ID A0A182E3Z9_ONCOC Unreviewed; 1182 AA.
AC A0A182E3Z9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=NOO_LOCUS2713 {ECO:0000313|EMBL:VDK66900.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t02713-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t02713-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK66900.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYRW01000452; VDK66900.1; -; Genomic_DNA.
DR STRING; 42157.A0A182E3Z9; -.
DR WBParaSite; nOo.2.0.1.t02713-RA; nOo.2.0.1.t02713-RA; nOo.2.0.1.g02713.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087}.
FT DOMAIN 301..467
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 574..754
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 183..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 134932 MW; EA62C934EBE404F0 CRC64;
MKKKITRSTT ENECINLRQT EISSGDYNNA ADTTNALILP AKIKKKNIKK KSDKVINRKK
DEARKRRLEE TEAKISKTKR KKLIKIMEKK KKKESKESLL ENLMQYQLPT DTMSKLTAKV
HPRKPEKLEE SFIPKKLSSL AGREFIPLPE LKKDPVQENY YETGSESEDD VLLTEEITMK
AESSKCSVDS NDMGEKQIED NTDRRSENLA NQSQPSFFAN EMIDIDDNKS KIECHKEMHL
LDSNTSELDI ANLPVKISSI TKKISILEDA QKIKFVPVHR SESVEAQRSK LPIYAEEQSI
MEAVNDNCAT IICGETGSGK TTQLPQFLYE AGYSRHGKLI GITEPRRVAA ISMAARVAQE
MNLPNAVSYQ IKYEGNRSAD TSILFMTDGV LMKEMQKDVM LSAYSVIIID EAHERSMYSD
VLIGLLTRIA PYRLRMGSPL KLIIMSATLR LDDFRNKRVL DASVLDPSFR LFPVSLPPVL
SIDVRQYPVS IHFEKRTPEN YLTAAFHKIC EIHEHKSPGT ILVFLSGKLE VMALLKWLVE
RYTIRQKTYK RKKKKVGEEK LKQNQLELGK TIPNKSKRIE KPADEEQTDD RFADADLDCG
DSGSEMDELN FCPEASRPRN SSALPLFCLP LYSLLSSKKQ QRIFEPVPDG HRMCVIATNV
AETSLTIPAV RYVVDSGREK RRNYDPVTGV SQFVVSWISQ ASADQRAGRA GRVQPGEVYR
LYSSAVYSDF EKFSAPEILT KPVDQLVLHL KSMNIVKVTN FPFPTPPDKD SLEEAEKRLI
RLGALQVTVR NNVKEARISL FGKTLSIFPL APVFAKILVM ANQHSLISHA CCLVAALSVR
EPLVPLYSLR GGSAQETQAL MLEALKQRRS WCPPGQARNF GDLTVLLRAI LSAETSEGSE
KECHRLGVRY KALIEIRKLR QQLTKIINSK CPQDKSLMVN LDMKPPTDEE ILMLRQIVTA
SLTDNIARRV DPIATESVPK GAYQSQKLKD YVYIDPSSIL FKDEPDWVLY HEIVERKDKK
YMQNVICVEE NWLPRLANTY CHFKPIKEVE PRYDSATDNI VIFMNGTFSD MHWPLGKIEQ
PLPVNINLYR YFAQFFLDGS ICPSLAVYSD KLLLSPNTMT KPWAKLQLRT EKLLNALIEY
EVTNRKRLLE VWRNKSEYLL DEYLEWLPQF LHENVQMNWP PN
//
