ID   A0A0C4YLM7_9BURK        Unreviewed;       535 AA.
AC   A0A0C4YLM7;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:AJG23470.1};
DE            EC=1.1.99.1 {ECO:0000313|EMBL:AJG23470.1};
GN   ORFNames=RR42_s1882 {ECO:0000313|EMBL:AJG23470.1};
OS   Cupriavidus basilensis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=68895 {ECO:0000313|EMBL:AJG23470.1, ECO:0000313|Proteomes:UP000031843};
RN   [1] {ECO:0000313|EMBL:AJG23470.1, ECO:0000313|Proteomes:UP000031843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4G11 {ECO:0000313|EMBL:AJG23470.1};
RX   PubMed=25977418;
RA   Ray J., Waters R.J., Skerker J.M., Kuehl J.V., Price M.N., Huang J.,
RA   Chakraborty R., Arkin A.P., Deutschbauer A.;
RT   "Complete Genome Sequence of Cupriavidus basilensis 4G11, Isolated from the
RT   Oak Ridge Field Research Center Site.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|PIRSR:PIRSR000137-2};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR   EMBL; CP010537; AJG23470.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C4YLM7; -.
DR   STRING; 68895.RR42_s1882; -.
DR   KEGG; cbw:RR42_s1882; -.
DR   OrthoDB; 9785276at2; -.
DR   Proteomes; UP000031843; Chromosome secondary.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU003968};
KW   Oxidoreductase {ECO:0000313|EMBL:AJG23470.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031843}.
FT   DOMAIN          83..106
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00623"
FT   DOMAIN          257..271
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00624"
FT   BINDING         85
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT   BINDING         222
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT   BINDING         501
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ   SEQUENCE   535 AA;  58303 MW;  1FF007F4A0554339 CRC64;
     MKTATYDYIV IGAGSAGCVL ASRLSEDPSV KVLLIEAGAP ASSIFVQMPA GIRVLYKSQK
     FNWRYWTEPQ TQLDNRNIYI PRGKVVGGSS SINSMIAIRG NRSDYDNWAS QGLSGWDYES
     LRPYFRKIED ASLVTKARND DRGYAGPIRL SYGTQQNAIS TAFIESAVSA GMPENNGFNG
     ASQVGAGFYE LTIAEGKRSG AYRYLDRAGN RSNLTLMANC KVRRILLAGK RAQGVVIEDG
     WEEVELRADR EVILTAGAIA SPQLLMLSGI GPAKHLQSIG IAPVVDLQGV GENLQDHLDC
     AIRLEASQPN TLTPYIGLVR GGMAGARYLL SGGGPASSQG VEAGAFYNSD RNPDLPEWQA
     HLIIALRNPP PNEKVPHGFA VRVCQLRPKS RGVLRLRSSD PSDSPRIDPR FLSDESDLES
     LVRGVERTCE IVDQPALRKY IKRRLDIDAF STGAARKAWI RSHAETIYHP VGTCRMGVDD
     NAVVDEELKV RGVENLRVID GSVMPTIISG NTNLPIMAMA EKAADLIRNS RTSAR
//