ID A0A1I7VK35_LOALO Unreviewed; 742 AA.
AC A0A1I7VK35; A0A1S0U856;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=LOAG_02619 {ECO:0000313|EMBL:EFO25869.1,
GN ECO:0000313|WBParaSite:EN70_3434};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_3434};
RN [1] {ECO:0000313|EMBL:EFO25869.1, ECO:0000313|Proteomes:UP000095285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Loa loa.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:EN70_3434}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
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DR EMBL; JH712096; EFO25869.1; -; Genomic_DNA.
DR RefSeq; XP_003138204.1; XM_003138156.1.
DR AlphaFoldDB; A0A1I7VK35; -.
DR STRING; 7209.A0A1I7VK35; -.
DR EnsemblMetazoa; EFO25869.1; EFO25869.1; LOAG_02619.
DR GeneID; 9940003; -.
DR KEGG; loa:LOAG_02619; -.
DR WBParaSite; EN70_3434; EN70_3434; EN70_3434.
DR CTD; 9940003; -.
DR eggNOG; KOG0925; Eukaryota.
DR InParanoid; A0A1I7VK35; -.
DR OMA; MKVYPLY; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0022414; P:reproductive process; IEA:UniProt.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EFO25869.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT DOMAIN 91..259
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 284..464
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..35
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 85109 MW; 1AB0113F1F0B1448 CRC64;
MSSRHKLDIE DGDRKRERDR RKSRSKSRSP RRNRSRSRER GWERSRSPTE KLRRPTVEVN
PFNGQPYTQR YFEIFKKRTT LPVWEYKDKF LEVLDKNQCL TLVGETGSGK TTQIPQWCLE
YCKARTPPGH RRLVACTQPR RVAAMSVATR VAEEMDVQLG AEVGYSIRFE DCVSERTILK
YCTDGMLLRE AMNSPLLDSY GVIILDEAHE RTLATDILMG LIKEIVRQRK DIKIVVMSAT
LDSGKFQNYF ENCPLMSVPG RTYPVEIFYT PEPEKDYLEA AIRTVVQIHV CEEVEGDVLL
FLTGQEEIEE ACKRIKREID NLGPEIGELK CIPLYSTLPP NLQQRIFEPP PLKRPNGAIG
RKCVVSTNIA ETSLTIDGVV FVIDPGFSKQ KVYNPRIRVE SLLVCPISKA SAMQRAGRAG
RTKPGKCFRL YTEKAYKNEM TDQTYPEILR SNLGTVVLQL KKLGVEDLVH FDFMDPPAPE
TLMRALEMLN YLAAIDDNGE LTQLGSLMAE FPLDPQLAKM VIASTELNCS NEILSVTAML
SVPQCFVRPT EAKKAADDAK ARFAHIDGDH LTLLNVYHAF KQNREDVQWC YDNFINYRAL
KNADNVRTQL ARIMDKFSLK RISTDFKSKD YYINIRKALV AGFFMQVAHL ERSGHYITVK
DNQLVQLHPS TVLDHKPEWA LYNEFVLTTK NFIRTVTDVK PEWLVQMAPQ YYDMTTFPEC
DAKKKLQHTI ATLQSLRTTR GI
//
