ID A0A1B8E5G6_9PEZI Unreviewed; 1007 AA.
AC A0A1B8E5G6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=VE03_03946 {ECO:0000313|EMBL:OBT66614.1};
OS Pseudogymnoascus sp. 23342-1-I1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1524831 {ECO:0000313|EMBL:OBT66614.1, ECO:0000313|Proteomes:UP000091879};
RN [1] {ECO:0000313|EMBL:OBT66614.1, ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|EMBL:OBT66614.1,
RC ECO:0000313|Proteomes:UP000091879};
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Comparative genomics of Pseudogymnoascus destructans, the fungus causing
RT white-nose syndrome of bats.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000091879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=23342-1-I1 {ECO:0000313|Proteomes:UP000091879};
RX PubMed=29295979; DOI=10.1038/s41467-017-02441-z;
RA Palmer J.M., Drees K.P., Foster J.T., Lindner D.L.;
RT "Extreme sensitivity to ultraviolet light in the fungal pathogen causing
RT white-nose syndrome of bats.";
RL Nat. Commun. 9:35-35(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
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DR EMBL; KV454993; OBT66614.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B8E5G6; -.
DR STRING; 1524831.A0A1B8E5G6; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000091879; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000091879}.
FT DOMAIN 323..486
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 508..683
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 113115 MW; 14315183B4C307CD CRC64;
MAGEDGFQSP KRRKIDFNPL RNDDRFAIPS RPTSRSQSQA PPRSHSQAPP RSQSRLGASS
SRASTPRGQS QYPSTPRQHE FDGPEPAVAV EDSNALDRDW YGGDEGGHVF GDEMHNPFGS
YDTSWEERQR EAALVEKKTA KRVTARAAQK QRDVDAWETN RMLTSGVAQR RDFGDDFEDD
EEQTRVHLLI HDLRPPFLDG RTVFTKQVDP VPAIRDNQSD MAVFSRKGSR VVKERRQQKE
RQKQAQEATN MAGTALGNLM GVKEDEGDSA APAPGEEGGG KGDSKFAEHM AKKSEGASNF
SQSKTLREQR EYLPAFAVRE DLLRVIRDNQ VVIVVGETGS GKTTQLTQFL YEDGYGKRGM
IGCTQPRRVA AMSVAKRVSE EMECKLGSTV GYAIRFEDCT SKDTVIKYMT DGVLLRESLN
ESDLDRYSCV IMDEAHERAL NTDVLMGLFK KVLARRRDLK LIVTSATMNS KRFSDFYGGA
PEFFIPGRTF PVDVMFHRSP VEDYVDQAVQ QVLAIHVSMG AGDILVFMTG QEDIECTCEL
IQDRLNALND PPKLSILPIY SQMPADLQAK IFDRAAPGVR KVIVATNIAE TSLTVDGIMY
VVDAGYSKLK VYNPRMGMDT LQITPISQAN ASQRSGRAGR TGPGKAFRLF TEAAYKDELY
IQTIPEIQRT NLSNTVLLLK SLGVKDLLDF DFMDPPPQDT ITTSLFDLWA LGALNNIGDL
TDVGLKMTPF PMDPSLAKLL ITSEEYGCSE EMLTIVSMLS VPSIFYRPKE RQEESDAARE
KFFVPESDHL TYLHVYSQWK SNGYSDAWCT RHFLHPKSLR RAKEIREQIG DIMKMQKMTM
VSCGTDWDVI RKCICSGYYH QAAKVKGIGE YVNLRTSVAI QLHPTSALYG LGYLPDYVVY
HELILTSKEY MSTVTSVDPK WLAELGGVFY SVKEKGYSAR EKRVTEVEFN RKMEIETQMA
EDKKNEEERL ERERGRGEAK TEGVVVKKVA QRGAVRRPVV KRSGRGF
//
