ID   A0A0H1BKY8_9EURO        Unreviewed;      1154 AA.
AC   A0A0H1BKY8;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=EMPG_12727 {ECO:0000313|EMBL:KLJ12209.1};
OS   Blastomyces silverae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=2060906 {ECO:0000313|EMBL:KLJ12209.1, ECO:0000313|Proteomes:UP000053573};
RN   [1] {ECO:0000313|Proteomes:UP000053573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 139 {ECO:0000313|Proteomes:UP000053573};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KLJ12209.1}.
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DR   EMBL; LDEV01001104; KLJ12209.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0H1BKY8; -.
DR   STRING; 2060906.A0A0H1BKY8; -.
DR   OrthoDB; 5477883at2759; -.
DR   Proteomes; UP000053573; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF17; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053573};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ   SEQUENCE   1154 AA;  130974 MW;  55B4822888670C4A CRC64;
     MEIFCRNVPN QVQDNHLKRQ FKPVLESFGI HSFNCRKLPN CNAILTIADS NKALKLLAVY
     GQASGQGRVR RPPRQQLKMF GQNIFIQEGR NAPDEYLLRT LINEEETRLS RGAVSGNVQA
     YHQPAPVKRP KSFSIISMSC EAKFGAMFQS QQKWQRGPPP KTRVGHFGDE HESLAGTCFV
     YRFLLTDARD LNAVRDLGNE RHIPNIARWL DHRAQYDVPY STLMQRLMDF LSQGRLPYRV
     RFQLQKLVWN GDISPAKAIS FASRVQAALV AENLDIVVQA LMRLPQNINW PSPDVDPSEV
     DVPALIATFT NALEDAIREH RRASTNRQTH PNHISIHRAQ VTPCGIYLYG PYMETKNRVL
     RLYADHVDHF LRVEFIDESG DPVRYDPRAS VDRIFQHRFK GVLKNGINIA GRKFEFLGFS
     HSSLRSQTCW FVAPFYADGI LFNTTTIIQN LGRFDHINSP AKQAARIGQT FSDTLTSIPI
     SEDMISLAQD VKRNDRVFSD GVGTISRSVM YMIWKDYSLR TIVKPTVFQI RIAGAKGMIS
     LDSRKKGKSL VLRPSMIKFQ VPTSLNASNI EICGSGIRSL PFFLNAQLIK ILEDLGVDDS
     AFLKLQGDEI LRLRATATST TKAARFLDDT NIAKSVGLPW LIGILEALGL RHSDDEFLRR
     VMELTVLIKL RDLKYRARIR VPKAVTLFGI MDETGVLKEG EIFCTSLSDK GHREVLLNPM
     VVVTRSPAMH PGDVQIAKAV DVPADSPLRQ LHNCIAFSQH GPRDLPSMLS GGDLDGDLYN
     VIFEDTLIPR IISAPAEYPR VKEKVLDRPV VREDIIDFFV TFMQQDQLGR IATIHQTIAD
     QKPLGTFDPQ CLLLAELHST AVDFSKSGVP VDLARIPKFP RYRPDFQAPG PRVRIAESLS
     LLETHDQMTV PDDDDEDEDE RPNARYYKSE NILGKLYRAI DEVEFLQHRQ NAMERSLAMA
     APSVLRGVWA FVQSETAGFL WDHLVENALE IRQIYEDILL GIMARYSSTP WKSSITEYEV
     FIGTILGHGQ KLNQRQKDAS KQMREEYEDL VQFVTAMIQD REAGGMESLE RSIACLYIAV
     EEERKQNNHP SRVSKRDTSA ARYHHKLEQQ HQDQSGDGYG TDKQGKRQRL LSFPWIAAIV
     CLKEVDKLQR TMPF
//