ID A0A168FAA1_9HYPO Unreviewed; 1199 AA.
AC A0A168FAA1;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=AAL_02223 {ECO:0000313|EMBL:KZZ99651.1};
OS Moelleriella libera RCEF 2490.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Moelleriella.
OX NCBI_TaxID=1081109 {ECO:0000313|EMBL:KZZ99651.1, ECO:0000313|Proteomes:UP000078544};
RN [1] {ECO:0000313|EMBL:KZZ99651.1, ECO:0000313|Proteomes:UP000078544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCEF 2490 {ECO:0000313|EMBL:KZZ99651.1,
RC ECO:0000313|Proteomes:UP000078544};
RX PubMed=27071652; DOI=10.1093/gbe/evw082;
RA Shang Y., Xiao G., Zheng P., Cen K., Zhan S., Wang C.;
RT "Divergent and convergent evolution of fungal pathogenicity.";
RL Genome Biol. Evol. 8:1374-1387(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZZ99651.1}.
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DR EMBL; AZGY01000003; KZZ99651.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A168FAA1; -.
DR STRING; 1081109.A0A168FAA1; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000078544; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd21691; GH2-like_DHX8; 1.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR049588; DHX8_GH2-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KZZ99651.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000078544}.
FT DOMAIN 231..302
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 543..706
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 724..904
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 133..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 134816 MW; 270C5CF016D80039 CRC64;
MDDFFNLELL SLISKVTSEL QNHVGVGDKT LAEFLIAQRL ESTNTDVFRK KLDDIGADFP
PSLVDSIDRL VLAMHPKFKG KGDENNEVEH QSRTLAEKEK VFSGLALADK AVENGGTDAI
DETLALLESL EGELKRGKAS RKRSRSPEHY DDDKSLRKRR DRSRSHEQRD HRHRSRSRSR
ERGDEDWRDG YNSKRRERRG RRRRSFEYDS EDHDRFRRAP EPEIDDAPQM HKVYKGHVTG
VKDFGAFVNL HHVRGRVDGL VHISRIVAGQ RVNHPSDLLS KDQTVWVKVC SIEGSRIGLS
MKDVDQETGM DLEPQARLTT GANMEALGGS AKNGSSHVAS GMPRDSIGPP RQHKKRMTSP
ERWEIRQLIA SGVAKASDYP DLEEDYNATL RGDGEMELEE DVDIEVREEE PPFLAGQTKQ
SLELSPIRVV KAPDGSMNRA AMSGTAIAKE RKELKQQEAD TAAKERKSGQ DLSSQWHDPM
AEPDKRSFAS DLRQARMNAE AEQVPEWKKA AVPKAQATVK RTNLSMKEQR ESLPVFTFRS
QIIKAVEENQ ILIVVGETGS GKTTQLTQYL AEAGFSDKGI IGCTQPRRVA AMSVAKRVAE
EVGCRLGGEV GYLVRFDDCT SPDTRIKYMT DGMLQREILM DSDLKRYSVI MLDEAHERTI
ATDVLFALLK KAVKRRPDLK IIVTSATLDA DKFSSYFNEC PIFTIPGRTY PVEILYSREP
ESDYLDAALV TVMQIHLTEP KGDILLFLTG KEEIDTACEI LYERMKALGP SVPDLLVLPV
YAQLPPEMQS RIFEPAPPGS RKVVIATNIA ETSITIDEIY YVVDPGFVKQ NAYDPKLGMD
SLVITPVSQA QANQRAGRAG RTGPGKCFRL YTEAAYQSEM LPTTIPEIQR QNLSHTILML
KAMGINDLLH FDFMDPPPVN TMLTALEELY ALSALDNEGL LTRLGRKMAD FPMDPSSAKV
LLAAVDHECS DEALSIIAML SLQGVVFYRP KEKQTQADQK KAKFHDAHGD HLTLLNVYNS
WKQNGFSNPW CFENYIQARS MRRAKDVRDQ LVKIMERYKH PIVSCGRSTD KIRRALCAGF
FRNAARKDPQ EGYKTLTEGT PVYLHPSSAL FGKQAEWVIY HDLVLTTKEY MHCTSAIEPK
WLVDAAPTFF KVAPSDKLSK RKQAERIQPL YNKFAGDDDW RLSAQRRGGR GGGGGGTWG
//
