ID   A0A182I1D9_ANOAR        Unreviewed;       673 AA.
AC   A0A182I1D9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA007385-PA.2, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA007385-PA.2}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA007385-PA.2};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; APCN01000054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182I1D9; -.
DR   EnsemblMetazoa; AARA007385-RA; AARA007385-PA; AARA007385.
DR   VEuPathDB; VectorBase:AARA007385; -.
DR   VEuPathDB; VectorBase:AARA21_005811; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd17978; DEXHc_DHX33; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ   SEQUENCE   673 AA;  75594 MW;  6AABAD2817242BB2 CRC64;
     MDSGLSSRNS SLGNQYSRSY MKQEQAKQQR LSLPIYSVRK SLMEMVRKSS TIIVLGETGS
     GKTTQMPQFI YEAGLNGDKM IAITQPRRVA AITVAKWVAQ EMGTNLGDLV GYTVRFEDMT
     SENTQVKYMT DGILCREALS DRQLRNYNVI ILDEVHERTI ATDVLLGVVK KAQQIRALKR
     MTPLKVIIMS ATMDCDHFAS YFSDCPIVYL QGRTYQVKVY QMVEKMHYIE ACLKTVVEIH
     QTQPAGDVLV FLTGQEEIEA TVGKMRRLAK SFSPDLPKLA VHPMYAALPQ NQQLDVFNPA
     PGNVRKVIFA TNIAETSITI NGIRYVVDCG RAKVRAYDPI TGMDMLKVSW ISQAQAHQRT
     GRAGRLSDGV CYRTYSKEVY GHLEKMTTPE ILRCNMAATI LNLLVMGVNY KDFDFIDKPP
     EEAIVGGLLE LKALNAISSV ENPILTALGT KMARFPLDPK YSKMLLSAPK FGCLEEMLTI
     IAMLSGENVF TNSVHKREQM LIAHSKFFDR SGDHITLLNV FNEFKTRAKP KVWCFDNFLN
     ERNLTHVASI REQLSEICKA LDLPSSTCGK DTTPVAKCLL TGLFANIATK QPDHLYLTST
     SALKARIHPS SAVCGKFRPP VVVYTELVAT RLNYLRNVTE IDPAWIDEVV PNVSQYQTKG
     FKENHFRAFQ SHK
//