ID A0A1B0CSB1_LUTLO Unreviewed; 904 AA.
AC A0A1B0CSB1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Proline dehydrogenase 1, mitochondrial {ECO:0000256|ARBA:ARBA00041059};
DE EC=1.5.5.2 {ECO:0000256|ARBA:ARBA00012695};
DE AltName: Full=Proline oxidase {ECO:0000256|ARBA:ARBA00041725};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ007760-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:LLOJ007760-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ007760-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC glutamate; L-glutamate from L-proline: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004739}.
CC -!- SIMILARITY: Belongs to the proline oxidase family.
CC {ECO:0000256|ARBA:ARBA00005869}.
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DR EMBL; AJWK01025870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01025871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0CSB1; -.
DR EnsemblMetazoa; LLOJ007760-RA; LLOJ007760-PA; LLOJ007760.
DR VEuPathDB; VectorBase:LLOJ007760; -.
DR OrthoDB; 5473051at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0004657; F:proline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.220; -; 3.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR002872; Proline_DH_dom.
DR InterPro; IPR015659; Proline_oxidase.
DR PANTHER; PTHR13914:SF0; PROLINE DEHYDROGENASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13914; PROLINE OXIDASE; 1.
DR Pfam; PF01619; Pro_dh; 2.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062}.
FT DOMAIN 178..627
FT /note="Proline dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF01619"
FT DOMAIN 656..873
FT /note="Proline dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF01619"
SQ SEQUENCE 904 AA; 104354 MW; 0EA8361C7ED83225 CRC64;
MAFLRSAVRY NHLLFTRKAT GKASSLDFLS GQCLNVTPAA TLSLFSIFEQ RTTPRNISVR
HLSQRPAGQV VDPTKQDVKG TRANSTVAAA GHLEQPQRDP LDVRFSDPHA AFKSKTTFEL
VRAYLVYLVC SSSYLVEHNM QLMKLAQALL GDKLFIWLMQ STFYGHFVAG EDRFKIVPTL
ERLRSFGVKP ILDYSVEEDI SQEEAEKREV ESSVSESTQD TTTMPQYKVD KTFADRRYKV
QSARTYFYLN EATCERNMET FIECLEAVSG ATFGTGITAI KLTALGRPQL LLQLSEVIMR
ARQYMLELCG GTGNVLTHHK TIKDLEQYYS GVSDNKEVKD FLKNMTTDKE GILHLFPWSG
IINENFELSD SFRVPDPKTG QMRRLISQIP PKEEEMFRNM IRRVNTIVKT AEELDVRIMI
DAEQTYFQPA ISRITLEMMR QYNTKKAIVF NTYQCYLKDA FQEVTTDLEQ AKRQNFYFGA
KLVRGAYIEQ ERARAAALGY PDPTNPNFEA TTEMYHKTLT ECLRRIRHQH YRFGRYCDDA
KKIGIMVASH NEDTVRFAIE KMNEIGILPE DKVICFGQLL GMCDYITFPL GQSGYSAYKY
IPYGPVKEVL PYLSRRAQEN KGVLKKIQKE KQLLRAEIVR RLFRGKLFYT PKGNYTAEEL
DVRIMIDAEQ TYFQPAISRI TLEMMRQYNT KKAIVFNTYQ CYLKDAFQEV TTDLEQAKRQ
NFYFGAKLVR GAYIEQERAR AAALGYPDPT NPNFEATTEM YHKTLTECLR RIRHQHYRFG
RYCDDAKKIG IMVASHNEDT VRFAIEKMNE IGILPEDKVI CFGQLLGMCD YITFPLGQSG
YSAYKYIPYG PVKEVLPYLS RRAQENKGVL KKIQKEKQLL RAEIVRRLFR GKLFYTPKGN
YVPI
//
