ID A0A0L1IE35_PLAFA Unreviewed; 1174 AA.
AC A0A0L1IE35;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=PFMG_03657 {ECO:0000313|EMBL:KNG77455.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG77455.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG665312; KNG77455.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1IE35; -.
DR EnsemblProtists; KNG77455; KNG77455; PFMG_03657.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KNG77455.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562}.
FT DOMAIN 448..611
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 636..911
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 137926 MW; 90912567A345215E CRC64;
MNEKSDLHKR SIEFTDNDES KKKIKTDGEE NDIMESKGKD SYSLYLEYQK GRNKKLKNNE
EYIEYLKKDA RRKYLKEREK EKLDITKKLL DDELLYSTVK LEGKDLKELQ FSKKIYNIAK
ENINLREKLQ EESYYFQQDI DKNKKTQTYE NDKVDKSLYN YDEQILNKGI LKFGSAISKQ
NIQKQNNNEF VFDDDIITTN RKSIKRESFE EKKMNESPTK KKKKRKDDIE SDNKCDKDEK
YDKYGKFYKR DKHHKYDKHD KHDKYDKHDK HDKHDKHDKH DKHDKHDKND KHDKHDKHDK
HDKHNKKYHS KYKELNTSYD NNSPTDSTYK SEEESSSSGD KNHRNNKYDS DKIKHEKKKK
KKSIMTDEER NVDSNKRSFE KKESELNENG LTDVVEFVHL ESFYGMNEKE KELEKLFEDI
KKRKEKKMKK IIDERKRLPI YSYRYDILKA IKNNKILILV GETGSGKSTQ LTQYLYECKY
HMYGNIICTQ PRRIACIAIA NRVAEEMNVK IGKEVGYVIR FQNKTSEATK IMYMTDGMFL
RLLLYNPTLE DISVLIIDEA HERALHTDVI LPIVKDICNF RENIRVVISS ATLDAEKIST
YFNCAPIFYV PGRKYNVDIY YTINNESNYI SAIVITILQI HITQGKGDIL VFLPGQYEIE
LVQQELENKL NELAPKYRNL VILPIYSSLP VEYQARIFED VTEEDNMKFL EDINDKKDER
NKNHKDDEND ENGENEKNDK NEKNDKNEKN DKNDKNYKNE KNEKNNDKND KNNVGNNSKM
NVSQSKNKRN INEEIEELKR INTNNKIRRK IILSTNICET SITIDNIVYV IDSGLCKQKI
YNPNSGIESL VTLPCSKASV NQRTGRAGRK RDGKCFRLFT KKSFIDLSDN SIPEIQRCEI
SSMILLLKSL GMDDIINFDF LDPPSPIVII KGLELLYSLG ALNDEGNLTR TGRKMAEFPT
DVKSSKMILS AAEKYNCVDE ILNVASMLTH ANNIFYVQKG KEKEAENIKK MFIIEGGGDF
LLFLNIYKQC EENNFSTSFC YDHFLQYHTL IKVKDVKTQL LSICEKIDIP ITTCGIENHE
SINNIKKSIV SAFFTNAALP VNKTELKIIK LNQVVSIYPN SVLFKKNIME ENENVCIIFY
EVIKLNKSYI RHNIPVNKNL LFQIADFYFL NKTE
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