ID   A0A151GHA2_9HYPO        Unreviewed;      1267 AA.
AC   A0A151GHA2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=DCS_03474 {ECO:0000313|EMBL:KYK56474.1};
OS   Drechmeria coniospora.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Drechmeria.
OX   NCBI_TaxID=98403 {ECO:0000313|EMBL:KYK56474.1, ECO:0000313|Proteomes:UP000076580};
RN   [1] {ECO:0000313|EMBL:KYK56474.1, ECO:0000313|Proteomes:UP000076580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 6962 {ECO:0000313|EMBL:KYK56474.1,
RC   ECO:0000313|Proteomes:UP000076580};
RX   PubMed=26975455; DOI=10.1038/srep23122;
RA   Zhang L., Zhou Z., Guo Q., Fokkens L., Miskei M., Pocsi I., Zhang W.,
RA   Chen M., Wang L., Sun Y., Donzelli B.G., Gibson D.M., Nelson D.R.,
RA   Luo J.G., Rep M., Liu H., Yang S., Wang J., Krasnoff S.B., Xu Y.,
RA   Molnar I., Lin M.;
RT   "Insights into Adaptations to a Near-Obligate Nematode Endoparasitic
RT   Lifestyle from the Finished Genome of Drechmeria coniospora.";
RL   Sci. Rep. 6:23122-23122(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYK56474.1}.
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DR   EMBL; LAYC01000002; KYK56474.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151GHA2; -.
DR   STRING; 98403.A0A151GHA2; -.
DR   InParanoid; A0A151GHA2; -.
DR   OrthoDB; 2735303at2759; -.
DR   Proteomes; UP000076580; Chromosome 02.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   Gene3D; 1.10.8.790; RNA-dependent RNA polymerase, slab domain, helical subdomain-like; 1.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF14; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076580};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT   REGION          122..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..152
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1267 AA;  143895 MW;  6A49158740F88FE2 CRC64;
     MGHEMENEFR RIISSLDKNH RLGLSPTDPS LSPRSSIEQL HEGTEKDRLR TIYQGLQFLH
     SSQPPRFWQC LERFRVEALK IHEQFNLHQS EGSRSSNAYV AERKELQRCL FNILFAEPST
     ASSSNKAKRS SDDFGKSNFK RPRNRSTDEP PKSNKNKILL VDSIPVRSRE SSPCVGVFAQ
     EGRKTSIMSY FSKSSAKVSS SSSASSSFPS RTSNGIGKSP SEQTSFTTVT TDDLFPLCSQ
     EYRALSESFS AFDSSSCRNT DATYANMKLT SPTKEPEVSW TLQDRLKNIW PNLPNESFNE
     APLAISWEVT RISQHCGVNL AGCDLVYNPN WRDQTTMREG LATCGPFLGK VLPQIVDTQL
     WMAALGTFEL HPQIVTISAK LEYNASHDGP LFITRLHPLK LEFGHRLSRR FGADRFLEIL
     VPSLATKERP ASAKHGSNID IINWLATTSH FMLGRNWRLY YMTKKKKTVQ LASKSKTVYL
     DRLHFFAVDG ITFRPSNTSG GPPPPEEAFS PNRRTKMKLG ALLDWTIHIS NNLSQPVPKL
     FSRIALSLTR TTPTVELQKH EIIHESKDII VDSIVMNDGI GRMSKSLAKR IADHLKLENT
     PAAYQARIGS AKGMWIINTD DDGFSDDFWI STYPSQRKWD CDFDDPLHRT FEVKDWPRRP
     RPAALNQQFI PVLEERASDP AAMRQAIAEH LRSSLLADMD AFKEALVHPE NLRHWLDQSR
     QSRQDHISHG HVPYSGGLPT SPEYALICLL DAGFDLQKNK YMQDRCQDIA DRISKRLSDK
     THIKIPQSTN LFMVPDFCSV LEEGEVHVAF STMYQTDGFS DTLLEGMDIL VGRSPAHFES
     DIQKARAVSH PKLRQLKDVI VFPMKGKSCL ADMLSGGDYD GDRAWICWDR KIVDNFCNAP
     VPNCDDLFQQ GYLTKLDLPV QDFCDEKWDI DMVCDKFVSN GVQFNMQPFL LGICTNCKEK
     LSYYENTVSG PKIVAYSNLL KHLVDQSKQG IWFSFNDLSR FQNEVVGSKK YLDEPEYMSD
     RPSGHVWGPI NGQVRQKHIL DYLKFDVAKP AIDDARESFS KAFQGTAGQY YDEDLTKCVN
     HYEKKRATSE TWNIVFKHLQ SKIEAVASEW QDKMGQGPGD FAIRVSRTKQ IHQRWMQIGP
     PEGLPSNDAV SDLMESWSRD PGSATWSLLK ASLTFKLYHK RKPKFTWQIA GRQLCKIKDR
     MTCDNGETAS VVIGARMFAA LRSDRRFNAT LGVPRGMPRD NESMLAMDEV RRYDEVGTQL
     IYDEPSL
//