ID A0A060VVU5_ONCMY Unreviewed; 1077 AA.
AC A0A060VVU5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAH box protein 9 {ECO:0000256|ARBA:ARBA00031576};
DE AltName: Full=Nuclear DNA helicase II {ECO:0000256|ARBA:ARBA00033216};
GN ORFNames=GSONMT00079803001 {ECO:0000313|EMBL:CDQ56455.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ56455.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ56455.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ56455.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; FR904263; CDQ56455.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060VVU5; -.
DR STRING; 8022.A0A060VVU5; -.
DR PaxDb; 8022-A0A060VVU5; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0033679; F:3'-5' DNA/RNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-KW.
DR CDD; cd17972; DEXHc_DHX9; 1.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044447; DHX9_DEXHc.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW Transcription {ECO:0000256|ARBA:ARBA00022472};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00022472};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472}.
FT DOMAIN 74..142
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 271..343
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 489..655
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 726..899
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1077 AA; 119913 MW; 61329657D52E05F3 CRC64;
MRWCDGGHTL SMHIGQGPVS LLTVCTIHLQ RMPDRLVPQC YHVCRLNGLY LLAGSFEKVS
GGGRVEKYKS AMADIKNFLY AWCGKKKLTP SYDIRAAGNK NRQKFLCEVR IDGFNYTGMG
NSTNKKDAQA NAARDFVNYL VRVGEMNAAE VPALGASGPD FSVPDCGGGG EGGNVGFGSL
PPSGPIPPHL VVKAEQVNAP SAPVPGVTGL GYSGGSGNFS GGGSNSNAPW DRGANLKDYY
SKRDEQEAQA TLESEEVDLN AGLHGNWTLE NAKARLNQFF QKEKNQTDYK YSQVGPDHNR
SFIAEMQLFV RQLGRKIIAR EHGSNKKLAA QSSALSIVRQ LYHLGVIEPY SGVTKKKEGE
ILEAFEVNVV DELQHQLQSM AQELGVAIPP PPPDPSTPVS LVQGKMAVFE PSQKQSMAGV
VPWSPPQVNW NPWTSSNIDD GPLAFCTPEQ ISTDLHHELT YQLEQDQSLQ KVIGERDGLP
VKKFEEEIMT AVQGSSVVII RGATGCGKTT QVPQYILDQF IKSGRASECN IIVTQPRRIS
AVSVAERVSY ERGEDVGKSC GYSVRFESIL PRPHASIMFC TVGVLLRKLE AGIRGISHVI
VDEIHERDIN TDFLMVVLRD VVHTYPEVRI ILMSATIDTT MFREYFFNCP VIEVFGRTFP
VQEYFLEDCI QMTHFIPPPS DRKRKDKDEE GGDEEANCNV ICGPEYTPET KRSMAQMNEK
ETPFELVEAL LKYIETLQVA GAVLVFLPGW NLIYSMQKHL EMNPHFGSQR YLILPLHSQI
PREEQRRVFE PVPENITKVI LSTNIAETSI TINDVVYVID SCKQKVKLFT SHNNMTNYAT
VWGSKTNLEQ RKGRAGRVRA GFCFHLCSRA RFDKLETHMT PEIFRTPLHE VALSIKLLRL
GAIGHFLSKA IEPPPLDAVI EAEHTLRELD ALDTNDELTP LGRILAKLPI EPRLGKMMIM
GCIFNVGDAV CTISAASCFP EPFINDGKRL GYVHRNFAGT RFSDHVALLS VFQAWDDVRM
GGEDAESRFC EHKRLNMSTL RMTWEAKVQL KEILINSGFP EGRFFFSSVS QMTPFPL
//
