ID A0A0D2S4M5_GOSRA Unreviewed; 1454 AA.
AC A0A0D2S4M5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=ABC-type xenobiotic transporter {ECO:0000256|ARBA:ARBA00012191};
DE EC=7.6.2.2 {ECO:0000256|ARBA:ARBA00012191};
GN ORFNames=B456_012G174600 {ECO:0000313|EMBL:KJB78047.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB78047.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB78047.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00034018};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily.
CC {ECO:0000256|ARBA:ARBA00009726}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001751; KJB78047.1; -; Genomic_DNA.
DR RefSeq; XP_012459701.1; XM_012604247.1.
DR STRING; 29730.A0A0D2S4M5; -.
DR EnsemblPlants; KJB78047; KJB78047; B456_012G174600.
DR GeneID; 105780116; -.
DR Gramene; KJB78047; KJB78047; B456_012G174600.
DR KEGG; gra:105780116; -.
DR eggNOG; KOG0054; Eukaryota.
DR OMA; MTWILAT; -.
DR OrthoDB; 3384185at2759; -.
DR Proteomes; UP000032304; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF222; OS01G0902100 PROTEIN; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1111..1129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1138..1158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 270..550
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 585..811
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 889..1165
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1202..1436
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1454 AA; 163597 MW; 232036040E5CBDBB CRC64;
MEVSLEVVNV PFAIALLAWI IIDILKRRGH ENDSNNDDDV KGKIRGYLRV FNVVTVVFSI
IIFVLNLGFG FYTYWNYGIV PTKSVCLAIT WFVASLVLIY WMNRGFSELK PRPPLVLILW
WVFSFGLVSF SVLVYVVRLL GFRELPYRLP EPDIVDVVSL PLLVLFCCRC CCRPLSHGEL
ERPLLLRKEN DDDSSFNNAS LWSQLTFQWL NPLFEKGRIE KLELHHIPSV PESETADNAS
LLLEESIRKQ KTKSTSLPKA ITGTVWKSLA INAVFAGLNT IASYIGPFLI SNFVNFLTQK
DDSSSYHYGL VLAFIFFFSK TVESLTQRLW YFGAHRIGIR VRAALTVLIY KKSLSTKFVG
PSNGKVINLI NVDAERIGDF CWYIHGVWLL PIQVFLALVI LYWNLGAAPS VAAVFATILV
MVSNTPLANR QERLHSKIME AKDSRIKVTS ETLKSMRVLK LHSWEPTFLN KLLQLRETER
NWLKKYLYTC SAVAFLFWAS PTLVSVITFG VCILLETPLT SGTVLSALAT FRILQEPIYN
LPELISMIAQ TKVSFDRIQE FLGEEDQRKF ITSSGPKESG VAVEIKAGEY AWDSSSQSLK
NPTIKITEKM KIMKGYKIAI CGSVGSGKSS LLCSILGEIP RISGAVIKVY GKKAYVPQRP
WVQTGTIREN ILFGKDMDDA FYERVLEACA LNQDIEMWDN KDMSVVGERG MNLSGGQKQR
IQLARAVYSD SDIYILDDPF SAVDAHTGTH LFKKCLKGLL SEKTVIYATH QLEFLDAADL
VLVMKDGLVV QSGKYEELIA DSDGELVRQM NAHRKSLDQM NPPQDNDSLI AKPCQISQIE
VIEEKYGDPI CFGKLFERSQ EEETETGRVK WSVYSTFVTA AYKGALVPVV LLCQVLFQGL
QIGSNYWIAW ATEENHKVSR EQLIGTFVML SGGSSIFILG RAVLLATIAI ETAQRLFLGM
ITSVFRAPIS FFDSTPSSRI LNRSSTDQST LDTDIPYRLA GLAFALIQLF SIIILMSHVA
WQIFLLFIAI LGISFWYQTY YITTARELAR MVGSRKAPIL HHFSESITGA GTIRCFNQED
RFIEKNLSLI DDYSRVAFHN SGTMEWLCVR INFLFNFVFF LVLIILVSLP RSTIDPSLAG
LAATYGLNLN VLQAWVIWNL CNVENKMISV ERVLQFTNIA SEAPLVIEDR RPKPEWPTEG
TIELENLQVQ YKPTLPVVLK GITCTFPGEM KIGVVGRTGS GKSTLIQALF RVVEPSGGRI
IIDGVDISTI GLQDLRSRLG IIPQDPTLFQ GTIRTNLDPL QQHTDQEIWE VLDKCRLADI
VRQDQRLLDA PVAEDGENWS VGQRQLVCLA RVLLKKRRIL VLDEATASID TATDNVIQET
IREETSKCTV ITVAHRIPTV IDNDLVLVLD KGKIVEYDKP GNLLEDSCSS FSKLVAEFLR
SSPKSNNNNN VHHR
//
