ID A0A1R4ABE6_BABMR Unreviewed; 874 AA.
AC A0A1R4ABE6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=BMR1_03g01185 {ECO:0000313|EMBL:SJK86318.1};
OS Babesia microti (strain RI).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=1133968 {ECO:0000313|EMBL:SJK86318.1, ECO:0000313|Proteomes:UP000002899};
RN [1] {ECO:0000313|EMBL:SJK86318.1, ECO:0000313|Proteomes:UP000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RI {ECO:0000313|EMBL:SJK86318.1,
RC ECO:0000313|Proteomes:UP000002899};
RX PubMed=22833609; DOI=10.1093/nar/gks700;
RA Cornillot E., Hadj-Kaddour K., Dassouli A., Noel B., Ranwez V.,
RA Vacherie B., Augagneur Y., Bres V., Duclos A., Randazzo S., Carcy B.,
RA Debierre-Grockiego F., Delbecq S., Moubri-Menage K., Shams-Eldin H.,
RA Usmani-Brown S., Bringaud F., Wincker P., Vivares C.P., Schwarz R.T.,
RA Schetters T.P., Krause P.J., Gorenflot A., Berry V., Barbe V.,
RA Ben Mamoun C.;
RT "Sequencing of the smallest Apicomplexan genome from the human pathogen
RT Babesia microti.";
RL Nucleic Acids Res. 40:9102-9114(2012).
RN [2] {ECO:0000313|EMBL:SJK86318.1, ECO:0000313|Proteomes:UP000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RI {ECO:0000313|EMBL:SJK86318.1,
RC ECO:0000313|Proteomes:UP000002899};
RX PubMed=27752055; DOI=10.1038/srep35284;
RA Silva J.C., Cornillot E., McCracken C., Usmani-Brown S., Dwivedi A.,
RA Ifeonu O.O., Crabtree J., Gotia H.T., Virji A.Z., Reynes C., Colinge J.,
RA Kumar V., Lawres L., Pazzi J.E., Pablo J.V., Hung C., Brancato J.,
RA Kumari P., Orvis J., Tretina K., Chibucos M., Ott S., Sadzewicz L.,
RA Sengamalay N., Shetty A.C., Su Q., Tallon L., Fraser C.M., Frutos R.,
RA Molina D.M., Krause P.J., Ben Mamoun C.;
RT "Genome-wide diversity and gene expression profiling of Babesia microti
RT isolates identify polymorphic genes that mediate host-pathogen
RT interactions.";
RL Sci. Rep. 6:35284-35284(2016).
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DR EMBL; LN871598; SJK86318.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R4ABE6; -.
DR VEuPathDB; PiroplasmaDB:BMR1_03g01185; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000002899; Chromosome IIIa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:SJK86318.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:SJK86318.1};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002899}.
FT DOMAIN 246..409
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 432..607
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 874 AA; 99604 MW; 372753DA17D519A5 CRC64;
MSDADYALEA AKGRNEKLKS NSKYLERLRI EARRNYLSKR EEERLQLAER LLAEKEFVYS
AYAGKRGKEV IELEKRTIEL AKEAAEARNR LESQLEYHLP DSYDDNVSAK LALINKRAID
RSSKTTQDNE FLSWESSKIA NVKKSLRTPS GKKALFDLVP NEDGIEFIKS EIHGEMKFDT
NAPAASTIEI KKTFDEEDYD TDDSDAPETF AEKVLWKKTK QERLQHQKLT EERTKLPVFS
YRQELLEAVR KYPIVIVVGE TGSGKTTQIP QYLYEVGYGK AGRIACTQPR RVAAMAVASR
VAKEQNVKLG TRVGYTIRFE DCTSKETVIK YMTDGMLLRE MMSEPDLSSY SCLMIDEAHE
RTIHTDIIFG LAKDLSRYRQ NFRLIVSSAT LEAEKFAAYF DGAPIFNVPG RRYPVQIYYT
KAPEANYLTA SVVTALQIHL TQPLGDILIF LPGQLEIEQV QEELEARIRG FQKEIKELIV
LPIYATLPSE LQAKIFEPTP PNARKVILAT NIAETSITLD NIVYVVDPGF CKQNSYSPKT
GMESLITVPC SKASANQRAG RAGRVRAGHC FRLYTKFSYE KEMDDTNLPE IQRCNLSHTV
LMLKSLGIDD LINFDFMDPP SPDTLIKSLE LIYALGALNS SGELTRLGRR MSELPIDPMF
SKMIIGADKY ECVDECITIC AMLSVGNSIF YRPKEKAMHA DNARKNFFKP GGDHLVLLNV
YKQWEETEFN ASWCFENYVQ QKSMRRAKDV REQLLDMIEK VQLKISSSPT NYDGIKKAVT
GGFFPNAARK VSPDPKSSYK TLKHPHTVEI HPQSSLFGQE SKFVIYTELV LTTKEYMRNV
IEIQQDWLVE LAPHYYKESD SCFKVMSNKG RPRS
//
