ID A0A1A9Z7A1_GLOPL Unreviewed; 1262 AA.
AC A0A1A9Z7A1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Glossina pallidipes (Tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=7398 {ECO:0000313|EnsemblMetazoa:GPAI006083-PA, ECO:0000313|Proteomes:UP000092445};
RN [1] {ECO:0000313|Proteomes:UP000092445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092445};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPAI006083-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPAI006083-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A1A9Z7A1; -.
DR STRING; 7398.A0A1A9Z7A1; -.
DR EnsemblMetazoa; GPAI006083-RA; GPAI006083-PA; GPAI006083.
DR VEuPathDB; VectorBase:GPAI006083; -.
DR Proteomes; UP000092445; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd17971; DEXHc_DHX8; 1.
DR CDD; cd21691; GH2-like_DHX8; 1.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044762; DHX8/Prp22_DEXHc.
DR InterPro; IPR049588; DHX8_GH2-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 307..378
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 618..781
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 799..977
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 76..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..260
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1262 AA; 143568 MW; 91A4AA3FDC58C45C CRC64;
MDELQKLEHL SLVSKLCTEL DNHLGINDKD LAEFIIHLES QNPTLEDFRK ALNQHGAEFP
NSLVANLQRI IKLMRPSSAN NNGEQNTYDK ASNSNDQNSR TAQLAKMFPG LAMPNDKFSE
EHVSSDKIYG KEESKVKQNN LGNDDLNIVD AAMNELAALA SESDKMNKQN ESVKKKEGKS
CSESKYKDRK RRKSYEEEKK ARKERSRSRS KYRRDVSKRS PGRDRSKTRG HRHREHRRYS
RSRSNDRSNR RRKSRSHSNE RSNRKRNSRP RSHDRSNHRR NSHSQSPESK RGKTVSSIPI
TDDPEPGKIY SGKVANIVPF GCFVQLYGLR KRWEGLVHIS QLRSEGRVTD VTEIVSRNSI
VKVKVLSITG VKVSLSMKEV DQDTGEDLNP LSHAPPPENE LLDRNPDRPF GGGTSLLNLQ
RAGDNDESDS RKRVTRISSP ERWEIKQMIS SGVLDRSDLP DFDEETGLLP KDEDDEEDIE
IEIVEEEPPF LAGHGRALHD LSPVRIVKNP DGSLAQAAMM QSALSKERRE QKMLQREQDM
EAAPTGLNKN WIDPLPDEDT SRTLAANIRG VGGGPAEVPE WKKHVIGGKK SSFGKKTDMS
LVEQRQSLPI YKLRDDLIKA VTNNQILIVI GETGSGKTTQ ITQYLAECGF TARGKIGCTQ
PRRVAAMSVA KRVAEEYGCR LGQEVGYTIR FEDCTSPETV IKYMTDGMLL RECLIESDLK
SYSVIMLDEA HERTIHTDVL FGLLKSAVQK RPELKLIVTS ATLDAVKFSQ YFFEAPIFTI
PGRTFPVEVL YTKEPETDYL DASLITVMQI HLREPPGDIL LFLTGQEEID TACEILYERM
KSLGPDVPEL IILPVYSALP SEMQTRIFDP APPGSRKVVI ATNIAETSLT IDGIFYVVDP
ALMYNHFATT VLQFIYLFCN VLAAAKQRAG RAGRTGPGKC YRLYTERAYR DEMLPTPVPE
IQRTNLATTV LQLKTMGIND LLHFDFMDAP PVESLVMALE QLHSLSALDD EGLLTRLGRR
MAEFPLEPNL SKMLIMSVAL QCSDEILTIV SMLSVQNVFY RPKDKQALAD QKKAKFNQIE
GDHLTLLAVY NSWKNNKFSN AWCYENFVQI RTLKRSQDVR KQLLGIMDRH KLDVVSAGKK
SVRIQKAICS GFFRNAAKKD PQEGYRTLVD SQVVYIHPSS ALFNRQPEWV IYHELVQTTK
EYTREVTTID PKWLVEFAPS FFRFSDPTKL SKFKKNQRLE PLYNKYEEPN AWRISRVRRR
RN
//
