ID   A0A1G4MF11_LACFM        Unreviewed;      1119 AA.
AC   A0A1G4MF11;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=LAFE_0F05512G {ECO:0000313|EMBL:SCW02396.1};
OS   Lachancea fermentati (Zygosaccharomyces fermentati).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=4955 {ECO:0000313|EMBL:SCW02396.1, ECO:0000313|Proteomes:UP000190831};
RN   [1] {ECO:0000313|Proteomes:UP000190831}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Devillers H.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; LT598490; SCW02396.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G4MF11; -.
DR   STRING; 4955.A0A1G4MF11; -.
DR   OMA; DPMVAPE; -.
DR   OrthoDB; 3682876at2759; -.
DR   Proteomes; UP000190831; Chromosome f.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008186; F:ATP-dependent activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:UniProt.
DR   GO; GO:0022613; P:ribonucleoprotein complex biogenesis; IEA:UniProt.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd05684; S1_DHX8_helicase; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR049621; S1_DHX8_helicase.
DR   InterPro; IPR003029; S1_domain.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50126; S1; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190831}.
FT   DOMAIN          194..266
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   DOMAIN          467..630
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          652..828
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          322..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1119 AA;  126679 MW;  23799BDF2695376E CRC64;
     MGLLEKKICS LLGIEDDVVA EFIVEIHSKC SGLKEFQDKI AELDGGVDSD TASIIHDIIT
     GRNHDLKTDF DNSPGLKDLL LMKEQVANIL RDSIGSDDPT VVDFMIDICS KSESSREFQE
     KMTNMDTGLS NETVDKIYEC VWDTANAAAK FDVLGMPNEK VNWDDFKESE VKRSLSQNRN
     SQLPIAQDSE PIINKIYEGV VKNITVFGCF VRILGVRNTR LDGLVHISEL SSHRVDKVSD
     VVSTGQHVFI KVIRIQSNGK ISLSMKNVNQ TTGVEEQISR GRNLRKPEIK RRKLTSPERW
     EIRQLIASGV ASIDDYPELK EELEQNSQTT KRPDPEMDNV EIELNTDDEP KFLKGQNEHE
     NRYEMPTITK VPKGSLTRTA IGGSQIMKDH RDEKLRRKRE LEQEMRKTAN PDDPASKPSS
     YKSQQMALTA WERTRNREQI SYGKRTNLPM KEQRESLPVF GMRQQLIEAV EKNKFLVIVG
     ETGSGKTTQI TQYLDEEGFS AHGMIGCTQP RRVAAVSVAK RVAEEMGCRV GEDVGYTIRF
     EDETSPKTRI KYMTDGMLQV EALMDQLMTK YSVILLDEAH ERTIATDVLF ALLKNAALKR
     SDLKVIVTSA TLDAEKFSSY FMDCPIIQIP GKTFPVDVLY SQTPQMDYIE SALDTVMEIH
     INEGPGDILV FLTGQEEIDT CCEILYERVK TLGDSIQQLL VLPVYSALPS EIQSKIFEPT
     PDGCRKVIFA TNIAETSITI DGIYYVVDPG FSKINTYNPH IGMEQLVVSP ISQAQANQRK
     GRAGRTGPGK CFRLYTESAF RNEMLPNTIP EIQRQNLSHT ILMLKAMGIN DLLHFEFMDP
     PPRGSMFSAL EDLYNLQALE ENGALTKLGK QMSLFPMEPA LSKTLIASVS NNCSEEIAII
     ISMLSVQNVF YRPKDKQQDA DNKKVRFHHP YGDHLTLLNV YKRWKENNYS KAFCTNNYLH
     ERHLRRAKDV MTQLISIFKK LHLPIVSCYG DLDLVRKTLV SGFFKNAAKR DSQVGYKTIS
     DGTSVSIHPS SALFGKDHEY VIYHSLVLTS REYMSHVTAI DPQWLVQSAP HFYKVAGADS
     ENRKRAKIAP LHNKFSRDQD SWRLSSIRQT KEKALGIRR
//