacyl CoA thiolase [KO:K00626] [EC:2.3.1.9]
SGR_4450  putative thiolase [KO:K00626] [EC:2.3.1.9]
SGR_5494  putative thiolase [KO:K00626] [EC:2.3.1.9]
SGR_6835  putative nonspecific lipid-transfer protein [KO:K00626] [EC:2.3.1.9]
SGR_994  putative acyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
SGR_1380  putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
sgr00020  Citrate cycle (TCA cycle)
sgr00240  Pyrimidine metabolism
sgr00290  Valine, leucine and isoleucine biosynthesis
sgr00640  Propanoate metabolism
sgr00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

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