ID A0A0V1HB77_9BILA Unreviewed; 1139 AA.
AC A0A0V1HB77;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=Supv3l1 {ECO:0000313|EMBL:KRZ08094.1};
GN ORFNames=T11_7427 {ECO:0000313|EMBL:KRZ08094.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ08094.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ08094.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ08094.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the CRELD family.
CC {ECO:0000256|ARBA:ARBA00005897}.
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|ARBA:ARBA00008708}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ08094.1}.
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DR EMBL; JYDP01000092; KRZ08094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1HB77; -.
DR STRING; 268475.A0A0V1HB77; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016817; F:hydrolase activity, acting on acid anhydrides; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17913; DEXQc_Suv3; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00064; FU; 1.
DR CDD; cd18805; SF2_C_suv3; 1.
DR Gene3D; 1.10.1740.140; -; 1.
DR Gene3D; 1.20.272.40; -; 1.
DR Gene3D; 1.20.58.1080; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR021852; DUF3456.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR022192; SUV3_C.
DR InterPro; IPR041082; Suv3_C_1.
DR InterPro; IPR044774; Suv3_DEXQc.
DR InterPro; IPR041453; Suv3_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF1; ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL; 1.
DR Pfam; PF11938; DUF3456; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF12513; SUV3_C; 1.
DR Pfam; PF18147; Suv3_C_1; 1.
DR Pfam; PF18114; Suv3_N; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00261; FU; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KRZ08094.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1082..1100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1107..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 297..487
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1023..1062
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 1139 AA; 127393 MW; 5F76E5F2D20CE250 CRC64;
MASVKAVVTG LRNIGRLPQL RHLSGSKKSF EDLVVPLTVK SASTVNDVDV GVEFGGILAK
DALASVLSKF ARRPAVRKLG AEHGLTGKFL LQALASFRRY CQESAVLPVD LHIMLADILQ
NSRHVDDLFP LFLRHARQVF PHLECIEELK NISDLRLPQN WYPEARSIQR RVIFHAGPTN
SGKTYQALQR YLAAKSGVYC GPLKLLASEV FHKSNAAGVP CDLITGEERC LANGQTCSEH
ISCTVEMLDT RIHYEVAVID EIQMMRDLQR GWAWTRALLG VCADEIHVCG ELAAVDLVKE
LLVSVGDDFE LHTYERKTPL KILDSPLGSL DSIQPYDCIV AFNRNDLFKV TRQVEASGRS
VAMIYGSLPP GTKLAQARKF NDPDDPCDVL VATDAIGMGL NLSIRRVIFY SLVKVTLNES
GEKELEPIST SQALQIAGRA GRFGTFHESG EVTTLRMEDL PALKAILTKP TEPIHAAGLF
PTLEQIEMFA YYLPKATLSN LLDIFVSLSA VDENRFFMCN VDDLKFLADM IEHVPLTLKV
RYVFCMAPIS RKKPFVCGMF LRYARKFSRG EPLTSDWLAR TIGWPFSAPT KIIDLVHLED
VFDVLDTYLW LGYRFTDMFP ETEQVRAMQK ELDVLIRESL QNVKQLLKTV QVAGLFEQQG
LNFDSRNPTT ATNAAAAAVA KDSSTKMKQA TTTTTVRKGG VIQSLIKQGL LTPGMLGFTL
QTRSQRISFC NVSFLWRWIR PNKTILTTNR HQQNPLACCC AINVLLVVDL ACRATDVPPG
DRCDTCRFLA RSFEKGFNDT NKSHFEGGNT AWENENLGKY STSETRFIEI MELICSKKSK
DVKEESKIKN LESKCHAMAE EYEETLETWY YHNQKKYPDL FDWFCIKTVK GICLKIIVLL
QYVVQTIHSV LPVRHALAIQ NGHVLEMAFV RAVEADLDRE NVNATGDIRE NCAGIVTVIF
SKSIPTKRIF CVNVRLKCAI TLFNIRCTAC HESCKGGCSG EGPKECHSCR VGWIMDEDTG
CKDIDECESS PCTDQFEKCE NTPGSYKCVC AEAFRREDGV CIPDPDVPRP KPVFFGLLAQ
EVLRYASYFG LLLSFLLILL RPKTPLIVLF TCSLVIIALI EAGHAVRMLN AIFLGDQAL
//
