ID A0A182Q5Z8_9DIPT Unreviewed; 1633 AA.
AC A0A182Q5Z8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=[histone H4]-N-methyl-L-lysine(20) N-methyltransferase {ECO:0000256|ARBA:ARBA00012188};
DE EC=2.1.1.362 {ECO:0000256|ARBA:ARBA00012188};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF003732-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF003732-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF003732-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AXCN02001228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 69004.A0A182Q5Z8; -.
DR EnsemblMetazoa; AFAF003732-RA; AFAF003732-PA; AFAF003732.
DR VEuPathDB; VectorBase:AFAF003732; -.
DR OrthoDB; 5396777at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140941; F:histone H4K20me methyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd19186; SET_Suv4-20; 1.
DR Gene3D; 1.10.10.1700; Histone-lysine N-methyltransferase; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR041938; Hist-Lys_N-MTase_N.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR039977; Suv4-20/Set9.
DR InterPro; IPR025790; Suv4-20_animal.
DR InterPro; IPR044426; Suv4-20_SET.
DR PANTHER; PTHR12977:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B-RELATED; 1.
DR PANTHER; PTHR12977; SUPPRESSOR OF VARIEGATION 4-20-RELATED; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 153..264
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1536..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..951
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1536..1552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1553..1570
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1633 AA; 170735 MW; E643F261E7CD9C9B CRC64;
MCEHAMNLTC TDEQSHQQQQ HQPQQQQQQH TRNSNQLHKL AQVASPGTGM TPKELSDNDD
LATGLVLDTI LGFQTHKMSL KYRPLKANKD EIKNIIEEFI RTQNYGKCYQ QLINGSWMPR
SVLNKNKLAL KRLEAHIYRY LRVFDQHSGF VIEACYRYSL EGQKGAKICS TRRWMKNEKI
ECLVGCIAEL TEREEEDLLH PGRNDFSVMY SCRKNCAQLW LGPAAYINHD CRANCKFVAT
GRDTACVKVL RDIQVGEEIT CFYGEDFFGD NNCYCECETC ERRGTGAFAA RARLYEGPAA
LLGSGMPGGS IGYAGESGAG ATYIEGGTMV NGGGHGVGEA GCYAPGLYAA AGGANGVVGG
GGGLGGGIVI GVANGGSIRY RLRETDNRLN RMKNKRLNGG VAGAELNGGG PGVKVVSTTA
IGKEPPSALS LLTVRELRDK GMTKYDAEML LAQQKPYCTT GGGAAAAPAP SIPPHPIPAR
PAAATTTATP PDESKKAPPT SDKSERQQKR ATRSSTCGGG KAAPGGAKPA EDDKPTDAPT
TGGSKNPRRR NSSYSSATAE LLSTSASADG RKSQPLAGKQ RQTVGPSAGR KRSKKDDGMV
RRRAASVVPS GGAKGDRARS KDPSDDVIVI DDDCSNSSTG SSATTTTTTT TSTTNSTATS
TAGAQLRFND GALNRKRRAS MYTSSSRSIY TFHEDEPVEG PTVNGVYALR NSTVPFADVT
RQARTKAGAA PATRKRTRES TPDGGGTKRP DSSTGTGNAT STTNTNNING RIVTRRMSLR
LAGGSAMVTP EPVPVPPPWA PPAETTTEEA AASATAPTST TRVTRGMMRL LEDSESAAEK
QPVGGKTTTP TPTPPSLTTR RLTRRWSMML SGEERSAMDS EVVVTAAEAE PAEATVGIRA
TTAASTTRRR KQTPQHKRHP QRSGGSTAHD DNDGGLGAKQ AEEEEVLERL QHSQGVRPTA
SSAGGTSTSN RNRKQLAPTK RARGGVGGVV NSSSSASSAS SSSSCASAIP PVSAAKHRTL
QAIADQQRLK LKLRMKPTEP MAMEGSAECK ADGQSTSVGT TTVASDEDDE DDIILSKMLQ
RGSAYQRPRA QAASSEASRA ASTISSAAIS SSTPAVAAVA APTTPPKAPR DQPAAELSPS
IYSLSSTSSS TAALDPSMRT PERRLKLTLR MKRSPVIDEI IESGNSLSDA PDNNGGSPSA
YRREYEILRM EGLRDPDEEE LEEADDRRRQ SVAAATTTAT GYRHHSRRTL TYDSLGNGNE
QQQLEQDDER EGNGGGGCGG DDDDEEEDLT SYSSSCSSLN GSATLLPPPP PAPLTLPNGT
VDPSYCPSAS YVLLPSQEQS SMYQQQQRVP PNHHQQSVIL SGSGGGDGDD WYNIHPVNLR
WTLPSNNVAA SGTSCGATPS VASAVGGGNG GVGLPLKRLR LIFDNETLTR NIPPYEGEGG
NRAIPSAAAA AAATAPAACD SLTLVGRPSS EAVTPLQRNV LHCALPELGL INNTPGVIVS
PAPRTSSGGG VGGGGDGGVS AASNGLLLRP QQLRHQLQAT KASTVTTTAS VPSFPQPPAP
PPPPAPAPLP ASVTSSGAPG SAPGDDSGVG GGGGGGGGGA GAGAGGLQTT VSIEWWRLPQ
THRGAPVSNK CIT
//
