ID A0A0V1BZD7_TRISP Unreviewed; 1115 AA.
AC A0A0V1BZD7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX37 {ECO:0000313|EMBL:KRY42156.1};
GN ORFNames=T01_11025 {ECO:0000313|EMBL:KRY42156.1};
OS Trichinella spiralis (Trichina worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6334 {ECO:0000313|EMBL:KRY42156.1, ECO:0000313|Proteomes:UP000054776};
RN [1] {ECO:0000313|EMBL:KRY42156.1, ECO:0000313|Proteomes:UP000054776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS3 {ECO:0000313|EMBL:KRY42156.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRY42156.1}.
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DR EMBL; JYDH01000005; KRY42156.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1BZD7; -.
DR STRING; 6334.A0A0V1BZD7; -.
DR eggNOG; KOG0926; Eukaryota.
DR InParanoid; A0A0V1BZD7; -.
DR Proteomes; UP000054776; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KRY42156.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054776}.
FT DOMAIN 241..408
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 511..685
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1115 AA; 127338 MW; E4A76D82A100935B CRC64;
MSRQISFNIG EIMSEEPTYI LAHDTSNAFV LEPRKKQVNK SNKDASIKGV NISTKKKLKA
KCISKKKAKE LKKILSRKRK NVDRNVIYEK LSRWKISDEE MKLLNSVSGL HEKLKRRKSD
LKFDEKIQSE ELNYPAENGN FVNNNLIQYF ETETSAENEK SEHDNHEYVQ NNISNADISV
QEQSVKLAVS AESTVSSVIE NKQSLKLVNN KTATYVPIYR QPDIEKQRLK LPVVAEEQVI
MEAIKECPVV IICGETGSGK TTQVPQFLYE AGMALNGKII GITEPRRVAA ISMSKRVAEE
MNVGVDVVSY QIRFEGNTTE HTKVKFMTDG VLLREIQKDF LLSNYSAILI DEAHERSMYS
DILIGLLSRI ILLRQKRNDK LHLVIMSATL RVEDFLSPKL FKQTPRVIHV SSRQYPVTVY
FNRHTDEDYL AAAFRKVCQV HRLLPEGAIL VFVSGQQEVY TLVSWLKKTF PMEGIVKIDN
NSSEKFQRRN FSMKSKRKRE NYRPRNDTVI NLDDYIIPAD DKVDLNEMDA PDLDLFDTVE
PKDDIILSDL KNEEIPLYCL PLYSLMESKK QARIFEPIPE GCRLCIISTN VAETSITIPN
VRYVVDTGKE KVRLYDPVTG ISKFVVHWIS KASADQRAGR AGRVAPGHCY RLYSSAVYNE
FEKYSTPEIL TKPPDDLVLQ MKSMNILRVQ NFPFPSPLSV EALQASEERL LKLDLLERQV
DCKGKEVTKI TNLGRSVALF PLAPRYGKML SLACQRNLLA HAVCLVAALS VREVLINPSS
ISAPNVEEKK KRIKACLNCR RDLAGQGQSL LMGDFGVMLQ SVLLAEKSNN LSGVCKSYSI
RMKALLEIRK LRRQLTNMIN LIFPGIDLTL DQKLEIPNSE RMILLRQLLL IGLCDNVARR
NDAVSNNNRI AYSSSVIKDH LWIHPSSTLV KLQPEWVVYQ EVIDGCNEKK CMINVLAIEP
DWLPKLAKGY CHFGEPLKTI QPHYSAEQDC ITCIVDCTYG VSGWFLSRLQ VKHAENLDYY
RYLAVEFLNG NVFSKLQAYK KYLVTSPSII FKPWAKIQTR TDRFLRALVN GKISSKADLI
RVWSTEKKFL RSEYLEWLIE AKHAEVMSIW PPLDK
//
