ID A0A1I7RNS8_BURXY Unreviewed; 1182 AA.
AC A0A1I7RNS8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=BXYJ_LOCUS12289 {ECO:0000313|EMBL:CAD5232198.1};
OS Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides
OS xylophilus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Aphelenchoidea; Aphelenchoididae;
OC Bursaphelenchus.
OX NCBI_TaxID=6326 {ECO:0000313|Proteomes:UP000095284, ECO:0000313|WBParaSite:BXY_0236500.1};
RN [1] {ECO:0000313|WBParaSite:BXY_0236500.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:CAD5232198.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ka4C1 {ECO:0000313|EMBL:CAD5232198.1};
RA Kikuchi T.;
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; CAJFDI010000005; CAD5232198.1; -; Genomic_DNA.
DR EMBL; CAJFCV020000005; CAG9124262.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I7RNS8; -.
DR SMR; A0A1I7RNS8; -.
DR WBParaSite; BXY_0236500.1; BXY_0236500.1; BXY_0236500.
DR eggNOG; KOG0922; Eukaryota.
DR Proteomes; UP000095284; Unplaced.
DR Proteomes; UP000582659; Unassembled WGS sequence.
DR Proteomes; UP000659654; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd21691; GH2-like_DHX8; 1.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR049588; DHX8_GH2-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000659654}.
FT DOMAIN 221..291
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 532..695
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 713..893
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 79..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..188
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 134685 MW; 73EE55997940666A CRC64;
MDDLERLEHL SLVSKIVTEL ENHFDINDKE VAEFVISLAK ENPTFDKFKN ALIQFELDQF
DDNLIQHLLR LVVTMEPKKV TKKKRTPSPE VEHKEDGDHF IKTIADEKEV LKKKLPALAM
PNEPQPTSES LLGELEQLYQ KDLQAKQRNR SRSRSPHGRK RRSRSRDRDR RRRSRSPDGS
RRRRSRSRDR GRSDRDRDGR RRRSRSPRDR KPQLLDEVEV GKIYEGRVNN IQSFGAFIVL
DGFRKKTEGL CHISQLRNGA RVKEVTEVVN RGDRVKVKVL KTGDKISLSL KEVDQRTGED
LNPVDAPLSE DAIGVADRRP DAPWMNPERE TAEQTSVAAP GTSSRSRVRL STPERWELQQ
MKGGGAISLM DYPDFDEEKG ILNNPDESDG EDLEIELVED EPAFLKGYGK HVQEIEAVKV
VKNPDGSLAQ AALMQSALSK ERRDMKTQQQ REKEGQKPRG GVSGNKILDP MAPNETRYEE
DEPAPPSRGR EMPEWMKHVT AGGTATYGKR TSLTMKEQRE SLPIFQLKTA LLQAIHDNQI
LVVIGETGSG KTTQMTQYLV EAGYASRGRI GCTQPRRVAA MSVAKRVSEE FGVRLGQEVG
YTIRFEDCTC SDTIIKYMTD GMLLRECLLD PDLMSYSCIM LDEAHERTIH TDVLFGLLKA
AVKKRPELKL IVTSATLEME KFSEYFFGAP TFTIPGRTFP VEILYTKEPE TDYLDAALIT
VMQIHLTEPP GDILVFLTGQ EEIDTACEIL FERMKKLGSE VPDLIILPVY GALPSEMQTR
IFEPAPPGSR KVVIATNIAE TSLTIDGIYY VVDPGFVKQK IYNPKSGMDS LVVTPISQAA
AKQRCGRAGR TGPGKCYRLY TERAFRDEML PSPIPEIQRT NLASTLLQLK AMGINNLLEF
DFMDAPPAEA MITALAQLYD LSALDDDGLL TKLGRRMAEF PLEPSLSKLL IMSVDLSCSD
EVLTIVSMLS VQNVFYRPKE KQELADEKKS KFHQPEGDHC TLLAVYNSWK HHHFSQSWCF
ESFIQVRTLK RAQDVRKQLL TIMDRHKLNI ISCGRDVQRV QKAICSGFFR NAAKRDPQEG
YRTLVDGQTV YIHPSSSLFQ NQPEWVVYHE LVMTTKEYMR EVTLIDPRWL IEFAPSFFKF
ADNTKLSAYK KNQRIDPLHN KYEDPNAWRL SRLKKKIYNP NR
//
