ID   A0A0V0WZS6_9BILA        Unreviewed;       719 AA.
AC   A0A0V0WZS6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Proline dehydrogenase {ECO:0000256|RuleBase:RU364054};
DE            EC=1.5.5.2 {ECO:0000256|RuleBase:RU364054};
GN   Name=slgA {ECO:0000313|EMBL:KRX81297.1};
GN   ORFNames=T06_7555 {ECO:0000313|EMBL:KRX81297.1};
OS   Trichinella sp. T6.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92179 {ECO:0000313|EMBL:KRX81297.1, ECO:0000313|Proteomes:UP000054673};
RN   [1] {ECO:0000313|EMBL:KRX81297.1, ECO:0000313|Proteomes:UP000054673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS34 {ECO:0000313|EMBL:KRX81297.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC       {ECO:0000256|RuleBase:RU364054}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a
CC         quinol + H(+); Xref=Rhea:RHEA:23784, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17388, ChEBI:CHEBI:24646, ChEBI:CHEBI:60039,
CC         ChEBI:CHEBI:132124; EC=1.5.5.2;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004739}.
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
CC       {ECO:0000256|ARBA:ARBA00005869, ECO:0000256|RuleBase:RU364054}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRX81297.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JYDK01000032; KRX81297.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V0WZS6; -.
DR   STRING; 92179.A0A0V0WZS6; -.
DR   Proteomes; UP000054673; Unassembled WGS sequence.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.220; -; 2.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR002872; Proline_DH_dom.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914:SF0; PROLINE DEHYDROGENASE 1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR   Pfam; PF01619; Pro_dh; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|RuleBase:RU364054};
KW   Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU364054};
KW   Proline metabolism {ECO:0000256|ARBA:ARBA00023062,
KW   ECO:0000256|RuleBase:RU364054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054673}.
FT   DOMAIN          119..520
FT                   /note="Proline dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF01619"
SQ   SEQUENCE   719 AA;  81909 MW;  3062A650C2067B96 CRC64;
     MTFYLMSSGS VKLEYFSKIC KNTRRTFAVL SNGGLKRNGT VGEVKFGDSK IAFGHKTKIQ
     LLRSMAVLKL CSTKMVLDRG EDLFKILRWT FGDRISNSLM KATFYGHFVA GENLHDAVET
     VKRLKARNVR SLLDYCFEQT LDNDSDGSVE ECTLKTLIGC IDALAGLNDP LQMVAIKLTS
     LGCPKMLLTL SDSWTRTLTM VERRTGLSWE NLLESPIAAD KFNLNNSNLR CGDHQLTAEL
     YNKWLDNLRK TDDGLVDLYP YGILDRVDAW KCIKRMMLAD CGMLDDENLQ WKYEAMVRRL
     NEIVDHAVRR NVRIVVDAEQ SYFLPMTNIL SLELMRKYCK NEPAVFITYQ AYLKQANKLV
     ANALQLARRW QCVIGTKLVR GAYMEHERQR ALLLGYPSPI NDTYDLTNET YDNILDLLIK
     EINSRQIGKV HLICATHNEQ SVKHLLANLK SLQVHSTRPT SKWADNISFG QLYGMCDQIS
     FPLADAGFLV YKYLPFGPVG EVLPYLLRRA QENSAVMEKT QFEYNLMKQE LKRRLFCIFW
     LKMENVPKES KANFENDDDS DSSTVTAIID DDLATSDDDS EIIGLNKAEK EIPVCGNDNE
     QFSSDSLAQC PLHSISLESG EAKSDAESEE TSRLIEGLLD EYPTLGECSL VSVHQTEREV
     ALLEDSLNIS ESFWRNDTEI QWVEDAKEVM EFLEMLGVSR SVEQLPELSV EQIEMFLNE
//