ID A0A0L1IPR5_ASPNO Unreviewed; 978 AA.
AC A0A0L1IPR5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ATP-dependent RNA helicase DBP2 {ECO:0000256|ARBA:ARBA00039329};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=ATP-dependent RNA helicase dbp2 {ECO:0000256|ARBA:ARBA00039605};
GN ORFNames=ANOM_010027 {ECO:0000313|EMBL:KNG81464.1};
OS Aspergillus nomiae NRRL 13137.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1509407 {ECO:0000313|EMBL:KNG81464.1, ECO:0000313|Proteomes:UP000037505};
RN [1] {ECO:0000313|EMBL:KNG81464.1, ECO:0000313|Proteomes:UP000037505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13137 {ECO:0000313|EMBL:KNG81464.1,
RC ECO:0000313|Proteomes:UP000037505};
RA Moore M.G., Shannon B.M., Brian M.M.;
RT "The Genome of the Aflatoxigenic Filamentous Fungus Aspergillus nomius.";
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent RNA helicase involved nonsense-mediated mRNA
CC decay and ribosome biogenesis through rRNA processing.
CC {ECO:0000256|ARBA:ARBA00037752}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBUNIT: Associates with polysomes. {ECO:0000256|ARBA:ARBA00038583}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC subfamily. {ECO:0000256|ARBA:ARBA00009334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNG81464.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JNOM01000445; KNG81464.1; -; Genomic_DNA.
DR RefSeq; XP_015402387.1; XM_015555283.1.
DR AlphaFoldDB; A0A0L1IPR5; -.
DR STRING; 1509407.A0A0L1IPR5; -.
DR GeneID; 26811831; -.
DR OrthoDB; 5477821at2759; -.
DR Proteomes; UP000037505; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0050334; F:thiaminase activity; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd17966; DEADc_DDX5_DDX17; 1.
DR CDD; cd01169; HMPP_kinase; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd19367; TenA_C_ScTHI20-like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 1.20.910.10; Heme oxygenase-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR InterPro; IPR004305; Thiaminase-2/PQQC.
DR InterPro; IPR027574; Thiaminase_II.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR NCBIfam; TIGR04306; salvage_TenA; 1.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF150; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR Pfam; PF03070; TENA_THI-4; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48613; Heme oxygenase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000037505}.
FT DOMAIN 553..581
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 584..759
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 787..934
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 944..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 553..581
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
SQ SEQUENCE 978 AA; 108123 MW; 154796C07A91909F CRC64;
MSVKRVLVIA GSDSSGGAGL EADQRVLAAH GCYALTATTG LTAQNTLGVQ DIFVVPAEFV
KKQINAGLED IGADAVKLGM LSSAETIDII AETLVAHQVP SVVLDPVMIS TSGSKLLPEE
AVEKLRTKLL PLTTVLTPNI PEAKLLLKDA GLDVSEPEGL SDVLQLVKQV KALGPKAVLL
KGGHLPLTKD HKTARNQEEA TTVIDVLYDG EDVTLFETDF LLSKNTHGTG CSLASSIAAN
LALGKDLKRA VHSAVRFVEA GIKTSFDIGK GSGPINHFHS VYTLPFAPGR FLEYVLDRPD
IRPVWKKFTE HDFVLGMGSG TLPVEKFKEY LVQDYLYLVQ FARSNALAAY KAKNMESIAA
SAQIVLHIQR ETALHLDYCA SFGLSKQEME RTPETIACTA YSRYILDVGQ SEDWLALQMA
LAPCLIGYGA IAQRLYTDKD TLRQGNRYWK WIENYVAEDY SEAVRLGSEL LERHMREVSP
SRMEELIKIF IRATELEIRF WDMGLDLDSL PKFEKSFYKE HPDVASRSQR DVDDFRKKFE
MSVQGKNIPR PVETFDEAGF PQYVLSEVKA QGFERPTAIQ SQGWPMALSG RDVVGIAETG
SGKTLSYCLP AIVHINAQPL LAPGDGPIVL VLAPTRELAV QIQTEITKFG KSSRIRNTCV
YGGVPKGPQI RDLSRGVEVC IATPGRLIDM LEAGRTNLRR VTYLVLDEAD RMLDMGFEPQ
IRKIISQIRP DRQTCMWSAT WPKEVRQLAS DFLNDYIQVN IGSMDLSANH RITQIVEVVS
DFEKRDKMIK HLEKIMENRG NKCLIFTGTK RIADEITRFL RQDGWPALSI HGDKQQQERD
WVLNEFKTGK SPIMVATDVA SRGIDVRDIT HVLNYDYPNN SEDYVHRIGR TGRAGAKGTA
ITFFTTDNSK QARDLVTILT EAKQQIDPRL AEMVRYSGGG GGGGRGGYGR WGGRGGGRGR
GGNYTASNAA PLGGNRRW
//
