ID A0A0E3NTW8_9EURY Unreviewed; 413 AA.
AC A0A0E3NTW8;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=3-hexulose-6-phosphate synthase {ECO:0000256|ARBA:ARBA00012890};
DE EC=4.1.2.43 {ECO:0000256|ARBA:ARBA00012890};
GN ORFNames=MSMTP_0201 {ECO:0000313|EMBL:AKB23670.1};
OS Methanosarcina sp. MTP4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB23670.1, ECO:0000313|Proteomes:UP000033049};
RN [1] {ECO:0000313|EMBL:AKB23670.1, ECO:0000313|Proteomes:UP000033049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MTP4 {ECO:0000313|EMBL:AKB23670.1,
RC ECO:0000313|Proteomes:UP000033049};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC 6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC Evidence={ECO:0000256|ARBA:ARBA00000718};
CC -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC {ECO:0000256|ARBA:ARBA00006350}.
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DR EMBL; CP009505; AKB23670.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0E3NTW8; -.
DR STRING; 1434100.MSMTP_0201; -.
DR KEGG; metm:MSMTP_0201; -.
DR PATRIC; fig|1434100.4.peg.261; -.
DR HOGENOM; CLU_637161_0_0_2; -.
DR OrthoDB; 15246at2157; -.
DR Proteomes; UP000033049; Chromosome.
DR GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR CDD; cd16841; RraA_family; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.50.30.40; Ribonuclease E inhibitor RraA/RraA-like; 1.
DR InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017120; Bifunct_HPS/DMK_prd.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR005493; RraA/RraA-like.
DR InterPro; IPR036704; RraA/RraA-like_sf.
DR NCBIfam; TIGR03128; RuMP_HxlA; 1.
DR PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR Pfam; PF03737; RraA-like; 1.
DR PIRSF; PIRSF037137; HPS_DMK_prd; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR SUPFAM; SSF89562; RraA-like; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:AKB23670.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033049}.
FT DOMAIN 1..192
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 413 AA; 44152 MW; 67768CBAB7D794CB CRC64;
MDRSVKIARE AIAGGADWIE IGTPLIKSEG MDTVRTMRKA FPDRTILADM KTVDTGAMEV
EMAAKAGADV AIVLGSADDS TILDALRSAH KYGIRLMADL ISAPEPVGRA VELEALGVDY
INVHVGIDQQ MMGKDPVSIL MEIAEKVNVK LAVAGGLDAE SAAQAVRAGA EIVIVGGNIT
RSDNVTEAAQ KIRQSVDAPG SIEIRDRGTL DQEIREILME VSTSNISDAL HRKGAMKGIH
PLVRGKVVGT AITVQSFAGD WAKTVEAIDE AKEGDVIVIY NECKDIACWG GLATLSSLNK
GIAGVVIEGA VRDIDEVEKL GLPIYTSNTV PNAGDPKGFG EMNAEITCGG QTVKPGDYIV
GDESGVVVVP KERAYEIARR AKEVYKTENR IFDEIRRGGT LSEILELKKW EKL
//
